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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
251

Interactions non-linéaires d'ondes et tourbillons en milieu stratifié ou tournant / Non-linear interactions of waves and vortices in stratified or rotating fluids

Bordes, Guilhem 16 July 2012 (has links)
Les ondes gravito-inertielles jouent un rôle majeur dans les échanges d'énergie globaux sur la planète. Si la génération des ondes est bien connue dans l'atmosphère et l'océan, le devenir de ces ondes au cours de leur propagation n'est pas complètement défini aujourd'hui. Ces ondes peuvent interagir de façon non-linéaire avec elles-mêmes et créer des structures de plus petite échelle qui vont se dissiper plus facilement. Ainsi, le phénomène d'instabilité paramétrique sous-harmonique (PSI), a été étudié de façon expérimentale. Nous avons effectué la première mise en évidence expérimentale de l'interaction de trois ondes planes inertielles bi-dimensionnelles, sous la forme d'une triade résonnante. Cette étude améliore en outre la compréhension de la turbulence en rotation. Les ondes internes peuvent aussi créer, ou interagir avec des écoulements lents de grande échellequi peuvent modifier la biodiversité au fond des océans. Nous avons mis en évidence une situation expérimentale à l'origine d’un tel écoulement moyen induit par les ondes et, à l'aide d'un modèle théorique simplifié, nous avons expliqué la formation de ces écoulements. Enfin, on étudie également des tourbillons en fluide stratifié pour permettre de futures études sur l'interaction d'ondes gravito-inertielles avec des tourbillons. / Inertia-gravity waves play a major role in the global transfer of energy on Earth. Even if wave generation is well understood in the atmosphere and in the ocean, their subsequent evolution is not completely understood. These waves can interact nonlinearly with themselves and create small-scales structures that dissipate more rapidly. Motivated by this, the phenomenon of parametric subharmonic instability (PSI), was studied experimentally. We conducted the first laboratory demonstration of the interaction of three two-dimensional inertial plane waves, as a resonant triad. Inertia-gravity waves can also interact with, and create, mean flows of large scale that can modify the transport of energy, chemical and biological compounds, and thereby have an impact on biodiversity in the ocean. We therefore also demonstrated an experimental situation that gives rise to such a flow field and using a simplified theoretical model, we explained the formation of this flow. Finally, we performed some studies of vortices in stratified fluid, to assist future studies of the interaction of inertia-gravity waves with vortices.
252

Modélisation multidimensionnelle des pressions et teneurs en eau dans le sol et le sous-sol : effets capillaires et gravitaires en présence d'hétérogénéités et de fluctuations / Multidimensional modeling of pressures and water contents in soils and the subsurface : capillary and gravitational effects in the presence of heterogeneity and fluctuations

Mansouri, Nahla 11 July 2016 (has links)
Cette recherche doctorale porte sur la modélisation 3D de la dynamique des teneurs en eau dans le sol et le soussol lorsque les écoulements sont à saturation variable. La modélisation est basée sur une version généralisée de la loi de Darcy-Buckingham et de l’équation de Richards multidimensionnelle. Les recherches présentées dans cette thèse concernent différents volets, présentés ci-dessous, dont le fil conducteur est l’analyse de phénomènes d’écoulements en milieux poreux, contenant de fortes hétérogénéités et/ou perturbés par des fluctuations temporelles. Dans le cadre d’un partenariat de recherche entre l’IMFT et l'IRSN sur la problématique du stockage souterrain de déchets radioactifs, nous avons modélisé en 3D la dynamique du front de désaturation d’une couche argileuse autour d’une galerie souterraine ventilée, à l’aide du code volumes finis BIGFLOW 3D. Ce travail a permis de mettre au point une approche d’immersion pour la modélisation des écoulements en milieux composites. Un autre volet de cette thèse concerne une étude analytique et numérique des profils verticaux de succion et de teneur en eau lors d’une infiltration verticale, non-saturante, dans un sol hétérogène finement stratifié. Des solutions analytiques exactes et approchées sont obtenues en régime permanent, à l’aide de transformations de variables, et sont comparées avec des solutions numériques pour différents degrés d’hétérogénéité. De même, les phénomènes de « barrière capillaire » sont étudiés d’une part analytiquement et d’autre part, par expérimentations numériques transitoires d’infiltration sur des systèmes bicouches, en présence d’une nappe plus ou moins profonde. D’autre part, les écoulements nonsaturés sont étudiés, cette fois, en présence d’un forçage transitoire fortement oscillatoire, dans une colonne de sable fin homogène, sous l’effet de fluctuations périodiques du niveau de la surface libre. Une méthode multi-front mise au point lors d’une thèse précédente à l’IMFT est validée numériquement en montrant que cette méthode simule efficacement la dynamique oscillatoire des flux et des profils de pression avec un nombre limité de « fronts ». De plus, nous avons analysé la phénoménologie capillaire/gravitaire des écoulements oscillatoires dans la colonne grâce à un suivi dynamique du plan de flux nul. Enfin, nous présentons, comme extension aux travaux précédents, une étude préliminaire des phénomènes 3D d’infiltration et de redistribution d’eau, notamment lorsque l’hétérogénéité du sol est de type aléatoire. Les premiers essais d’infiltration permettent de tester, en réplique unique, des méthodes de prises de moyennes spatiales des champs de succion et teneur en eau et évaluer la taille minimum du domaine de calcul 3D permettant d’obtenir des profils verticaux moyens représentatifs de l’infiltration dans une réplique unique du sol aléatoire. / This doctoral research, defended at the Institut de Mécanique des Fluides de Toulouse, is devoted to modeling water pressure and water content in soils and in subsurface geologic formations, in the case of variably saturated flow. One of the main scientific objectives of this work is to analyze the response of unsaturated flow systems, and particularly capillary and gravitational effects, in the presence of material heterogeneities, discontinuities, and/or space-time fluctuations. Modeling is based on a generalized version of Darcy- Buckingham’s law, and of Richards’ flow equation. Overall, the topics developed in this PhD thesis focus on several related aspects of variably saturated water flow in the subsurface. These aspects all occur at once in most applications (drying/wetting,heterogeneity, temporal forcing), but they are "decoupled" here for convenience. A preliminary research (collaborative project IMFT / IRSN) was developed to study the 2D/3D drying process at the porous wall of a deep cylindrical excavation in response to hydrometeorological signals. This project has motivated the design and testing of a novel approach to include cavities in the modeling domain. A detailed study of steady state infiltration was developed for the case of finely stratified soils, with parameters that vary continuously and cyclically with depth. Exact and approximate analytical solutions are calculated based on variable transformation methods and on perturbation type approximations, and they are tested numerically using a finite volume code (BIGFLOW 3D). The sensitivity of suction fluctuations vs. stratification wavelength is investigated, as well as the effect of the degree of heterogeneity, and of water table depth. Capillary barrier effects are studied for the case of unsaturated infiltration in multilayer soil systems characterized by a discontinuity of soil properties at interfaces. Numerical experiments are developed for transient infiltration towards a water table through a two-layer system, the goal being to analyze possible capillary barrier effects under various scenarios. On the other hand, we study numerically the case of a partially saturated / unsaturated soil column submitted to highly variable oscillatory pressure at the bottom of the column: this leads to vertical flow oscillations in the unsaturated zone above the water table influenced by tides (coastal beach sand). We analyze the dynamics of this oscillatory flow, where capillary and gravitational effects compete; for this purpose we use a novel method that tracks the positions of the zero flux plane in the unsaturated column. Finally, we also present, as an extension to the previous studies, a preliminary investigation of multidimensional infiltration/redistribution phenomena, particularly for the case of fully 3D random-type soil heterogeneity. The first numerical experiments of 3D infiltration are undertaken based on the single realization approach to soil heterogeneity, and assuming a uniform distribution of wetting at soil surface.
253

A pilot study on the influence of educational interventions on domestic electricity consumers

Bukula, Thembani 11 1900 (has links)
This pilot study consists of two parts. The first part investigates the extent to which the domestic electricity consumers intend to use and use energy efficiently using the Theory of Planned Behaviour. The second part investigates the extent to which the Energy @ Home educational intervention changed the domestic electricity consumers’ behaviour. For the first part of the study an advertisement was published and a convenience stratified sample of 61 domestic electricity consumers were selected from the 290 respondents. Data was collected from the domestic electricity consumers via a questionnaire and a telephone response log. The co-relational research design was used to investigate the relationship between the predictor variables the independent variables in the constructs of the Theory of Planned Behaviour. Simple linear regression analysis resulted in F statistic for the predicted behavioural intention was 29.74 with a p value less than 0.0001 which indicates significant statistical evidence of a linear relation between the predictor variables and the independent variables. The r2 of 0.87 implies that data points that fall closely along the best fit line. Therefore the predictor variables were good predictors of the response variable. All the participants that intended to use electricity efficiently confirmed via the telephone that they were using electricity efficiently. In the second part of the study 11 out of the 61 participants were chosen to participate in the Energy @ Home educational intervention and television program. Data was collected via the Energy audit log and the electricity consumption log. The participants intended to save between 2% and 35% of their electricity consumption and the actual electricity consumption savings were between 2% and 30%. / Science and Technology Education / M. Sc. (Mathematics, Physics & Technology Education (Physics Education))
254

Analysis of a stratified pre-chamber spark ignition system under lean mixture conditions

Pagano, Vincenzo 19 October 2020 (has links)
[EN] In the current work, the characterization of the combustion process inside a stratified pre-chamber spark ignition (PCSI) system is performed. An extensive bibliographical review about the pre-chamber systems developed from the second half of the 20th century until modern times is presented. The review shows that the latest generation systems have the potential to accomplish the emissions limits while providing high performance and low fuel consumption. Nevertheless, many efforts of the scientific community are still needed to allow the large-scale application of the technology. Indeed, based on the outstanding challenges observed, the investigation plan is developed including both experimental and numerical parts. All experiments were performed by means of the rapid compressionexpansion machine (RCEM) in the CMT-Motores Térmicos laboratory. The original cylinder head layout was modified to allow the housing of the prechamber itself, fuel injectors, spark plug, pressure transducers in both chamber, and a thermocouple. The test methodology involved the acquisition of the pressure evolution in both main chamber and pre-chamber, the piston position (used to compute the instantaneous cylinder volume), the duration of the auxiliary injection, and the spark ignition point. These are used as input for the zero-dimensional thermodynamic model which simulates the fundamental parameters aims to characterize the PCSI system working cycle. Therefore, a deeper knowledge of the mass interchanged process, induced turbulence field, heat release rate, combustion speed, and flame regime is generated. Subsequently, to calibrate the zero-dimensional model coefficients under motoring conditions, several 3D CFD simulations were carried out by means of Converge software. Hence, the results of the simulations in terms of interchanged mass and pre-chamber turbulent kinetic energy have been used to calibrate the nozzle discharge coefficient and the turbulence sub-model coefficients for all the pre-chamber geometries. Furthermore, the 3D CFD simulations outputs are analysed to fully understand the flow field structure and the local effect induced by the different nozzles at the spark activation time. The turbulent kinetic energy in terms of intensity and orientation is investigated over several relevant pre-chamber sections. The results reveal a clear relationship between the turbulence developed within the pre-chamber and the orifices structure. Straight orifices or perpendicular jets impact, promote more intense local turbulence due to direct collision while tilted orifices guarantee more homogeneity due to the swirling motion. Additionally, increase the orifice numbers shows benefits on the fluid dynamic homogeneity. Thus, preceding the experimental campaign several fundamental aspects of the system are evaluated. The cycle-to-cycle dispersion is explored by means of the statistical assessment showing low pressure peak deviation. The auxiliary injection pressure and timing are optimized for avoiding wall wetting phenomena while ensuring proper air/fuel mixing. Finally, the spark activation point is chosen as a function of the theoretically maximum turbulent flame speed. Thereby, the experimental campaign is carried out according to tests matrix, in order to evaluate the effect of the equivalence ratio of both chambers, and how the orifices diameter, number, and distribution affect the combustion process. Moreover, chemiluminescence visualization tests, performed by means of the available optical access of the RCEM, are combined with zerodimensional and 3D CFD results to shed light on the work cycle. Conclusions suggest a slightly rich mixture inside the pre-chamber combined with the highest number of tilted orifices as the better configuration for improving combustion efficiency under lean and ultra-lean main chamber mixture conditions. Nevertheless, axial orifices should be considered for further investigations. Finally, the author proposes a series of developments considered interesting in both the experimental and numerical fields. / [ES] En el presente trabajo se realiza la caracterización del proceso de combustión dentro de un sistema de encendido por pre-cámara bajo carga estratificada. Por lo tanto, se presenta una extensa revisión bibliográfica sobre los sistemas de pre-cámara desarrollados desde la segunda mitad del siglo XX hasta los tiempos modernos. El resumen muestra que los sistemas de última generación tienen el potencial de cumplir con los límites de las emisiones, al tiempo que proporcionan un alto rendimiento y un bajo consumo de combustible. No obstante, todavía se necesitan muchos esfuerzos de la comunidad científica para permitir la difusión a gran escala de la tecnología. De hecho, sobre la base de los desafíos abiertos observados, se desarrolla el plan de investigación incluyendo tanto una parte experimental como numérica. Todos los experimentos se realizan mediante la máquina de compresión-expansión rápida (RCEM) de que dispone el laboratorio CMT-Motores Térmicos . La disposición original de la culata se modificó para permitir el alojamiento de la propia pre-cámara, los inyectores , la bujía, los sensores de presión y un termopar. La metodología de ensayo implica la adquisición de la evolución de la presión tanto en cámara principal como en pre-cámara, el volumen del cilindro, la duración de la inyección auxiliar y el punto de ignición de la bujía. Estos se utilizan como parámetros de entrada para el modelo termodinámico cero-dimensional que devuelve los parámetros fundamentales que caracterizan ciclo de trabajo del sistema PCSI. Por lo tanto, se genera un conocimiento más profundo del proceso de intercambio de masas, del campo de turbulencias inducidas, de la tasa de liberación de calor, de la velocidad de combustión y del régimen de la llama. Posteriormente, para calibrar los coeficientes del modelo cero-dimensional bajo condiciones de arrastre, se llevaron a cabo varias simulaciones CFD en 3D mediante el software Converge. Por lo tanto, los resultados de las simulaciones en términos de masa intercambiada y energía cinética turbulenta de la precámara se han utilizado para calibrar el coeficiente de descarga de la tobera y los coeficientes del sub-modelo de turbulencia para todas las geometrías de la pre-cámara. Además, se analizan los resultados de las simulaciones CFD para comprender plenamente la estructura del campo de flujo y el efecto local inducido por las diferentes geometriás en el tiempo de activación de la chispa. La energía cinética turbulenta en términos de intensidad y orientación se investiga en varias secciones relevantes de la pre-cámara. Los resultados revelan una clara relación entre la turbulencia desarrollada dentro de la pre-cámara y la estructura de los orificios. Los orificios rectos o los chorros perpendiculares, promueven una turbulencia local más intensa debido a la colisión directa mientras que los orificios inclinados del campo fluido y del dosado. Precedentemente al desarrollo de la campaña experimental se evalúan varios aspectos fundamentales del sistema. La dispersión ciclo a ciclo se explora por medio de la evaluación estadística que muestra una baja desviación de los picos de presión. La presión y el punto de inyección auxiliar se optimizan para evitar los fenómenos de mojado de las paredes, asegurando al mismo tiempo una mezcla adecuada de aire/combustible. Finalmente, el punto de activación de la chispa se elige en función de la velocidad máxima teórica de la llama turbulenta. De este modo, la campaña experimental se lleva a cabo de acuerdo con la matriz de pruebas, con el fin de evaluar el efecto del dosado equivalente de ambas cámaras, y cómo el diámetro, el número y la distribución de los orificios afectan al proceso de combustión. Además, las pruebas de visualización de quimioluminiscencia, realizadas mediante el acceso óptico disponible de la RCEM, se combinan con resultados de CFD y resultados del modelo cerodimen para arrojar luz sobre el ciclo de trabajo. Las conclusiones sugieren que una mezcla ligeramente rica dentro de la pre-cámaracombinadaconelmayornúmerodeorificiosdesfasadoseslamejor configuración para garantizar un elevada eficiencia de la combustión en condiciones de mezcla pobre y ultra-pobre de la cámara principal. No obstante, los orificios axiales deben ser considerados para investigaciones futuras. Por último, el autor propone una serie de desarrollos considerados interesantes tanto en el campo experimental como en el numérico. / [CA] En el present treball es realitza la caracterització del procés de combustió dins d'un sistema d'encesa de pre-cambra soto càrrega estratifi-cada. Per tant, es presenta una extensa revisió bibliogràfica sobre els sistemes de precambra desenvolupats des de la segona meitat del segle XX fins als temps moderns. El resum mostra que els sistemes d'última generació tenen el potencial de complir amb els límits de les emissions, al mateix temps que proporcionen un alt rendiment i un baix consum de combustible. No obstant això, encara es necessiten molts esforços de la comunitat científica per a permetre la difusió a gran escala de la tecnologia. De fet, sobre la base dels desafiaments oberts observats, es desenvolupa el pla d'investigació incloent tant una part experimental com numèrica. Tots els experiments es realitzen mitjançant la màquina de compressió-expansió ràpida (RCEM) de què disposa el laboratori CMT-Motors Tèrmics. La disposició original de la culata es va modificar per a permetre l'allotjament de la pròpia pre-cambra, els injectors , la bugia, els sensors de pressió i un termoparell. La metodologia d'assaig implica l'adquisició de l'evolució de la pressió tant en cambra principal com en pre-cambra, el volum del cilindre, la duració de la injecció auxiliar i el punt d'ignició de l'espurna. Aquests s'utilitzen com a paràmetres d'entrada per al model termodinàic zero-dimensional que retorna els paràmetres fonamen-tals que caracteritzen cicle de treball del sistema PCSI. Per tant, es genera un coneixement més profund del procés d'intercanvi de masses, del camp de turbulències induïdes, de la taxa d'alliberament de calor, de la velocitat de combustió i del règim de la flama. Posteriorment, per a calibrar els coefi-cients del model zerodimensional sota condicions d'arrossegament, es van dur a terme diverses simulacions CFD en 3D mitjançant el programari Converge. Per tant, els resultats de les simulacions en termes de massa intercanviada i energia cinètica turbulenta de la pre-cambra s'han utilitzat per a calibrar el coeficient de descàrrega de la tovera i els coeficients del sub-model de turbulència per a totes les geometries de la pre-cambra. A més, s'analitzen els resultats de les simulacions CFD per a comprendre plenament l'estructura del camp de flux i l'efecte local induït per les diferents geometries en el temps d'activació de l'espurna. L'energia cinètica turbulenta en termes d'intensitat i orientació s'investiga en diverses seccions rellevants de la pre-cambra. Els resultats revelen una clara relació entre la turbulència desenvolupada dins de la pre-cambra i l'estructura dels orificis. Els orificis rectes o els dolls perpendiculars, promouen una turbulència local més intensa a causa de la col·lisió directa mentre que els orificis inclinats garanteixen una major homogeneïtat a causa de la generació d'un macro-remolì. A més, l'augment del nombre d'orificis mostra beneficis en l'homogeneïtat fluid-dinàmica. Llavors, abans de la campanya experimental s'avaluen diversos aspectes fonamentals del sistema. La dispersió cicle a cicle s'explora per mitjà de l'avaluació estadística que mostra una baixa desviació dels pics de pressió. La pressió i el punt d'injecció auxiliar s'optimitzen per a evitar els fenòmens de mullat de les parets, assegurant al mateix temps una mescla adequada d'aire/combustible. Finalment, el punt d'activació de l'espurna es tria en funció de la velocitat màxima teòrica de la flama turbulenta. D'aquesta manera, la campanya experimental es duu a terme d'acord amb la matriu de proves, amb la finalitat d'avaluar l'efecte del dosatge equivalent de totes dues cambres, i com el diàmetre, el numero i la distribució dels orificis afecten el procés de combustió. A més, les proves de visualització de quimioluminescència, realitzades mitjançant l’accés òptic disponible de la RCEM, es combinen amb resultats de CFD i resultats del model zero-dimensional per a llançar llum sobre el cicle de treball. Les conclusions suggereixen que una mescla lleugerament rica dins de la pre-cambra combinada amb el major nombre d’orificis desfasats és la millor configuració per a garantir un elevada eficiència de la combustió en condicions de mescla pobra i ultra-pobre de la cambra principal. No obstant això, els orificis axials han de ser considerats per a investigacions futures. Finalment, l’autor proposa una sèrie de desenvolupaments considerats interessants tant en el camp experimental com en el numèric. / Pagano, V. (2020). Analysis of a stratified pre-chamber spark ignition system under lean mixture conditions [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/152486
255

Fragmentation and Restoration: Generational Legacies of 21st Century Māori

Malcolm-Buchanan, Vincent Alan January 2009 (has links)
The content of this thesis is premised on a reflexive examination of some historical juxtapositions culminating in critical aspects of being Māori in the twenty first century and how such aspects have informed contemporary indigenous identity. That is, the continuing acknowledgement and exponential public recognition of critical concepts which inextricably link indigenous and civic identity. The theoretical sources for this research are, in the main, derived from anthropological and religious studies, particularly on the significance of mythologies and oral histories, as well as from the oral theorising of elders in Aotearoa New Zealand. A very significant contribution from one such elder, a senior Māori woman academic, has been included in the form of the transcript of an interview. She herself had collected the views of a number of elders on myth, creating a rare and valuable resource. In the interview she married her reflections on these with her own experiences and her cogent analyses. From the outset, it was necessary to be discerning so as to ensure the thesis workload was manageable and realistic. For this reason the selected critical aspects that have been used to frame this research are (1) a developing Western validation (that is, acknowledgement and respect) of Māori, Māori culture and their mythology; (2) oral history (genealogy) and traditions that have remained constant despite the influences of modernity; and (3) notions of fluidity, negotiation and pragmatism regarding kinship legacies and cultural heritage. The thesis is comprised of six chapters starting from a subjective narrative leading through increasingly objective discourses that culminate in a conclusion which supports a belief that modern Māori require a balancing of critical aspects of cultural heritage, with a broad understanding of the world of the 'other', in order to realise and develop their contemporary indigenous identity. Ultimately, indigenous ideologies, practices and knowledge recorded and examined in the world of academia today, become potential resources for tomorrow. The intention of this research is to aggregate and discuss intrinsic aspects of the Māori past as well as developing aspects of the present, in order to better understand the significance of the future, and to add to the growing corpus of indigenous worldviews.
256

Genetics of ankylosing spondylitis

Karaderi, Tugce January 2012 (has links)
Ankylosing spondylitis (AS) is a common inflammatory arthritis of the spine and other affected joints, which is highly heritable, being strongly influenced by the HLA-B27 status, as well as hundreds of mostly unknown genetic variants of smaller effect. The aim of my research was to confirm some of the previously observed genetic associations and to identify new associations, many of which are in biological pathways relevant to AS pathogenesis, most notably the IL-23/T<sub>H</sub>17 axis (IL23R) and antigen presentation (ERAP1 and ERAP2). Studies presented in this thesis include replication and refinement of several potential associations initially identified by earlier GWAS (WTCCC-TASC, 2007 and TASC, 2010). I conducted an extended study of IL23R association with AS and undertook a meta-analysis, confirming the association between AS and IL23R (non-synonymous SNP rs11209026, p=1.5 x 10-9, OR=0.61). An extensive re-sequencing and fine mapping project, including a meta-analysis, to replicate and refine the association of TNFRSF1A with AS was also undertaken; a novel variant in intron 6 was identified and a weak association with a low frequency variant, rs4149584 (p=0.01, OR=1.58), was detected. Somewhat stronger associations were seen with rs4149577 (p=0.002, OR=0.91) and rs4149578 (p=0.015, OR=1.14) in the meta-analysis. Associations at several additional loci had been identified by a more recent GWAS (WTCCC2-TASC, 2011). I used in silico techniques, including imputation using a denser panel of variants from the 1000 Genomes Project, conditional analysis and rare/low frequency variant analysis, to refine these associations. Imputation analysis (1782 cases/5167 controls) revealed novel associations with ERAP2 (rs4869313, p=7.3 x 10-8, OR=0.79) and several additional candidate loci including IL6R, UBE2L3 and 2p16.3. Ten SNPs were then directly typed in an independent sample (1804 cases/1848 controls) to replicate selected associations and to determine the imputation accuracy. I established that imputation using the 1000 Genomes Project pilot data was largely reliable, specifically for common variants (genotype concordence~97%). However, more accurate imputation of low frequency variants may require larger reference populations, like the most recent 1000 Genomes reference panels. The results of my research provide a better understanding of the complex genetics of AS, and help identify future targets for genetic and functional studies.

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