[pt] Na indústria do petróleo e gás, uma das atividades de maior importância é a intervenção em poços para serviços de manutenção, a qual é necessária para garantir a produção de petróleo. Estas intervenções são realizadas por sondas workover que são disponibilizadas para atender uma grande quantidade de poços segundo um itinerário. Nesta tese são propostos três modelos de programação linear inteira para abordar eficientemente o problema de intervenção em poços terrestres de petróleo. O primeiro modelo determina o itinerário de um conjunto de sondas homogêneas, visando minimizar a perda total de produção. Este modelo é um aprimoramento do modelo proposto por Costa e Ferreira Filho (2004). O segundo modelo é uma extensão do anterior e considera também o dimensionamento de uma frota de sondas heterogênea, procurando minimizar o custo de perda de produção e o custo de aluguel de sondas. O terceiro modelo é uma abordagem estocástica que estende o segundo modelo e consiste em dimensionar uma frota de sondas considerando o tempo de intervenção incerto. A incerteza do tempo de intervenção é representada mediante a geração de cenários, usando para este fim os métodos de Monte Carlo, Redução de Cenários e Quasi-Monte Carlo. Os testes de estabilidade propostos por Kaut e Wallace (2003) são aplicados para avaliar os métodos de geração de cenários e estabelecer o número de cenários adequados para resolver o problema. Para avaliar o desempenho dos modelos propostos, diversos experimentos computacionais foram realizados em instâncias de pequeno, médio e grande porte. Todas as instâncias são baseadas em casos reais no Brasil. Os resultados mostram que os modelos propostos foram capazes de resolver todas as instâncias utilizadas, inclusive aquelas de grande porte, demonstrando serem eficientes quando comparadas com várias metaheurísticas, pois produzem soluções exatas em um curto tempo computacional. Uma análise do impacto nas soluções quando ocorre uma mudança no preço de petróleo e no horizonte de planejamento também é realizada. A metodologia de resolução empregada no terceiro modelo mostrou que o método Quasi-Monte Carlo proporcionou os melhores cenários para representar a incerteza e também o potencial do modelo para resolver problemas de grande porte. / [en] In the oil and gas industry, one of the most important activities is the intervention in wells for maintenance services, which is necessary to ensure the production of oil. These interventions are performed by workover rigs that are available to serve a large number of wells according to a schedule. In this thesis, we proposed three integer linear programming models to efficiently address the problem of intervention in onshore oil wells. The first model determines the schedule of a set of homogeneous rigs, with the objective of minimizing the total production loss. This model is an improvement of the model proposed by Costa and Ferreira Filho (2004). The second model is an extension of the previous one and also considers the sizing of a heterogeneous rig fleet, with the objective of minimizing the production loss cost and the rig rental cost. The third model is a stochastic approach that extends the second model and consists of sizing a rig fleet considering the uncertainty in the intervention time. The uncertainty in the intervention time is represented by the generation of scenarios, using for this purpose the Monte Carlo, Scenario Reduction, and Quasi-Monte Carlo methods. The stability tests proposed by Kaut and Wallace (2003) are applied to evaluate the scenario generation methods and to establish the number of appropriate scenarios to solve the problem. To evaluate the performance of the proposed models, several computational experiments were performed in small, medium and large instances. All instances are based on real cases in Brazil. The results show that the proposed models were able to solve all of the instances considered, including the large instances, proving to be efficient when compared to various metaheuristics, as they produce exact solutions in small computational time. An analysis of the impact on the solutions when there is a change in the oil price and the planning horizon is also carried out. The resolution methodology employed in the third model showed that the Quasi-Monte Carlo method provided the best scenarios to represent the uncertainty and also the potential of the model to solve large-scale problems.

La voie des RLR (RIG-I like Receptors) joue un rôle essentiel dans la détection des virus à ARN, déclenchant une réponse immunitaire antivirale grâce au recrutement de la protéine adaptatrice mitochondriale MAVS (Mitochondrial AntiViral Signaling protein). Nous avons mis en évidence que les souris déficientes pour la protéine MAVS (MAVS KO) présentaient un phénotype proallergénique dans un modèle d'inflammation stérile d'hypersensibilité retardée de contact (HSRC) qui reproduit la dermatite allergique de contact (DAC) chez l'homme. Nous avons caractérisé le système immunitaire des souris MAVS KO en condition d'équilibre et durant la réponse d'HSRC. Nous avons identifié un rôle du microbiote intestinal des souris MAVS KO dans l'exacerbation de réponse d'HSRC et mis en évidence une dysbiose du microbiote bactérien. Nous avons démontré que la dysbiose était responsable du phénotype inflammatoire observé, phénotype transmissible à des souris sauvages par des expériences de cohébergement et de transplantation fécale. Cette dysbiose induit une augmentation de la perméabilité intestinale chez les souris MAVS KO lors de la réponse d'HSRC, aboutissant à une translocation bactérienne dans les organes lymphoïdes et à la modulation des réponses immunitaires à l'origine de l'exacerbation de réponse d'hypersensibilité. La 2ème partie de ma thèse vise à étudier les conséquences de la déficience en MAVS sur le métabolisme glucidique. Nos expériences ont démontré que les souris MAVS KO développaient une surcharge pondérale et une insulino-résistance sous régime riche en lipides et sucrose, dépendants de la dysbiose intestinale. Au niveau cellulaire, une altération des interactions aux points de contact entre la mitochondrie et le réticulum endoplasmique a été observée. Nos résultats permettent d'envisager le développement de nouvelles approches thérapeutiques des pathologies allergiques et métaboliques humaines par la modulation du microbiote intestinal / RIG-I like receptors (RLRs) play a major role in response to cytosolic viral RNAs by initiating an antiviral immune response through the recruitment of the mitochondrial adaptor protein MAVS (Mitochondrial AntiViral Signaling protein). We showed that MAVS-deficient mice developed an exacerbated response in a sterile inflammatory model of Contact Hypersensitivity (CHS), that reproduces the pathophysiology of allergic contact dermatitis (ACD) in human. We characterized the immune system of MAVS KO mice at steady state and during CHS response. We found that MAVS deficiency leads to changes in the gut bacterial composition suggesting an unexpected role of the RLR pathway in the regulation of intestinal homeostasis. We demonstrated that intestinal dysbiosis is responsible for the increased CHS response, and showed that the inflammatory phenotype of MAVS KO mice can be transferred to WT mice by cohousing and fecal transplantation. We demonstrated that the dysbiotic gut microbiota exerts its effect due to an increased intestinal permeability during DTH sensitization. The ensuing bacterial translocation within lymphoid organs enhances characteristic cytokines production that increases CHS response. The 2nd part of my thesis aimed to study the consequences of MAVS deficiency on glucose metabolism. Our experiments showed that MAVS KO mice exhibit disorders of glucose homeostasis during high fat diet (HFD) associated with the development of overweight and insulin resistance. We also observed alterations of MAM (Mitochondria-associated endoplasmic reticulum membranes), contact poins between mitochondria and endoplasmic reticulum. Recent preliminary data suggested that the metabolic disorders associated with MAVS deficiency are due to intestinal dysbiosis. Our results highlight a new role for the RLR pathway and allow to consider the development of new therapeutic approaches to human allergic and metabolic diseases by modulation of the intestinal microbiota

Various research has shown the potential and robustness of deep learning-based approaches to synthesise novel motions of 3D characters in virtual environments, such as video games and films. The models are trained with the motion data that is bound to the respective character skeleton (rig). It inflicts a limitation on the scalability and the applicability of the models since they can only learn motions from one particular rig (domain) and produce motions in that domain only. Transfer learning techniques can be used to overcome this issue and allow the models to better adapt to other domains with limited data. This work presents a study of three transfer learning techniques for the proposed Objective-driven motion generation model (OMG), which is a model for procedurally generating animations conditioned on positional and rotational objectives. Three transfer learning approaches for achieving rig-agnostic encoding (RAE) are proposed and experimented with: Feature encoding (FE), Feature clustering (FC) and Feature selection (FS), to improve the learning of the model on new domains with limited data. All three approaches demonstrate significant improvement in both the performance and the visual quality of the generated animations, when compared to the vanilla performance. The empirical results indicate that the FE and the FC approaches yield better transferring quality than the FS approach. It is inconclusive which of them performs better, but the FE approach is more computationally efficient, which makes it the more favourable choice for real-time applications. / Många studier har visat potentialen och robustheten av djupinlärningbaserade modeller för syntetisering av nya rörelse för 3D karaktärer i virtuell miljö, som datorspel och filmer. Modellerna är tränade med rörelse data som är bunden till de respektive karaktärskeletten (rig). Det begränsar skalbarheten och tillämpningsmöjligheten av modellerna, eftersom de bara kan lära sig av data från en specifik rig (domän) och därmed bara kan generera animationer i den domänen. Kunskapsöverföringsteknik (transfer learning techniques) kan användas för att överkomma denna begränsning och underlättar anpassningen av modeller på nya domäner med begränsade data. I denna avhandling presenteras en studie av tre kunskapsöverföringsmetoder för den föreslagna måldriven animationgenereringsnätverk (OMG), som är ett neural nätverk-baserad modell för att procedurellt generera animationer baserade på positionsmål och rotationsmål. Tre metoder för att uppnå rig-agnostisk kodning är presenterade och experimenterade: Feature encoding (FE), Feature clustering (FC) and Feature selection (FS), för att förbättra modellens lärande på nya domäner med begränsade data. All tre metoderna visar signifikant förbättring på både prestandan och den visuella kvaliteten av de skapade animationerna, i jämförelse med den vanilla prestandan. De empiriska resultaten indikerar att både FE och FC metoderna ger bättre överföringskvalitet än FS metoden. Det går inte att avgöra vilken av de presterar bättre, men FE metoden är mer beräkningseffektiv, vilket är fördelaktigt för real-time applikationer.

<p>This report is product of a degree project accomplishment at Linnaeus University in Växjö, Sweden. It is about designing a testing rig for impact loading of beams for laboratory use.</p><p>The specimens to be used were 1 meter long 8 standard profiles given in the project assignment. The first step in this project was to design and dimension a testing rig which is suitable for laboratory use. The height and the maximum mass were chosen according to laboratory use conditions and safety issues. The second step was designing the fixation for the test sample to the testing rig without any dislocation by the impact load. The third step was to measure the falling height of the mass onto the test sample and measure the deflection of the beam. In this case, the precision of falling height was not very important but measuring the deflection of the beam with the highest possible precision was most important. A measurement system is used considering this factor.</p><p>The project started with the idea of affecting the impact loads on the standard steel construction beams. The aim of this project is to design an impact loading testing rig which can be used for the purpose of laboratory experiments and compare the real results from the experiments with the theoretical results from the calculations.</p><p>In the project, Solid Works and AutoCAD software are often used both in the drawings and strength and stress analyses.</p>

Accelerated durability testing of automotive components has become a major interest as it may predict the life characteristics of the vehicle by testing fatigue failure at higher stress level within a shorter period of time. In this work, a specially designed sub-scaled experimental testing bed with the rigid and elastic supports of a simply supported beam was designed and built to compare the effects of the elastic foundation on the change of modal parameters of the tested structure which was later used to tune the FE model. Afterwards, the accelerated loading profiles of both sine sweep and random vibration were applied on the FE model to compare the deviation of the cumulative fatigue damage between the elastic and rigid supports. This work reveals a significant amount of inaccuracy in the current laboratory testing system where the dynamic properties of the tested structure are not maintained close to the real situation. / October 2016

A estampagem incremental é um processo de deformação incremental de chapa que pode ser classificado em três modos distintos: estampagem incremental sem matriz, estampagem incremental com matriz parcial e estampagem com matriz total. A deformação ocorre devido ao contato entre a ferramenta e a chapa, localmente e progressivamente, ao longo de uma trajetória pré-definida. A chapa permanece presa a suportes que fixam as suas extremidades de maneira a impedir os deslocamentos provocados pela passagem da ferramenta. A primeira parte deste trabalho compreende estudos em elementos finitos, usando o software LS-Dyna, sobre a trajetória das deformações na estampagem incremental para a fabricação de flanges em chapas previamente furadas de liga de alumínio AA1050. Foram realizados testes de contato e de linha que permitiram definir parâmetros da simulação. Os resultados para as deformações foram confrontados com os resultados obtidos experimentalmente por outros autores e permitiram verificar o comportamento das deformações nos flanges. As deformações crescem montonicamente até os valores máximos. Este resultado confirma a teoria de que na estampagem incremental de chapas a fratura ocorre sem o prévio aparecimento da estricção. A segunda parte deste trabalho trata do desenvolvimento de um suporte modular aplicável a estampagem incremental, tanto na sua variante sem matriz quanto com matriz, com o intuito de aumentar a flexibilidade do processo com relação à geometria da peça a ser deformada. Foi empregada a técnica de análise de valor objetivando alcançar a melhor funcionalidade do sistema. Como resultado foi obtido um suporte modular que atende os requisitos de rigidez, flexibilidade, modularidade, agilidade na troca da chapa a ser deformada e simplicidade construtiva. / The sheet incremental forming can be classified into three basic configurations, depending on the number of contact points between the sheet, tool and die (when present). Single incremental forming (absence of specific dies) and two point incremental forming (presence of a partial or full die) can be distinguished. The process makes use of a simple, low-cost, hemispherical tipped tool to precisely and progressively shape a blank into a metal sheet along a predefined tool path. The sheet is fixed onto the rig to prevent lateral displacements caused by tool movement. The first part of this work includes studies about finite elements, using the LS-Dyna software, applied to deformation path in hole-flanging produced by incremental sheet forming. The investigation was carried out using aluminum alloy AA1050. Contact and line numerical results support simulation parameters choices. The results from the strains were compared with empirical ones obtained by other authors. The results showed the deformation mechanics behavior of the hole-flanging. The strain paths of hole-flanging produced by incremental sheet forming grew linearly and monotonically from the origin to the maximum achievable strains. This result confirms the absence of local necking along plane strain directions. The second part of this work deals with the development of a modular rig that can be applied to dieless, partial or total die single point incremental forming in order to increase the flexibility of the process concerning the geometry of the part to be deformed. The result was a modular rig with constructive simplicity and requirements of stiffness, flexibility and modularity when exchanging sheets.

A estampagem incremental é um processo de deformação incremental de chapa que pode ser classificado em três modos distintos: estampagem incremental sem matriz, estampagem incremental com matriz parcial e estampagem com matriz total. A deformação ocorre devido ao contato entre a ferramenta e a chapa, localmente e progressivamente, ao longo de uma trajetória pré-definida. A chapa permanece presa a suportes que fixam as suas extremidades de maneira a impedir os deslocamentos provocados pela passagem da ferramenta. A primeira parte deste trabalho compreende estudos em elementos finitos, usando o software LS-Dyna, sobre a trajetória das deformações na estampagem incremental para a fabricação de flanges em chapas previamente furadas de liga de alumínio AA1050. Foram realizados testes de contato e de linha que permitiram definir parâmetros da simulação. Os resultados para as deformações foram confrontados com os resultados obtidos experimentalmente por outros autores e permitiram verificar o comportamento das deformações nos flanges. As deformações crescem montonicamente até os valores máximos. Este resultado confirma a teoria de que na estampagem incremental de chapas a fratura ocorre sem o prévio aparecimento da estricção. A segunda parte deste trabalho trata do desenvolvimento de um suporte modular aplicável a estampagem incremental, tanto na sua variante sem matriz quanto com matriz, com o intuito de aumentar a flexibilidade do processo com relação à geometria da peça a ser deformada. Foi empregada a técnica de análise de valor objetivando alcançar a melhor funcionalidade do sistema. Como resultado foi obtido um suporte modular que atende os requisitos de rigidez, flexibilidade, modularidade, agilidade na troca da chapa a ser deformada e simplicidade construtiva. / The sheet incremental forming can be classified into three basic configurations, depending on the number of contact points between the sheet, tool and die (when present). Single incremental forming (absence of specific dies) and two point incremental forming (presence of a partial or full die) can be distinguished. The process makes use of a simple, low-cost, hemispherical tipped tool to precisely and progressively shape a blank into a metal sheet along a predefined tool path. The sheet is fixed onto the rig to prevent lateral displacements caused by tool movement. The first part of this work includes studies about finite elements, using the LS-Dyna software, applied to deformation path in hole-flanging produced by incremental sheet forming. The investigation was carried out using aluminum alloy AA1050. Contact and line numerical results support simulation parameters choices. The results from the strains were compared with empirical ones obtained by other authors. The results showed the deformation mechanics behavior of the hole-flanging. The strain paths of hole-flanging produced by incremental sheet forming grew linearly and monotonically from the origin to the maximum achievable strains. This result confirms the absence of local necking along plane strain directions. The second part of this work deals with the development of a modular rig that can be applied to dieless, partial or total die single point incremental forming in order to increase the flexibility of the process concerning the geometry of the part to be deformed. The result was a modular rig with constructive simplicity and requirements of stiffness, flexibility and modularity when exchanging sheets.

Esta tese apresenta, o projeto de uma perfuratriz que permite a execução de cinco tipos de fundação profunda, e o desenvolvimento de um ensaio de campo que possibilita avaliar as resistências por atrito lateral desenvolvidas entre o instrumento envolvido pelo solo escavado e o terreno natural. A perfuratriz foi projetada para executar estacas dos tipos hélice contínua monitorada, escavadas com trado mecânico, hélice segmentada monitorada, raiz e hollow-auger. As estacas dos tipos hélice contínua monitorada e as escavadas com trado mecânico são muito utilizadas no Brasil; as estacas raiz e hollow-auger são utilizadas em situações especiais e a estaca hélice segmentada monitorada é mais recente, mas sua aplicação tem tido um crescimento importante nos últimos dez anos. Para a perfuratriz multifuncional são apresentados cálculos e desenhos básicos dos principais conjuntos. Para a nova investigação de campo, denominada FDT - Full Displacement Test, é apresentado um desenvolvimento teórico com base no princípio universal da conservação de energia que, em termos práticos, resulta na obtenção da parcela de atrito lateral, denominado atrito lateral unitário equivalente (fse). Os resultados obtidos a partir dos dados aquisitados pelo sistema de monitoramento eletrônico da perfuratriz apresentaram-se concordantes entre si, indicando a possibilidade de praticamente se conseguir a repetibilidade do ensaio. Entre os diversos ensaios realizados, foi dada ênfase aos ensaios realizados no campo experimental de Fundações e Geotecnia da Faculdade de Engenharia Agrícola FEAGRI, da Universidade de Campinas - UNICAMP e foram feitas correlações com as resistências obtidas nas provas de carga estáticas realizadas no local por Albuquerque (2001), a partir dos ajustes feitos para o nível instrumentado na profundidade de 11,70 m para o qual foi determinado um fator (G2), para cada tipo de estaca ensaiada (escavada, hélice contínua e ômega). A partir dos ajustes feitos para o nível 11,70 m foram feitas previsões de capacidade de carga por atrito lateral para os outros níveis instrumentados (5,00 m; 11,10 m e 12,00 m), sendo que os resultados apresentaram-se concordantes. / This thesis presents the design of a drilling rig that allows the execution of five types of deep foundation, and the development of a field test that allows measuring the skin friction resistance developed between the instrument involved by the excavated ground and the natural soil. The drilling rig was designed to make continuous flight auger, bored pile, continuous flight auger with segmented auger, root pile and hollow-auger pile. The continuous flight auger and bored piles are widely used in Brazil; the root pile and hollow-auger pile are used for in special conditions, and the continuous flight auger with segmented auger, is although more recent, but its application has had increased application grown in over the last ten years. For the multifunctional drilling rig, calculations and basic designs of the main sets are presented. For the new field test denominated FDT - Full Displacement Test, a theoretical development based on the universal principle of energy conservation was made carried out resulting and the result, in practical terms, was to obtain in the attainment of the skin friction defined in this thesis as equivalent unit skin friction (fse). The results obtained from the data acquired by the electronic monitoring system of drilling rigs were consistent among themselves, indicating the possibility of practically achieve the repeatability of the test. Among the various tests performed, emphasis was given to tests in the experimental field of foundations and geotechnics, of the College of Agricultural Engineering FEAGRI, Campinas University UNICAMP, and were correlated to the skin friction resistance obtained from the static load tests performed on site by Albuquerque (2001), based on the adjustments done to the instrumented level depth of 11.70 m, for which a factor (G2) was given in each type tested (bored, C.F.A and omega). From the adjustments made to the 11,70 m level, load-bearing capacity of skin friction predictions were made for other instrumented levels (5.00 m; 11.10 m and 12.00 m) presenting consistent results.

Syfte och frågeställningar Syftet har varit är att öka kunskapen om lärares bedömning av elevers praktiska färdighet i innebandy på den nationella idrottsutbildningen (NIU). Vidare syftar studien till att jämföra lärarnas bedömning med kursplanens kunskapskrav. Vilka färdigheter är det som de intervjuade lärarna bedömer hos eleverna? Hur bedömer de intervjuade lärarna elevernas färdigheter? Hur erfar de intervjuade lärarna arbetet med bedömning och betygsättning? Metod Med hänsyn till studiens kvalitativa ansats valdes intervju som metod. Studien avgränsar sig till de lärare som undervisar innebandy som specialidrott. Urvalet gjordes med hänsyn till geografisk spridning. I studien deltog sex lärare från sex olika skolor i landet.Som teoretisk ansats användes en mätteori där verklighetsmängden, lärarnas uttryckta bedömningar, jämfördes mot symbolmängden, kursplanens uttryckta bedömningar. I analysen av lärarnas bedömning användes ”Performance analysis” som utgångspunkt. Resultat Resultatet visade att lärarna bedömde eleverna i teknik, tekniskt användande, taktik, rörelse, och beteende utifrån modellen ”Performance Analysis” samt fysisk förmåga och elevernas utveckling över tid. Bedömningarna skedde på olika sätt, men med en tyngdpunkt på den subjektiva bedömningen. Lärarna erfar betygsprocessen som utmanande och att riktlinjerna för bedömning är otydliga i styrdokumenten. Slutsats Lärarna är väl lämpade för att genomföra bedömningar på goda grunder utifrån forskning om idrottsliga prestationer. Deras erfarenhet tillsammans med de bedömningar de som de gör, ger en god grund för en prestationsbedömning. Det saknas dock tydliga riktlinjer från Skolverket och Svenska Innebandyförbundet om vilka färdigheter som ska bedömas och hur bedömningarna ska ligga till grund för betygsättningen. Detta innebär att bedömningen ser annorlunda ut från skola till skola och på det följer en betygssättning som riskerar att inte vara likvärdig. / Aim The aim of this study has been to investigate how teachers assess students practical skills in floorball at the Elite Sports Programs in the Swedish Upper Secondary School. Furthermore, the study aims to compare teachers assessment with the standards of attainment formulated by The Swedish National Agency for Education (SNAE) What skills do the interviewed teachers assess? How do the interviewed teachers assess the student’s skills? How do the interviewed teacher experience the work with assessment? Method With regards to the study's qualitative approach interview was chosen as method. The study delimits itself to the teachers who teach floorball as special sports. The selection was made taking into account the geographical spread and six teachers from six different schools participated in the study. As a theoretical approach, a measure theory were used where true amount, the teachers expressed assessments, compared to the symbol rate, the curriculum expressed judgments. The analysis of teachers' assessment used the model of "Performance analysis" as departure point. Results The results show that teachers assessed students in technique, technical use, tactics, movement and behavior based on the model, "Performance Analysis", as well as physical ability and pupils development over time. The assessment differed and there was an emphasis on a subjective assessment. Teachers experienced the grading process as challenging and fuzzy regarding the guidelines from the SNAE. Conclusion Teachers are well capable of assessing. Their basis for assessment is in accordance with research of athletic performance. There are no clear guidelines from SNAE or the Swedish Floorball Federation regarding the skills that should be assessed and furthermore how the assessment should form the basis for grading. This means that the assessment differs from school to school, with the risk that the grading is based on different grounds.

This report is product of a degree project accomplishment at Linnaeus University in Växjö, Sweden. It is about designing a testing rig for impact loading of beams for laboratory use. The specimens to be used were 1 meter long 8 standard profiles given in the project assignment. The first step in this project was to design and dimension a testing rig which is suitable for laboratory use. The height and the maximum mass were chosen according to laboratory use conditions and safety issues. The second step was designing the fixation for the test sample to the testing rig without any dislocation by the impact load. The third step was to measure the falling height of the mass onto the test sample and measure the deflection of the beam. In this case, the precision of falling height was not very important but measuring the deflection of the beam with the highest possible precision was most important. A measurement system is used considering this factor. The project started with the idea of affecting the impact loads on the standard steel construction beams. The aim of this project is to design an impact loading testing rig which can be used for the purpose of laboratory experiments and compare the real results from the experiments with the theoretical results from the calculations. In the project, Solid Works and AutoCAD software are often used both in the drawings and strength and stress analyses.