Approved for public release; distribution is unlimited. / MBA Professional Report / This project provides an analysis of the Army's acquisition of the Land Warrior (LW) Soldier System. Its objectives are to document the history of the LW and provide an overview of the program to establish the components of both it development and deployment and its associated business and management characteristics. The product is a document that provides an analysis of the actions taken and the obstacles encountered and how the materiel developers, warfighters, user representatives and lawmakers dealt with them. The LW was approved in 1993. The requirement was to provide improvements for dismounted soldiers in the five specific capabity caategories of lethality, command and control, mobility, survivability and sustainment. For a period lasting approximately 15 years, the LW has evolved. Despite this evolution, the Army in FY 2007 terminated it in FY 2007. Regardless, it has laid the foundation for follow-on soldier system initiatives. The LW was unsuccessfu initially due to the misalignment of three interrelated and supporting components; 1) technical immaturity, 2) poor user acceptance, and 3) lack of senior leadership support. Successes that are more recent can be attributed to: 1)soldier-driven design, 2) improved technical maturity, and 3) proven employment of the system in combat by warfighters.

Milling is a widely used cutting process, most commonly applied to machining external surfaces of workpieces. When machining operations are required within hard to reach areas of components, or deep within the bore of components, alternative methods of metal removal are generally employed. Typically when milling at extended reaches, difficulties may increase exponentially when trying to achieve distances several meters into a component. Essentially every topic of the milling process becomes difficult and more convoluted. Firstly to generate a stable cutting condition, and ultimately for an operator to be able to understand the cutting conditions, when all normal senses to interpret the machining stability are removed. The aim for the research is, to enable the operation of high slenderness ratio internal milling operations to become a viable technology, by detailing the measures required, to obtain a stable cutting condition. The process needs to be monitored for degradation of the tooling due to wear, and to prevent catastrophic machine damage from tool breakage or machine component failure. This research addresses the lack of knowledge available for milling with extended reaches, and the knowledge gained to overcome the real difficulties that exist for this process. Initial experiments are conducted on a prototype machine to gain experience of the internal machining operation and the many issues that it faced. Establishing requirements of the process via investigation of the tooling and necessary auxiliary equipment, it becomes possible to consider countermeasures to address the errors generated by torsional twisting of the milling arm. A system for applying a counter torque to reduce torsional deflection errors has been employed to successfully reduce the unavoidable issue over such long distances. For the process to become manageable for an industrial operator without a high level of specialist knowledge, the application of tool condition monitoring (TCM) and process condition monitoring (PCM) had to be applied. This addresses a void in available literature and research with respect to internal machining, and enables the process to become practical for an industrial environment. For this reason the research project will concentrate on the application of TCM and PCM onto the machining system. The completion of the research resulted in the process becoming satisfyingly stable, and with a resulting accuracy that satisfies the requirements of the component. Performance of the final system rivalled or achieved better results than had been experienced by the project sponsor.

Introdução: Os efeitos metabólicos do uso combinado dos triglicerídeos de cadeia média (TCM) e do óleo de peixe (OP) na esteatose hepática ainda não estão totalmente esclarecidos. Objetivo: O presente estudo teve o objetivo de verificar os efeitos da combinação dos TCMs e OP na esteatose hepática e estresse oxidativo induzidos pela dieta hiperlipídica (HL+) termolizada em ratos. Material e Métodos: Foram utilizados no total 50 ratos machos da linhagem Wistar. O grupo Controle (n=10) recebeu a dieta controle. Os grupos HL+ receberam a dieta contendo 50% de gordura animal (GA) termolizada e 50% de ração. A adaptação às dietas HL+ foi realizada durante 5 dias. Os grupos HL+GA, HL+TCM, HL+OP e HL+TCM/OP (n=10) receberam a dieta HL+ com 50% de lipídios (gordura animal termolizada) durante 30 dias. Após este período, os grupos HL+TCM, HL+OP e HL+OP/TCM receberam as dietas HL+ adicionadas de óleo de TCM (OTCM), OP e OTCM + OP, respectivamente, durante 20 dias. As análises realizadas foram a gordura hepática total, frações lipídicas hepáticas e séricas, glicemia, vitamina E e retinol séricos, glutationa reduzida (GSH) e malondialdeído (MDA) sérico e hepático e aminotransferases séricas. Resultados: Os grupos HL+ apresentaram acúmulo significativo de gordura total e triglicerídeos hepáticos, exceto o HL+OP. Apenas o grupo HL+TCM não apresentou acúmulo significativo de colesterol total hepático (CT). Este mesmo grupo apresentou valores maiores de CT e HDLcol séricos e menor razão triglicerídeos/HDLcol. Os valores séricos de aminotransferases foram significativamente maiores nos grupos que receberam os OTCM e/ou OP. A peroxidação lipídica (LPO) hepática foi maior foi nos grupos HL+, exceto o HL+TCM. Apenas o grupo HL+GA apresentou maior LPO sérica. Verificou-se que a GSH foi maior nos grupos HL+GA, HL+TCM e HL+OP/TCM, a vitamina E sérica foi menor nos grupos HL+GA, HL+OP e HL+OP/TCM e o retinol sérico foi maior nos grupos HL+GA e HL+TCM. Conclusões: As alterações séricas não refletiram as alterações hepáticas em relação aos lipídios, estresse oxidativo e antioxidantes. O uso do óleo de TCM e óleo de peixe em associação na dieta HL+ resultou em efeito negativo devido ao maior acúmulo de gordura hepática tanto na forma de triglicerídeos quanto de colesterol, maior peroxidação lipídica hepática e menor vitamina E sérica. / Introduction: The metabolic effects of combined use of medium chain triglycerides (MCT) and fish oil (FO) on non alcoholic hepatic steatosis are not fully understood. Objective: The aim of this study was to investigate the effects of the combination of MCT and FO on hepatic steatosis and oxidative stress induced by high fat (HF+) thermolyzed diet in rats. Methodology: Fifty wistar male rats were studied. The Control group (n = 10) received the standard diet. The HF+ groups received diet with 50% of thermolyzed animal fat (AF) and 50% of ration. Five days were dedicated for adaptation to high-fat diets. The groups HF+AF, HF+MCT, HF+FO and HF+MCT/FO (n = 10) received HF+ diet with 50% thermolyzed fat during 30 days. After this period, the groups HF+MCT, HF+FO and HF+MCT/FO received HF+ diets with MCT oil (MCTO), FO and MCTO + OP, respectively, during 20 days. Analysis of total liver fat, liver and serum lipid fractions, serum glucose, vitamin E and retinol, serum and liver reduced glutathione (GSH) and malondialdehyde (MDA), and serum aminotransferases (AST and ALT) were performed. Results: The groups HF+ showed higher total fat and triglycerides, except HF+FO. Only HF+MCT group didn´t have higher liver total colesterol (TC). This same group had higher serum TC and HDLcol and lower triglycerides/HDLcol ratio. The groups fed with MCTO and/or FO had higher serum aminotransferase. Liver lipid peroxidation (LPO) was higher in HF+ groups, except HF+MCT. Serum LPO was higher in HF+AF. The hepatic GSH was higher in the groups HF+AF, HF+MCT and HF+MCT/FO, serum vitamin E was lower in groups HF+AF, HF+FO and HF+MCT/FO, and serum retinol was higher in groups HF+AF and HF+MCT. Conclusions: Lipids, oxidative stress and antioxidant serum and liver alterations didnt correspond. The association of MCTO with FO in HF+ diet resulted in a negative effect when it concerns liver fat, triglyceride and cholesterol accumulation, higher liver lipid peroxidation and lower serum vitamin E.

Approved for public release; distribution is unlimited. / Trellis-Coded Modulation (TCM) is employed with quadrature amplitude modulation (QAM) to provide error correction coding with no expense in bandwidth. There are two common implementations of TCM, namely pragmatic TCM and Ungerboeck TCM. Both schemes employ Viterbi algorithms for decoding but have different code construction. This thesis investigates and compares the performance of pragmatic TCM and Ungerboeck TCM by implementing the Viterbi decoding algorithm for both schemes with 16-QAM and 64-QAM. Both pragmatic and Ungerboeck TCM with six memory elements are considered. Simulations were carried out for both pragmatic and Ungerboeck TCM to evaluate their respective performance. The simulations were done using Matlab software, and an additive white Gaussian noise channel was assumed. The objective was to ascertain that pragmatic TCM, with its reduced-complexity decoding, is more suitable to adaptive modulation than Ungerboeck TCM. / Civilian

Natural bioactive compounds have drawn the interest of many researchers worldwide in their effort to find novel treatments, including prostate cancer (PC) treatment which is estimated to be 13.1% of all new cancer cases in the U.S. in 2021. Many of these bioactive compounds have been identified from treatments in traditional Chinese medicine (TCM), that often have multiple bioactive compounds present. However, in vitro studies frequently focus on the compounds in isolation, or in simple combinations of two compounds. We used mixture design response surface methodology (MDRSM) to assess changes in PC cell viability after 48 hours of treatment to identify the optimal mixture of all 35 three-compound combinations of seven bioactive compounds from TCM. We used Berberine, Wogonin, Shikonin, Curcumin, Triptolide, Emodin, and Silybin to treat PC-3, DU145, and LNCaP human PC cells, and a drug-resistant PC-3 cell line. Berberine and Wogonin most frequently contributed to the optimal combination to reduce cell viability in PC-3 and LNCaP cells; DU145 cells more frequently responded best to a single compound.

Schönherr Qwick, R-M Öronakupunktur. Upplevelser och känslor av öronakupunktur isamband med rökavvänjning. Examensarbete i omvårdnad 15 högskolepoäng, D-nivå.Malmö högskola: Hälsa och samhälle, Utbildningsområde omvårdnad, 2009.Bakgrund Tobaksbruket medför stora hälsorisker och för många en för tidig död. Mångarökare önskar inget hellre än att sluta. Att sluta röka är ofta svårt, då nikotinet är en starkdrog och abstinserna kan vara svåra, även om evidens baserad hjälp finns i form avmetoder och hjälpmedel. Allt fler patienter önskar hjälp med akupunktur menkunskaperna och erfarenheterna om hur metoden fungerar och upplevs av rökare är få.Metod Åtta kvinnliga rökare, anställda inom Vård och Omsorg i Malmö, intervjuades dåde som frivilliga deltog i rökslutarbehandling med öronakupunktur under tre veckorvåren 2009. Intervjuerna analyserades enligt Burnards innehålls analys och resultaten hardiskuterats i relation till folkhälsoteorierna av Ajzen ”The Theory of Planned Behavior”och Prochaska & Di Clemente “The stage of Change Model.” Vårdgivarens upplevelserhar diskuterats i relation till omvårdnadsteorin av Jean Watson och Barbara Carper.Syftet Med denna studie har varit att undersöka upplevelser och känslor avöronakupunktur i samband med rökavvänjning. Vidare att se om behandlingen skullekunna ge lindring av abstinens och undersöka vilka bakomliggande motiv som ligger tillgrund för beslutet att sluta röka. Syftet var också att undersöka vårdgivarens upplevelserav att ge denna behandling.Resultat Presenteras utifrån olika kategorier av känslor och upplevelser som framkommithos deltagarna under behandlingen med öronakupunktur. Deltagarna rapporteradepositiva effekter av behandlingen. Samtliga deltagare var från början väl motiverade attsluta röka och till metoden. De ansåg att det var en verksam behandlingsmetod somhjälpte dem att sluta röka eller minska på nikotin behovet. De uttryckte lindring iabstinensen till följd av behandlingen samt känslor av välbefinnande och harmoni.Vårdgivaren upplevde arbetet givande och metoden som ett bra verktyg.Konklusion Mottagaren av öron akupunktur i samband med rökavvänjning upplever enlindring av abstinens. Den upplevs lugnande och rogivande. Vårdgivaren upplevdemetoden som ett effektivt, förtroende ingivande hjälpmedel. Mera forskning behövs föratt vidare utforska behandlingens effektivitet när det gäller den procentuella andelen sompå sikt slutar röka helt. / Schönherr Qwick, R-M. Earacupuncture. Experience and feelings of ear acupuncture inconjunction to quit smoking. Degree Project, 15 Credit Points, Advanced level. MalmöUniversity and Society, Department of Nursing, 2009.Background The use of tobacco smoking has severe health hazards and for many anincreased risk of premature death. Many smokers have a strong wish to quit tobacco.However smoking cessations is difficult, since nicotine is a strong addictive drug, and hasmany with- drawl symptoms, even if evidence based methods and nicotine replacementsare used. Many quitters wants to try alternative methods in smoking cessation asacupuncture but knowledge and experience about effect and sensations combined withthe treatment of smokers is scarce among caregivers.Aim Of this study was to explore the experiences and feelings of ear acupuncture inconjunction with smoking cessation. Further to examine if the treatment were able toreduce abstinences, to examine motives for smoking cessation and to examine thecaregivers experiences in providing this form of treatment.Method Eight women from the health care sector in Malmö volunteered to participate inthis tobacco cessation project by ear acupuncture during three weeks in spring 2009 inMalmö, Sweden. This qualitative interview study were analyzed using content analysisby Burnard and the findings have been analyzed in relation and people health theory ofAjzen “Theory of planned behavior” and Prochaska & Di Clemente” The stage ofChange Model.” The experiences from the caregiver in providing the treatment wereanalysed in relation to the caring theory by Jean Watson, Barbara Carper.The results All participants were motivated to quit smoking using ear acupuncture.Participants reported positive effects of ear acupuncture as a treatment reducing“crawings” for nicotine associated with in smoking cessation. The results also show thatparticipants were relived in main abstinences and they felt comfort and harmony in thecontext of the individual treatments. The caregiver experienced the method as efficient,rewarding and as a good tool.Conclusion The patient who receives ear acupuncture feels relief in symptoms ofwithdrawal associated with smoking cessation. The treatment perceives as calming andsoothing. More research is needed to further explore the efficiency of the treatment insuccess rate of smoking cessation.

In the United States alone, there were 25.8 million people suffering from diabetes in 2010. The prevalence of diabetes is expected to markedly increase worldwide over the next 30 years, an estimated 2.8% in 2000 and 4.4% in 2030. For individuals diagnosed with type 2 diabetes mellitus (T2DM), treatment is essential to control adverse effects such as hypertension and diabetic neuropathy. The focus of this study is to examine various approaches to maintain and improve the lifestyle of individuals suffering from T2DM. A comparative approach has been used to evaluate the differences in the treatment of T2DM with the use of traditional Chinese medicine (TCM) and Western medicine. In Western society, pharmaceuticals are commonly used as a treatment method to manage hyperglycemia, along with life-style modifications. Furthermore, TCM views the human body and its functioning in a holistic way, stating that no single body part or symptom can be understood apart from its relation to a whole. Herbal medications and other treatments in TCM are targeted to treat underlying medical complaints that resulted in symptoms, instead of treating one specific manifestation. Data collection has been gathered through Qualitative over the phone interviews with patients suffering from T2DM, as well as TCM physicians. Interviews were conducted on patients that were diagnosed with T2DM (fasting plasma glucose levels of 126 or greater and HbAlc levels [greater than] 8%), and had continued treatment longer than three months prior to interviews. Collection of chart notes containing glucose levels, levels of pain, lifestyle changes, and vital signs were also used. A total of 21 patients from a family practice were interviewed, answering 23 constructed questions based on treatment of choice (TCM or western) and their personal input on treatment satisfaction. Patients varied in age, ethnicities, and gender, ranging from 39-70 years of age. Two traditional Chinese medicine physicians were also interviewed. Interviews with TCM physicians elaborated on course of treatment and steps taken to diagnose T2DM. Furthermore, prescription medications were also charted and documented to further analyze with secondary data. Upon completing the interviews, the data stated 21 patients (total population questioned) had not experienced alternative medicine and were exposed only to western medicine as treatment. A major concern for most patients were the pharmaceutical side effects, and 85.1% of patients stated they would be interested in an alternative treatment. Due to insufficient sources and knowledge on TCM treatment, 14.2% of patients stated they were satisfied with their western medicine treatment of choice and would not change treatment. The research's objective was to evaluate the differences in treatment of T2DM. Data collected supported the objective and showed the lack of sources to alternative treatments aside from western medicine. The researcher informed and educated interviewees about literature review on traditional Chinese medicine about alternative treatments available to treat T2DM.

No description available.

本研究在探討中藥產業價值鏈的價值活動中因為：(1)科技的進步；(2)醫療觀念的改變；(3)政府政策及法規的制定；(4)市場需求的擴大等四個外在因素的變動影響而促成中藥產業的新價值鏈形成。 　　在新價值鏈的價值活動切割考量，我們以(1)群聚效應；(2)關鍵因素效應～①不可或缺性；②資金障礙；③技術障礙；(3)蛙跳效應；(4)規模經濟效應等四個價值效應來作為切割的依據。主要的考量是因為價值鏈中的價值程度是因立場不同而有變動的。所以若由整個產業以俯瞰的角度，價值鏈切割應有產業想具有的價值存在才是，因此本研究以這四個效應來做切割依據。 　　新舊價值鏈的分析研究中，我們可以發現由於技術的演進、市場的成熟度、法規限制的破除都尚未有突破的情形下，舊中藥產業價值鏈中的研發一直是被忽略的，有的也是一些零星的基礎研究，而一些次要價值鏈中的價值活動其實是可以突顯的，如保鮮配送及全球行銷也都沒而不顯。直到因外在因素的衝擊下，新價值鏈形成時，這些價值活動也都因環境因素成熟而顯得重要。至此一個完整的新的產業價值鏈形成，使進入者或轉型者也可以在此產業價值鏈中挑取符合本身能耐的價值活動涉入參與。 　　接著本研究以新價值鏈的價值活動作SWOT分析時，本研究得出(1)種源資料庫；(2)藥用植物栽植；(3)飲片炮製；(4)製程及研發為台灣中藥產業可著力切入的價值活動。並以此建議政府及傳統中藥製造廠未來的發展方向。 　　值此關鍵變動之際，希望本研究能給予台灣中藥產業界在轉型或欲往專業分工的路線發展時，能有一個實際有效的參考準則。 / This study tried to find some changes in environment that formed the new value chain in TCM industry. The changes are, 　　1.biotechnological breakthrough, 　　2.change of therapeutic concept, 　　3.settlement of new recognition standard of rules by government, 　　4.increasing market demand. 　　As we segmented the new value chain in TCM industry into several value activities, we considered the following effects : 　　1.cluster effect, 　　2.barrier effect such as indispensable, capital, and technology, 　　3.frog-leap effect, 　　4.economic scale effect. 　　This study also discovered a finding that was neglected by most participants in TCM industry. Some value activities like logistic, global marketing are becoming more and more important in the new TCM value chain. Every participant who knows his own core competence will select the most suitable part of the new TCM value chain to enter. 　　Then, the study applied SWOT analysis to analyze every new TCM value activity in Taiwan. The finding from the SWOT analysis is that there are four new TCM value activities that can be focal development in Taiwan. The four new TCM value activities are, 　　1.date base settlement of TCM species, 　　2.planting and growing ways of TCM herb, 　　3.standard of raw material made for TCM, 　　4.R&D and manufacturing process improvement. 　　Hopefully, the study can give practical suggestions to TCM participants or new entrants in Taiwan in the transition.

No description available.