Submitted by Biblioteca Central (biblioteca@unicap.br) on 2018-02-23T18:15:43Z No. of bitstreams: 2 luzia_valladao_ferreira.pdf: 6748466 bytes, checksum: 456c8c5dd6423b02ae270a0fa29943d2 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2018-02-23T18:15:43Z (GMT). No. of bitstreams: 2 luzia_valladao_ferreira.pdf: 6748466 bytes, checksum: 456c8c5dd6423b02ae270a0fa29943d2 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-12-11 / This research turns to the second half of the twentieth century, when the Archdiocese of Natal/RN undertook numerous iniciatives aimed at alleviating the suffering of rural families and people from the outskirts of cities. These initiatives have become internationally known as “Movimento de Natal”. Among these initiatives, the experience of the Parish Vicars in Nísia Floresta/RN was impressive. Due to the lack of priests in the Archdiocese, Bishop Eugênio de Araújo Sales gave the administration of the Parish of Nísia Floreta/RN to the Missionaries of Jesus Crucified, granting the Sisters all the rights and duties of parish vicars, except for the administration of the sacraments of Penance and of the Euchatist, proper to the priestly ministry. The experience lasted 25 years, from October1963 to August 1989, and its importance was to favor conditions for rural workers to become protagonists of their life. In a dynamic of decentralization and respect for local culture, they prepared the people to fight for their rights, in line with the social doctrine of the Catholic Church. This experience shows that an evangelization as an inserted pastoral ministry induces evangelizers. Its uniqueness opened space for a reflection on the role of women in the Church, extremely restricted at the time. Hence it drew so much attention to the whole world. / Esta pesquisa volta-se para a segunda metade do século XX, quando a Arquidiocese de Natal/RN empreendeu inúmeras iniciativas com o fim de amenizar o sofrimento das famílias rurais e das periferias das cidades. Essas iniciativas tornaram-se internacionalmente conhecidas como “O Movimento de Natal”. Dentre essas iniciativas, impactante foi a experiência das Vigárias Paroquiais em Nísia Floresta/RN. Em função da carência de sacerdotes na Arquidiocese, Dom Eugênio de Araújo Sales entregou a administração dessa Paróquia às Missionárias de Jesus Crucificado, concedendo às Irmãs todos os direitos e deveres de vigárias paroquiais, exceto a administração dos sacramentos da Penitência e da Eucaristia, próprios do ministério sacerdotal. A experiência teve a duração de 25 anos, de outubro de 1963 a agosto de 1989, e sua importância consistiu em favorecer, aos trabalhadores rurais, condições de tornarem-se protagonistas do seu destino. Numa dinâmica de descentralização e respeito à cultura local, prepararam o povo para lutarem pelos seus direitos, em consonância com a doutrina social da Igreja Católica. Essa experiência mostra que uma evangelização nos moldes de uma pastoral inserida gera evangelizantes. Sua singularidade abriu espaço para uma reflexão a respeito do papel da mulher na Igreja, extremamente restrito na época. Daí porque chamou tanto a atenção do mundo inteiro.

A prevalência de Toxoplasma gondii em mamíferos silvestres, quando próximos a áreas urbanizadas, deve ser analisada para diagnosticar riscos à saúde humana e animal. Em Natal-RN, duas Unidades de Conservação (UC), Parque da Cidade e Parque das Dunas, se destacam pela importância ecológica. Nestas UCs a presença de gatos domésticos errantes é constante. O objetivo foi avaliar e comparar a presença de T. gondii através de teste sorológico (MAT) e molecular (gene B1) em gatos e pequenos mamíferos silvestres. Houve associação entre o número de animais silvestres soropositivos em cada parque (p = 0,018), sendo que o Parque da Cidade demonstrou um quadro mais alarmante. A positividade para T. gondii através da amplificação do gene B1 foi positiva em 16,3% do total de animais silvestres analizados e 8,1% do total de gatos avaliados nas duas Ucs. Não houve associação entre o número de animais silvestres positivos para o gene B1 em cada parque (p = 1,00). Existe a participação de ambos os grupos de animais (silvestres e domésticos) no ciclo local do T. gondii. / The prevalence of Toxoplasma gondii in wild mammals close to urbanized areas should be analyzed to diagnose risks to human and animal health. In Natal-RN State, two protected areas, Parque da Cidade and Parque das Dunas are distinguished by ecological importance. In these protected areas, the presence of domestic cats is constant. The aim was to evaluate and compare the presence of T. gondii by serological testing (MAT) and molecular (B1 gene) in cats and small wild mammals. There was an association between the number of wild seropositive animals in each park (p = 0.018). The Parque da Cidade showed a more alarming situation. The positivity for T. gondii by B1 gene amplification was positive in 16.3% on wild animals analyzed and 8.1% on the cats evaluated in the two protected areas. There was no association between the number of wild animals positive for the B1 gene in each park (p = 1,00). There is a participation of both groups of animals (wild and domestic) in the local cycle of T. gondii.

L’objectif de cette étude est de caractériser des altérations de qualité de la viande du porc et de la dinde. Chez porc, la qualité de la viande est handicapée par une lésion de type de myopathie exsudative appelée PSE ou viandes déstructurées dans sa forme localisée. La transformation de ces viandes conduit à de faible rendements suite à une perte d’eau importante et un grave défaut de présentation du produit fini et donc à des pertes économiques importantes. Parmi les facteurs conditionnant l’apparition de la lésion, la génétique des animaux aux loci HAL et RN occupe un premier plan. Au second plan, l’environnement pre-mortem a une influence tout aussi importante et en particulier les conditions d’abattage. L’histologie comparative des muscles montre que la structure du réseau vasculaire et la typologie des fibres musculaires chez le porc des différents génotypes HAL et RN sont responsables de leur vulnérabilité. Chez la dinde, les expressions du problème PSE dans le muscle sont vraisemblablement similaires à celles observées chez le porc. Les caractéristiques de qualité de 3 souches de dinde (Hybride, Nicholas et BUT9) ont été étudiées : la chute du pH post mortem et la couleur de la viande évaluée dans le système L*a*b* nous confortent dans cette position / The objective of this study is to characterize the alteration of meat quality of the pork and the turkey. In pork, the quality of the meat is handicapped by a lesion exsudative myopathy called PSE (Pale Soft Exsudative) or localized destructured meats. The transformation of these meats leads to a reduced performance following an important water loss and a serious defect of presentation of the end product will cause massive losses in economy. Among the factors influencing the appearance of the lesion, HAL and RN genotypes occupy the first plan to limit these effects in pork. In the second plan, the pre-mortem environment has an all-important influence also and in particular the slaughter conditions. Comparative histology of muscles shows that the structure of the vascular network and the typology of muscle fibers of various genotypes HAL and RN in pork are responsible for their vulnerability. In turkey, the expressions of PSE muscle problem are probably similar to those observed in pork. Quality characteristics of 3 lines of turkey (Hybride, Nicholas and BUT9) were studied. The rate of pH fall post-mortem and the colour of the meat (which were evaluated in the L*a*b* system) have reinforced us in this position.

No description available.

The National Council Licensure Examination for Registered Nurses (NCLEX-RN) first-time pass rate for an associate degree in nursing (ADN) program was below the national mean, presenting a problem for graduates who failed the NCLEX-RN and could not enter the workforce as registered nurses. Knowles's assumptions of adult learning, Ebbinghaus's forgetting curve, and Zull's neuroscience research served as the theoretical frameworks for this study. The purpose of this study was to identify which academic and time-lapse variables predict the graduate's first-time passage for the NCLEX-RN. Archived academic records and NCLEX-RN results for all 786 graduates from one ADN program who took the NCLEX-RN for the first time in 2015 were reviewed. Binary logistic regression analysis of the data identified multiple academic and one time lag factor as significant predictors for first-time NCLEX-RN passage. Key results included positive relationships between academic variables (prerequisite grade point average [GPA], nursing GPA, cumulative GPA, final course grade in 1 medical surgical course) and NCLEX-RN passage. An inverse relationship was shown between NCLEX-RN pass and the number of nursing component failures and time lag between clinical capstone completion and first NCLEX-RN attempt. Results informed a policy recommendation to provide timely intervention and resources for students at risk, with a goal of promoting success on the first attempt of the NCLEX-RN. Increasing the numbers of graduates who successfully complete the NCLEX-RN on the first attempt and promptly join the nursing workforce will demonstrate positive social change by mitigating the nursing shortage, which promotes safe patient care.

Roughness is an important indicator of pavement riding comfort and safety. It is a condition indicator that should be carefully considered when evaluating primary pavements. At the same time, the use of roughness measurements plays a critical role in the pavement management system. There are many devices used for roughness evaluation. The major tools used for road roughness quantify are the road profilers. In the thesis research, in order to obtain useful pavement surface condition data for pavement evaluation, two direct type road roughness evaluation systems were developed with the combination of modern sensor technology and computer technology. The thesis will focus on the development of the direct type profiler systems, including the improvement of the hardware design, the new direct type road roughness-measuring system using different method, the software development, which makes it more functional. In order to evaluate the accuracy and correction of the direct type profiler system, different roughness devices (including FDOT High-Speed laser profiler, FACE Dipstick and direct type I profiler) were operated in 4 calibration sites. The research focused on several performance measures, such as correlativity, repeatability. IRI and RN results from these devices were analyzed to evaluate the correlativity between these devices. After verified that direct type I profiler has good repeatability and correlation with FDOT High-Speed laser profiler, FACE Dipstick, 10 calibration sites data in Tampa were collected using direct type I profiler and direct type II profiler. The repeatability and correlation analysis between the two profilers were performed. From field experiments and data analysis, it shows: 1.Direct type I profiler showed satisfactory repeatability performances; 2.Direct type I profiler has good RN correlations High-Speed laser profiler; 3.Direct type I profiler has good correlations with Dipstick, High-Speed laser profiler in terms of IRI 4.Direct type II profiler does not has good correlation with direct type I profiler; the performance needs to be improved. Except for these conclusions, it is also found that the High-Speed profiler can be operated at different speeds with little differences in RN values, the sampling rate did show impact on RN value.

Prostate cancer remains a significant health concern for men throughout the world. Accumulating epidemiologic and molecular evidence suggests that inflammation is an important component in the aetiology of prostate cancer. Supporting this hypothesis, population studies have found an increased risk of prostate cancer in men with a prior history of certain sexually transmitted infections or prostatitis. More general evidence of a relationship between inflammation and prostate cancer has been provided by reports indicating that daily use of non steroidal anti-inflammatory drugs (NSAIDs) may be associated with a lower incidence of prostate cancer. The exact mechanism whereby inflammation might act in tumour development and progression remains to be elucidated, but is likely to be complex. The genetic contribution to inflammatory responses involved in the development of prostate cancer has not yet been extensively or systematically studied. However, this thesis evaluates the role of various inflammation-related genes in the pathogenesis of prostate cancer. The macrophage scavenger receptor 1 (MSR1) is a transmembrane protein that is mainly expressed by macrophages. This receptor mediates the binding, internalization and processing of a wide range of macromolecules, and is suggested to play a major role in the recognition and clearance of pathogenic and damaged cells. Recent reports have suggested MSR1 to be a candidate gene for hereditary prostate cancer. Therefore, we screened the MSR1 gene among men with hereditary prostate cancer and identified 18 sequence variants. One previously reported truncation mutation was found more frequently in men with prostate cancer than in unaffected men, in accordance with previously published results. However, the difference in frequencies we found between these groups was not statistically significant. In addition, we genotyped five common polymorphisms in MSR1 in 215 men with unselected prostate cancer and 425 controls. No association between any of the five common variants and prostate cancer were found. We then performed a comprehensive genetic study using extensive populationbased case-control material to evaluate possible associations between sequence variants in inflammation-related genes and prostate cancer. The first gene to be examined was interleukin-1 receptor antagonist (IL-1-RN), encoding a cytokine that plays an important role in regulation of the inflammatory response by binding to the IL-1 receptor and thus inhibiting the binding of the pro-inflammatory cytokines IL-1α and IL-1β. Collectively, these three cytokines exert a central role in the protection against diverse lesions, ranging from microbial colonisation to infection and malignant transformation. The genetic analysis of IL-1RN revealed that the most common haplotype was significantly associated with prostate cancer risk for patients with prostate cancer, and further this association appears to be stronger in cases with advanced disease. The macrophage inhibitory cytokine-1 (MIC-1), a member of the transforming growth-factor-β superfamily has been shown to exert diverse biological functions, including regulation of macrophage activity in the inflammatory response and both growth inhibition and induction of apoptosis in epithelial and other tumour cell lines. The genetic analysis of MIC-1 revealed that a seuqence variant (H6D) appears to be associated with a decreased prostate cancer risk. We also performed measurements of MIC-1 serum levels among patients with prostate cancer and healthy controls. These data indicate that serum MIC-1 levels are associated with an increased risk for prostate cancer. Further, the clear relation between clinical stage and MIC-1 level also suggest that MIC-1 may be useful as a prognostic factor, where high serum concentration is associated with a poor prognosis. In summary, our results provide further support for the assumption that polymorphisms in inflammatory genes play critical roles in prostate cancer susceptibility. Additional studies are needed to elucidate the mechanisms whereby the demonstrated variations contribute to prostate cancer development.

L'objectif de ma thèse est de conduire et d'utiliser les observations de haute précision de gaz à effet de serre pour estimer les émissions de ces gaz à différentes échelles en France, du locale au régionale. Le réseau français de mesure de gaz à effet de serre, géré par l'équipe RAMCES, est constitué de trois observatoires équipés de systèmes de mesure par chromatographie en phase gazeuse. Ces chromatographes en phase gazeuse sont situés à Gif-sur-Yvette, Trainou (forêt d'Orléans) et au sommet du Puy-de-Dôme. Ils ont été optimisés pour la mesure continue et de haute précision des principaux gaz à effet de serre : CO2, CH4, N2O et SF6. Ayant installé le GC au Puy-de-Dôme au cours de l'année 2010, je présenterai et analyserai en détail la série temporelle obtenue depuis son installation. Les mesures de gaz à effet de serre et des traceurs associés m'ont permis d'utiliser une approche multigaz pour contraindre leurs émissions à différentes échelles. A une échelle départementale et régionale, j'ai utilisé le 222Rn comme traceur de masses d'air pour quantifier les flux surfaciques mensuels de N2O à Gif-sur-Yvette et Trainou. Les émissions annuelles de N2O estimées à Gif-sur-Yvette et Trainou sont respectivement de 0.34/0.51 et 0.52 g(N2O) m-2 a-1. Le cycle saisonnier des émissions de N2O a permis de mettre en évidence l'impact de l'agriculture sur les émissions lors de l'apport d'engrais azoté dans les sols. J'ai mis en évidence une corrélation entre les flux de N2O annuels et les précipitations annuelles à Gif-sur-Yvette. A une échelle locale, j'ai utilisé le CO2 et ses isotopes mesurés lors d'une campagne réalisée pendant l'hiver 2010 à Paris, pour estimer les flux de CO2 parisien. Les mesures de 14CO2 atmosphérique m'ont permis de montrer que les flux de CO2 parisien en hiver sont essentiellement anthropiques (77 %) avec une contribution significative des émissions biogéniques (23 %). L'analyse du 13CO2 à quant à lui mis en évidence que les 77 % d'émission de CO2 d'origine fossile sont dues à 70 % à l'utilisation de gaz naturel et 30 % à l'utilisation de pétrole.

This thesis aims the design and the realization of a radio noise meter which can be used to measure radio interference of a high-voltage transmission line due to partial discharges like conductor corona. The radio noise meter is the common equipment for radio noise and radio interference voltage measurements. The corona of transmission lines, its characteristics, its effects on radio interference and measurement of corona caused radio noise in the scope of relevant international standards are investigated. A radio noise meter fed by a monopole antenna, centered to 1 MHz with a bandwidth of 4.5 KHz and using a Quasi-Peak detector having 1 ms charge time and 600 ms discharge time is realized. The conductor corona from the radio interference point of view is observed, measured and analyzed with the help of the realized radio noise meter.

No description available.