Altered sexual function is one of the most devastating consequences of spinal cord trauma (SCT). Despite this fact, current knowledge of the neural circuitry regulating sexual response in the spinal cord (SC) in healthy humans is remarkably incomplete. In order to better understand the changes that occur to sexual responses following SCT, we must elucidate the neural transmission of sexual function in healthy humans. Functional magnetic resonance imaging (fMRI) techniques to map neuronal function have been adapted for the SC and can now reveal this neural circuitry. We mapped, with spinal fMRI, neuronal activity in the lower thoracic, lumbar and sacral SC in healthy men (n = 10) and women (n = 9) that occurs in response to intermittent audiovisual stimulation (AVS), intermittent genital self-stimulation (GSS) and the combination of the former and latter, applied continuously and simultaneously until orgasm (AVGSS). MR images revealed predominantly increased signal intensity changes (ΔS+) in the autonomic preganglionic nuclei of the lower thoracic, lumbar and sacral SC in women and mostly decreased signal intensity changes (ΔS-) in comparable regions in men. In functional MR images, ΔS+ are related to increased neuronal input while ΔS- are associated with diminished neuronal input to a particular region. Linear regression analyses uncovered a greater number of inverse correlations between SC ΔS and scores of sexual function in women than in men indicating greater descending modulation of SC circuits regulating sexual responses in women than in men. Taken together, our results demonstrate that spinal fMRI is an effective and sensitive technique that can reveal signal intensity changes in the lower thoracic, lumbar and sacral SC associated with AVS, GSS and AVGSS in healthy men and women. / Thesis (Master, Neuroscience Studies) -- Queen's University, 2009-10-06 21:26:15.011

No description available.

institutochedraui@gmail.com / Objective: To assess predictors of sexual function in mid-aged women. Methods: We analyzed data of 262 healthy sexually active women (40–59 years) who filled out the Female Sexual Functioning Index (FSFI), the Menopause Rating Scale (MRS) and a general questionnaire containing female/partner data. Correlations between these two measures were also analyzed. Results: Significant inverse correlations were found between all FSFI and MRS scores. This was most evident for the MRS urogenital score in relation to FSFI total, pain and lubrication scores. Multiple linear regression analysis determined best model predicting total FSFI index scores that explained a 66% of the variance. In this model, MRS urogenital score was an important predictor of female sexual function (total FSFI scores) with a significant inverse relation. Additionally total FSFI scores displayed a significant positive correlation with female educational level and HT use and an inverse relation with partner age and female parity. Conclusion: Several female/partner factors predicted female sexual function in this mid-aged series. MRS urogenital scores significantly correlated with total FSFI scores.

Antidepressants are associated with sexual side effects (Clayton, Keller, & McGarvey, 2006). Sexual side effects are associated with non-compliance or discontinuance of antidepressants (Werneke, Northey, & Bhugra, 2006). Despite this, there are few empirically supported treatments for antidepressant side effects. However, in laboratory studies, exercise immediately before sexual stimuli improved sexual arousal of women taking antidepressants (Lorenz & Meston, 2012). I evaluated if exercise improves sexual functioning in women experiencing antidepressant-induced sexual side effects. Fifty-two women reporting antidepressant sexual side effects were followed for 3 weeks of sexual activity only. They were randomized to complete either three weeks of exercise immediately before sexual activity (3x/week) or 3 weeks of exercise separate from sexual activity (3x/week). At the end of the first exercise arm, participants crossed to the other. I measured sexual functioning, sexual satisfaction, depression and physical health. Completers showed modest improvements in sexual functioning and satisfaction. For women taking selective serotonin and norepinephrine reuptake inhibitors, exercising immediately before sexual activity was superior to exercise in general. As well as known effects in improved physical and psychological health, exercise may help improve sexual health and pleasure in women taking antidepressants. These findings have important implications for public health, as exercise is accessible, cheap, and does not add to burden of care. / text

Introdução: Durante a transição menopausal, as mulheres podem sofrer alterações na atividade sexual, devido à diminuição dos níveis plasmáticos de estrogênio e androgênio. Além disso, fatores como a idade, o tempo de relacionamento e o aumento de morbidades que causam diminuição do bemestar podem levar à redução da atividade sexual. Objetivo: Estimar a prevalência da disfunção sexual em mulheres no período da transição menopausal e pós-menopausa e identificar potenciais fatores de risco. Método: estudo transversal que incluiu 756 mulheres de 35 a 65 anos cadastradas na Saúde da Família de Pindamonhangaba. Para avaliar a função sexual, foi utilizado o Female Sexual Function Index (FSFI), questionário composto por 19 perguntas referentes às últimas quatro semanas, que abrange seis domínios: desejo, excitação, lubrificação, satisfação, orgasmo e dor. Foi realizado um modelo de regressão múltipla de Poisson, no programa Stata 11. Resultados: A prevalência de disfunção sexual foi de 57,7 por cento (IC95 por cento : 54,0 por cento 61,4 por cento). Quando consideradas apenas as mulheres sexualmente ativas, foi de 39,8 por cento (IC95 por cento : 35,4 por cento 44,2 por cento). A disfunção sexual associou-se positivamente a idade (p<0,001), ao estado civil (p<0,001), a religião (p=0,003), a depressão (p<0,001) e a diabetes (p=0,013). Dentre as mulheres sexualmente ativas, a disfunção sexual associou-se positivamente também com a idade (p<0,001), a depressão (p<0,001) além do uso de medicamento ansiolítico (p=0,011). Conclusão: Houve alta prevalência de disfunção sexual entre as mulheres participantes do PROSAPIN, e os fatores associados foram: idade, o estado civil, a religião, a depressão, diabetes e uso de medicamento ansiolítico / Introduction: During the menopausal transition women may experience changes in sexual activity due to decreased plasma levels of estrogen and androgen. Beyond that, factors such as age, length of relationship and increased morbidities that cause decreased well-being can lead to reduced sexual activity. Objective: To estimate the prevalence of sexual dysfunction in women during the menopausal transition and postmenopausal women and to identify potential risk factors. Method: A cross-sectional study that included 756 women from 35 to 65 years indexed in the program Saúde da Família in Pindamonhangaba. To evaluate sexual function, we used the Female Sexual Function Index (FSFI) questionnaire consisting of 19 questions concerning the last four weeks, covering six domains: desire, arousal, lubrication, satisfaction, orgasm and pain. We performed a multiple regression model the Poisson in the Stata 11. Results: The prevalence of sexual dysfunction was 57.7 per cent (95 per cent CI: 54.0 per cent - 61.4 per cent). When considered only sexually active women, was 39.8 per cent (95 per cent CI: 35.4 per cent - 44.2 per cent). Sexual dysfunction was positively associated with age (p <0.001), marital status (p <0.001), religion (p = 0.003), depression (p <0.001) and diabetes (p = 0.013). Among sexually active women, sexual dysfunction also was positively associated with age (p <0.001), depression (p <0.001) and the use of anxiolytic medication (p = 0.011). Conclusion: there is a high prevalence of sexual dysfunction among women participants PROSAPIN, and associated factors were: age, marital status, religion, depression, diabetes and use of anxiolytic medication

This descriptive, comparative, correlational study explored the relationships among demographic characteristics, health histories, disease characteristics, body image, anxiety and depression, sexual relationship power, female sexual function, and sexual satisfaction; examined sexual self-schema as a moderator or mediator on female sexual function and sexual satisfaction; and compared the differences in female sexual function and sexual satisfaction between women with gynecological or rectal cancer and women without any cancer. Fifty-five females with gynecological or rectal cancer in the study group and 72 females without any cancer in the comparison group completed seven structured questionnaires. For females in the study group, a significant negative relationship existed between time since surgery and anxiety and depression, between the number of cancer treatments and female sexual function, and between performance status and anxiety and depression. In addition, a significant positive relationship existed between performance status and sexual relationship power and between the number of cancer treatments and sexual satisfaction. Further, body image was significantly related to anxiety and depression, sexual relationship power, sexual self-schema, and sexual satisfaction. The anxiety and depression factor was significantly linked with sexual relationship power, female sexual function, and sexual satisfaction. There was a significant negative relationship between sexual satisfaction and sexual relationship power and between sexual satisfaction and female sexual function. Also, females in the study group reported significantly worse sexual function and sexual satisfaction than females in the comparison group. A hierarchical multiple regression model accounted for 40% of the variance in female sexual function, and gynecological/rectal cancer, body image, and the interaction between sexual relationship power and sexual self-schema were three significant predictors. After controlling for gynecological/rectal cancer, body image, sexual relationship power, sexual self-schema, and the interaction term between sexual relationship power and sexual self-schema, female sexual function accounted for 17% of the variance in sexual satisfaction. In unsolicited comments, females in the study group described the changes in their sexual lives after surgery and treatments, emphasizing that sexual information should be provided promptly and effectively by health care providers. The study findings led to implications and recommendations for the conceptual framework, nursing practice, research, and education. / text

Recent studies have shown that sexual functioning and sexually related personal distress are weakly related in women, with only a minority of sexual difficulties resulting in significant levels of distress. However, there has been little systematic research to date on which factors moderate the relationship between sexual functioning and sexual distress. Our aim was to assess the degree to which relational intimacy and attachment anxiety moderate the association between sexual functioning and sexual distress in college-age women. Two hundred women (mean age = 20.25) completed surveys assessing sexual functioning, relational intimacy, attachment anxiety, and sexual distress. Relational intimacy and attachment anxiety moderated the association between multiple aspects of sexual functioning and sexual distress. For lubrication and sexual pain, functioning was more strongly associated with distress in low-intimacy vs. high-intimacy relationships, but only for women with high levels of attachment anxiety. Results regarding desire were mixed and neither intimacy nor attachment anxiety interacted with subjective arousal or orgasm in predicting distress. We conclude that both relational intimacy and attachment anxiety are important moderators of the association between sexual functioning and subjective sexual distress in women. Theoretical and practical implications are discussed. / text

No description available.

Introdução: Durante a transição menopausal, as mulheres podem sofrer alterações na atividade sexual, devido à diminuição dos níveis plasmáticos de estrogênio e androgênio. Além disso, fatores como a idade, o tempo de relacionamento e o aumento de morbidades que causam diminuição do bemestar podem levar à redução da atividade sexual. Objetivo: Estimar a prevalência da disfunção sexual em mulheres no período da transição menopausal e pós-menopausa e identificar potenciais fatores de risco. Método: estudo transversal que incluiu 756 mulheres de 35 a 65 anos cadastradas na Saúde da Família de Pindamonhangaba. Para avaliar a função sexual, foi utilizado o Female Sexual Function Index (FSFI), questionário composto por 19 perguntas referentes às últimas quatro semanas, que abrange seis domínios: desejo, excitação, lubrificação, satisfação, orgasmo e dor. Foi realizado um modelo de regressão múltipla de Poisson, no programa Stata 11. Resultados: A prevalência de disfunção sexual foi de 57,7 por cento (IC95 por cento : 54,0 por cento 61,4 por cento). Quando consideradas apenas as mulheres sexualmente ativas, foi de 39,8 por cento (IC95 por cento : 35,4 por cento 44,2 por cento). A disfunção sexual associou-se positivamente a idade (p<0,001), ao estado civil (p<0,001), a religião (p=0,003), a depressão (p<0,001) e a diabetes (p=0,013). Dentre as mulheres sexualmente ativas, a disfunção sexual associou-se positivamente também com a idade (p<0,001), a depressão (p<0,001) além do uso de medicamento ansiolítico (p=0,011). Conclusão: Houve alta prevalência de disfunção sexual entre as mulheres participantes do PROSAPIN, e os fatores associados foram: idade, o estado civil, a religião, a depressão, diabetes e uso de medicamento ansiolítico / Introduction: During the menopausal transition women may experience changes in sexual activity due to decreased plasma levels of estrogen and androgen. Beyond that, factors such as age, length of relationship and increased morbidities that cause decreased well-being can lead to reduced sexual activity. Objective: To estimate the prevalence of sexual dysfunction in women during the menopausal transition and postmenopausal women and to identify potential risk factors. Method: A cross-sectional study that included 756 women from 35 to 65 years indexed in the program Saúde da Família in Pindamonhangaba. To evaluate sexual function, we used the Female Sexual Function Index (FSFI) questionnaire consisting of 19 questions concerning the last four weeks, covering six domains: desire, arousal, lubrication, satisfaction, orgasm and pain. We performed a multiple regression model the Poisson in the Stata 11. Results: The prevalence of sexual dysfunction was 57.7 per cent (95 per cent CI: 54.0 per cent - 61.4 per cent). When considered only sexually active women, was 39.8 per cent (95 per cent CI: 35.4 per cent - 44.2 per cent). Sexual dysfunction was positively associated with age (p <0.001), marital status (p <0.001), religion (p = 0.003), depression (p <0.001) and diabetes (p = 0.013). Among sexually active women, sexual dysfunction also was positively associated with age (p <0.001), depression (p <0.001) and the use of anxiolytic medication (p = 0.011). Conclusion: there is a high prevalence of sexual dysfunction among women participants PROSAPIN, and associated factors were: age, marital status, religion, depression, diabetes and use of anxiolytic medication

Orientadores: Lucia Helena Simões da Costa Paiva, Ana Lucia Ribeiro Valadares / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-26T04:19:52Z (GMT). No. of bitstreams: 1 Politano_CarlosAlberto_M.pdf: 1829653 bytes, checksum: 34141a8e9529dcb0ce0a53a5f5733b67 (MD5) Previous issue date: 2014 / Resumo: Introdução: A Síndrome Metabólica é uma condição bastante frequente na população e em especial em mulheres climatéricas. Alguns estudos associam a SM com baixa função sexual, porém com resultados ainda controversos. Objetivo: Avaliar se existe associação entre síndrome metabólica e função sexual e os fatores associados à baixa função sexual em mulheres climatéricas. Sujeitos e métodos: Realizou-se uma análise secundária de um estudo maior de corte transversal sendo que o grupo controle constituiu a presente amostra onde foram incluídas 256 mulheres climatéricas com idade variando entre 40 a 60 anos, acompanhadas nos Ambulatórios de Planejamento Familiar e Menopausa da Faculdade de Ciências Médicas da UNICAMP. As mulheres responderam a um questionário realizado em ambiente confidencial, contendo dados sócio-demográficos, comportamentais e a avaliação da função sexual através do Short Personal Experience Questionnaire (SPEQ) que avalia 9 domínios da função sexual considerando-se baixa função sexual um escore ?7. Foram feitas mensurações antropométricas, de pressão arterial e dosagens séricas de glicemia em jejum, colesterol HDL, triglicérides, FSH e TSH. Resultados: A prevalência de Síndrome Metabólica, considerando-se o critério adotado pelo International Diabetes Federation (IDF)-2005, foi de 62,1% e de baixa função sexual de 31,4%. O único fator relativo à função sexual feminina que se associou à síndrome metabólica foi a disfunção sexual do parceiro. Os fatores associados à baixa função sexual foram idade > 50 anos (p=0,003), não ter companheiro (p<0,001), estar na pós menopausa (p=0,046), presença de fogachos (p=0,02), pior auto-percepção de saúde (p=0,04), idade do parceiro ? a 50 anos e tempo que vive com parceiro ? 21 anos. O relato de relação oral ativa (p=0,02) e oral passiva (p=0,01) foram associados a ausência de disfunção sexual. Na analise de regressão múltipla o único fator que se associou a baixa função sexual foi ter cinquenta anos ou mais. Conclusões: A prevalência de Síndrome Metabólica foi alta e não se associou com a baixa função sexual em mulheres climatéricas. O único fator associado a baixa função sexual foi a idade acima de 50 anos / Abstract: Introduction: Metabolic syndrome is a fairly common condition in the population and especially in perimenopausal women. Some studies associate SM with low sexual function, but with still controversial results. Objective: To evaluate whether there is an association between metabolic syndrome and sexual function and the factors associated with low sexual function in menopausal women. Subjects and methods: We performed a secondary analysis of a larger cross-sectional study and the control group comprised the sample where this 256 menopausal women were included age between 40 to 60 years, accompanied in Ambulatory Family Planning and Menopause Faculty of Medical Sciences, UNICAMP. The women answered a questionnaire conducted in a confidential environment, including socio-demographic, behavioral data and the evaluation of sexual function using the Short Personal Experience Questionnaire (SPEQ) that assesses nine domains of function sexual considerando low sexual function is a score ? 7. Anthropometric measurements, blood pressure, serum fasting glucose, HDL cholesterol, triglycerides, FSH and TSH were made. Results: The prevalence of metabolic syndrome, considering the criterion adopted by the International Diabetes Federation (IDF) -2005, was 62.1% and low sexual function of 31.4%. The only on female sexual function factor associated with metabolic syndrome was sexual dysfunction partner. Factors associated with low sexual function factors were age> 50 years (p = 0.003), not having a partner (p <0.001), being postmenopausal (p = 0.046), presence of hot flushes (p = 0.02), worse self- perception of health (p = 0.04), age of partner ? 50 years and while living with partner ? 21 years. Active oral sex (p = 0.02) and passive oral sex (p = 0.01) were associated with absence of sexual dysfunction. In multivariate regression analysis the only factor associated with low sexual function was age >50 years. Conclusions: The prevalence of metabolic syndrome was high and was not associated with low sexual function in menopausal women. The only factor associated with low sexual function was the age of 50 years / Mestrado / Fisiopatologia Ginecológica / Mestre em Ciências da Saúde