The work is divided into two chapters. In the first one the World's and Czech poets (chosen on the basis of Orten's list of reading) are analyzed. Those authors could be understood as impersonators or predecessors of the existential tendencies and it's provable Orten knew their works well (i.a. Rilke, Rimbaud, Akhmatova, Mácha, Weiner, Halas, Holan, Zahradníček, Bonn and Daniel). The second and more voluminous chapter consists of the motives' and topics' analysis of Orten's literary work, focused mainly on the poetry and less on the other literary genres - notes, letters, prose. The most of his poems and notes is based on the factual life experience and their ethos is founded on both existential and Christian moral philosophy. There's also an influence of some other intellectual tendencies and artistic styles like folk literature, romanticism, impressionism, less intensively expressionism, naturalism, psychoanalysis, surrealism and naturism. To get the coherent interpretation of Orten's work it's necessary to reflect (beside the existential motives) the pathos of the intimate traumatic relationship to the father, the girl(friend)s and the unborn child as well as the deeply Christian understanding of reality (connected with the biblical /The Old Testament/ dialogical relation to the God, the...

The thesis deals with the subject of dying and death and focuses on secondary school students' awareness of this issue. The theoretical part of the thesis describes stages of dying, the needs of a dying person and their emotional state. Furthermore, it distinguishes between dying at home and dying in a health care institution. In the following chapters, the thesis focuses on palliative care, the process of grieving, funeral rites and the issue of euthanasia. The method of the theory was reading of literature that specializes in the issue. The practical part of the thesis compares data from questionnaires given to secondary school students on the topic of death and dying. The research shows that the students' awareness of the issue is considerably low - 84% respondents did not know what the term "palliative care" meant, 88% respondents did not know what the term "hospice" meant and 74% respondents were not familiar with the term "euthanasia". The research has found that there is a need to broaden the secondary school students' knowledge on the topic of dying. KEYWORDS thanatology, dying, death, euthanasia, palliative care

L'athérosclérose consiste en l'accumulation de cholestérol dans les artères causant la formation de plaques rigides pouvant causer attaques et malaises cardiaques. Il existe des molécules réduisant les taux de cholestérol dans le sang, mais sont inefficaces pour les patients souffrant d'hypercholestérolémie familiale. Il est donc crucial de développer de nouvelles molécules. L'inhibition de HDAC7 influence la conversion du cholestérol en acides biliaires en augmentant l'activité de la 7α-cholestérol hydroxylase, enzyme limitante du catabolisme du cholestérol. Ainsi cibler HDAC7 pourrait constituer une nouvelle stratégie pour réduire les taux de cholestérol. Le projet s'est articulé autour de deux principaux axes : comprendre et améliorer la spécificité des inhibiteurs de HDAC7 et explorer l'interaction SMRT-HDAC7 comme stratégie alternative d'inhibition de HDAC7. Des étapes successives d'ingénierie de HDAC7 ont été menées à l'aide de la technologie ESPRIT. Des essais de cristallisation et des tests d'inhibition avec un composé prometteur ont été effectués. Ce composé est un dérivé de SAHA, pan-inhibiteur des HDACs, modifié par substitution en position méta de son groupe phényle. Des essais de cristallisation sont en cours. ESPRIT a également été appliquée à la protéine SMRT. Les fragments solubles de SMRT ont été testés pour interaction avec HDAC7 par 15N-HSQC RMN. Un fragment de SMRT a été identifié comme interagissant avec HDAC7. Cette interaction a été confirmée par anisotropie de fluorescence et résonance plasmonique de surface. Des expériences de RMN complémentaires sont en cours pour attribuer les résidus impliqués dans l'interaction.

The aim of this thesis is to analyze the topics of crime, violence and brutality in four novels written by a contemporary British novelist Ian McEwan. The aim of the thesis is also to define the motivational development of these topics and moral questions of guilt and punishment based on the analysis of Ian McEwan's novel Solar. The goal is to reflect problems of the society of the 21st century including the basic moral questions connected with the professional life and career of McEwan's characters.

Our research dealt with the support for the relatives in their final goodbyes to the deceased. We set ourselves two goals for our work upon the information obtained. The first one was to find out to what extent relatives are enabled to stay at the bed of a dying and deceased person in a hospital. The other goal was to make clear in what manners the final goodbyes are arranged in a hospital. Six research questions were then set: To what extent are relatives enabled to stay at the bed of a dying and deceased person in a hospital? In what setting are relatives given the information on the death? How are patient's belongings handed over to the survivors? How are the final goodbyes to the deceased arranged? How does the hospital staff care about the bereaved? And to what extent are the relatives enabled to speak to a priest or a psychologist? We chose a qualitative research method based on a semi structured interview for the research. The research was held in the České Budějovice Hospital and in the Písek Hospital at the LTC and Anaesthetic departments. 16 nurses participated on the interviews altogether. We found from the performed interviews that nurses allow relatives to stay at the bed of a dying person. They stressed the importance of an agreement and the respect to the run of the department. We also found out that the message of a client's death is usually communicated on the phone. A subsequent talk between a physician and the relatives is only held upon request of the relatives, mostly in the privacy of an office or a surgery. The handover of the belongings by a nurse is not so often held in privacy. The nurse first expresses her sympathy to the relatives after their arrival, then the handover of the belongings against an ID follows, they are checked and formalities are arranged. The only support provided at the handover of the belongings was in the form of reference to a priest or a physician. The handover of the belongings thus resembles a routine where only a minimum of the nurses care of sensitive communication and empathy. The replies of the nurses from the LTC and the Anaesthetic departments differed in the issue of the final goodbyes. At the Anaesthetic department the relatives always have the possibility of the final goodbyes. The final goodbyes are automatically allowed to the family of an organ donor. At the LTC, on the other hand, the bereaved must show active interest in the last goodbyes, which are allowed to them at a room or in a department bathroom. Although there is a final goodbye room at the pathology department of the Písek Hospital, most of the nurses did not know about this possibility or just were not sure. Another situation is in the case of death at presence of the family. In such an instance the relatives may stay at the bed how long they need. Nevertheless, the care focused directly on the client's family was what we missed about the nurses. A rare opinion was that some nurses mentioned a direct form of support, some do realize its absence and would appreciate an improvement, however the rest of the nurses do not consider a direct support for the family necessary or they do not perceive its absence. A priest was the most frequently mentioned profession. Nurses actively offer his services to clients and their families. Cooperation with a hospital priest and the possibility to visit the Space of Silence are very popular in Písek. Contracted priests, who were also praised by most of the nurses, visit the hospital in České Budějovice. There were however two remarks in this relation, that the hospital should have its priest and also a chapel. Cooperation with a hospital psychologist was only mentioned in two cases. A feedback for the head nurses of the named hospitals will be the output of the thesis. The purpose of the work is to offer and to the strengthen support to families and give them the opportunity to say their final goodbyes.

This thesis deals with the topic of borders and includes art series, which focuses on the development of social perception and thinking of pupils of second grade of primary school. The theoretical part of the thesis maps the border issue within society. The beginning of the work clarifies the borders in terms of psychology. Afterwards, different ways of dealing with the subject boundaries in art are presented. There are primarily highlighted figures of visual arts and artistic styles that inspired the creation of art series. Works of artists are chronologically ordered into artistic styles and semantically clarified with regard to time, cultural and social context. The next part of this work is devoted to a school curriculum and the possibilities of including the chosen theme to teaching of art subject within the school educational programs, for which the project was implemented. At the end of the theoretical part there is outlined the history of the project teaching and the method used for the creation of the art series.The project part is a set of seven lessons dealing with the topic of boundaries, which are focused on working with different techniques. The whole project was based on the perception and understanding of the issue of boundaries by the pupils of primary school during particular lessons. The course of the lessons and their content is described chronologically. The end of the practical part presents additional possibilities of how, according to the author of this qualification work, the topic of boundaries can be used for further processing.

The diploma thesis focuses on counselling for survivors in the Czech Republic. The aim is to outline the form of counselling for survivors in the CR and to clarify the meaning and the role of counselling services for survivors from the perspective of hospice facilities and counselling for survivors. The first part of thesis is the fundamental concept of death, mourning, counseling for survivors and it´s process. This part is followed by the operationalization chapter that explains the research questions. The research was conducted with employees in hospice facilities and counseling offices. The research results shed light on the form, meaning and role of counseling for survivors in the process of coping with grief. The thesis also deals with the institutionalization and professionalization of counselling for survivors and highlights the lack of systematic education in this area.

This diploma thesis deals with the interpretation of fiction with the theme of the Holocaust. An integral part of the work is a methodological chapter, which is focused on the issues of hermeneutics and other issues that needed to be taken into account when handling the chosen theme. This thesis further focuses on the description of the historical context, which ultimately played a significant role. The main part of the work consists of an independent analysis of selected works of Czech and foreign authors and their subsequent comparison.

This thesis deals with the phenomenon of death and dying. The paper tries to compare the obtained findings from research conducted in their own home for elderly Welfare Centre Netolice and social assistance Vodnany and results from the literature. The aim of the study was to determine how workers home for the elderly perceive death and dying.

The diploma thesis deals with the motivation of nurses, which work at palliative care. The thesis is divided into a theoretical and a practical part. The specifics of palliative care, the motivation of nurses, and the process of dying and death are described in the theoretical part. The practical part contains the processing and the evaluation of results gained in the research. Three aims are set in the thesis. The first aim is to determine the purpose, which nurses have for working at palliative care. The second aim is to find out what motives lead nurses to work with terminal patients. The last aim is to point out the disadvantages of providing palliative care. I chose the semi-structured interview for achieving the aims. The interview contains thirty questions. Ten nurses, which work at palliative care, answered the questions. The results support the fact that nurses perceive the palliative care as an important part of health care. According to nurses, the nursing care preserves the dignity of dying patient. It also respects his or her autonomy, individual needs, and their wish. The motivation for working with terminal patients results from previous experience with a hospice facility or from encounter with death in a previous employment. Another motivational factor is the need to care for dying patients or the experience of the death of a close family member. The substantial part of the job is a strong collective, which contributes to the motivation. The meaningful care and the positive reactions of terminal patients and their families are very fulfilling. The negative motivational factors are the physical and psychological exhaustion, another caregivers' sceptical view about the palliative care, or close relationships with the patients and their families.