<p>Elevated blood pressure (BP) is a significant risk factor for cardiovascular diseases (CVD), which are the leading cause of morbidity and mortality. Dietary minerals such as sodium (Na) and potassium (K) play a crucial role in overall health and play a specific function in regulating blood pressure in the human body. Numerous studies have been conducted on the association between blood pressure and dietary intervention. While many nutritional intervention studies have shown adverse effects of excessive Na intake and the beneficial impact of supplemental K in humans, less is understood on Na and K tissue retention and health outcomes of such retention. The most commonly used biomarkers to study Na retention and regulation is urine Na. However, the use of urine Na concentration as an indicator of Na retention has its limitations and has been recently questioned. In-vivo neutron activation analysis (IVNAA) is a unique and powerful technique for elemental analysis in the human body that has the potential to quantify Na and K retention and monitor their bio-kinetics. This research work designed an in vivo neutron irradiation system with high sensitivity and minimal radiation dose to measure Na/K and monitor Na/K bio-kinetics. The system was characterized, tested, and validated for K measurement in mice and rats. Moreover, we developed a methodology for in vivo quantification of Na in pigs in bone and soft tissue after dietary intervention. The project's overall goal is to exploit the potential of a compact DD neutron generator-based neutron activation analysis system for in vivo quantification of Na and K in humans and small animals.</p>

This thesis investigates a new approach for dealing with the adverse effects of large-scale deformations in the main reflector of large Cassegrain antennas. In this method, the incident aperture distribution is imaged onto a tertiary focal plane. This is accomplished by using an optical imaging system consisting of a lens mounted behind the Cassegrain focus of the antenna. The lens forms a real image of the product of the incident aperture distribution and the pupil function of the antenna. The pupil function describes the profile of the main reflector of the antenna. If the incident aperture distribution is a plane wave, a real image of the pupil function of the main reflector will be produced at the focal plane of the image lens. Any imperfections in the main reflector will be imaged onto the tertiary focal plane but over a smaller area as defined by the magnification of the system. In principle, an active correcting element placed into the tertiary focal plane could compensate for these errors, thus preserving the maximum efficiency of the antenna. Experimental verification of this principle was carried out in the lab using a dielectric lens 152.4mm in diameter. Phase perturbations were simulated by placing dielectric shims in the incident aperture plane. The phase of these shims in most cases was measured to within 10 degrees in the image plane. This degree of accuracy is found to be quite adequate for correcting large-scale errors in the main reflector of the antenna.

Radio frequency interference has become a large problem to radio astronomers. This thesis proposes the idea that radio frequency interference can be mitigated using a phased array feed in conjunction with a large reflector. A phased array feed would allow radio astronomers to observe fainter signals than is currently possible, while at the same time enabling rapid sky surveys. A phased array feed was designed and simulated, and sensitivity optimization was performed on the array feed. It was shown that higher sensitivity can be achieved using a 7-element phased array feed than with a conventional waveguide feed. Simulations were ran using RFI mitigation algorithms on the array to show that interference cancellation can, in principle, be performed using a phased array feed. In addition to these simulations, improvements were made to a previously designed RF receiver so that radio astronomy observations could be made and interference mitigation algorithms tested on a receiver platform.

Insight Photonic Solutions Inc. has continued to develop their patented VT-DBR laser design; these wavelength tunable lasers promise marked image-quality and acquisition time improvements in SS-OCT applications. To be well suited for SS-OCT, tunable lasers must be capable of producing a highly linear wavelength sweep across a tuning range well-matched to the medium being imaged; many different tunable lasers used in SS-OCT are compared to identify the optimal solution. This work electrically and spectrally characterizes two completely new all-semiconductor VT-DBR designs to compare, as well. The Neptune VT-DBR, an O-band laser, operates around the 1310 nm range and is a robust solution for many OCT applications. The VTL-2 is the first 1060 nm VT-DBR laser to be demonstrated. It offers improved penetration through water over earlier designs which operate at longer wavelengths (e.g. - 1550 nm and 1310 nm), making it an optimal solution for the relatively deep imaging requirements of the human eye; the non-invasive nature of OCT makes it the ideal imaging technology for ophthalmology. Each laser has five semiconductor P-N junction segments that collectively enable precise akinetic wavelength-tuning (i.e. - the tuning mechanism has no moving parts). In an SS-OCT system utilizing one of these laser packages, the segments are synchronously driven with high speed current signals that achieve the desired wavelength, power, and sweep pattern of the optical output. To validate the laser’s fast tuning response time necessary for its use in SS-OCT, a circuit model of each tuning section is created; each laser section is modeled as a diode with a significant lead inductance. The dynamic resistance, effective capacitance, and lead inductance of this model are measured as a function of bias current and the response time corresponding to each bias condition is determined. Tuning maps, spectral linewidths, and side-mode suppression ratio (SMSR) measurements important to SS-OCT performance are also collected. Measured response times vary from 700 ps to 2 ns for the Neptune and 1.2 to 2.3 ns for the VTL-2. Linewidth measurements range from 9 MHz to 124 MHz for the Neptune and 300 kHz to 2 MHz for the VTL-2. SMSR measurements greater than 38 dB and 40 dB were observed for the Neptune and VTL-2, respectively. Collectively, these results implicate the VT-DBR lasers as ideal tunable sources for use in SS-OCT applications.

Problem of traffic routing in autonomous system is under consideration. The solution of this problem would stabilize the operation of the network in case of accidents and high loads. A method for generating analogy of routing table based on the modification of the actual table. Two test sites were constructed for testing and finding a method of stabilization of an autonomous system routing information. The result of the introduction of an autonomous system route reflectors showed that route reflectors increases the stability of the system routing within an autonomous system and reduces the lack of communication between the nodes. / В работе актуализируется проблема маршрутизации трафика внутри автономной системы. Решение этой задачи позволит стабилизировать работу сети при авариях и высоких нагрузках. Разработан метод генерирования аналога таблицы маршрутизации на основе модификации реальной таблицы. Построены две тестовые площадки для тестирования и поиска метода стабилизации маршрутной информации автономной системы. Результат внедрения в автономную систему отражателей маршрутов показал, что они увеличивают стабильность системы маршрутизации трафика и уменьшают время отсутствия связи между узлами

Metamaterials are artificially designed materials with desired electromagneticresponses for advanced wave manipulation. Their key constituent is often somenoble metal, thanks to its well localized plasmonic effects with highextinction cross section. In this project, a metamaterial based onmetal-insulator-metal (MIM) structure is investigated to create a compactplanar reflector which mimics the function of a parabolic mirror. In such ametamaterial, each MIM unit is essentially a sub-wavelength resonator whichexhibits magnetic-dipole resonance. To achieve focusing effect, phase shift onreflected wave by each MIM unit upon a plane-wave incidence is calculatedrigorously through finite-element method. By carefully selecting unitgeometries and thereby introducing a phase gradient along the reflector plane,one can control propagation direction of reflected wave at each reflectorposition. The principle can be explained in terms of either ray-optics theoryor generalized Snell’s law. As a particular demonstration, we have designed inthe thesis a planar reflector consisting of eleven MIM units with a totaldevice width of 5.5 µm. FEM simulation showed that the reflector focuses lightat 1.2 µm wavelength with a nominal focus length of 6 µm. Such compactmetamaterial devices can be potentially fabricated on chips for sensing andtelecom applications, circumventing many inconveniences of includingconventional lenses in an optical system. / Metamaterial är artificiellt konstruerade material med vissa önskadeelektromagnetiska egenskaper, vilket kan utnyttjas för avancerad styrning avelektromagetisk vågutbredning. Metamaterialet som undersöks i denna rapportär baserad på en metall-isolator-metall (MIM) struktur, denna strukturkommer användas för konstruktion av en platt parabolisk reflektor. Vilket isin tur består av en serie MIM-strukturer med varierande storlekar. VarjeMIM-struktur är i princip en resonator med en storleksordning mycket mindreän våglängden och ger upphov till en magnetisk resonans. För att sedan uppnåfokus genomförs en rigorös beräkning av fasen med hjälp av finita elementmetoden, varpå man kan beräkna fas och amplitud från strukturen efterreflektion från en plan våg. Därefter kan man välja ut de geometrierna somkrävs för att styra riktningen av vågpropagationen med en fasgradient.Fysikaliska principerna kan förklaras genom stråloptik eller med hjälp avgeneraliserade Snell's lag. I denna rapport presenteras en design av en planreflektor med elva MIM strukturer där den totala storleken är 5.5 µm. FEMsimulering visade att reflektorn fokuserade ljuset vid våglängden 1.2 µm medden nominella fokallängden 6 µm. Dessa kompakta metamaterial kan eventuellttillverkas på chip för detektering och telekom, vilket löser problemen medatt inkludera konventionella linser i optiska system.

Tellurite glass is a material with advantageous optical properties, such as high transparency from visible to mid-infrared wavelengths, high nonlinearity, and high solubility of light-emitting rare earth dopants. Although tellurite has been investigated in fibers and in some waveguide studies, there is still much to explore about it in integrated photonics. Here, we use a hybrid platform that monolithically combines tellurite with commercially available silicon nitride chips. The platform leverages silicon nitride’s many advantages, including its low propagation losses, mature fabrication techniques with small feature sizes, and low cost for mass production, to enable the development of new on-chip tellurite glass light sources. This thesis aims to study the optical properties of distributed Bragg reflector cavities and explore their potential for lasing when the tellurite is doped with different rare earths, namely erbium and thulium. Chapter 1 provides an overview of the context of this work, introducing the materials and cavity used here. Chapter 2 introduces the basic theory behind waveguides and Bragg gratings, as well as rare earth rate equation gain models, coupled mode theory, and a laser model based on the shooting method. Chapter 3 discusses the design, fabrication, and characterization of passive properties of distributed Bragg reflector cavities using undoped tellurite. Chapters 4 and 5 present proof-of-concept laser demonstrations, by using tellurite doped with erbium and thulium, respectively. These lasers constitute the first demonstrations of distributed Bragg reflector lasers in this hybrid tellurite-silicon nitride platform. Chapter 6 combines the laser model introduced in Chapter 2 with the designs and results from Chapters 3–5 to investigate different routes to optimize the laser performances by studying how their efficiencies vary with different parameters, such as background loss, cavity and grating lengths, and rare earth concentration. Chapter 7 summarizes this work and provides insights into future research work. / Thesis / Doctor of Philosophy (PhD) / Integrated photonics is an emerging technology that revolves around tiny circuits on chips, similar to electronics, but using light instead of electricity. Photonic integrated circuits can help achieve faster and more power-efficient devices for a wide range of applications. In this work, we explore the potential of tellurite glass, a material that has promising optical properties, to achieve on-chip lasers. Lasers are one of the fundamental components in these light-driven circuits but are challenging to be realized on a chip-scale. We achieved compact lasers, which are more than ten times thinner than a strand of hair, a couple of centimeters long, and emit invisible (infrared) eye-safe light. These devices are compatible with volume production and there is much room for optimizing them. The lasers investigated here are highly promising for applications including imaging systems (LiDAR) for autonomous vehicles, augmented and virtual reality, data communications, and chemical and physical sensors.

Plasma is the 4th state of matter with complex permittivity that can be exploited to give advantages in communication system. Its negative permittivity has been studied in many research papers and it was proven to have similar characteristics as metal material in terms of electrical conductivity. While keeping permeability in the positive region, plasma will respond to electromagnetic waves in the similar manner as metal. Therefore, this thesis aimed to use plasma as an alternative to metal in the construction of reconfigurable antennas. The first part of this thesis is dedicated to characterize a plasma model based on the commercially available plasma source. Since there are many type of plasma source in terms of their electrical properties and physical shapes, it is important to characterize a particular plasma source so that it can be modeled in simulations to construct other types of plasma antennas. The second part presents the realization of plasma reflector antennas. Two types of plasma reflector antennas have been simulated, fabricated and measured at 2.4 GHz. The first one is are round reflector antenna (RRA) and the second one is corner reflector antenna (CRA). The performances of RRA have been validated and it was proven to provide beam shaping and beam scanning capability. The measured radiation patterns are in a good agreement with simulation ones. The capability of RRA is exceptional since it can steer its main beam from 0° up to 360°. Moreover, the scanning gain remains the same as the main beam is being moved from one direction to another. The CRA that has been introduced in this thesis is a novel design since it integrates two corner-reflector antennas on a single ground plane. The CRA offers three beam shapes which are electrically switchable from one shape to another. The CRA was simulated, fabricated and finally its performances were validated throughout a series of agile measurements. The measured reflected radiation patterns are in good agreements with the simulation ones. The measured gains of the RRA and CRA are 5 dB higher than the gain of classical monopole antenna with an identical size of finite ground plane. The fourth part deals with plasma as radio waves radiator. Two plasma antennas using commercially available U-shaped compact fluorescent lamp (CFL) have been fabricated and measured and it was proven that these antennas can be to radiate radio signal. The last part discusses about radar cross section performance of the plasma reflector antennas. The two plasma reflector antennas (RRA and CRA) were tested and measured for their RCS performance.

A near-field technique known as evanescent interferometric lithography allows for high resolution imaging. However its primary limitation is that the image exponentially decays within the photoresist due to physical limits. This thesis aims to overcome this limitation and presents a method to considerably enhance the depth of focus of images created using evanescent interferometric lithography by using a material underlay beneath the photoresist. A key enabler of this is the understanding that evanescent fields couple to surface states and operating within proximity of a resonance, the strength of the coupling allows for considerable energy extraction from the incident beam and redistribution of this energy in a photoresist cavity. This led to the analysis of the Fresnel equations, which suggested that such coupling was in fact the result of an enhanced reflectance that takes place at boundaries of carefully chosen materials. While it is known that metals and lossy dielectrics result in surface plasmon polaritons (SPP) and surface exciton polaritons (SEP) as conventional solutions to the Fresnel reflection equations for the TM polarization of light, there is no such naturally occurring surface state that allows evanescent wave enhancement with the TE polarization of light. Further investigation of the Fresnel reflection equations revealed both for TM and TE that in fact another solution exists that is but unconventional to enhance the reflectivity. This solution requires that one of the media have a negative loss. This is a new type of surface resonance that requires that one of the media be a gain medium; not one in the optical pumped sense but one that would naturally supply energy to a wave to make it grow. This new surface resonance is also a key result of this thesis. Clearly, however this is only a hypothetical solution as a real gain medium would violate the conservation of energy. However, as it is only the reflectance of this gain medium that is useful for evanescent wave enhancement, in fact a multilayered stack consisting of naturally occurring materials is one way to achieve the desired reflectivity. This would of course be only an emulation of the reflectivity aspect of the gain medium. This multilayered stack is then an effective gain medium for the reflectivity purposes when imaging is carried out at a particular NA at a particular wavelength. This proposal is also a key idea of this thesis. At λ = 193 nm, this method was used to propose a feasible design to image high resolution structures, NA = 1.85 at an aspect ratio of ~3.2. To experimentally demonstrate the enhancements, a new type of solid immersion test bed, the solid immersion Lloyd's mirror interference lithography test-bed was constructed. High quality line and space patterns with a half-pitch of 55.5 nm were created using λ = 405 nm, corresponding to a NA of 1.824, that is well in the evanescent regime of light. Image depths of 33-40 nm were seen. Next, the evanescent image was coupled to an effective gain medium made up of a thin layer of hafnium oxide (HfO) upon silicon dioxide (SiO2). This resulted in a considerable depth enhancement, and 105 nm tall structures were imaged. The work in this thesis details the construction of the solid immersion lithography test-bed, describes the implementation of the modeling tools, details the theory and analysis required to achieve the relevant solutions and understanding of the physical mechanism and finally experimentally demonstrates an enhancement that allows evanescent interferometric lithography beyond conventional limits.

[pt] O objetivo desta monografia é investigar a aplicação de distintas metodologias de alocação de energia firme de usinas hidrelétricas através da teoria dos jogos de coalizão. Mostra-se que não existe uma maneira ótima, única, de se fazer esta repartição, mas existem critérios para verificar se uma metodologia de repartição específica apresenta algum aspecto inadequado. Um desses critérios é a justiça. Mostra-se que este critério equivale a pertencer ao chamado núcleo de um jogo cooperativo. O cálculo da energia firme será formulado como um problema de otimização linear e serão investigadas vantagens e desvantagens de distintos métodos de alocação (a benefícios marginais, geração média no período crítico, última adição e nucleolus). Em seguida será desenvolvida uma aplicação do esquema Aumann-Shapley (AS) à repartição da energia firme de usinas hidrelétricas. Demonstra-se que além de robusto em relação aos tamanhos dos recursos e eficiente computacionalmente, este método fornece para o problema do firme uma alocação pertencente ao núcleo e, portanto, atende à condição de justiça. A aplicação do esquema AS será apresentada para o Sistema Brasileiro e serão comparados os resultados obtidos por este método com outros esquemas de alocação adotados no Sistema Hidrelétrico Brasileiro. / [en] The objective of this work is to investigate the application of different methodologies of allocation of firm energy rights among hydro plants using a gametheoretic framework. It is shown that there is not an optimal and unique approach to make this allocation but there are criteria to verify if a given approach presents any inadequate aspect. One of these criteria is the justice, or fairness. It is shown that this criterion is equivalent to the condition of the core of a cooperative game. The calculation of the firm energy will be formulated as a linear program and advantages/disadvantages of different allocation methods (marginal allocation, average production on the dry period, incremental allocation and nucleolus) will be investigated. Next, an application of the Aumann-Shapley (AS) scheme to the problem of allocation of firm energy rights will be developed. It is shown that, besides being robust and computationally efficient, this scheme provides an allocation that belongs to the core of the game and therefore meets the condition of justice. The AS scheme will be applied to the Brazilian system (composed of about 100 hydro plants) and the results obtained will be compared with the allocation schemes currently adopted in the Brazilian system.