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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
401

A Multi-Disciplinary Investigation of Essential DNA Replication Proteins

Gadkari, Varun V. 03 August 2017 (has links)
No description available.
402

Mechanistic Studies of DNA Replication, Lesion Bypass, and Editing

Raper, Austin T. 18 October 2018 (has links)
No description available.
403

High Temperature Transient Creep Analysis of Metals

Mirmasoudi, Sara January 2015 (has links)
No description available.
404

[pt] ANÁLISE NUMÉRICA DO COMPORTAMENTO DINÂMICO DE FUNDAÇÕES DE MÁQUINAS / [en] NUMERICAL ANALYSIS OF THE DYNAMICAL BEHAVIOR OF MACHINE FOUNDATIONS

GABRIEL OLIVEIRA FREITAS SANTOS 25 January 2021 (has links)
[pt] Este trabalho analisa excitações verticais dinâmicas de máquinas para fundações com embutimento. Combinações de fundações superficiais e profundas, para simulação de bloco de fundações, são analisadas com uso de diferentes metodologias. Analisam-se soluções de Novak e Beredugo em combinação com Novak e El-Sharnouby, com uso de porcentagens de recalque adicional retiradas do trabalho de Poulos e Davis. Também são analisadas soluções simplificadas de fundações superficiais com embutimento de Wolf em combinação com fundações profundas de Novak e El-sharnouby, com uso de porcentagens de recalque adicional dinâmicas,obtidas com elementos finitos neste trabalho. São comparados os valores de deslocamentos de regime permanente com os obtidos por elementos finitos tridimensionais com uso do programa Plaxis 3D, comprovando a eficácia dos valores de taxa de recalque adimensional dinâmico e uso de modelo simplificado de fundações superficiais de Wolf. / [en] This paper analyzes dynamic vertical loadings due to machine foundations on embedded foundations. Combinations of shallow and deep foundations, to pile raft foundations, are analyzed using diferent approaches. First, solutions of Novak and Beredugo combined with Novak and El- Sharnouby, using additional settlement ratios from Poulos and Davis. Then it is compared to simplified embedded shallow foundations solutions by Wolf combined with Novak and El-Sharnouby, using dynamic additional settlement ratio obtained by finite elements on this paper. Settlements obtained on the steady state regime are compared to the values obtained by tridimensional finite elements using the program Plaxis 3D, proving the efficiency of dynamic additional settlement ratio and the simplified model of shallow foundations by Wolf.
405

Optimization of Heat Exhaust in the Edge of Tokamaks via Controlled Magnetic Stochastization

Kharwandikar, Amit January 2020 (has links)
The protection of plasma facing components from heat and particle overloads is paramount to ensure the operability and desired lifetime of magnetic fusion devices. The possibility of using external 3D magnetic perturbations to improve the steady-state heat exhaust in diverted tokamaks has been studied in this thesis. This approach involves producing a controlled stochastic region in the plasma edge without significantly affecting the core of the plasma. Using field line tracing and 3D advection-diffusion heat transport models, the resulting magnetic and heat flux footprints on the divertor have been analyzed. An optimized configuration has been obtained, which reveals the potential of this approach for considerably reducing the peak heat load on the divertor. / Att skydda plasmakomponenter mot höga värmeflöden och snabba partiklar är av största vikt föratt säkerställa funktionsduglighet och önskad livslängd för en magnetisk fusionsreaktor. Möjlighetenatt använda externa 3D-magnetiska störningar för förbättrad statisk värmeavledningeni tokamaker med magnetiska avledare har studerats i denna avhandling. Tillvägagångssättetinnebär att man producerar en kontrollerad stokastisk region i plasmakanten utan att väsentligtpåverka plasmakärnan. Med hjälp av fältlinjespårning och 3D-modellering av värmetransportsom en advektions-diffusionsprocess har de resulterande magnetiska fotspåren och värmeflödetpå avledaren analyserats. En optimerad konfiguration har erhållits, vilket visar potentialen i dettatillvägagångssätt för att avsevärt minska den maximala värmebelastningen på avledaren.
406

Simulation and Optimal Design of Nuclear Magnetic Resonance Experiments

Nie, Zhenghua 10 1900 (has links)
<p>In this study, we concentrate on spin-1/2 systems. A series of tools using the Liouville space method have been developed for simulating of NMR of arbitrary pulse sequences.</p> <p>We have calculated one- and two-spin symbolically, and larger systems numerically of steady states. The one-spin calculations show how SSFP converges to continuous wave NMR. A general formula for two-spin systems has been derived for the creation of double-quantum signals as a function of irradiation strength, coupling constant, and chemical shift difference. The formalism is general and can be extended to more complex spin systems.</p> <p>Estimates of transverse relaxation, R<sub>2</sub>, are affected by frequency offset and field inhomogeneity. We find that in the presence of expected B<sub>0</sub> inhomogeneity, off-resonance effects can be removed from R<sub>2</sub> measurements, when ||omega||<= 0.5 gamma\,B<sub>1</sub> in Hahn echo experiments, when ||omega||<=gamma\,B<sub>1</sub> in CPMG experiments with specific phase variations, by fitting exact solutions of the Bloch equations given in the Lagrange form.</p> <p>Approximate solutions of CPMG experiments show the specific phase variations can significantly smooth the dependence of measured intensities on frequency offset in the range of +/- 1/2 gamma\,B<sub>1</sub>. The effective R<sub>2</sub> of CPMG experiments when using a phase variation scheme can be expressed as a second-order formula with respect to the ratio of offset to pi-pulse amplitude.</p> <p>Optimization problems using the exact or approximate solution of the Bloch equations are established for designing optimal broadband universal rotation (OBUR) pulses. OBUR pulses are independent of initial magnetization and can be applied to replace any pulse of the same flip angles in a pulse sequence. We demonstrate the process to exactly and efficiently calculate the first- and second-order derivatives with respect to pulses. Using these exact derivatives, a second-order optimization method is employed to design pulses. Experiments and simulations show that OBUR pulses can provide more uniform spectra in the designed offset range and come up with advantages in CPMG experiments.</p> / Doctor of Philosophy (PhD)
407

Transients in Polymer Electrolyte Membrane (PEM) Fuel Cells

Verma, Atul 24 November 2015 (has links)
The need for energy efficient, clean and quiet, energy conversion devices for mobile and stationary applications has presented proton exchange membrane (PEM) fuel cells as a potential energy source. The use of PEM fuel cells for automotive and other transient applications, where there are rapid changes in load, presents a need for better understanding of transient behavior. In particular at low humidity operations; one of the factors critical to the performance and durability of fuel cell systems is water transport in various fuel cell layers, including water absorption in membrane. An essential aspect to optimization of transient behavior of fuel cells is a fundamental understanding of response of fuel cell system to dynamic changes in load and operating parameters. This forms the first objective of the dissertation. An insight in to the time scales associated with various transport phenomena will be discussed in detail. In the second component on the study, the effects of membrane properties on the dynamic behavior of the fuel cells are analyzed with focus on membrane dry-out for low humidity operations. The mechanical behavior of the membrane is directly related to the changes in humidity levels in membrane and is explored as a part third objective of the dissertation. Numerical studies addressing this objective will be presented. Finally, porous media undergoing physical deposition (or erosion) are common in many applications, including electrochemical systems such as fuel cells (for example, electrodes, catalyst layer s, etc.) and batteries. The transport properties of these porous media are a function of the deposition and the change in the porous structures with time. A dynamic fractal model is introduced to describe such structures undergoing deposition and, in turn, to evaluate the changes in their physical properties as a function of the deposition. / Ph. D.
408

Development &amp; Automation of Thermal Resistance Measurement System for Assessment of Thermal Interface Materials

Allahyarbigi, Sepinood January 2024 (has links)
Effective heat management is essential for preserving performance and dependability as electronic equipment becomes increasingly powerful and smaller. This project presents the developed system, TeRMeS, which was created to test the thermal resistance of thermal interface materials (TIMs) essential for the thermal management of electronic devices, including battery systems. This work focuses on using steady-state techniques to evaluate TIMs under various operational forces and temperatures in real-world electronic packaging conditions. A noteworthy breakthrough is the creation of a user-friendly graphical user interface (GUI), which offers sophisticated options for real-time thickness measurement and enables researchers to alter parameters and dynamically display outcomes, thereby improving the measuring process. The results of the experiment highlight the importance of TIM thickness and applied force in lowering thermal resistance and increasing thermal conductivity. These elements are necessary to prevent battery packs and electrical parts from overheating. To improve heat management strategies in high-performance computing and electronics, the study provides accurate, reliable data by focusing on steady-state measurements.
409

Network flux analysis of central metabolism in plants

Masakapalli, Shyam Kumar January 2011 (has links)
The aim of this thesis was to develop stable-isotope steady-state metabolic flux analysis (MFA) based on <sup>13</sup>C labeling to quantify intracellular fluxes of central carbon metabolism in plants. The experiments focus on the analysis of a heterotrophic cell suspension culture of Arabidopsis thaliana (L) Heynh. (ecotype Landsberg erecta). The first objective was to develop a robust methodology based on combining high quality steady-state stable labeling data, metabolic modeling and computational analysis. A comprehensive analysis of the factors that influence the outcome of MFA was undertaken and best practice established. This allowed a critical analysis of the subcellular compartmentation of carbohydrate oxidation in the cell culture. The second objective was to apply the methodology to nutritional perturbations of the cell suspension. A comparison of growth on different nitrogen sources revealed that transfer to an ammonium-free medium: (i) increased flux through the oxidative pentose phosphate pathway (oxPPP) by 10% relative to glucose utilisation; (ii) caused a substantial decrease in entry of carbon into the tricarboxylic acid cycle (TCA); and (iii) increased the carbon conversion efficiency from 55% to 69%. Although growth on nitrate alone might be expected to increase the demand for reductant, the cells responded by decreasing the assimilation of inorganic N. Cells were also grown in media containing different levels of inorganic phosphate (Pi). Comparison of the flux maps showed that decreasing Pi availability: (i) decreased flux through the oxPPP; (ii) increased the proportion of substrate fully oxidised by the TCA cycle; and (iii) decreased carbon conversion efficiency. These changes are consistent with redirection of metabolism away from biosynthesis towards cell maintenance as Pi is depleted. Although published genome-wide transcriptomic and metabolomic studies suggest that Pi starvation leads to the restructuring of carbon and nitrogen metabolism, the current analysis suggests that the impact on metabolic organisation is much less extreme.
410

Increasing wind power penetration and voltage stability limits using energy storage systems

Le, Ha Thu 22 September 2010 (has links)
The research is motivated by the need to address two major challenges in wind power integration: how to mitigate wind power fluctuation and how to ensure stability of the farm and host grid. It is envisaged that wind farm power output fluctuation can be reduced by using a specific type of buffer, such as an energy storage system (ESS), to absorb its negative impact. The proposed solution, therefore, employs ESS to solve the problems. The key research findings include a new technique for calculating the desired power output profile, an ESS charge-discharge scheme, a novel direct-calculation (optimization-based) method for determining ESS optimal rating, and an ESS operation scheme for improving wind farm transient stability. Analysis with 14 wind farms and a compressed-air energy storage system (CAES) shows that the charge-discharge scheme and the desired output calculation technique are appropriate for ESS operation. The optimal ESSs for the 14 wind farms perform four or less switching operations daily (73.2%-85.5% of the 365 days) while regulating the farms output variation. On average, the ESSs carry out 2.5 to 3.1 switching operations per day. By using the direct-calculation method, an optimal ESS rating can be found for any wind farm with a high degree of accuracy. The method has a considerable advantage over traditional differential-based methods because it does not require knowledge of the analytical form of the objective function. For ESSs optimal rating, the improvement in wind energy integration is between 1.7% and 8%. In addition, a net increase in grid steady-state voltage stability of 8.3%-18.3% is achieved by 13 of the 14 evaluated ESSs. For improving wind farm transient stability, the proposed ESS operation scheme is effective. It exploits the use of a synchronous-machine-based ESS as a synchronous condenser to dynamically supply a wind farm with reactive power during faults. Analysis with an ESS and a 60-MW wind farm consisting of stall-regulated wind turbines shows that the ESS increases the farm critical clearing time (CCT) by 1 cycle for worst-case bolted three-phase-to-ground faults. For bolted single-phase-to-ground faults, the CCT is improved by 23.1%-52.2%. / text

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