Thesis (MPhil)--University of Stellenbosch, 2004. / ENGLISH ABSTRACT: This thesis discusses the value of medical futility as an action guide for neonatal endof- life decisions. The concept is contextualized within the narrative of medical progress, the uncertainty of medical prognostication and the difficulty of just resource allocation, within the unique African situation where children are worse off today than they were at the beginning of the last century. parties actively engage in an interactive deliberation for a plan of action. Both parties ought to accept moral responsibility. Such a model of deliberation has the added advantage of transcending the limitations of the participants to arrive at a higher-level solution, which is considered more than just a consensus. It has been argued that medical progress has obscured the basic need for human compassion for the dying and for their loved ones. The literature furthermore reports that the quality of end-of-life care is unsatisfactory for both patients and their families. It is within this context that the concept of medical futility is positioned as a useful action guide. As we do not have the luxury of withdrawing from the responsibility to engage in the deliberation of end-of-life decisions, such responsibility demands an increasing awareness of ethical dilemmas and a model of medical training where communication, conflict-resolution, inclusive history taking, with assessment of patient values and preferences, is focussed on. The capacity for empathetic care has to be emphasized as an integral part of such approach. Finally, in this thesis, the concept of medical futility is tested and applied to clinical case scenarios. It is argued that the traditional medical paradigm, with its justification of an 'all out war' against disease and death, in order to achieve utopia for all, is outdated. Death in the neonatal intensive care unit is increasingly attributed to end-of-life decisions. Futile treatment could be considered a waste of scarce resources, contradicting the principle of nonmaleficence and justice, particularly in an African context. The ongoing confidence in, and uncritical submission to the technological progress in medicine is understood as a defence and coping mechanism against the backdrop of the experience of life's fragility, suffering and the inevitability of death. Such uncritical acceptance of the technological imperative could lead to a harmful fallacy that cure is effected by prolonging life at all cost. What actually occurs, instead, is the prolongation of the dying process, increasing suffering for all parties involved. The historical development of the concept of medical futility is discussed, highlighting its applicability to the paradigmatic scenario of cardio-pulmonary resuscitation. Particular attention is given to ways in which the concept could endanger patient-autonomy by allowing physicians to make unilateral, paternalistic decisions. It is argued that the informative model of the patient-physician relationship, where the physician's role is to disclose information in order for the patient to indicate her preferences, ought to be replaced by a more adequate deliberative model, where both / AFRIKAANSE OPSOMMING: Hierdie tesis bespreek die waarde van mediese futiliteit as 'n maatstaf vir aksie in gevalle van neonatale 'einde-van-lewe' besluite. Die konsep word gekontekstualiseer binne die wêreldbeskouing van mediese vooruitgang, die onsekerheid van mediese prognostikering en die probleme wat geassosieer IS met regverdige hulpbrontoekenning; spesifiek binne die unieke Afrika-situasie. Dit word aangevoer dat die tradisionele mediese paradigma, met regverdiging vir voorkoming van siekte en dood ten alle koste, verouderd is. Sterftes in neonatale intensiewe sorgeenhede word toenemend toegeskryf aan 'einde-van-lewe' besluite Futiele behandeling sou dus beskou kon word as 'n vermorsing van skaars hulpbronne, wat teenstrydig sou wees met die beginsels nie-skadelikheid ('nonmaleficence') en regverdigheid. Die volgehoue vertroue in en onkritiese aanvaarding van aansprake op tegnologiese vooruitgang lil geneeskunde, kan beskou word as verdediging- en hanteringsmeganisme in die belewenis van lewenskwesbaarheid, lyding en die onafwendbaarheid van die dood. Sodanige onkritiese aanvaarding van die tegnologiese imperatief kan tot 'n onverantwoordbare denkfout, naamlik dat genesing plaasvind deur verlenging van lewe ten alle koste, lei. Wat hierteenoor eerder mag plaasvind, is 'n verlenging die sterwensproses en, gepaard daarmee, toenemende lyding van all betrokke partye. Die historiese ontwikkeling van die konsep van mediese futiliteit word bespreek met klem op die toepaslikheid daarvan op die paradigmatiese situasie van kardiopulmonêre resussitasie. Spesifieke aandag word gegee aan maniere waarop die konsep pasiënte se outonomie in gevaar stel, deur die betrokke medici die reg te gee tot eensydige, paternalistiese besluitneming. Die argument is dan dat die informatiewe model, waar die verhouding tussen die dokter en pasiënt gebasseer is op die beginsel dat die dokter inligting moet verskaf aan die pasiënt sodat die pasiënt 'n ingeligte besluit kan neem, vervang moet word met 'n meer toepaslike beraadslagende model, waar sowel die dokter as die pasiënt aktief deelneem aan interaktiewe beraadslaging oor 'n aksieplan. Albei partye word dan moreel verantwoordbaar. So 'n model van beraadslaging het die bykomende voordeel dat dit die beperkings van die deelnemers kan transendeer. Sodoende word 'n hoër-vlak oplossing - iets meer as 'n blote consensus - te weeg gebring. Die argument word ontwikkel dat mediese vooruitgang meelewing met die sterwendes en hul geliefdes mag verberg. Verder dui die literatuur daarop dat die kwaliteit van einde-van-lewe-sorg vir sowel die pasiënte as hul familie onaanvaarbaar is. Dit is binne hierdie konteks dat die konsep van mediese futiliteit kan dien as 'n maatstaf vir aksie. Medici kan nie verantwoordelikheid vir deelname aan beraadslaging rondom eindevan- lewe beluitneming vermy nie, en as sodanig vereis die situasie toenemende bewustheid van sowel die etiese dilemmas as 'n mediese opleidingsmodel waann kommunikasie, konflikhantering, omvattende geskiedenis-neming, met insluiting van die pasient se waardes en voorkeure, beklemtoon word. Die kapasiteit vir empatiese sorg moet weer eens beklemtoon word as 'n integrale deel van hierdie benadering. Ten slotte, hierdie tesis poog om die konsep van mediese futiliteit te toets en toe te pas op kliniese situasies.

Bakgrund: För ambulanssjuksköterskor innefattar arbetet ofta långa transporter till sjukhus. Transporttiden kan variera mellan 20 - 60 minuter. Vid pågående avancerad hjärt-lungräddning med manuella kompressioner står ambulansteamet obältade i höga hastigheter, då mekanisk kompressionsutrustning saknas. Syfte: Syftet med studien var att undersöka ambulanssjuksköterskors upplevelse vid hjärtstoppsituationer med efterföljande längre transport till sjukhus. Metod: Tio ambulanssjuksköterskor intervjuades. Till analysen av insamlad data användes kvalitativ innehållsanalys med induktiv ansats. Resultat: Resultatet visade att situationer då ambulanssjuksköterskor behöver utföra avancerad hjärt-lungräddning under längre transport till sjukhus medför känslor av att vara otrygg och utlämnad. Mekanisk kompressionsutrustning är inte standardiserad i alla ambulanser. För att utföra manuella kompressioner under transport krävs det att ambulanssjuksköterskan står obältad. De säkerhetsrisker detta innebär för ambulanssjuksköterskan och patienten, leder till känslor av utsatthet och otrygghet. I den prehospitala miljön krävs ofta snabba beslut som kan vara livsavgörande, och ambulanssjuksköterskorna menar att en höjd kompetens inom ambulanssjukvården skulle ge dem en tryggare yrkesroll.  Ambulanssjuksköterskorna värdesätter samverkanslarmen och ser dessa som välfungerande. Slutsats: Resultatet visar att det finns behov av standardiserad mekanisk kompressionsutrustning i alla ambulanser, åtgärder för att stärka teamarbetet, samt kompetensutveckling i det dagliga arbetet. För att skapa trygga team bör erfarenhet vara en viktig aspekt vid rekrytering av ambulanssjuksköterskor. Detta för att öka tryggheten, säkerheten och effektiviteten för ambulanssjuksköterskor vid längre transport till sjukhus. Nyckelord: Ambulanssjuksköterska, upplevelse, avancerad hjärt-lungräddning, prehospital transport, säkerhet, bröstkompressionssystem, kvalitativ innehållsanalys / Abstract Background: For ambulance nurses work often involves long journeys to the hospital. Journey times vary between 20-60 minutes. When the mechanical compression equipment doesn`t exist, the ambulance team is performing advanced cardiopulmonary resuscitation with manual compressions, unbelted at high speeds. Aim: The aim of this study was to investigate the ambulance nurses experience of cardiac arrest situations with following longer transports to the hospital. Method: Ten ambulance nurses were interviewed. For the analysis of the collected data, qualitative content analysis with inductive approach was used. Results: The results showed that the situations when ambulance nurses need to perform advanced cardiopulmonary resuscitation during longer transports to the hospital, causes feelings of being unsafe and deserted. Mechanical compression equipment is not standardized in all ambulances, and manual compressions during transport requires that ambulance nurses are unbelted. The security risks this implies for the ambulance nurse and the patient, lead to feelings of vulnerably and insecurity. In the prehospital environment that often requires quick decisions that can be life changing, ambulance nurses believe that a higher competence in ambulance service would give them a more secure profession. Ambulance nurses value the interaction with rescue and police, and see them as well functioning. Conclusion: The results show that there is a need for standardized mechanical compression equipment in the ambulances, measures to strengthen the teamwork, and competence in the daily work. These measures could contribute to increased efficiency and greater security in the professional role of ambulance nurses during longer transports to the hospital. In order to create safety and confidence in the ambulance teams, experience should be considered as an important aspect when recruiting ambulance nurses. Keyword: Paramedic, experience, advanced cardiopulmonary resuscitation, prehospital transport, safety, chest compression, qualitative content analysis

This thesis is concerned with comparing the education of nurses working in intensive care in the Czech and Slovak Republics. In the theoretical part of the thesis there are described the options for nursing education in anaesthesia, resuscitation and intensive care, both in the past and at present. Presented here is the comparison of the Czech and Slovak educational system, regulation of education, their similarities and differences. The aim of the empirical part is to find out what kind of education are nurses working with in the intensive care, what is their motivation to further education and to look at the current possibilities of nursing education in anaesthesia, resuscitation and intensive care in the Slovak and Czech Republic. To obtain the data for answers to these and other questions the questionnaire has been used; specifically the methods of quantitative research. The results are processed in tables and graphs. Keywords: History of nursing education, Specialized education, Anaesthesiology, Resuscitation and Intensive Care, Regulation, Slovak Republic, Czech Republic

Purpose: Interpersonal communication is one of the most important abilities and skills in everyday life. But when patient's communication ability is limited due to endotracheal or tracheostomy tube insertion, the patient, who had communicated verbally, is not able to convey their feelings, needs and wishes anymore. The purpose of this thesis is to help improve communication skills of nurses in the area of communication with conscious, unconscious and analgosedated patients whose airways are intubated. Methods: The survey has form of quantitative research, the questionnaire method was used. Research data was obtained from a total of 144 nurses working at resuscitation departments at four hospitals in Prague. Results: By studying this issue, it has been found nurses have trouble communicating with intubated patients. The most difficult communication is with conscious patients, who are intubated by endotracheal tube. Communicating with patients with impaired consciousness is also very problematic. Conclusion: Despite the fact, that communication with intubated patients is inherently difficult, more than half of the respondents have never been educated about how to communicate with these patients. Not only but also to address this issue, the outcome of this thesis is information brochure with...

This thesis deals with the knowledge of processes and practical skills of cardiopulmonary resuscitation among nurses working in the field of anesthesia and intensive medicine. The theoretical part of this paper defines the notion of cardiopulmonary resuscitation, deals with its history, changing definitions, and the latest recommendations. It also describes and specifies terms such as competence, knowledge of the processes and the role of the nurse in the system. The empirical part, using a questionnaire survey, assesses orientation of nurses and nurses specialists in the latest recommendations in cardiopulmonary resuscitation and the related knowledge and competences in the use of resuscitation itself. The questionnaire survey was answered by 152 respondents from 3 large hospitals in Prague. There were also the results of its investigation, compared with the results of research conducted by Václav Kukol in 2010 - 2011 as part of their thesis. In the final discussion paper evaluates the confirmation of the hypotheses. Then attach the recommendations for practice.

Este estudo objetivou conhecer a prevalência de parada cardiorrespiratória (PCR) atendida pelo SAMU de Araras entre 2001 e 2007, caracterizar as vítimas segundo o sexo, faixa etária, antecedentes mórbidos, natureza traumática do evento; a parada ter sido presenciada, realização de ressuscitação cardiopulmonar (RCP) por familiares/acompanhantes, tempo resposta, tipo de suporte de vida recebido na cena, indicação de choque pelo Desfibrilador Externo Automático (DEA), assim como identificar as variáveis significativas para o retorno da circulação espontânea na cena. Os dados foram coletados retrospectivamente das fichas de atendimento das vítimas de PCR do SAMU de Araras após aprovação do Comitê de Ética em Pesquisa da EEUSP. Foram selecionadas 328 fichas que preencheram os critérios de inclusão. O SAMU de Araras realizou 28.924 atendimentos gerais no período estudado, dos quais em 330 foram iniciadas as manobras de ressuscitação cardiopulmonar. A taxa de PCR no período avaliado é 1,13%, com predomínio do sexo masculino 208 (64,60%) e faixa etária entre 70 e 79 anos, média de idade 63,35 anos. Os antecedentes mórbidos mais citados foram cardiopatias (29,48%), hipertensão arterial sistêmica (25,43%) e diabetes (12,14%), a maioria com citação de um único antecedente ou sem este registro. Não havia trauma associado em 302 (92,64%) vítimas. O DEA foi utilizado em 280 (85,37%) vítimas, com indicação de choque em 95 (29%). A PCR foi presenciada em 115 (35,00%) vítimas, para as quais houve maior percentual de início de RCP (p=0,004) pela família/ acompanhante e houve mais indicação de choque pelo DEA(p<0,001) em relação às vítimas que foram encontradas em PCR. Houve maior proporção do retorno da circulação espontânea nas vítimas que receberam suporte avançado de vida na cena 54(31,76%), (p=0,018) em relação às que receberam somente suporte básico de vida. O tempo resposta médio foi de 05:24 minutos. Pela análise univariada, as seguintes variáveis foram significativas (p<0,05) para o retorno da circulação espontânea: faixa etária (p=0,018), diabetes melitus (p<0,001), responsividade (p=0,041), pulso carotídeo presente na avaliação inicial (p= 0,001), compressões torácicas pelo SAMU (p=0,028), choque pelo DEA (p<0,001), suporte avançado de vida (p=0,018), intubação traqueal (p<0,001). No modelo de regressão logística múltipla apenas \"pulso carotídeo presente na abordagem inicial\" foi selecionada como preditora independente para o retorno da circulação espontânea na cena (Odds Ratio 4,03), p =0,002.Concluiu-se que o serviço oferece um tempo resposta dentro dos padrões mundialmente recomendados e que as vítimas que tiveram PCR presenciada, apesar de receberem proporcionalmente mais RCP pela família/acompanhante e terem mais indicação de choque pelo DEA, não apresentaram mais retorno da circulação espontânea na cena. As vítimas com pulso presente na avaliação inicial do SAMU, isto é, as que tiveram a PCR presenciada pela equipe, ou tempo resposta \"zero\" têm 4,03 mais chances de retorno da circulação espontânea na cena, sendo esta variável a única preditora independente. O investimento em capacitação permanente da equipe do SAMU, ensino da população a reconhecer um evento crítico, iniciar manobras de reanimação e acionar precocemente o SAMU poderão contribuir para aumentar as chances de sobrevivência de vítimas de PCR em ambiente pré-hospitalar / The objective of this study was to know the prevalence of cardiac arrest (CA) assisted by Emergency Medical Service of the City of Araras (SAMU-Araras), SP, Brazil, between 2001 and 2007, classifying victims according to the gender, age groups, morbid antecedents, traumatic nature of the event, witnessed arrest, accomplishment of cardiopulmonar ressuscitation (CPR) by bystanders, time elapsed between the call of SAMU and the arrival of the EMS team to the site (time-response), type of life support received on-scene, shock indication for AED, as well as to compare the outcome of these cases, in terms of return of the spontaneous circulation (ROSC) still on scene, according to those variables. Data were collected from the records of SAMU of Araras, after approval of the Research Ethics Board of the Nurse School of University of São Paulo (EEUSP). 328 records that fulfilled the criteria were selected. SAMU-Araras accomplished 28.924 general medical attendances in the period of the study. In 330, CPR was performed (1.13%). Man (64.60%) and age group between 70 e 79 years old were predominants, and 63,35 yo. was the average. The mentioned prior diseases were cardiopathy (29.48%), sistemic arterial hypertension (25.43%) and diabetes (12.14%), most of all with just one problem cited or even no prior diseases. There was not associated trauma in 92.64% of the cases. AED was used in 85.37% of the cases were CPR was performed, with shock indication in 95 (29%) victims. CA was witnessed in 115 (35.00%) victims. In these cases, CPR performed by relatives were more frequent (p=0.004), as well as shock was more frequently indicated (p <0.001) compared with those where CA was not witnessed. There was larger proportion (51.83%) of ROSC in the victims that received advanced life support on scene, (p=0.018) comparing to the ones that received only basic life support. The time-response average was 05:24 minutes. The following variables presented statistical association (p <0.05) for ROSC: age group (p=0.018), diabetes (p <0.001), responsivity (p=0.041), carotid pulse present at the time of initial assesment (p=0,001), thoracic compressions by the SAMU team (p=0.028), shock delivered by AED (p <0.001), advanced life support performed (p = 0.018), and use of tracheal tube (p <0.001). In the statistical model of multiple logistics regression only the variable \"carotid pulse present at the time of initial assesment\" was selected as independent predictor for the return of the spontaneous circulation on scene (Odds Ratio 4.03), p =0.002. In conclusion, the SAMU-Araras offers a time-response according to international recommendations. Victims that have had witnessed CA, although received more frequenty CPR and recommended shock, they did not have better outcomes. The victims with present pulse in the initial assessment by the SAMU team, or in other words, the ones that presented CA witnessed by the SAMU team, had 4.03 more times in terms of chances of ROSC on scene, being this an independent predictor. The investment in permanent training of the SAMU professionals, the education for the people recognize a critical event and immediately to begin CPR can contribute to increase the survival chances for victims of CA in prehospital environment

Os profissionais da área de saúde deparam-se constantemente com situações que envolvem risco de vida para os clientes, uma delas é a parada cardiorrespiratória (PCR) e necessita que sejam instituídas mais rapidamente as manobras de ressuscitação cardiopulmonar (RCP) que compreende o Suporte Básico de Vida (SBV) e o uso de Desfibrilador Externo Automático (DEA). Trata-se de um estudo exploratório descritivo com o objetivo de identificar a HABILIDADE (prática) e o CONHECIMENTO (teórico) dos alunos dos cursos de graduação da área da saúde, de uma universidade privada no interior do Estado de São Paulo, antes e após serem submetidos ao curso/ treinamento. A coleta dos dados foi dividida em duas etapas sendo: 1ª. Etapa - avaliação do conhecimento teórico e prático prévio antes de um curso teórico com demonstração prática das manobras de RCP com uso do DEA e treinamento utilizando o laboratório de práticas com o manequim de RCP e o DEA; 2ª. Etapa avaliação teórica e prática individual. Foram incluídos 173 alunos com faixa etária de 17 a 23 anos, 151 (87,3%) do sexo feminino; na Avaliação da HABILIDADE na 1ª. Etapa, a pontuação máxima foi de 91 pontos 69 (39,9%) alunos e 104 (60,1%) alunos não pontuaram, na 2ª. Etapa a pontuação máxima obtida foi de 260 pontos por 101(58,4%) alunos. Na Avaliação do CONHECIMENTO, a pontuação máxima foi de 5,75 pontos e a pontuação mínima de 1,0 ponto na 1ª. Etapa. Na 2ª. Etapa, a pontuação máxima foi de 10,0 pontos por sete (4,0%) alunos, nenhum aluno obteve pontuação inferior a 7,5 pontos. Para 19 itens a diferença foi significativa na Avaliação da HABILIDADE da 1ª para a 2ª. Etapa em todos os grupos de conteúdos sendo: Avaliação inicial e responsividade 2 itens; Abertura das vias aéreas e manobras de respiração - 6 itens; Avaliação do pulso carotídeo e compressões torácicas - 3 itens e Manuseio do DEA 8 itens. Para 9 questões a diferença foi significativa na Avaliação do CONHECIMENTO da 1ª para a 2ª. Etapa em dois grupos de conteúdos: Abertura das vias aéreas e manobras de respiração - 3 questões e Manuseio do DEA 6 questões. As 13 questões que não apresentaram bom desempenho na 2ª. Etapa do estudo, no Conhecimento, estão agrupadas nos conteúdos: Avaliação inicial e responsividade; Abertura das vias aéreas e manobras de respiração e Manuseio do DEA. Quanto comparados a HABILIDADE e o CONHECIMENTO verifica-se que houve melhora no desempenho da primeira para a segunda etapa em todos os itens e questões (p=0,0001). Quanto ao treinamento a média do tempo de observação foi de 78,3 minutos e o tempo de treino foi de 117,1 minutos. Em relação à HABILIDADE os itens que não atingiram bom desempenho na 2ª. Etapa estão nos conteúdos Avaliação inicial e responsividade e Manuseio do DEA e em relação ao CONHECIMENTO as questões que não atingiram bom desempenho estão nos conteúdos Avaliação inicial e responsividade; Abertura das vias aéreas e manobras de respiração e Manuseio do DEA. Conclui-se que tanto na HABILIDADE quanto no CONHECIMENTO houve melhora no desempenho dos alunos. / The health professionals faced with situations involving risk of life for patients, one of them is cardiopulmonary arrest (CA) and needs to be established more quickly cardiopulmonary resuscitation (CPR) involving the Basic Life Support (BLS) and use of Automated External Defibrillator (AED) This is a exploratory study aiming to identify the skill (practice) and knowledge (theoretical) of the students in health undergraduate students in a private university in the state of São Paulo, before and after their submitted to the course / training. Data collection was divided into two stages as follows: 1st. Step - Evaluation of knowledge practical and theoretical and course with prior practical demonstration of CPR maneuvers using the AED, 2nd. Step - training and theory/practice evaluation individual, using laboratory practices with the manikin CPR and AED. 173 students were included aged 17 to 23 years, 151 (87.3%) were female; the skill evaluation in the 1st. Step, the maximum score of 91 points was 69 (39.9%) and 104 students (60.1%) were not scored in the 2nd. Step a maximum score of 260 points was obtained for 101 (58.4%) students. The Knowledge evaluation, the maximum score was 5.75 points in the 1st. Stage and a minimum score of 1.0 in the 2nd. Step, the maximum score was 10.0 points in seven (4.0%) students, no students scored less than 7.5 points. For 19 items the difference was significant in the skill evaluation the 1st to 2nd. Step in all groups of content being: \"Initial evaluation and responsiveness\" - 2 items, \"Opening the airway and breathing maneuvers\" - 6 items, \"Evaluation of the carotid pulse and chest compressions - items 3 and \" Handling the DEA \"- 8 items. In nine questions for the difference was significant in the Knowledge evaluation from the 1st to 2nd. Step into two groups of content: \"Opening the airway and breathing maneuvers\" - three questions and \"Handling the DEA\" - 6 issues. The 13 questions that did not show good performance in the 2nd. Stage of the study on Knowledge, are grouped by content: \"Initial evaluation and responsiveness,\" \"Opening the airway and breathing maneuvers\" and \"Handling the DEA.\" As compared with the skill and knowledge there is a significant improvement in performance from first to second step on all the items and issues (p = 0.0001). As for training the average observation time was 78.3 minutes and the workout time was 117.1 minutes. Regarding skill items that did not achieve good performance in the 2nd. Step in the contents are Initial evaluation and responsiveness and Handling the DEA and about the knowledge the questions that are not achieved a good performance in the contents Initial evaluation and responsiveness, Opening the airway and breathing maneuvers and Handling the DEA. We conclude that both the skill and knowledge in significant improvement in student performance.

Introdução: O objetivo do estudo foi avaliar os efeitos da terapia guiada por metas (TGM) sobre desfechos em pacientes de alto risco submetidos à cirurgia cardíaca. Métodos: Estudo prospectivo randomizado que avaliou 126 pacientes submetidos às cirurgias de revascularização do miocárdio ou valvar internados na Unidade de Terapia Intensiva Cirúrgica (UTI) do Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo. Os pacientes foram randomizados para um algoritmo de terapia guiada por metas (grupo TGM, n=62) ou grupo controle (n=64). No grupo TGM, um índice cardíaco superior a 3 L/min/m2 foi utilizado como alvo através de fluidos, inotrópicos e transfusão de concentrado de hemácias, com início após desmame da circulação extracorpórea e com término após 8 horas de admissão na UTI. Resultados: O desfecho primário foi um composto de mortalidade e complicações maiores em 30 dias. Os pacientes do grupo TGM receberam maior volume (mediana e intervalo interquartílico) de fluidos em relação ao grupo controle [1000 (625 - 1500) vs. 500 (500 - 1000) mL (P < 0,001)], e não houve diferença na administração de inotrópicos ou hemotransfusão. A incidência do desfecho primário foi menor no grupo TGM (27,4 vs. 45,3%, p=0,037). O grupo TGM apresentou menor incidência de infecção (12,9 vs. 29,7%, P=0,002) síndrome do baixo débito cardíaco (6,5 vs. 26,6%, P=0.002). Foram também observados menor dose acumulada de dobutamina (12 vs. 19 mg/Kg, P=0,003), menor tempo de internação na UTI (3 [3-4] vs. 5 [4-7] dias; P < 0,001) e no hospital (9 [8-16] vs. 12 [9-22] dias, P=0,049) no grupo TGM comparado ao grupo controle. Não houve diferença nas taxas de mortalidade em 30 dias. (4,8% vs. 9,4%, respectivamente; P = 0,492). Conclusão: A estratégia de terapia guiada por metas através de fluidos, inotrópicos e transfusão sanguínea reduziu a incidência de complicações maiores em 30 dias em pacientes de alto risco submetidos a cirurgia cardíaca / Introduction: The objective of the study was to evaluate the effects of goal-directed therapy on outcomes in high-risk patients undergoing cardiac surgery. Methods: A prospective randomized controlled trial that evaluated 126 patients undergoing coronary artery bypass or valve repair in a Surgical Intensive Care Unit (ICU) of the Heart Institute/Faculty of Medicine of University of Sao Paulo. Patients were randomized to a cardiac output-guided hemodynamic therapy algorithm (GDT group, n=62) or to usual care (n=64). In the GDT arm, a cardiac index of greater than 3 L/min/m2 was targeted with intravenous fluids, inotropes and red blood cell transfusion starting from cardiopulmonary bypass and ending eight hours after arrival to the ICU. Results: The primary outcome was a composite endpoint of 30-day mortality and major postoperative complications. Patients from the GDT group received a greater median (interquartile range) volume of intra-venous fluids than the usual care group [1000 (625 - 1500) vs. 500 (500 - 1000) mL (P<0.001)], with no differences in the administration of either inotropes or red blood cell transfusions. The primary outcome was reduced in the GDT group (27.4 vs. 45.3%, p=0.037). The GDT group had a lower incidence of infection (12.9 vs. 29.7%, P=0.002) and low cardiac output syndrome (6.5 vs. 26.6%, P=0.002). We also observed lower ICU cumulative dosage of dobutamine (12 vs. 19 mg/Kg, P=0.003) and a shorter ICU (3 [3-4] vs. 5 [4-7] days; P < 0.001) and hospital length of stay (9 [8-16] vs. 12 [9-22] days, P=0.049) in the GDT compared to the usual care group. There were no differences in 30-day mortality rates (4.8% vs. 9.4%, respectively; P = 0.492). Conclusions: Goal directed therapy using fluids, inotropes and blood transfusion reduced 30-day major complications in high-risk patients undergoing cardiac surgery

L’arrêt cardiaque extra-hospitalier (ACEH) est un problème de santé publique majeur. La réanimation cardio-pulmonaire (RCP) précoce ainsi que la défibrillation par les témoins sont associées à une augmentation du taux de survie. Cependant, malgré d’importants efforts ces dernières années, les taux de survie restent faibles dans la plupart des pays. Ce travail avait pour objectif d’identifier des facteurs ayant un impact sur la défibrillation publique, la RCP précoce et les connaissances du public sur la défibrillation. Nous avons testé différentes stratégies de déploiement des défibrillateurs automatisés externes (DAE). Nous avons également analysé l’effet du niveau socio-économique des quartiers sur la RCP par les témoins. Enfin, nous avons cherché à évaluer les connaissances du public concernant la localisation et les conditions d’utilisation du DAE le plus proche dans des lieux publics très fréquentés. Tous les ACEH survenus à Paris entre 2000 et 2010 ont été enregistrés dans un registre et géocodés. Nous avons comparé une stratégie basée sur les recommandations de placement d’un DAE dans les lieux où plus d’un ACEH survenait tous les cinq ans à deux nouvelles stratégies : une stratégie de maillage régulier du territoire avec des DAE placés à distances régulières et une stratégie de placement dans différents types de lieux publics. Le nombre de DAE nécessaires ainsi que la distance médiane entre les ACEH et le DAE le plus proche étaient calculés pour chaque stratégie. Nous avons également recherché l’association entre le niveau socio-économique des quartiers sur le fait de bénéficier d’une RCP. Enfin, nous avons réalisé une enquête dans des lieux publics très fréquentés (gare, centres commerciaux, jardin public) auprès de toutes les personnes situées dans un rayon de 100 mètres autour d’un DAE pour analyser leur connaissance de la localisation du DAE et leur capacité à l’utiliser. Parmi 4176 ACEH, 1372 (33%) sont survenus dans des lieux publics. La stratégie basée sur les recommandations aurait conduit au placement de 170 DAE avec une distance aux ACEH de 416 (180-614) mètres et une augmentation continue du nombre de DAE. Avec la stratégie de maillage régulier du territoire, le nombre de DAE et la distance aux ACEH auraient changé selon la taille du maillage avec un nombre optimal de DAE évalué entre 200 et 400. Avec la stratégie de placement dans différents types de lieux publics, la distance médiane entre les ACEH et les DAE aurait été de 324 mètres pour les bureaux de poste (195), 239 mètres pour les stations de métro (302), 137 mètres pour les stations Velib’ (957) et 142 mètres pour les pharmacies (1466). Parmi les 4009 ACEH géocodables enregistrés, 777 (19,4%) ont bénéficié d’une RCP par un témoin. Ceux qui en ont bénéficié étaient plus fréquemment dans un lieu public, en présence d’un témoin et dans un quartier de statut socio-économique (SSE) non défavorisé. Dans une analyse multiniveaux la RCP par les témoins était significativement moins fréquente dans les quartiers de SSE défavorisé que dans les quartiers d’autres SSE (OR 0,85 ; 95% IC 0,72-0,99). Notre enquête a été menée auprès de 301 participants. Environ la moitié des participants (49%) avaient bénéficié d’une formation aux premiers secours, dont 70% après 2007 et 37% qui avaient suivi une initiation d’une heure. Le logo universel des DAE était reconnu par 37% des participants et 64% pouvaient reconnaître un DAE en photo. La localisation du DAE le plus proche était connue par 16% des participants avec un impact positif des formations après 2007 et de la reconnaissance du logo ou des photos (p<0,0001). Une majorité de participants (66%) savaient qu’ils avaient le droit d’utiliser un DAE et 59% savaient dans quelles circonstances l’utiliser. Seulement 25% des participants déclaraient savoir comment utiliser un DAE. Notre travail présente une approche originale pour optimiser les stratégies de déploiement des DAE. (...) / Out-of-hospital cardiac arrest (OHCA) is a major public health concern. Early bystander cardiopulmonary resuscitation (CPR) and defibrillation are associated with higher survival rates for OHCA victims. Unfortunately, despite major efforts over the past decade, survival rates remain low in many communities. This work sought to highlight factors affecting public defibrillation, early CPR and public knowledge on defibrillation. We assessed different strategies for Automated External Defibrillators (AEDs) deployment. We also aimed to focus effect of neighborhood socio-economic status on bystander CPR. Finally, we sought to analyze public awareness of the AED nearest location and knowledge of AED use. All OHCAs attended by EMS in Paris between 2000 and 2010 were prospectively recorded and geocoded. We compared a guidelines-based strategy of placing an AED in locations where more than one OHCA had occurred within the past five years to two novel strategies: a grid-based strategy with a regular distance between AEDs and a landmark-based strategy. The expected number of AEDs necessary and their median (IQR) distance to the nearest OHCA were assessed for each strategy. We also evaluated the relationship between neighbourhood SES characteristics and the fact of receiving bystander CPR. Then, we performed a survey in three kinds of places (train station, city mall and public park) of all individuals within 100 meters from an AED to analyze their knowledge of the closest AED location and their confidence to use it. Of 4,176 OHCAs, 1,372 (33%) occurred in public settings. The guidelines-based strategy would result in the placement of 170 AEDs, with a distance to OHCA of 416 (180-614) meters and a continuous increase in the number of AEDS. In grid-based strategy, the number of AEDs and their distance to the closest OHCA would change with the grid size, with a number of AEDs between 200 and 400 seeming optimal. In landmark-based strategy, median distances between OHCAs and AEDs would be 324 meters if placed at post offices (n=195), 239 at subway stations (n=302), 137 at bike-sharing stations (n=957), and 142 at pharmacies (n=1466). Of the 4,009 OHCA with mappable addresses recorded, 777 (19.4%) received bystander CPR. Those receiving it were more likely to be in public locations, have had a witness to their OHCA, and to have collapsed in a non-low SES neighbourhood. In a multilevel analyses, bystander CPR provision was significantly less frequent in low than in higher SES neighbourhoods (OR 0.85; 95% confidence interval [CI] 0.72-0.99). A total of 301 people responded to the survey. About half respondents (49%) had a Basic Life Support training experience with 70 % of them trained after 2007 and 37% who attempted a one hour training initiation. The universal AED sign was recognized by 37% of all respondents and 64% could recognize an AED on a picture. The closest AED location was known by 16% of the respondents with a positive impact of training after 2007 and knowledge of AED sign and picture (p<0.0001). A majority of respondents (66%), considered they had the right to use an AED and 59% knew in which circumstances it is necessary to use it. Only 25% of the respondents declared to know how to use an AED. Our work presents an original evidence-based approach to strategies of AED deployment to optimize their number and location. This rational approach can estimate the optimal number of AEDs for any city. In Paris, OHCA victims were less likely to receive bystander CPR in low SES neighbourhoods. These first European data are consistent with observations in North America and Asia. Our survey conducted in places known to be at risk of OHCA highlights the need for a better AED visibility in public places and the need to improve public knowledge and confidence in the use of AED. (...)

Os profissionais da área de saúde deparam-se constantemente com situações que envolvem risco de vida para os clientes, uma delas é a parada cardiorrespiratória (PCR) e necessita que sejam instituídas mais rapidamente as manobras de ressuscitação cardiopulmonar (RCP) que compreende o Suporte Básico de Vida (SBV) e o uso de Desfibrilador Externo Automático (DEA). Trata-se de um estudo exploratório descritivo com o objetivo de identificar a HABILIDADE (prática) e o CONHECIMENTO (teórico) dos alunos dos cursos de graduação da área da saúde, de uma universidade privada no interior do Estado de São Paulo, antes e após serem submetidos ao curso/ treinamento. A coleta dos dados foi dividida em duas etapas sendo: 1ª. Etapa - avaliação do conhecimento teórico e prático prévio antes de um curso teórico com demonstração prática das manobras de RCP com uso do DEA e treinamento utilizando o laboratório de práticas com o manequim de RCP e o DEA; 2ª. Etapa avaliação teórica e prática individual. Foram incluídos 173 alunos com faixa etária de 17 a 23 anos, 151 (87,3%) do sexo feminino; na Avaliação da HABILIDADE na 1ª. Etapa, a pontuação máxima foi de 91 pontos 69 (39,9%) alunos e 104 (60,1%) alunos não pontuaram, na 2ª. Etapa a pontuação máxima obtida foi de 260 pontos por 101(58,4%) alunos. Na Avaliação do CONHECIMENTO, a pontuação máxima foi de 5,75 pontos e a pontuação mínima de 1,0 ponto na 1ª. Etapa. Na 2ª. Etapa, a pontuação máxima foi de 10,0 pontos por sete (4,0%) alunos, nenhum aluno obteve pontuação inferior a 7,5 pontos. Para 19 itens a diferença foi significativa na Avaliação da HABILIDADE da 1ª para a 2ª. Etapa em todos os grupos de conteúdos sendo: Avaliação inicial e responsividade 2 itens; Abertura das vias aéreas e manobras de respiração - 6 itens; Avaliação do pulso carotídeo e compressões torácicas - 3 itens e Manuseio do DEA 8 itens. Para 9 questões a diferença foi significativa na Avaliação do CONHECIMENTO da 1ª para a 2ª. Etapa em dois grupos de conteúdos: Abertura das vias aéreas e manobras de respiração - 3 questões e Manuseio do DEA 6 questões. As 13 questões que não apresentaram bom desempenho na 2ª. Etapa do estudo, no Conhecimento, estão agrupadas nos conteúdos: Avaliação inicial e responsividade; Abertura das vias aéreas e manobras de respiração e Manuseio do DEA. Quanto comparados a HABILIDADE e o CONHECIMENTO verifica-se que houve melhora no desempenho da primeira para a segunda etapa em todos os itens e questões (p=0,0001). Quanto ao treinamento a média do tempo de observação foi de 78,3 minutos e o tempo de treino foi de 117,1 minutos. Em relação à HABILIDADE os itens que não atingiram bom desempenho na 2ª. Etapa estão nos conteúdos Avaliação inicial e responsividade e Manuseio do DEA e em relação ao CONHECIMENTO as questões que não atingiram bom desempenho estão nos conteúdos Avaliação inicial e responsividade; Abertura das vias aéreas e manobras de respiração e Manuseio do DEA. Conclui-se que tanto na HABILIDADE quanto no CONHECIMENTO houve melhora no desempenho dos alunos. / The health professionals faced with situations involving risk of life for patients, one of them is cardiopulmonary arrest (CA) and needs to be established more quickly cardiopulmonary resuscitation (CPR) involving the Basic Life Support (BLS) and use of Automated External Defibrillator (AED) This is a exploratory study aiming to identify the skill (practice) and knowledge (theoretical) of the students in health undergraduate students in a private university in the state of São Paulo, before and after their submitted to the course / training. Data collection was divided into two stages as follows: 1st. Step - Evaluation of knowledge practical and theoretical and course with prior practical demonstration of CPR maneuvers using the AED, 2nd. Step - training and theory/practice evaluation individual, using laboratory practices with the manikin CPR and AED. 173 students were included aged 17 to 23 years, 151 (87.3%) were female; the skill evaluation in the 1st. Step, the maximum score of 91 points was 69 (39.9%) and 104 students (60.1%) were not scored in the 2nd. Step a maximum score of 260 points was obtained for 101 (58.4%) students. The Knowledge evaluation, the maximum score was 5.75 points in the 1st. Stage and a minimum score of 1.0 in the 2nd. Step, the maximum score was 10.0 points in seven (4.0%) students, no students scored less than 7.5 points. For 19 items the difference was significant in the skill evaluation the 1st to 2nd. Step in all groups of content being: \"Initial evaluation and responsiveness\" - 2 items, \"Opening the airway and breathing maneuvers\" - 6 items, \"Evaluation of the carotid pulse and chest compressions - items 3 and \" Handling the DEA \"- 8 items. In nine questions for the difference was significant in the Knowledge evaluation from the 1st to 2nd. Step into two groups of content: \"Opening the airway and breathing maneuvers\" - three questions and \"Handling the DEA\" - 6 issues. The 13 questions that did not show good performance in the 2nd. Stage of the study on Knowledge, are grouped by content: \"Initial evaluation and responsiveness,\" \"Opening the airway and breathing maneuvers\" and \"Handling the DEA.\" As compared with the skill and knowledge there is a significant improvement in performance from first to second step on all the items and issues (p = 0.0001). As for training the average observation time was 78.3 minutes and the workout time was 117.1 minutes. Regarding skill items that did not achieve good performance in the 2nd. Step in the contents are Initial evaluation and responsiveness and Handling the DEA and about the knowledge the questions that are not achieved a good performance in the contents Initial evaluation and responsiveness, Opening the airway and breathing maneuvers and Handling the DEA. We conclude that both the skill and knowledge in significant improvement in student performance.