京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20993号 / 医博第4339号 / 新制||医||1027(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 妹尾 浩, 教授 羽賀 博典, 教授 坂井 義治 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Introduction: A hallmark of the human aging process is the gradual loss of muscle mass and strength, a phenomenon commonly referred to as sarcopenia. Although sarcopenia is likely the result of both a reduction in fiber size and a loss of muscle fibers, it has become abundantly clear that sarcopenia is primarily characterized by the reduction in type II fiber size. The mechanism(s) driving this fiber type-specific loss still remain largely unknown, but it has become evident that the dysregulation of a muscle-specific stem cell population called satellite cells (SC) plays an important role in its progression. Luckily, older adults still retain the ability to activate and expand their SC in response to exercise; what remains unclear is which modality of exercise is optimal for promoting SC contribution to skeletal muscle remodelling. We sought to test the hypothesis that both resistance exercise (RE) and high-intensity interval training (HIIT) would stimulate greater expansion of SC when compared to traditional aerobic exercise (AE). Furthermore, we also sought to determine potential extrinsic/intrinsic factors that might contribute to regulating the differences in SC behavior across the different modalities of exercise Methods: Sedentary older men (n=22; 67 ± 4 yr; BMI: 27.0 ± 2.6 kg•m-2 [mean ± SEM]) were randomly assigned to complete an acute bout of either RE (3 sets of leg extensor and press, 95% 10RM, n = 7), HIIT (10 x 1min, 95% maximal heart rate [HRmax], n= 8) or AE (30min, 55-60% HRmax. n = 7). Muscle biopsies were obtained before and at 24h and 48h following each exercise bout, while blood samples were taken before and at 24h after exercise. The SC response was analyzed using immunofluorescent microscopy and whole-muscle mRNA analysis, while the variability in exercise-induced muscle damage (EIMD) was estimated by analyzing serum samples for creatine kinase (CK) concentration. Results: The muscle SC content increased 45% (p < 0.001) and 52% (p = 0.001) relative to baseline at 24h and 48h respectively following RE, while HIIT stimulated a significant increase of 33% (p = 0.007) at 48h. Fiber type-specific analysis further revealed that both RE and HIIT were capable of inducing significant increases in both type I and type II-specific SC by 48h post-exercise. Further analysis of individual SC responses also revealed a correlation (r = 0.737, p < 0.001) between the change in SC content across the acute time-course and the relative change in creatine kinase (CK) activity levels 24h post-exercise. The lack of any notable SC expansion following AE was to some degree explained by insufficient changes to cell cycle and myostatin (MSTN)-related genes. Conversely, RE produced the greatest reduction in MSTN mRNA over the 48h time-course while inducing a noticeable decrease of 124% in SMAD3 (a mediator of MSTN signaling) mRNA at 48 post-exercise. Conclusions: These data illustrate that RE is the most potent stimulator of acute SC activity in older men, while also showing for the first time that of HIIT can induce a SC response in the same population. The positive relationship between the changes in SC content in response to exercise and CK activity levels suggests that the level of muscle damage induced by an exercise type may influence the magnitude of the subsequent SC response. The magnitude of each SC response is also likely influenced by unique changes in MSTN signaling that follow each modality of exercise. / Thesis / Master of Science in Kinesiology

Sarcopenia and diabetes are two conditions that reflect ongoing changes in global health trends: aging and obesity. Sarcopenia affects approximately 10-40% of the global population and type II diabetes affects around 415 million individuals (6.28% globally), with obesity contributing to a majority of the cases. Currently, approximately 9.3% of the population (727 million individuals) is aged 65 years or older; this number is predicted to reach 16% of the global population (around 1.5 billion individuals) in 2050. Many developed countries are undergoing demographic population pyramid rearrangements whereby an increasingly aging population must be supported by a shrinking youth cohort. Sarcopenia involves progressive loss of muscle mass as a natural, physiological result of the aging process and is proving a pressing concern for the modern-day, aging population, as it may contribute to increased risk of falls, accidents, hospitalization, decreased range of motion and mobility, increased comorbidities, and overall decreased quality of life, particularly in elderly populations. Type II diabetes occurs when normal insulin function and regulation is impaired. It often features symptoms of hyperglycemia, insulin resistance, polydipsia, polyuria, and fatigue and is among one of the most alarming metabolic conditions for the modern world. Both sarcopenia and diabetes involve complex metabolic disturbances. Several studies have established a reciprocal relationship between sarcopenia and diabetes, where the presence of one condition influences or exacerbates the other. However, to the best of our knowledge, no studies have analyzed if a difference in the strength of the relationship exists among different ethnic groups. The main objective of this project is to conduct a review and meta-analysis to further explore the relationship between sarcopenia and diabetes, to determine whether a statistically significant difference in the strength of the relationship exists among different ethnic groups, and to suggest future research directions and perspectives based on given results.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第23753号 / 医博第4799号 / 新制||医||1055(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 中本 裕士, 教授 松田 秀一, 教授 山本 洋介 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Introdução - O envelhecimento traz consigo alterações da composição corporal que podem ser desencadeadas ou agravadas pelo estilo de vida. A presença simultânea da reduzida massa magra, da osteopenia (reduzida densidade óssea) e da obesidade emerge como possível fator de risco para morbimortalidade de forma mais proeminente do que quando tais parâmetros são considerados separadamente. Objetivo - Investigar a prevalência da presença concomitante da obesidade, da osteopenia e da reduzida massa magra em amostra de indivíduos a partir dos 50 anos; e avaliar se a presença simultânea dessas alterações está associada a menores concentrações de 25- hidroxivitamina D [25(OH)D], a pior perfil glicêmico e lipídico, ao reduzido gasto energético e nível de atividades físicas e à pior aptidão cardiorrespiratória. Métodos - Trata-se de estudo transversal com 218 indivíduos (52% do sexo feminino), de 63 (59 - 69) anos, participantes do ISA-Capital 2015 e ISA Nutrição 2015. A composição corporal foi obtida por DXA. Ajustou-se a massa gorda (kg) pela altura ao quadrado e a obesidade foi estabelecida quando >9kg/m2 para homens e >13kg/m2 para mulheres. A reduzida massa magra (MM) foi definida como MM apendicular/IMC <0,789 e <0,512 para homens e mulheres, respectivamente. T-score <-1,0 na coluna lombar e/ou colo do fêmur determinou a osteopenia. Os indivíduos foram agrupados de acordo com a presença/ausência dessas condições. Considerou-se como desfechos a força de preensão manual, as concentrações de 25(OH)D, os perfis lipídico e glicêmico e hábitos de vida (atividades físicas e ingestão alimentar). Uma subamostra de 43 indivíduos (55% sexo masculino), de 65 (62-71) anos foi selecionada para avaliação da aptidão cardiorrespiratória em esteira rolante, da taxa metabólica de repouso (TMR), por calorimetria indireta, e do gasto energético total (GET), por água duplamente marcada. Resultados - 50 dos 218 indivíduos (23%) apresentavam obesidade associada à reduzida MM e/ou à osteopenia, sendo que 14 (6%) destes apresentavam a combinação dos 3 componentes. A obesidade combinada a 1 ou 2 outras alterações de composição corporal foi associada a concentrações mais reduzidas de 25(OH)D (-3 ng/ml), à pior sensibilidade à insulina, à maior gordura visceral, à menor força muscular, ao maior tempo despendido em atividades sedentárias e à reduzida ingestão proteica por quilo de peso corporal. Adicionalmente, a análise da subamostra (N = 43) revelou haver pior aptidão cardiorrespiratória (-5 ml/kg/min no VO2pico), maior TMR (+300 kcal/dia) e GET (+140 kcal/dia), sem diferença, porém, quanto ao gasto energético em atividades físicas quando presença dessa condição. Esses resultados foram independentes da idade, do sexo e das concentrações de 25(OH)D. Conclusões - A prevalência da obesidade associada à reduzida MM e/ou à osteopenia foi de 23%. Tal condição foi associada à pior perfil de risco para manutenção dessas alterações de composição corporal, para inabilidade física, para doenças cardiovasculares e para mortalidade. Diante de um contexto de envelhecimento populacional atrelado a mudanças comportamentais desfavoráveis, esses resultados emergem a necessidade de estratégias a fim de se prevenir a evolução de um estado de alteração isolada de composição corporal para um estado de coexistência dessas alterações. / Introduction - Aging is related to changes in body composition that can be driven or worsen according to the lifestyle. Given the impact of obesity, osteopenia (low bone density), and reduced lean mass, it is suggested that their concomitant presence would even increase the risk for morbimortality. Objective - To investigate the prevalence of the concomitant obesity, low lean mass and osteopenia in a sample of adults aged from 50 years and evaluate if simultaneous disturbances on body composition are associated with lower 25-hidroxyvitamin D [25(OH)D], worse lipid and glycemic profile, lower total energy expenditure and physical activity level, and poorer cardiorespiratory fitness. Methods: This is a cross-sectional study with 218 individuals (52% female), aged 63 (59 - 69) years recruited from the ISA-Capital 2015 and ISA Nutrição 2015. Appendicular lean mass (ALM), fat mass and bone mineral density (BMD) were measured by DXA. Obesity was defined as fat mass (kg) divided by height squared >9 kg/m2 and >13kg/m2 for men and women, respectively. Low lean mass (LM) was defined as ALM/BMI <0.789 and <0.512 for men and women, respectively. Osteopenia was defined as T-score at lumbar spine and/or femoral neck lower < -1.0. Subjects were then clustered into subgroups according to the presence/absence of body composition disturbances. Outcomes included grip strength, 25(OH)D concentrations, lipid and glycemic profiles, and lifestyle (physical activity and food intake). From the 218 participants we extracted a subsample of 43 (55% male), aged 65 (62-71) years to assess their cardiorespiratory fitness on a treadmill, resting energy expenditure (REE) by indirect calorimetry, and total energy expenditure (TEE) by doubly labeled water. Results - From the 218 individuals, 50 (23%) showed obesity associated with low LM and/or osteopenia, with 14 (6%) showing the concomitant 3 disturbances of body composition. A condition of obesity plus low LM and/or osteopenia was associated with reduced serum VD (-3 ng/ml), lower insulin sensitivity, higher visceral adiposity, lower grip strength, longer time spent in sedentary activities, and reduced protein intake by body weight. The subsample analysis (N = 43) showed worse cardiorespiratory fitness (VO2peak 5 ml/kg/min lower), higher REE (+300 kcal/day) and TEE (+140 kcal/day) than those without body composition disturbances, with no difference in total amount of energy expended in physical activities. Age, sex, and VD concentrations did not change the results. Conclusions - The prevalence of concomitant obesity and low LM and/or osteopenia was 23%. Such condition was associated with risk factors to the maintenance of these body composition disturbances, physical disabilities, cardiovascular diseases, and mortality. Considering these results in a context of population aging and lifestyle changes indicate the need to define strategies to better screening those at higher risk and avoiding that an isolated body composition disturbance state become a concurrent state.

A menopausa é o final da vida reprodutiva da mulher e pode ter como consequência a perda da massa óssea e desenvolvimento da osteoporose. A sarcopenia decorrente do processo de envelhecimento acarreta na diminuição de massa e força muscular, déficit de desempenho e maior risco de quedas e fraturas. A Ressonância Nuclear Magnética (RNM) é uma ferramenta não invasiva e eficaz para a avaliação quantitativa e da dinâmica metabólica do músculo esquelético. Por meio do mapa T2 é possível captar as alterações musculares agudas causadas pela atividade física. A intensificação do sinal T2 é causada pelo movimento osmótico da água intramuscular, aumento da acidose e do volume do espaço intracelular. O objetivo desta pesquisa foi avaliar a influência da densidade mineral óssea no metabolismo muscular de mulheres pós-menopáusicas. Foram avaliadas 16 pacientes do sexo feminino, no período pós-menopausa há mais de 12 meses, com média de idade de 63 anos, divididas em Grupo-Osteoporose (GO=9) e Grupo Controle (CG=7). Todas foram submetidas ao exame de Ressonância Nuclear Magnética da região da coxa (RNM1) e em seguida fizeram uma dinamometria isocinética na velocidade de 180 graus/segundo (duas séries de 10 contrações voluntárias máximas) e exercícios específicos para ativação do músculo quadríceps (agachamento e \"step\"), e após os exercícios, fizeram a RNM2. Os resultados mostraram aumento do mapa T2, caracterizado pelo maior tempo de relaxamento nos dois grupos avaliados, sem diferença entre eles. Não se observou correlação significativa dos resultados da RNM2 com os parâmetros de força (pico de torque corrigido pela massa corporal) e potência (trabalho total das 10 repetições da segunda série) e com a dosagem de vitamina D. Também não houve correlação entre a dinamometria isocinética e dosagem de vitamina D. A osteoporose não afeta a resposta muscular do quadríceps ao exercício, avaliada pelo mapa T2 da ressonância nuclear magnética. A metodologia é robusta e eficiente, mostrando que a RM é um método sensível para medir mudanças metabólicas no músculo após o exercício / Menopause is the end of woman\'s reproductive life and consequences as loss of bone mass and osteoporosis may emerge. The ageing\'s sarcopenia entails the reduction of muscle mass and strength, deficit of physical performance and increases the risk of falls and fractures, which is also present in postmenopausal women. Magnetic resonance imaging (MRI) is a noninvasive and effective tool for quantitative assessment and metabolic dynamics of skeletal muscle. Through the T2 map is possible to capture acute muscle disorders caused by physical activity. Intensification of T2 sign is caused by osmotic movement of intramuscular water, increase of acidosis and intracellular space volume. The aim of this study was to evaluate bone mineral density in muscle metabolism in postmenopausal women. We evaluated 8 female patients in postmenopausal for more than 12 months, with a mean age of 63 years, divided into osteoporosis-group (GO=9) and control group (CG=7). They were submitted to MRI examination of thigh at rest (RM1), and then the isokinetic dynamometer at the speed of 180 degrees/second, 2 sets of 10 maximal voluntary contractions and specific exercises to activate the quadriceps muscle (squats and step) and then the RM2 to capture the muscle metabolic changes. For perception of fatigue level, samples of lactate were taken at rest (Lac1), after 1 minute (lac2) and 3 minutes (Lac3) from the end of the exercises. In both groups, it was observed variation of lac2 Lac3, confirming that fatigue levels and changes in RM2 compared to RM1 in the uptake of water were achieved due to intramuscular specific physical changes in post-exercise muscle metabolism. The results showed increased T2 map, characterized by the highest relaxation time in both groups and there are no difference between them. There was no significant correlation of the results of the RNM2 with the parameters of force (peak torque corrected by body mass) and potency (total work) and with the dosage of vitamin D. There was also no correlation between the isokinetic dinamometria and dosage of vitamin D. Osteoporosis does not affect the muscle response of the quadriceps to exercise, assessed by the T2 map of magnetic resonance imaging. The methodology proved to be robust and efficient, showing that MRI is a sensitive method to measure metabolic changes in muscle after exercise

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2018-08-09T16:41:36Z No. of bitstreams: 1 Isabel Clasen Lorenzet.pdf: 1711634 bytes, checksum: b909757711ada781d1726a583f08a938 (MD5) / Made available in DSpace on 2018-08-09T16:41:36Z (GMT). No. of bitstreams: 1 Isabel Clasen Lorenzet.pdf: 1711634 bytes, checksum: b909757711ada781d1726a583f08a938 (MD5) Previous issue date: 2017-11-22 / INTRODUCTION: Cognitive impairment is associated with several negative outcomes among the elderly, causing, among other damages, detriment in autonomy and independence. Changes in body composition have been associated with cognitive decline and dementia. Sarcopenia and sarcopenic obesity are conditions that have been widely studied, but there are few studies dealing with the relationship of these conditions with dementia. It is important to characterize the risk factors for cognitive decline in order to act on early prevention and treatment. OBJECTIVE: To evaluate the prevalence and the relation between cognitive decline and body composition in the elderly. Identify which of the different types of body composition is associated with greater cognitive decline in the elderly. METHODS: A cross-sectional study will be carried out, with a sample of 486 individuals aged 60 years and older attending the specialty outpatient clinic of the Catholic University of Pelotas. The elderly will respond to a socio-demographic questionnaire and will use instruments of functional and cognitive evaluation (Brief Cognitive Battery), anthropometric measures such as weight, height and circumference of the calf, evaluation of gait and palmar grip strength. EXPECTED RESULTS: It is expected to estimate the association of cognitive impairment with different nutritional statuses, emphasizing sarcopenia and sarcopenic obesity as a risk factor for cognitive decline. / INTRODUÇÃO: A perda cognitiva está associada a diversos desfechos negativos entre os idosos, ocasionando, entre outros prejuízos, o comprometimento na autonomia e independência. Mudanças na composição corporal têm sido associadas ao declínio cognitivo e demência. A sarcopenia e a obesidade sarcopênica são condições que vem sendo bastante estudada ultimamente, mas existem poucos estudos tratando da relação dessas condições com demência. É importante caracterizar os fatores de risco para o declínio cognitivo a fim de agir na prevenção e tratamento precoces. OBJETIVO: Avaliar a prevalência e a relação entre declínio cognitivo e composição corporal em idosos ambulatoriais. Identificar qual dentre os diferentes tipos de composição corporal está associado com maior declínio cognitivo em idosos. MÉTODO: Será realizado um estudo transversal, com uma amostra de 486 indivíduos com 60 anos ou mais atendidos no ambulatório de especialidades da Universidade Católica de Pelotas. Os idosos responderão a um questionário sócio-demográfico e serão aplicados instrumentos de avaliação funcional e cognitiva (Bateria Cognitiva Breve), medidas antropométricas como peso, altura e circunferência da panturrilha, avaliação da marcha e da força de preensão palmar. RESULTADOS ESPERADOS: Espera-se estimar a associação de comprometimento cognitivo com diferentes status nutricionais, destacando sarcopenia e obesidade sarcopênica como fatores de risco para declínio cognitivo.

Com o envelhecimento observa-se redução da massa muscular, aumento da resistência à insulina e queda nos níveis séricos de alguns hormônios, entre eles o DHEA. Ratos com 12-14 meses de idade apresentam regulação músculo-específica em vias da insulina e IGF 1 em músculos com populações distintas de tipos de fibras e como indicador de sarcopenia apresentam redução da proporção e tamanho de fibras tipo 2b. Dose única de DHEA não modula as vias da insulina e IGF 1 no músculo esquelético e reduz tamanho de fibras tipo 1 no EDL. / Reductions in skeletal muscle mass, increased insulin resistance, and decrements in several hormones serum levels, including DHEA, are features observed in aging. Twelve to fourteen months old rats present specific regulation in the insulin and the IGF-1 intracellular pathway in distinct skeletal muscle fiber composition and show reductions in size and proportion of muscle composed predominantly by fiber type 2. DHEA treatment had no effect in these intracellular pathways but induces reduction in the size of type 1 fiber in the EDL muscle.

Orientador: André Fattori / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-18T02:10:48Z (GMT). No. of bitstreams: 1 Moraes_ZeliaVieirade_M.pdf: 2183425 bytes, checksum: 4404a3b0fb6ea373f7f9f5b2941e39b3 (MD5) Previous issue date: 2011 / Resumo: Objetivos: Investigar relações entre indicadores de fragilidade, anemia e parâmetros hematimétricos (HGB, HTC, VCM, RDW, RETabs) em idosos de 65 anos e mais, recrutados na comunidade, segmentados por gênero e idade. Métodos: Os idosos foram recrutados em domicilio, em 35 setores censitários urbanos de Campinas selecionados por critério de conveniência dentre os 88 que integraram a amostra casualizada de um estudo populacional sobre fragilidade Em sessão única realizada em local publico, realizada coleta de sangue (hemograma e reticulocitos) e levantados dados sócio-demográficos, antropométricos, de saúde entre eles medidas de fragilidade, de acordo com os critérios definidos por Fried e col.(2001). Resultados: Participaram 255 idosos (68% mulheres), idade media = 73,12 anos (±5,98), escolaridade media = 4,39 anos ±4,21 anos; 25% analfabetos), e renda familiar media = 2,23 salários mínimos mensais ±2,74. A prevalência de fragilidade foi de 7,06% e de anemia, 9,8%. As mulheres frágeis apresentaram valores menores de HGB (p: 0,017/12,46 ±1,09) e maiores de RDW (p: 0,24/14,24 ± 1,43); menores valores de HGB associaram-se significativamente com baixa forca preensão e lentidão da marcha. Na amostra total, anemia (HGB <12g/dL para mulheres e < 13 g/dL para homens) associou-se com fragilidade e com perda de peso não intencional; RETabs e HGB associaram-se com idade; os valores de HGB e RETabs correlacionaram-se positiva e significativamente. Conclusões: Embora tenham sido atingidos valores no limite inferior da normalidade, em nenhum deles a média de HGB foi inferior a 12g/dL. As alterações hematimétricas estiveram mais correlacionadas com fragilidade entre as mulheres que entre os homens. Os dados sugerem a oportunidade de se buscar ativamente critérios diagnósticos mais exigentes para anemia e de empreender o rastreio sistemático dessa condição e de seus precursores na população idosa / Abstract: Objectives: To investigate relationships between indicators of fragility, anemia, and hematological parameters (HGB, HTC, MCV, RDW, RetAbs) in the elderly age 65 and over, recruited from the community, segmented by gender and age. Methods: Subjects were recruited at home, in 35 urban census tracts of Campinas selected by criteria of convenience among the 88 that made up the random sample of a population study on frailty in a single session held in a public place, was collected blood sample (blood count and reticulocytes) and collected sociodemographic, anthropometric, health, including measures of fragility, according to the criteria defined by Fried et al. (2001). Results: Participants were 255 elderly (68% women), mean age = 73.12 years ( ± .5,98), educational mean = 4.39 years ± 4.21 years, 25% illiterate), and median family income = 2 , 23 ± 2.74 times the minimum wage. The prevalence of frailty was 7.06% and anemia, 9.8%. Women showed lower values of fragile HGB (p: 0.017 / 12.46 ± 1.09) and higher RDW (p: 0.24 / 14.24 ± 1.43), lower values of HGB were significantly associated with low grip strength and slowness of gait. In the total sample, anemia (HGB <12 g / dL for women and <13 g / dL for men) was associated with frailty and with weight loss; RetAbs and HGB were associated with age, the values of HGB and RetAbs correlated positively and significantly. Conclusions: Although values have been reached at the lower limit of normal, none of them the average of HGB was less than 12 g / dL. Hematological alterations most closely correlated with weakness among women than among men. The data suggest the opportunity to actively seek more stringent diagnostic criteria for anemia and to undertake systematic screening of this condition and its precursors in the elderly / Mestrado / Mestre em Gerontologia

Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-03-24T12:31:54Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertação - Raphael Silva da Cruz - 2014.pdf: 2331298 bytes, checksum: 48f73362fb99734396ab1734092aeb86 (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-03-24T14:11:11Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertação - Raphael Silva da Cruz - 2014.pdf: 2331298 bytes, checksum: 48f73362fb99734396ab1734092aeb86 (MD5) / Made available in DSpace on 2015-03-24T14:11:20Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertação - Raphael Silva da Cruz - 2014.pdf: 2331298 bytes, checksum: 48f73362fb99734396ab1734092aeb86 (MD5) Previous issue date: 2014-09-29 / The increase of the elderly population requires the development of strategies to minimize the negative effects of advancing chronological age in the body. The sarcopenia is one of the main changes observed in aging that causes loss of muscle strength. The assessment of hand grip strength (HGS) is an important variable to estimate the impairment of overall muscular strength of a person and is used as an indicator in several countries. Has been highlighted the genetic susceptibility studies underlying the aging phenomenon. In this context, the objective of this study was to evaluate the possible relationship between the SNPs rs1800849 and rs15763 of UCP3 gene and the HGS in adults. This study was a cross-sectional that included 161 individuals from Goiás population, who underwent an evaluation of HGS, and the collection of biological samples for genotyping by qPCR of polymorphic sites rs15763 and rs1800849 of UCP3 gene. Of the participants, 69.9% were women. The mean age was 50.5 (± 19.9) years and the HGS was 29.7 (± 14.6) kgf. We observed a negative and statistically significant correlation between FPP and age (r = -0.55; p≤0,0001). Regarding the polymorphism CC individuals were stronger than those individuals TT + CT for both SNPs. The maximum of HGS was between 30 to 50 years. The greatest decrease of HGS/ year was associated with genotypes that had the T allele for both SNPs studied. Individuals who presented the T allele in rs18949 had 1,684 times more likely to reduce the HGS in relation to genotype rs15763, the OR was 1.876. The UCP3 appears to be an important variable to modulate muscle strength and therefore may be a useful marker to monitor the aging process. This data from will contribute to the specialized attention to health, especially for the elderly population group. / O aumento da população de idosos requer o desenvolvimento de estratégias que possam minimizar os efeitos negativos do avanço da idade cronológica no organismo. A sarcopenia é uma das principais alterações observada no envelhecimento que causa perda de força muscular. A avaliação da força da preensão palmar (FPP) é uma variável importante para se estimar o comprometimento da força muscular global de uma pessoa, sendo usada como indicador em diversos países. Tem merecido destaque os estudos de susceptibilidade genéticas subjacente ao fenômeno do envelhecimento. Neste contexto, o objetivo do presente estudo foi avaliar a possível relação entre os SNPs rs15763 e rs1800849 do gene UCP3 e a FPP em adultos. O presente estudo foi do tipo transversal, composto por161 participantes da população goiana, que foram submetidos a uma avaliação da FPP, e a coleta de amostras biológicas para a genotipagem através da qPCR dos sítios polimórficos rs15763 e rs1800849 do gene UCP3. Dos participantes, 69,9% eram mulheres. A média da idade foi 50,5 (±19,9) anos, e a da FPP foi de 29,7 (±14,6) kgf. Observou se correlação negativa e estatisticamente significativa entre FPP e idade (r=-0,55; p≤0,0001). Quanto ao polimorfismo os indivíduos CC eram mais fortes dos que os indivíduos CT+TT para os dois SNPs. O pico de FPP dos participantes foi entre 30 a 50 anos. O decréscimo maior de FPP/ano foi associado ao genótipos que apresentavam o alelo T (CT+TT) para ambos os SNPs estudados. Os indivíduos que aprestaram o alelo T em rs18949 tiveram 1,684 (p=0,001) vezes mais chance de reduzir a FPP e em relação ao genótipo rs15763, o OR foi de 1,876 (≤0,0001). A avaliação da qualidade de vida indicou valores altos nos domínios do SF-36, o domínio aspecto social apresentou maior escore com 84,1 e o domínio aspecto físico o menor com 66,1. A desacoplação mediada por UCP3 parece ser uma variável importante para modular a força muscular e, portanto, pode ser um marcador útil para se acompanhar o processo do envelhecimento. Nesse contexto, os dados deste estudo contribuirão para a atenção especializada à saúde, sobretudo para o grupo populacional de idosos.