O Estresse precoce pode ocasionar graves consequências na vida adulta. Entre pacientes com Transtorno Afetivo Bipolar sua ocorrência ainda carece de ser avaliada em estudos ampliados que contemplem sua complexidade de maneira mais abrangente, considerando fatores pessoais, ambientais e psicossociais. Com o objetivo de investigar e ampliar a compreensão da relação entre o Estresse precoce, sintomas do humor (depressão e mania), estratégias de enfrentamento e ideação suicida em pacientes com Transtorno Afetivo Bipolar em um serviço comunitário no interior de São Paulo, desenvolveu-se um estudo transversal, analítico, exploratório, de abordagem quantitativa, utilizando os instrumentos: entrevista clínica para confirmação diagnóstica, de acordo com os critérios do DSM-IV; questionário sociodemográfico, de condições clínicas e de saúde, Escala de Depressão de Hamilton (HAM-D); Escala de Mania (YOUNG); Escala de ideação suicida (BSI); Escala de modos de enfrentamento de problemas (EMEP) e Questionário sobre Traumas na Infância (CTQ). Utilizou-se estatística descritiva e analítica, realizando-se testes Qui-quadrado, com coeficiente de correlação de Pearson e regressão logística, considerando níveis de significância de 0,05. Obteve-se aprovação do Comitê de Ética em Pesquisa e a amostra foi de conveniência não probabilística com 50 pacientes com TAB. Prevaleceram mulheres (66,0%), com idade média de 42,7 anos (dp +12,3), 56,0% possuíam ensino médio, 44,0% eram casados ou com companheiro fixo, 90,0% moravam com a família, 88,0% tinham religião, 60,0% estavam afastados ou desempregados, 74,0% viviam com renda mensal de até um salário mínimo, 48,0% tiveram tentativas de suicídio, 58,0% passaram por internações psiquiátricas prévias, 84,0% não praticavam atividade física e 56,0% possuíam comorbidades. A prevalência de Estresse precoce foi de 68,0%, não houve associação estatisticamente significativa entre Estresse precoce, sintomas do humor, estratégias de enfrentamento e ideação suicida entre pacientes com TAB em seguimento em um serviço comunitário. Possivelmente, tais resultados reflitam o impacto que as ações de apoio e suporte social oferecidas pelo CAPS e pela família tem proporcionado a estes pacientes. Os resultados deste estudo indicaram alta prevalência de Estresse precoce que, embora não associado com as demais variáveis, mostra-se relevante na vida destes pacientes. Estudos sobre o Estresse precoce e TAB, relação entre serviço/paciente/família e estratégias de enfrentamento no contexto comunitário podem indicar melhores formas de tratamento e implementação de políticas públicas que garantam melhor qualidade de vida a estes pacientes / Early stress can have serious consequences in adult life. Among patients with Bipolar Affective Disorder, its occurrence still needs to be evaluated in expanded studies that contemplate its complexity in a more comprehensive way, considering personal, environmental and psychosocial factors. With the objective of investigating and broadening the understanding of the relationship between early stress, mood symptoms (depression and mania), coping strategies and suicidal ideation in patients with Bipolar Affective Disorder in a community service in the interior of São Paulo, a cross-sectional, analytical, exploratory, quantitative approach using the instruments: clinical interview for diagnostic confirmation, according to DSM-IV criteria; sociodemographic questionnaire, clinical and health conditions, Hamilton Depression Scale (HAM-D); Mania Scale (YOUNG); Suicidal ideation scale (BSI); Scale of problem coping modes (EMEP) and Trauma Questionnaire in Childhood (CTQ). Descriptive and analytical statistics were used, with Chi-square tests, with Pearson correlation coefficient and logistic regression, considering levels of significance of 0.05. Approval was obtained from the Research Ethics Committee and the sample was of non-probabilistic convenience with 50 patients with BAD. Prevalence of women (66.0%), mean age 42.7 years (dp +12.3), 56.0% had a high school education, 44.0% were married or had a fixed partner, 90.0% lived with the family, 88.0% had religion, 60.0% were retired or unemployed, 74.0% lived with monthly income of up to one minimum wage, 48.0% had attempted suicide, 58.0% had psychiatric hospitalizations 84.0% did not practice physical activity and 56.0% had comorbidities. The prevalence of early stress was 68.0%; there was no statistically significant association between early stress, mood symptoms, coping strategies, and suicidal ideation among patients with BD at follow-up at a community service. These results may reflect the impact that the support and social support actions offered by the CAPS and the family have provided to these patients. The results of this study indicated a high prevalence of early stress that, although not associated with the other variables, is shown relevant in the life of these patients. Studies on early stress and BD, relationship between service / patient / family and coping strategies in the community context may indicate better ways of treatment and implementation of public policies that guarantee a better quality of life for these patients

Background: Suicidal young adults often confide their distress to peers. It is unclear, however, what types of assistance a friend may offer in response to various symptoms of distress as well as whether the sex of either individual affects responses. Aims: We examined open-ended responses to e-mail vignettes from a fictitious friend exhibiting depressed, irritable, or overtly suicidal communications. Method: College student participants (n = 106) read e-mail messages from a fictitious friend, to which they composed a reply. Replies were coded to reflect the presence/absence of mention of professional help, problem-oriented (personal) help, and social support. Results: Problem-oriented help was offered the most across conditions; professional help was offered least in response to depressed or irritable vignettes. Women were more likely to offer any type of help than men. Patterns of help-giving and sex differences in help-giving varied by condition. Conclusions: Results indicate students’ preferences for solving peer problems personally rather than professionally. Campus prevention and intervention efforts should focus on enhancing students’ peer support and referral skills.

International studies of disasters indicate the risk for developing posttraumatic stress reactions among survivors is high. Modern life implicates increased traveling. During the last decades a large number of Swedish citizens were confronted with disasters taking place outside of their country. The prevalence of trauma reactions in a population that does not  normally  experience natural disasters, but are able to return to a community unaffected by the catastrophe, is not well studied. In addition, the effects of bereavement after traumatic circumstances have not been satisfactorily explored. Longitudinal studies on the effects of natural disasters are underrepresented and there are few studies investigating the course of recovery after traumatic exposure. The aim for this thesis was to examine long-term post-traumatic stress reactions, mental health, and complicated grief after disaster exposure and traumatic bereavement.  Data from returned questionnaires were analysed from bereaved Italian and Swedish relatives 18 months after the Linate airplane disaster 2001, and at 14 months and three years from Swedish travelers returning from Southeast Asia after the 2004 tsunami disaster, and from home staying bereaved relatives within the second year after the tsunami disaster. The main outcome measures were GHQ-12, IES-R and Inventory of Complicated Grief. The findings indicated many survivors were resilient and had ability to recover, but severe exposure to a disaster had considerable impact on psychological distress. Life threat was associated with higher levels of post-traumatic stress reactions, and increased the risk for affected mental health and suicidal ideation. Loss in combination with severe life threat exposure indicated a further increased risk of posttraumatic stress reactions and for complicated grief; this should be considered a substantial risk factor for general mental health. Loss of close relatives, especially loss of children, was associated with higher levels of posttraumatic stress and created a greater risk for complicated grief. Many survivors recovered over time; however, severe exposure and traumatic loss appeared to slow the recovery process. The findings have implications for government and health agencies, regarding the importance of knowledge and awareness of these risks for health, and for organizational structure, training, and accessibility of support and adequate treatment.

No description available.

INTRODUÇÃO: O Transtorno Bipolar (TB) é um transtorno psiquiátrico crônico e debilitante e sua etiologia e patologia ainda não são completamente conhecidos, apesar de um componente genético importante ser evidenciado em estudos de família, adoção e gêmeos. Recentemente, o TB tem sido relacionado a um processo de envelhecimento acelerado, com alguns estudos mostrando telômeros encurtados nesta população. O objetivo do presente estudo foi investigar a associação entre o comprimento telomérico, um dos parâmetros do processo de envelhecimento celular, com a ausência ou presença de TB em famílias com muitos membros afetados, além de associar a sintomatologia clínica e outras variáveis a esse parâmetro. Procurou-se também avaliar as influências genéticas e ambientais sobre o comprimento telomérico nessas famílias, estimando-se a herdabilidade desta característica. MÉTODOS: O comprimento telomérico (T) foi mensurado em uma amostra de 143 indivíduos de 22 famílias (60 deles com TB), em relação a um gene de cópia única (S) - beta-globina, através do método de PCR (Polymerase Chain Reaction) em tempo real quantitativo, no qual forneceu uma proporção do número de cópias de T por S (razão T/S). Considerando a estrutura familiar na análise estatística foi ajustado para cada análise o modelo misto poligênico. RESULTADOS: O efeito do TB no comprimento dos telômeros foi pequeno, não tendo sido observada uma associação estatisticamente significante entre TB e comprimento telomérico quando comparado com familiares saudáveis (p > 0,05). No entanto, observou-se associação do comprimento telomérico à covariável ideação suicida (p = 0,02) e à interação entre ideação suicida e curso da doença (p = 0,02). Associação do comprimento telomérico com idade materna e TB também foi observada (p < 0,05). Por fim, estimou-se em 68% a herdabilidade do comprimento telomérico nas 22 famílias do estudo. CONCLUSÕES: A teoria do envelhecimento acelerado em TB, vista pela óptica do comprimento dos telômeros, não pôde ser confirmada no presente estudo, pois não foi encontrada diferença no comprimento telomérico entre indivíduos saudáveis e com TB nas famílias. Por outro lado, covariáveis que indicam gravidade da doença, como a ideação suicida e a interação entre ideação suicida e curso da doença foram associadas ao comprimento telomérico (p < 0,05), ou seja, um encurtamento telomérico foi correlacionado à gravidade clínica do TB. Associação do comprimento telomérico com idade materna e TB (p < 0,05) sugeriu que a idade materna avançada não só pode ser um marcador de longevidade, como também o fenótipo TB pareceu reforçar essa condição. Por fim, a alta herdabilidade estimada do comprimento telomérico (0,68) revelou uma importante variabilidade genética desse fenótipo entre as famílias do estudo. Em súmula, este é o primeiro estudo que relatou uma associação entre ideação suicida, curso da doença, idade materna e comprimento telomérico em famílias com vários membros afetados pelo TB. Outras investigações independentes são necessárias para confirmar esses resultados preliminares / BACKGROUND: Bipolar Disorder (BD) is a debilitating and chronic mental illness. It is etiology and pathology are not completely known yet, despite the evidence of an important genetic component from family, twin and adoption studies. Recently, BD has been related to a process of accelerated aging, with some studies showing shortened leukocyte telomeres in this population. The purpose of the present study was to investigate the association between leucocyte telomere length (LTL) in BD patients compared with healthy relatives of 22 families with several affected members by this illness, besides associating clinical symptomatology and other covariates with this parameter. It was also examined the genetic and environmental influences on telomere length trait in these BD families, using a variance component approach, by estimating the heritability of this trait as well as covariate effects. METHODS: Telomere length (T) was estimated in a sample of 143 individuals, including 60 BD patients from 22 families, which was measured in relation to the single copy gene (S) - beta-globin gene, using a singleplex real time PCR (Polymerase Chain Reaction), providing a ratio of number of copies of T by S (T/S ratio). Taking in consideration the family structure, the statistical analysis was adjusted for the polygenic mixed model. RESULTS: The effect of BD illness in telomere length was small and we found no association between BD group and LTL (p > 0.05). However, LTL was associated with the variable suicidal ideation (p = 0.02) and interaction between suicidal ideation and course of disorder (p = 0.02). Association of LTL and maternal age and BD was also observed (p < 0.05). In addition, an important genetic component for telomere length was also observed (heritability = 0.68) in these families. CONCLUSIONS: The hypothesis of accelerated aging in BD, investigating the telomere length as one of its components, was not confirmed in our study. We found no difference between LTL and BD in our family group. However, using covariates that indicate severity of disease, both suicidal ideation and interaction between suicidal ideation and course of disorder were statistically significant with LTL, showing that shorter LTL was associated with worse clinical course (p < 0.05) and suicidal ideation (p < 0.05) in BD patients. Association of LTL with maternal age and BD (p < 0.05) suggests that advanced maternal age may not only be a marker of longevity, but also the BD phenotype may reinforce this condition. A high heritability for telomere length (0.68) also suggests an important genetic variability of this trait presented among those families. To our knowledge, this is the first study that found association between suicidal ideation, course of disorder, maternal age and LTL in families with several members affected by BD. Further investigations, including replication studies in other BD families, are needed to confirm these new findings

Introduction: Mood disorders are a serious burden on Canadians. Physical and sedentary activity are easily modifiable risk factors for many diseases. An association with depression could have important implications Objective: To investigate any cross-sectional or longitudinal association between physical activity, sedentary activity, and depression in the National Longitudinal Survey of Children and Youth (NLSCY). Methods: These studies used both a stacked cross-sectional and a trajectory/latent class analysis design Univariate and multivariate multinomial logistic regressions were used to assess the relationship between physical and sedentary activity and depression using the emotional disorder-anxiety scale for children and youth available in the NLSCY. Results: When accounting for covariates, physically inactive respondents had increased odds of higher depressive symptom scores. Sedentary activity was only statistically significantly associated with depressive symptoms in the cross-sectional design. Conclusions: Physical inactivity is significantly associated to depressive symptomatology. The relationship between sedentary activity and depression is inconclusive.

Objetivo. La presente investigación busca conocer y describir las características en la dinámica familiar ante la presencia de un miembro joven que tuvo ideación suicida. Método. Se utilizó el método cualitativo, con un diseño fenomenológico; se aplicó el análisis de contenido y el instrumento de recolección de información fue la entrevista semiestructurada, aplicada en los familiares del miembro joven que tuvo ideación suicida. Resultados. Fueron agrupados en cuatro categorías: contexto familiar, grado de relación entre los familiares, maneras de adaptarse y comunicación. Conclusión. Se concluyó que la dinámica familiar evidencia características que permiten conocer y describir el contexto en el que se encontraba la familia antes de la ideación suicida de su miembro joven, tales como antecedentes familiares de suicidio, diagnóstico de trastorno mental en el miembro joven y los conflictos a nivel familiar. Así como, características que se presentan a partir de las maneras en las que los familiares se adaptan ante la ideación suicida, mediante el cambio en las funciones de los roles y los acuerdos que llegan a establecerse. Otras características son las que se presentan en el grado de relación entre los familiares, evidenciándose en algunas familias, como cercanas, mientras que en otras las relaciones se encuentran lejanas. Por último, las características en la comunicación se ven reflejadas en la apertura que tienen algunos miembros para comunicarse entre ellos sobre aspectos personales y emocionales y, por otro lado, algunos familiares solo consiguen hablar de temas superficiales. / Objective. The present research seeks to know and describe the characteristics on the family dynamics with the presence of a young member who had suicidal ideation. Method. The qualitative method was used, with a phenomenological design; content analysis was applied and the information collection instrument was the semi-structured interview, applied to the family of the young member who had suicidal ideation. Results. They were grouped into four categories: family context, degree of relationship between family members, ways of adapting and communication. Conclusion. It was concluded that family dynamics show characteristics that allow knowing and describing the family context in which the family was before the suicidal ideation of its young member, presenting characteristics such as a family history of suicide, diagnosis of mental disorder in the young member and conflicts at the family level. As well as, characteristics that arise from the ways in which family members adapted to the suicidal ideation, through the change in the functions of the roles and the agreements that they came to be established. Other characteristics are those that appear in the degree of relationship between family members, being evidenced in some as close, while in others the relationship are distant. Finally, the characteristics of communication are reflected in the openness that some members have to communicate with their relatives about personal and emotional aspects, and on the other hand, some relatives only manage to talk about superficial topics. / Tesis

Prior research suggests a greater degree of suicidality and self-harm behavior in those involved with criminal justice and forensic mental health systems. Such individuals also evidence increased exposure to early childhood adversity, which is often associated with suicide risk. Other significant predictors of suicidality have been noted within forensic populations, however, including indicators of specific psychopathology and situational and demographic factors. These populations present with overlapping risk factors that remain underexamined. In the current study, 182 persons residing in secure forensic psychiatric care following incidents of illegal and aggressive behavior were evaluated. Adverse childhood experiences and other empirically derived potential predictors of suicide attempts and self-harm were examined via binomial logistic regression. Findings indicate frequent experiences of early adversity across participants, and that a combination of race, individual adverse childhood experiences, number of biological children, and diagnoses of either posttraumatic stress disorder or borderline personality disorder were significant predictors of suicide attempts, self-harm behavior, and first hospitalization resulting from a suicide attempt. Clinical and research implications are discussed.

Résumé Contexte : À partir de la mi-mars 2020, la plupart des dentistes en pratique libérale se sont retrouvés sans emploi étant donné le confinement imposé par le département de la santé publique du Québec en raison de la COVID-19. La pandémie a induit de multiples changements ayant pu affecter la santé psychologique des dentistes québécois. Objectif: Évaluer l’état de la santé psychologique des dentistes québécois dans le contexte de la pandémie de la COVID-19 lors du déconfinement à l’été 2020. Méthodes: Le 10 juin 2020, suite à la réouverture des cliniques dentaires après l’état d’urgence sanitaire, un sondage en ligne a été envoyé par courriel aux 5001 dentistes possédant un permis de pratique au Québec. L’Association des chirurgiens-dentistes du Québec (ACDQ), l’Ordre des dentistes du Québec (ODQ) et la Fédération des dentistes spécialistes du Québec (FDSQ) ont participé au recrutement des participants. Le statut du travail et les données sociodémographiques ont été recueillis et la santé psychologique évaluée. L’évaluation de la santé psychologique comprenait trois outils de mesures validés : l’échelle de symptômes dépressifs Patient Health Questionnaire (PHQ-9), l’échelle d’épuisement personnel, professionnel et relié au patient Copenhagen Burnout Inventory (CBI) et l’échelle de détresse psychologique Kessler-10 (K-10). La prévalence d’idéations suicidaires et de tentative de suicide a également été documentée. Les données ont été analysées en utilisant des tests statistiques bivariés et des analyses multivariées de régression logistique. Résultats: Le taux de réponse était de 18% (n=902) avec 835 répondants qui ont fourni complètement les données psychologiques inclues dans les analyses. Une prévalence élevée a été observée pour l’épuisement d’intensité modérée à sévère sur le plan personnel (49.7%, 95%CI=46.3-53.1), sur le plan professionnel (48.4%, 95%CI=44.9-51.8) et lié au patient (37.5%, 95%CI=34.2-40.9). Des symptômes dépressifs d’un niveau moyen à sévère ont été répertoriés chez 23.4% (95%CI=20.5-26.4) des participants et 39.5% (95%CI=36.2-42.9) des participants présentaient un niveau modéré à sévère de détresse psychologique. Les participants percevaient leur santé psychologique comme étant détériorée après le début de la pandémie comparativement à avant la pandémique (p<0.001). Des idéations suicidaires passées ont été relevées par 12.9% (95%CI=10.7-15.4) des participants, dont 1.7% (95%CI=0.9-2.8) qui rapportaient au moins une tentative de suicide. Être une femme était significativement associé au burnout personnel (aOR=1.90, p≤0.001), au burnout professionnel (aOR=1.56, p≤0.01) et à la détresse psychologique (aOR=1.47, p≤0.05). Les dentistes plus âgés (≥ 45 ans) étaient plus susceptibles d’avoir des idéations suicidaires dans les deux dernières semaines (OR= 1.57, p=0.055) comparativement aux dentistes moins âgés. Les dentistes vivant seuls ou étant propriétaires de clinique étaient significativement plus à risque de développer des idéations suicidaires dans les deux dernières semaines (aOR=2.52, p≤0.01, et aOR=2.09, p≤0.01, respectivement) et démontraient plus de troubles de santé psychologique. Faire de l’exercice régulièrement, minimiser la consommation d’alcool, un nombre augmenté d’heures de sommeil et un nombre augmenté de semaines de vacances étaient des marqueurs protecteurs contre un niveau modéré à sévère de troubles psychologiques pendant la pandémie de la COVID-19. L’anxiété d’attraper ou transmettre la COVID-19 aux patients ou les membres de la famille était positivement associée avec le burnout. Les trois stratégies de coping les plus populaires étaient les interactions sociales, le sport et l’écoute de la musique. Conclusion: La santé psychologique des dentistes québécois présente plusieurs défis dans le contexte de la pandémie de la COVID-19. Il y a un besoin urgent d’apporter un soutien psychologique aux dentistes québécois. / Abstract Context: Due to the COVID-19 pandemic, as of mid-March 2020, most Quebec dentists in private practice found themselves unemployed due to the confinement imposed by the Quebec public health department. The psychological health of Quebec dentists was challenged because of several sudden changes in their daily lives. Objectives: To assess the state of the psychological health of Quebec dentists in the context of the COVID-19 pandemic during the summer of 2020. Methods: An online questionnaire was sent to the 5001 licensed dentists in the province of Quebec, Canada on June 10, 2020. Working status, psychological health assessment, and sociodemographic data were evaluated. The validated psychological health measurement tools included the Patient Health Questionnaire (PHQ-9) to evaluate depression, Copenhagen Burnout Inventory (CBI) to measure burnout, and Kessler-10 scale (K-10) to evaluate psychological distress. Suicidal ideation and past suicidal attempts were also assessed. Data were analyzed using bivariate statistical tests and multivariate logistic regression analysis. Results: The response rate was 18% (n=902) with 835 participants providing complete data sets for psychological outcomes included in the analysis. Prevalence of moderate to severe level of personal (49.7%, 95%CI=46.3-53.1), professional (48.4%, 95%CI=44.9-51.8), and patient-related (37.5%, 95%CI=34.2-40.9) burnout was high. Moderate to severe depressive symptoms were found in 23.4% (95%CI=20.5-26.4) of participants and 39.5% (95%CI=36.2-42.9) had moderate to severe psychological distress. Participants perceived their psychological health as worse after the beginning of the pandemic compared to before the pandemic (p<0.001). Past suicidal ideation was reported by 12.9% (95%CI=10.7-15.4) of participants with 1.7% (95%CI=0.9-2.8) reporting at least one suicide attempt. Being a woman was significantly associated with personal burnout (aOR=1.90, p≤0.001), professional burnout (aOR=1.56, p≤0.01) and psychological distress (aOR=1.47, p≤0.05). Older dentists (≥ 45 years old) were more prone to have suicidal ideation over the past two weeks (OR= 1.57, p=0.055) compared to their younger counterparts. Dentists living alone and dental clinic owners were significantly more at risk to develop suicidal ideation over the last two weeks (aOR=2.52, p≤0.01, and aOR=2.09, p≤0.01, respectively) and had worst psychological outcomes. Regular physical exercise, minimizing alcohol consumption, an increased number of sleeping hours and an increased number of vacation weeks per year were found to be significant protective markers against moderate to severe psychological outcomes during the COVID-19 pandemic. Anxiety of getting or transmitting the COVID-19 virus to patients or family members was positively associated with burnout. The three most popular coping strategies during the COVID-19 pandemic were social interactions, sports, and listening to music. Conclusion: Psychological health among Quebec dentists presents several challenges in the context of the COVID-19 pandemic. There is an urgent need to provide psychological support to dentists.

(1) Background. Defeat and entrapment have been highlighted as major risk factors of suicidal ideation and behavior. Nevertheless, little is known about their short-term variability and their longitudinal association in real-time. Therefore, this study aims to investigate whether defeat and entrapment change over time and whether defeat predicts entrapment as stated by the integrated motivational–volitional model of suicidal behavior. (2) Methods. Healthy participants (n = 61) underwent a 7-day smartphone-based ecological momentary assessment (EMA) on suicidal ideation/behavior and relevant risk factors, including defeat and entrapment and a comprehensive baseline (T0) and post (T2) assessment. (3) Results. Mean squared successive differences (MSSD) and intraclass correlations (ICC) support the temporal instability as well as within-person variability of defeat and entrapment. Multilevel analyses revealed that during EMA, defeat was positively associated with entrapment at the same measurement. However, defeat could not predict entrapment to the next measurement (approximately two hours later). (4) Conclusion. This study provides evidence on the short-term variability of defeat and entrapment highlighting that repeated measurement of defeat and entrapment—preferably in real time—is necessary in order to adequately capture the actual empirical relations of these variables and not to overlook significant within-person variability. Further research—especially within clinical samples—seems warranted.