We apply a combination of suppression and release criteria to reconstruct the disturbance history of a ponderosa pine – Douglas-fir stand in central Idaho. In this stand, disturbance, likely fire, induced growth releases in some trees, and sudden, severe suppressions in others. To characterize growth release following disturbance, we developed boundary-line release criteria for Douglas-fir and ponderosa pine. Suppression criteria were applied to identify disturbances defined as a growth reduction of more than 1.8 standard deviations sustained for a minimum of five years. To prevent confusing a true release event with growth increases associated with recovery from suppression, release events were not tallied for at least fifteen years following a suppression event. Release and suppression events were combined to create a disturbance chronology characterized by a high frequency of disturbance between 1820 and 1920. This period of disturbance likely reflects post-European settlement land uses such as grazing and logging as well as an increase in fire frequency. Fire suppression in the latter part of the 20th Century likely explains the decrease in disturbance after 1940. We believe that a combination of release as well as suppression criteria best describes the disturbance history of this stand.

Background: Rates of care retention and maintenance of viral suppression differ by location in the Unites States due the varying public health policies and infrastructures. As a result, it is imperative to determine the rates of retention and viral suppression as well as factors associated with these changes during the prenatal and postpartum period in the state of Georgia Methods: Data on 161 HIV infected women was collected from birth certificate records and the enhanced HIV/AIDS Reporting System (eHARS). Multivariate logistic regression was used to determine the association between sociodemographic as well as clinical variables and outcome variables of retention, viral suppression and care engagement during and after pregnancy. Results: Women were more likely to be retained in care during pregnancy (79.50%) than during the postpartum period (55.28%). Women were also more likely to achieve viral suppression during pregnancy (68.94%) than during the postpartum period (49.69%). Approximately 43% of women engaged in HIV care within 90 days of giving birth. Women who were retained in HIV Care prior to pregnancy were more likely to be retained during pregnancy (95%) and the postpartum period (76%) than women diagnosed during pregnancy or not retained in care prior to pregnancy. Conclusion: Women face a myriad of challenges that make retention and viral suppression difficult. It is important that we utilize technology to help improve treatment received in the postpartum period.

Habitual suppression of emotions has been linked to adverse consequences such as avoidant attachment, lower social support, and reduced relationship closeness (e.g. John & Gross, 2004). However, accumulating evidence that expression and suppression can be both adaptive and maladaptive in different contexts suggests the importance of flexibility in emotional regulation. The present study examined the mechanisms underlying the only laboratory measure of emotional flexibility: the Expressive Flexibility (EF) task (Bonanno, Papa, Lalande, Westphal, & Coifman, 2004). This measure has been linked to adjustment over a one-year period, especially in the context of social threat, and among people who have experienced higher levels of life stress (Westphal, Seivert & Bonanno, 2010). We sought to test whether EF is related to physiological recovery from stress in the immediate term. Participants completed questionnaire measures, the EF Task and a stressful public speaking task. In the EF task, participants were filmed suppressing, exaggerating, and not altering facial reactions to negative and positive pictures. A “balanced EF” score was calculated reflecting their ability to suppress and exaggerate with equal success. Regression analyses used EF scores as predictors for psychophysiological indices of stress (SCR and HR) during and after the public-speaking task. The interaction of EF and social safeness (SSPS) was predictive of the magnitude of SCR recovery, such that for people with lower EF, higher SSPS is predictive of greater SCR recovery. These results converge with previous findings on the suggestion that EF is related to resilience, especially in the context of adversity.

Compost can suppress soilborne plant pathogens that cause significant damage on globally important food crops. However, reports of plant pathogen suppression are inconsistent likely because there are no established standards for feedstock material, application rate, and maturity age upon application. Excellent results can be achieved in greenhouse trials, but field applications are much less reliable. Disease suppression occurs through the activity of biocontrol organisms (direct antagonism), and general microbial competition. Biocontrol species are hypothesized to colonize the pile during the curing phase, but single species may not be as important as microbial consortia. Substrate composition during maturation may give rise to a suppressive microbial community. More research is needed to understand the relationships between feedstock, maturity, and production process on compost microbial ecology. The thesis had two main objectives: 1) identify biological indicators in compost that could (a) characterize maturity, process, and feedstock, and (b) predict disease suppression against R. solani, and 2) identify bacterial and fungal community composition and/or structure that is associated with suppression of soilborne disease. Rhizoctonia solani is a facultative saprophytic fungus and soilborne plant pathogen that attacks many globally important food crops and turfgrass. Prior research suggests that managing carbon quality and compost maturity will alter relative competition between biological control microbes and the R. solani pathogen. The pathogen is responsible for economic losses to organic vegetable production in Vermont and there are no available methods to manage the disease that meet organic certification. R. solani on radish was chosen as a model system given its global importance, competitiveness affected by carbon quality, and lack of disease management options for organic production. Compost samples were most abundant in the bacterial phyla Proteobacteria and Bacteroidetes, and known biocontrol species were not detected in abundance. Compost samples did not differ significantly in fungal community composition, suggesting a dominance effect from the native soil fungal community. Overall, anaerobic digestate and vermicompost were most suppressive against R. solani. Thermophilic composts were not very suppressive overall, though a specially made hardwood bark compost was comparable to the suppressiveness of vermicompost application. Ecoenzyme analysis was able to integrate information on environmental substrate composition, microbial nutrient acquisition, and microbial community metabolism, offering the best view of current ecological conditions in compost. Ecoenzyme analysis showed that the most suppressive composts, anaerobic digestate and vermicompost, were most nutrient limited. All compost samples were severely nitrogen (N) limited, and anaerobic digestate and vermicompost were severely limited in both N and phosphorus (P). The additional P limitation may support non-pathogenic species to outcompete R. solani. The key to disease suppression may lie in matching up the ecology of the plant pathogen with the ecology of biocontrol, which may be engineered in compost.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

In the US, the incidence and mortality rates of hepatocellular carcinoma (HCC) are alarmingly increasing since no effective therapy is available for the advanced disease. Activation of IGF signaling is a major oncogenic event in diverse cancers, including HCC. Insulin-like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling by binding to IGF-1 receptor (IGF-1R) and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). IGFBP7 abrogates tumors by inducing cancer-specific senescence and apoptosis and inhibiting angiogenesis. We now document that Igfbp7 knockout (Igfbp7-/- ) mouse shows constitutive activation of IGF signaling, presents with pro-inflammatory and immunosuppressive microenvironment, and develops spontaneous tumors in lungs and liver and markedly accelerated carcinogen-induced HCC. Loss of Igfbp7 resulted in increased proliferation and decreased senescence in hepatocytes and mouse embryonic fibroblasts that could be blocked by an IGF-1 receptor inhibitor. A significant inhibition of genes regulating immune surveillance was observed in Igfbp7-/- livers which was associated with marked inhibition in antigen cross presentation by Igfbp7-/- dendritic cells. IGFBP7 overexpression inhibited growth of HCC cells in syngeneic immune competent mice, which could be abolished by depletion of CD4+ or CD8+ T lymphocytes. Our studies unravel modulation of immune response as a novel component of pleiotropic mechanisms by which IGFBP7 suppresses HCC. Even though HCC has an immunosuppressive milieu, immune targeted therapies are beginning to demonstrate significant objective responses in clinical trials. IGFBP7 might be an effective anti-HCC therapeutic by directly inhibiting cancer cells and stimulating an anti-tumor immune response.

Since the offshore drilling for oil and gas is venturing into ever greater water depths, drilling risers face problems of vortex-induced vibrations due to the currents. Vortexinduced vibrations are a major fluid load and fatigue component on the long, smooth, and slender bodies placed in a fluid flow and measures must be taken to suppress the shedding of the Karman vortex sheets from its edges. One of the ways to reduce the vibration is to use marine fairings which are attached to the drilling risers with the help of weather vanes. In this thesis, CFD analysis based on solving RANS equations for K-w turbulence model at Reynolds number 10,000 is done for a regular cylinder and one with marine fairing attached. The motivation of such analysis is to compute the efficiency of the fairing arrangement in suppressing the vortex-induced vibrations of the corresponding bluff body.

Este trabalho tem a finalidade de apresentar e comparar técnicas de redução de ruído utilizando como critérios de avaliação a mínima distorção espectral e a redução de ruído, na reconstrução dos sinais de voz degradados por ruído. Para tanto, utilizou-se os filtros de Kalman de tempo discreto e de freqüência discreta em conjunto com a técnica de subtração espectral de potência. Os sinais utilizados foram contaminados por ruídos branco e colorido, e a avaliação do desempenho dos algoritmos foi realizada tendo-se como parâmetros a relação sinal/ruído segmentada (SNRseg) e a distância de Itakura-Saito (d(a,b)). Após o processamento, verificou-se que a técnica, proposta neste trabalho, de filtragem de Kalman no tempo em conjunto com a subtração espectral de potência, apresentou resultados um pouco melhores em relação à filtragem de Kalman na freqüência em conjunto com a subtração espectral de potência. / This work has as main objective to present and to compare techniques of noise reduction using as evaluation criterion the low spectral distortion and the noise reduction in the reconstruction of corrupted speech signals. For so much, it was used the Kalman\'s filters in the time and frequency domain together with the technique of power spectral subtraction. The used signals were corrupted by white and colored noises and the evaluation of effectiveness of the algorithms was accomplished using the segmental signal-to-noise ratio (SNRseg) and the Itakura-Saito distance (d(a,b)). After the processing, it was noticed that the Kalman filtering in the time together with power spectral subtraction presented better results than the Kalman filtering in the frequency together with power spectral subtraction.

Com o aumento progressivo do número de casos de infecção por diferentes arbovírus, por exemplo, dengue, zica e chikungunya, faz-se necessário o desenvolvimento de novas técnicas para o combate a esses arbovírus. A manipulação genética possibilitou a obtenção de mosquitos geneticamente modificados que sejam capazes de suprimir a população selvagem ou impedir a transmissão de agentes etiológicos gerando doenças. O estudo teve como objetivo o estabelecimento de linhagens para supressão populacional de Aedes aegypti. Esta construção apresenta esterilidade condicionada à presença ou ausência de antibiótico no meio em que esses mosquitos se desenvolvem durante a fase larval. Dessa forma, sem a necessidade de se utilizar radiação para obter insetos estéreis, é possível melhorar a qualidade dos machos adultos liberados e aumentar a competitividade dos mesmos em competir por fêmeas selvagens e adicionalmente gerar o desejado quadro de supressão populacional. / The increasing number of infection cases by arboviruses, for instance Dengue, Zika and Chikungunya, it is necessary to develop new techniques to fight against these arboviruses. Genetic manipulation allowed the production of genetically modified mosquitoes that are capable of suppressing the wild population or prevent pathogens transmission and avoid disease development. The project proposes to establish lines for population suppression of Aedes aegypti, one of the main vectors of those diseases. This construction presents the conditional sterility due to the presence or absence of antibiotics in the environment where these mosquitoes are developed during the larval stage. Thus, without the need to use radiation for sterile insects, it is possible to improve the quality of the released adult males and enhance the competitiveness thereof in competing with wild females and additionally generate population suppression.