Title: Evaluation of the most common injuries and health problems of professional table tennis players Objectives: The main aim of this work is to evaluate the most common injuries and health problems of professional table tennis players in the Czech Republic. Another goal is to determine the level of use of regenerative procedures and compensatory exercises within the training plan of athletes. Methods: The main method used in this thesis was a quantitative research by data analysis from non-standardized questionnaire. The questionnaire was distributed among professional table tennis players who participated actively in the district, regional, league or extra league competition in the Czech Republic or abroad in the 2018/2019 season. A total of 374 questionnaires were processed and evaluated, which corresponds to 62,33 % of the total number of sent questionnaires. Results: Of the 374 table tennis players, 240 were injured (197 men, 43 women), which corresponds to 64,17% of the interviewed players. A total of 361 injuries were recorded. The research confirmed four out of six hypotheses. Statistical significance was noted between the injury and sex, and the statistically significant relationship between the injury and the different playing style was confirmed. Most injuries were in the area of the...

European beech (Fagus sylvatica L.) and Norway spruce (Picea abies (L.) Karst) are the most abundant deciduous and coniferous tree species in the Czech Republic. Both beech and spruce are due to their sensitivity to drought threatened by ongoing climate change that can cause deterioration of their vitality in current habitats. Drought periods are already becoming longer and stronger and previously rare spring droughts become more frequent. The dissertation thesis is based on experiments with Norway spruce and European beech seedling exposed to different levels of drought (well-watered, moderate drought and severe drought). After three to six weeks of drought, the seedlings were well-watered for another two weeks and their response of physiology, anatomy and morphology was evaluated. Experiments were conducted with seedlings at early stage of leaf development and with fully developer leaves to compare response to spring and summer drought. Overall drought response was stronger in spring. Both spring and summer drought reduced gas exchange parameters (in both beech and spruce seedlings up to 100 %), hydraulic conductivity and less strongly also fluorometric parameters. Efficiency of water use in stressed seedlings decreased in spring, while it increased in summer. Shoot and leaves biomass was more reduced by drought than root biomass. Tree-ring width decreased about two times more in beech seedlings than in spruce seedlings. Vessel and tracheids in stem and shoots reduced their number and size, on the contrary, vessel size increased in beech petioles. After rewatering the reduced parameters increased, however, hydraulic conductivity, anatomy and morphology did not reach values of well-watered seedlings. While most of physiological parameters restored in moderately stressed seedlings, in severely stressed seedlings mainly gas exchange parameters remained lower.

Detailed knowledge of the role that particular genes and factors play during the development and in the normal function of the auditory system is necessary to develop successful regenerative inner ear therapies. Islet1 transcription factor and brain derived neurothrophic factor (BDNF) have great potential to play a role in regenerative inner ear therapy as both have been shown to be sufficient for self-repair regeneration in cochlea in animal studies. In this study we looked at the roles these two factors play in the development and function of the auditory system. In the transgenic mice used in the study, overexpression of Isl1 affected cell specification during embryonic development, leading to enlargement of the cochleovestibular ganglion and accelerated nerve fiber extension and branching in mutant embryos. The hearing of young transgenic mice was not affected. However, it started to decline in 1-month-old animals. This early onset of age-related hearing loss was found to be a consequence of the neurodegeneration of the olivocochlear system caused by Pax2-driven Isl1 misexpression in the hindbrain. Our data provide the first evidence that the alternation of the olivocochlear system efferent system accelerates the age-related functional decline of hearing without the loss of OHCs. The functional role of...

Mesenchymal stem cells and their regenerative and immunomodulatory potential Abstract Mesenchymal stem cells (MSCs) possess multidirectional regenerative ability, which, together with their immunomodulatory potential, makes them promising cell type for therapy of wide variety of diseases. Despite ongoing research, which proved MSCs application to be safe, reported effect of MSCs administration on patients is not convincingly beneficial yet. In our work we focused on elucidation of MSCs role in regeneration of vital organs, heart and liver, where a large damage is life threatening for patients and any improvement in therapy would save many lives. Similar situation is in Graft versus host disease (GVHD), where MSCs immunomodulatory properties could be beneficial. Role of MSCs in heart regeneration was examined in vitro. Primary adult swine cardiomyocytes (CMCs) were co-cultured with or without swine MSCs for 3 days and morphological and functional parameters (contractions, current, respiration) of CMCs were measured. MSCs showed supportive effect on CMCs survival, especially at day 3 of the experiment, where in co-culture was significantly higher number of viable CMCs with physiological morphology and maintained function. Effect of MSCs on liver regeneration was observed in swine model of chronic liver...

Conception of the complicated international question of the poor communities in the context of the Southamerican favelas.Urbanisation / suburbanisation with the accent to the concrete architectonic detail.

ZBROJOVKA BRNO - Opportunity for the city Strategies for Zbrojovka Brno, the third largest brownfield in the city. Urban policy and the process of integration of the site into the city and connection with his organism. Creating a territorial strategy or tactical urbanism procedure that tries successive interventions re- incorporate this into the organism of the city , in a way that fully reflect the needs , possibilities and polarity in the territory. It is essential that the established process allowed for long-term gradual regeneration, which can be interrupted by economic pressure, and in its every moment of creating a working environment that sudden interruption of restorative work in their stride. The entire process of restoring the site is divided into several phases , but at each flexibly connected and can run such a large area partially independently . Based on the current state of the complex, which is gradually opened , are removed objects that are in disrepair , and those that hinder the development of the area and its smooth functioning. Subsequently, traffic control , area connected to public transport. As a result, the situation will stabilize and rehabilitate the total area of the factory and its surroundings. All through individual interventions in its structure and public space. The whole process is documented on the basic objectives and approaches of the phases that are subsequently documented reference interventions and achievements typical of the condition of the site. All complemented by an analysis of the phenomenon of the basic tasks of rehabilitation of the site.

Title: Evaluation of the most frequent injuries in elite women basketball players in the Czech Republic Problem specification: Basketball is nowadays one of the most popular collective sport games in the world. In elite sports generally we can see many acute injuries as well as overfreight injuries and basketball is not the exception. At its beginnings, basketball was considered as a non-contact sport, but this is not true any more. This Diploma work focuses on evaluation of the most frequent injuries in elite women basketball players in the Czech Republic. Objective: Objective of this Diploma work is to evaluate most frequent injuries and evaluate level of regeneration and compensating instruments by basketball teams, who played EXCELSIOR Women basketball league. Methods: This Diploma work uses a method called non-standardized questionnaire. Information were get from individual women basketball teams that played in 2011/2012 season EXCELSIOR Women basketball league. There were analyzed 127 questionnaires on the whole. Results: Results shows that one of the most frequent injury by players playing EXCELSIOR Women basketball league is injury of ankle. Injury of ankle got 45% of players, injury of knee got 16% of players and 22% of players got injury of upper limbs. 14% of players got fracture of fingers. Less...

Title: Evaluation of the most frequent injuries in competition of league MOL and the 2nd league in women handbal in Czech republic. Objectives: The main objective in this work is evaluation of the most frequent injuries in women handball players, who play in season 2017/2018 the highest competition in Czech Republic - league MOL and the 3rd highest competition in Czech Republic - the 2nd league in women handball. The next objective is find out, if the teams have in their training unit the regenerative and compensatory practise, also there is physiotherapist in team or no. Methods: As the method for data pooling, I choose the form of a non-standardized questionnaire. The questionnaire was send between all women handball players in both competition, which are written in objective. Overall is analysed 112 questionnaires. Results: From the results, we can see, that for the most common injuries belongs to ankle. Overall 56,3 % suffered the injury of ankle, then injury of hands (50,9 %) and knees (46,4 %). Smaller group of injuries belongs to the of face, head, shoulders and elbows. Wings and lineplayers has the most common injuries of ankle, on the other hand the middle lineplayers, backs and goalkeepers has the most common injuries of hands and knees. Keywords: handball, regeneration and compensation...

This thesis deals with the definitions of rural development, rural areas, brownfields, greenfields. In the practical part compares two real locations in South County. Greenfield site is located in the village in the district Vidov Czech Budejovice and borwnfield site is located in the village in the district Želeč Tabor. Both locations are assessed according to the model of South Bohemia, which is based on studies němcekého Ministry of Environment. This model consists zetří criteria - potential sites in terms of community benefit in terms of potential investor and the change in the value space - public interest in the regeneration of brownfield sites. These three criteria are still my sub, under which then determines the significance of the site. Then, by calculating the preference index (PI) to determine which location is more suitable for implementation.

Human mesenchymal stromal cells (hMSC) are adult stem or progenitor cells, which physiological role is reparation of damaged tissues. This is achieved mostly by secretion of trophic, angiopoietic and immunomodulatory factors. Beside this, hMSC have potential to differentiate in vitro into specialized cells, especially of the mesodermal lineages. Human MSC also significantly support hematopoiesis in hematopoietic niche. This knowledge raised high hopes for therapeutic use of hMSC, especially in regenerative medicine and treatment of autoimmune diseases, including graft versus host disease (GvHD). As a proof of concept served initially crude preparations of bone marrow mononuclear cells (BMMC), which contain small numbers of hMSC. In our hospital, two pilot clinical studies with BMMC were performed: study of treatment of acute myocardial infarction (negative, prematurely terminated) and study of treatment of peripheral leg arthery disease (promising results). Further research was aimed on optimalisation of hMSC cultivation method for clinical use to obtain highest possible yield and get free from animal proteins. Human MSC were traditionally cultivated in research-grade media with fetal calf serum (FCS), which can lead to immunization of patients after repeated application of hMSC. We achieved...