O conhecimento sobre a composição de raios cósmicos de altas energias é fundamental na abordagem da maior parte das grandes questões referentes à astrofísica de altas energias. Entretanto, do ponto de vista experimental, determinar o tipo de partícula medida nesse regime de energia ainda é um enorme desafio e essa tarefa tem recebido especial atenção por parte das colaborações responsáveis pelos experimentos em atividade. A principal dificuldade está no fato das medidas serem realizadas indiretamente através das cascatas de partículas formadas a partir da interação do raio cósmico inicial com átomos da atmosfera, os chamados chuveiros atmosféricos. Entre os principais experimentos em funcionamento, o Observatório Pierre Auger se destaca por ter a maior área de detecção (3000 km2) e por utilizar pioneiramente um sistema híbrido de detecção, com detectores de superfície e de fluorescência funcionando simultaneamente. Os telescópios de fluorescência medem o número de partículas do chuveiro em função da profundidade, o que chamamos de perfil longitudinal. Alguns parâmetros extraídos desse perfil são sensíveis à composição das partículas primárias. No presente trabalho, aplicamos métodos estatísticos novos aos dados extraídos dos perfis longitudinais de chuveiros medidos pelo Auger com o objetivo de inferir informações sobre a massa média, ou seja, a composição dos raios cósmicos. A primeira análise apresentada é baseada no parâmetro XMax. A evolução do valor médio de XMax com a energia contém informações sobre a composição inicial. Com o objetivo de eliminar vieses experimentais, corrigindo os efeitos dos detectores, aplicamos métodos de deconvolução às distribuições de XMax. A segunda análise é do tipo multiparamétrica e aplica redes neurais do tipo Multilayer Perceptrons a outros parâmetros extraídos dos perfis longitudinais. A partir desse procedimento é possível obter informações sobre a composição média das partículas e também reconstruir a energia dos eventos. / The knowledge about high energy cosmic rays composition is fundamental to approach most of the big questions regarding high energy astrophysics. However, from the experimental point of view, to determine the kind of the measured particle in this energy range is still a huge challenge and this task has received special attention from the collaborations responsible for running the experiments in activity. The main difficulty is on the fact that the measurements are made indirectly by the secondary particles cascades formed by the interaction of primary particles with atmosphere atoms, which are called air showers. Among the main experiments in operation, Pierre Auger Observatory has the larger collecting area (3000 km2) and uses a pioneer hybrid detection system, with surface detectors and fluorescence telescopes working simultaneously. The fluorescence telescopes measure the number of particles in the shower as a function of atmospheric depth, which we call longitudinal profiles. Some parameters extracted from these profiles are sensitive to primary composition. In this study, we applied new statistical methods to the data from longitudinal profiles measured by the Pierre Auger Observatory aiming to infer information about the mean mass, in other words, the composition of cosmic rays. The first analysis shown (chapter 4) is based on the known parameter called XMax. The evolution of XMax mean value with energy contains information about primary composition. Unfolding methods have been applied to the XMax distribution in order to minimize experimental bias and to correct detector effects. The second analysis shown is of the multi-parametric type and applies neural networks of the Multilayer Perceptrons class to longitudinal profiles parameters. From this procedure, it is possible to obtain information about average composition and to reconstruct the energy of events.

With the rising popularity of online and hybrid learning, this study explores an innovative method to improve students’ learning experiences with Electrical and Computer Engineering lab equipment by employing cutting-edge technologies in augmented reality (AR) and artificial intelligence (AI). Automatic object detection component, aligned with AR application, is developed to recognize equipment, including multimeter, oscilloscope, wave generator, and power supply. The deep neural network model, namely MobileNet SSD v2, is implemented in the study for equipment recognition. We used object detection API from TensorFlow (TF) framework to build the neural network model. When a piece of equipment is detected, the corresponding augmented reality (AR) based tutorial will be displayed on the screen. In this study, a tutorial for multi-meter is implemented. In order to provide users an intuitive and easy-to-follow tutorial, we superimpose virtual models on the real multimeter. In addition, images and web links are added in the tutorial to facilitate users with a better learning experience. Unity3D game engine is used as the primary development tool to merge both framework systems and build immersive scenarios in the tutorial.

Single-molecule force spectroscopy (SMFS) with atomic force microscope (AFM) has advanced our knowledge of the mechanical aspects of biological processes, and helped us take big strides in the hitherto unexplored areas of protein (un)folding. One such virgin land is that of membrane proteins, where the advent of AFM has not only helped to visualize the difficult to crystallize membrane proteins at the single-molecule level, but also given a new perspective in the understanding of the interplay of molecular interactions involved in the construction of these molecules. My PhD work was tightly focused on exploiting this sensitive technique to decipher the intra- and intermolecular interactions in membrane proteins, using bacteriorhodopsin and bovine rhodopsin as model systems. Using single-molecule unfolding measurements on different bacteriorhodopsin oligomeric assemblies - trimeric, dimeric and monomeric - it was possible to elucidate the contribution of intra- and interhelical interactions in single bacteriorhodopsin molecules. Besides, intriguing insights were obtained into the organization of bacteriorhodopsin as trimers, as deduced from the unfolding pathways of the proteins from different assemblies. Though the unfolding pathways of bacteriorhodopsin from all the assemblies remained the same, the different occurrence probability of these pathways suggested a kinetic stabilization of bacteriorhodopsin from a trimer compared to that existing as a monomer. Unraveling the knot of a complex G-protein coupled receptor, rhodopsin, showed the existence of two structural states, a native, functional state, and a non-native, non-functional state, corresponding to the presence or absence of a highly conserved disulfide bridge, respectively. The molecular interactions in absence of the native disulfide bridge mapped onto the three-dimensional structure of native rhodopsin gave insights into the molecular origin of the neurodegenerative disease retinitis pigmentosa. This presents a novel technique to decipher molecular interactions of a different conformational state of the same molecule in the absence of a high-resolution X-ray crystal structure. Interestingly, the presence of ZnCl2 maintained the integrity of the disulfide bridge and the nature of unfolding intermediates. Moreover, the increased mechanical and thermodynamic stability of rhodopsin with bound zinc ions suggested a plausible role for the bivalent ion in rhodopsin dimerization and consequently signal transduction. Last but not the least, I decided to dig into the mysteries of the real mechanisms of mechanical unfolding with the help of well-chosen single point mutations in bacteriorhodopsin. The monumental work has helped me to solve some key questions regarding the nature of mechanical barriers that constitute the intermediates in the unfolding process. Of particular interest is the determination of altered occurrence probabilities of unfolding pathways in an energy landscape and their correlation to the intramolecular interactions with the help of bioinformatics tools. The kind of work presented here, in my opinion, will not only help us to understand the basic principles of membrane protein (un)folding, but also to manipulate and tune energy landscapes with the help of small molecules, proteins, or mutations, thus opening up new vistas in medicine and pharmacology. It is just a matter of a lot of hard work, some time, and a little bit of luck till we understand the key elements of membrane protein (un)folding and use it to our advantage.

No description available.

The following thesis project has been done in direct collaboration with Autokaross i Floby AB Rescue Vehicle Department, in Sweden.  The report contains the design development of a protective cover against weather conditions for the extendable ladder in a fire vehicle.   The aim of the report has been to develop a functional and low cost solution cover for the FEL on a fire truck, which is allocated on the roof, with the express intention of providing adequate access and protection against weather conditions in Nordic countries, so as to prevent premature deterioration of the FEL unit. The company has set the technical and conceptual boundaries, with the help of the two previous concepts currently used, the BMC and the ACP.   The initial requirements laid out by the company were expressed through a number of specific demands which can be categorized in two main points:   Cost: Designing a solution keeping in mind cost limits, assembly cost and time, and space optimization. This was done by taking into account the two existing solutions, particularly the BMC, which represents the lowest, cost wise and function wise. Therefore it was used as the basis on which to apply improvements, rather than trying to lower the high cost on the overqualified function of the ACP.   Function: Providing the adequate protection and access to the FEL. In this case, the problem was solved by establishing the correct degree of protection relevant to the Nordic weather conditions and FEL needs, and regarding the access, this was assured by fully automating the opening/closing process with the existing extraction operating system of the FEL.     The result of this report is a concept solution which meets the company’s demands, obtained by creative detailing, together with an analysis regarding possible considerations that could improve the creative detailing result in this report in the form of future work.     The report documents the process that has taken place in exploration, concept generation, concept evaluation, concept selection, and detailed CAD development. Each section shows the requirements and adjustments taken to fulfil the company’s needs.

Cette thèse traite de la classification analytique du déploiement de systèmes différentiels linéaires ayant une singularité irrégulière. Elle est composée de deux articles sur le sujet: le premier présente des résultats obtenus lors de l'étude de la confluence de l'équation hypergéométrique et peut être considéré comme un cas particulier du second; le deuxième contient les théorèmes et résultats principaux. Dans les deux articles, nous considérons la confluence de deux points singuliers réguliers en un point singulier irrégulier et nous étudions les conséquences de la divergence des solutions au point singulier irrégulier sur le comportement des solutions du système déployé. Pour ce faire, nous recouvrons un voisinage de l'origine (de manière ramifiée) dans l'espace du paramètre de déploiement $\epsilon$. La monodromie d'une base de solutions bien choisie est directement reliée aux matrices de Stokes déployées. Ces dernières donnent une interprétation géométrique aux matrices de Stokes, incluant le lien (existant au moins pour les cas génériques) entre la divergence des solutions à $\epsilon=0$ et la présence de solutions logarithmiques autour des points singuliers réguliers lors de la résonance. La monodromie d'intégrales premières de systèmes de Riccati correspondants est aussi interprétée en fonction des éléments des matrices de Stokes déployées. De plus, dans le second article, nous donnons le système complet d'invariants analytiques pour le déploiement de systèmes différentiels linéaires $x^2y'=A(x)y$ ayant une singularité irrégulière de rang de Poincaré $1$ à l'origine au-dessus d'un voisinage fixé $\mathbb{D}_r$ dans la variable $x$. Ce système est constitué d'une partie formelle, donnée par des polynômes, et d'une partie analytique, donnée par une classe d'équivalence de matrices de Stokes déployées. Pour chaque valeur du paramètre $\epsilon$ dans un secteur pointé à l'origine d'ouverture plus grande que $2\pi$, nous recouvrons l'espace de la variable, $\mathbb{D}_r$, avec deux secteurs et, au-dessus de chacun, nous choisissons une base de solutions du système déployé. Cette base sert à définir les matrices de Stokes déployées. Finalement, nous prouvons un théorème de réalisation des invariants qui satisfont une condition nécessaire et suffisante, identifiant ainsi l'ensemble des modules. / This thesis deals with the analytic classification of unfoldings of linear differential systems with an irregular singularity. It contains two papers related to this subject: the first paper presents results concerning the confluence of the hypergeometric equation and may be viewed as a particular case of the second one; the second paper contains the main theorems and results. In both papers, we study the confluence of two regular singular points into an irregular one and we give consequences of the divergence of solutions at the irregular singular point for the unfolded system. For this study, a full neighborhood of the origin is covered (in a ramified way) in the space of the unfolding parameter $\epsilon$. Monodromy of a well chosen basis of solutions around the regular singular points is directly linked to the unfolded Stokes matrices. These matrices give a complete geometric interpretation to the well-known Stokes matrices: this includes the link (existing at least for the generic cases) between the divergence of the solutions at $\epsilon=0$ and the presence of logarithmic terms in the solutions for resonant values of $\epsilon$. Monodromy of first integrals of related Riccati systems are also interpreted in terms of the elements of the unfolded Stokes matrices. The second paper goes further into the subject, giving the complete system of analytic invariants for the unfoldings of nonresonant linear differential systems $x^2y'=A(x)y$ with an irregular singularity of Poincaré rank $1$ at the origin over a fixed neighborhood $\mathbb{D}_r$ in the space of the variable $x$. It consists of a formal part, given by polynomials, and an analytic part, given by an equivalence class of unfolded Stokes matrices. For each parameter value $\epsilon$ taken in a sector pointed at the origin of opening larger than $2\pi$, we cover the space of the variable, $\mathbb{D}_r$, with two sectors and, over each of them, we construct a well chosen basis of solutions of the unfolded differential system. This basis is used to define the unfolded Stokes matrices. Finally, we give a realization theorem for the invariants satisfying a necessary and sufficient condition, thus identifying the set of modules.

La thèse est composée d’un chapitre de préliminaires et de deux articles sur le sujet du déploiement de singularités d’équations différentielles ordinaires analytiques dans le plan complexe. L’article Analytic classification of families of linear differential systems unfolding a resonant irregular singularity traite le problème de l’équivalence analytique de familles paramétriques de systèmes linéaires en dimension 2 qui déploient une singularité résonante générique de rang de Poincaré 1 dont la matrice principale est composée d’un seul bloc de Jordan. La question: quand deux telles familles sontelles équivalentes au moyen d’un changement analytique de coordonnées au voisinage d’une singularité? est complètement résolue et l’espace des modules des classes d’équivalence analytiques est décrit en termes d’un ensemble d’invariants formels et d’un invariant analytique, obtenu à partir de la trace de la monodromie. Des déploiements universels sont donnés pour toutes ces singularités. Dans l’article Confluence of singularities of non-linear differential equations via Borel–Laplace transformations on cherche des solutions bornées de systèmes paramétriques des équations non-linéaires de la variété centre de dimension 1 d’une singularité col-noeud déployée dans une famille de champs vectoriels complexes. En général, un système d’ÉDO analytiques avec une singularité double possède une unique solution formelle divergente au voisinage de la singularité, à laquelle on peut associer des vraies solutions sur certains secteurs dans le plan complexe en utilisant les transformations de Borel–Laplace. L’article montre comment généraliser cette méthode et déployer les solutions sectorielles. On construit des solutions de systèmes paramétriques, avec deux singularités régulières déployant une singularité irrégulière double, qui sont bornées sur des domaines «spirals» attachés aux deux points singuliers, et qui, à la limite, convergent vers une paire de solutions sectorielles couvrant un voisinage de la singularité confluente. La méthode apporte une description unifiée pour toutes les valeurs du paramètre. / The thesis is composed of a chapter of preliminaries and two articles on the theme of unfolding of singularities of analytic differential equations in a complex domain. They are both related to the problem of local analytic classification of parametric families of linear systems: When two parametric families of linear systems are equivalent by means of an analytic change of coordinates in a neighborhood of the singularity? The article Analytic classification of families of linear differential systems unfolding a resonant irregular singularity deals with the question of analytic equivalence of parametric families of systems of linear differential equations in dimension 2 unfolding a generic resonant singularity of Poincaré rank 1 whose leading matrix is a Jordan bloc. The problem is completely solved and the moduli space of analytic equivalence classes is described in terms of a set of formal invariants and a single analytic invariant obtained from the trace of the monodromy. Universal unfoldings are provided for all such singularities. The article Confluence of singularities of non-linear differential equations via Borel-Laplace transformations investigates bounded solutions of systems of differential equations describing a 1-dimensional center manifold of an unfolded saddle-node singularity in a family of complex vector fields. Generally, a system of analytic ODE at a double singular point possesses a unique formal solution in terms of a divergent power series. The classical Borel summation method associates to it true solutions that are asymptotic to the series on certain sectors in the complex plane. The article shows how to unfold the Borel and Laplace integral transformations of the summation procedure. A new kind of solutions of parameter dependent systems of ODE with two simple (regular) singular points unfolding a double (irregular) singularity are constructed, which are bounded on certain “spiraling” domains attached to both singular points, and which at the limit converge uniformly to a pair of the classical sectorial solutions. The method provides a unified treatment for all values of parameter.

Les mesures de sections efficaces de production di-bosons constituent une partie importante du programme de physique au Large Hadron Collider (Grand collisionneur de hadrons) au CERN. Ces analyses de physique offrent la possibilité d'explorer le secteur électrofaible du modèle standard à l'échelle du TeV et peuvent être une indication de l'existence de nouvelles particules au-delà du modèle standard. L'excellente performance du LHC dans les années 2011 et 2012 a permis de faire les mesures très compétitives. La thèse donne un aperçu complet des méthodes expérimentales utilisées dans la mesure de la section efficace de production de W⁺W⁻ dans les collisions proton-proton au √s = 7 TeV et 8 TeV. Le texte décrit l'analyse en détail, en commençant par l'introduction du cadre théorique du modèle standard et se poursuit avec une discussion détaillée des méthodes utilisées dans l'enregistrement et la reconstruction des événements de physique dans une expérience de cette ampleur. Les logiciels associés (online et offline) sont inclus dans la discussion. Les expériences sont décrites en détail avec en particulier une section détaillée sur le détecteur ATLAS. Le dernier chapitre de cette thèse présente une description détaillée de l'analyse de la production de bosons W dans les modes de désintégration leptoniques utilisant les données enregistrées par l'expérience ATLAS pendant les années 2011 et 2012 (Run I). Les analyses utilisent 4,6 fb⁻¹ de données enregistrées à √s = 7 TeV et 20,28 fb⁻¹ enregistré à 8 TeV. La section efficace mesurée expérimentalement pour la production de bosons W dans l'expérience ATLAS est plus grande que celle prédite par le modèle standard à 7 TeV et 8 TeV. La thèse se termine par la présentation des résultats de mesures différentielles de section efficace. / Measurements of di-boson production cross-sections are an important part of the physics programme at the CERN Large Hadron Collider. These physics analyses provide the opportunity to probe the electroweak sector of the Standard Model at the TeV scale and could also indicate the existence of new particles or probe beyond the Standard Model physics. The excellent performance of the LHC through years 2011 and 2012 allowed for very competitive measurements. This thesis provides a comprehensive overview of the experimental considerations and methods used in the measurement of the W⁺W⁻ production cross-section in proton-proton collisions at √s = 7 TeV and 8 TeV. The treatise covers the material in great detail, starting with the introduction of the theoretical framework of the Standard Model and follows with an extensive discussion of the methods implemented in recording and reconstructing physics events in an experiment of this magnitude. The associated online and offline software tools are included in the discussion. The relevant experiments are covered, including a very detailed section about the ATLAS detector. The final chapter of this thesis contains a detailed description of the analysis of the W-pair production in the leptonic decay channels using the datasets recorded by the ATLAS experiment during 2011 and 2012 (Run I). The analyses use 4.60 fb⁻¹ recorded at √s = 7 TeV and 20.28 fb⁻¹ recorded at 8 TeV. The experimentally measured cross section for the production of W bosons at the ATLAS experiment is consistently enhanced compared to the predictions of the Standard Model at centre-of-mass energies of 7 TeV and 8 TeV. The thesis concludes with the presentation of differential cross-section measurement results.

The nuclear design of fusion devices such as ITER (International Thermonuclear Experimental Reactor), which is an experimental fusion reactor based on the "tokamak" concept, rely on the results of neutron physical calculations. These depend on the knowledge of the neutron and photon flux spectra which is particularly important because it permits to anticipate the possible answers of the whole structure to phenomena such as nuclear heating, tritium breeding, atomic displacements, radiation shielding, power generation and material activation. The flux spectra can be calculated with transport codes, but validating measurements are also required. An important constituent of structural materials and divertor areas of fusion reactors is tungsten. This thesis deals with the measurement of the neutron fluence and neutron energy spectrum in a tungsten assembly by means of multiple foil neutron activation technique. In order to check and qualify the experimental tools and the codes to be used in the tungsten benchmark experiment, test measurements in the D-T and D-D neutron fields of the neutron generator at Technische Universität Dresden were performed. The characteristics of the D-D and D-T reactions, used to produce monoenergetic neutrons, together with the selection of activation reactions suitable for fusion applications and details of the activation measurements are presented. Corrections related to the neutron irradiation process and those to the sample counting process are discussed, too. The neutron fluence and its energy distribution in a tungsten benchmark, irradiated at the Frascati Neutron Generator with 14 MeV neutrons produced by the T(d, n)4He reaction, are then derived from the measurements of the neutron induced γ-ray activity in the foils using the STAYNL unfolding code, based on the linear least-square-errors method, together with the IRDF-90.2 (International Reactor Dosimetry File) cross section library. The differences between the neutron flux spectra measured by means of neutron foil activation and the neutron flux spectra obtained in the same assembly, making use of an NE213 liquid-scintillation spectrometer were studied. The comparison of measured neutron spectra with the spectra calculated with the MCNP-4B (Monte Carlo neutron and photon transport) code, which allows a crucial test of the evaluated nuclear data used in fusion reactor design, is discussed, too. In conclusion, this thesis shows the applicability of the neutron foil activation technique for the measurement of neutron flux spectra inside a thick tungsten assembly irradiated with 14 MeV from a D-T generator. / Die Konstruktion von Fusionsreaktoren wie ITER (International Thermonuclear Experimental Reactor), der ein experimenteller Fusionsreaktor ist und auf dem "Tokamak"-Konzept beruht, basiert unter neutronenphysikalischen Gesichtspunkten auf den Ergebnissen von umfangreichen Simulationsrechnungen. Diese setzen die Kenntnis der Spektren des Neutronen- und Photonenflusses voraus die besonders wichtig ist, weil sie, die möglichen Antworten der ganzen Struktur auf physikalische Prozesse vorauszuberechnen erlaubt wie z.B.: Heizen durch nukleare Prozesse, Tritium-Brüten, Atomverschiebung, Abschirmung von Strahlung, Leistungserzeugung und Materialaktivierung. Die Flußspektren können mittels Transportcodes berechnet werden, aber es werden auch Messungen zu ihrer Bestätigung benötigt. Ein wichtiger Bestandteil des Strukturmaterials und der Divertor-Flächen der Fusionsreaktoren ist Wolfram. Diese Dissertation behandelt die Messungen der Neutronspektren und ?fluenz in einer Wolfram-Anordnung mittels der Multifolien-Neutronenaktivierungstechnik. Um die anzuwendenden experimentellen Geräte und die Codes, die im Wolfram-Benchmark-Experiment eingesetzt werden, zu überprüfen und zu bestimmen, wurden Testmessungen in den D-T und D-D Neutronenfeldern des Neutronengenerator der Technischen Universität Dresden durchgeführt. Die Eigenschaften der D-T und D-D Reaktionen, die für die Erzeugung von monoenergetischen Neutronen verwendet werden, sowie die Auswahl der Aktivierungsreaktionen, die für Fusionsanwendungen geeignet sind und die Aktivierungsmessung werden detailliert vorgestellt. Korrekturen, die sich auf den Neutronen-Bestrahlungsprozess und auf den Probenzählungsprozess beziehen, werden ebenfalls besprochen. Die Neutronenfluenz und ihre Energieverteilung in einem Wolfram-Benchmark, bestrahlt am Frascati Neutronen Generator mit 14 MeV-Neutronen aus der T(d, n)4He Reaktion, werden aus den Messungen der γ-Strahlenaktivität, die von Neutronen in den Folien induziert ist, durch den STAYNL Entfaltungscode, der auf der Methode der kleinsten Fehlerquadrate basiert, zusammen mit der IRDF-90.2 Wirkungsquerschnitt-Bibliothek abgeleitet. Die Unterschiede zwischen den Neutronenflußspektren, die mit Hilfe der Multifolien-Neutronenaktivierung ermittelt wurden, und den Neutronenflußspektren, gemessen im selben Aufbau mit einem NE-213 Flüssigszintillator, wurden untersucht. Die gemessenen Neutronenspektren werden den aus MCNP-4B Rechnungen (Monte Carlo neutron and photon transport) ermittelten Spektren gegenüber gestellt. Der Vergleich stellt einen wichtigen Test der evaluierten Kerndaten für Fusionsreaktorkonzepte dar. Zusammenfassend zeigt diese Arbeit die Anwendbarkeit der Multifolien-Neutronenaktivierungstechnik bei Messungen der Neutronenflussspektren innerhalb eines massiven Wolframblocks bei Bestrahlung mit schnellen Neutronen aus D-T Generatoren.

Cette thèse traite de la classification analytique du déploiement de systèmes différentiels linéaires ayant une singularité irrégulière. Elle est composée de deux articles sur le sujet: le premier présente des résultats obtenus lors de l'étude de la confluence de l'équation hypergéométrique et peut être considéré comme un cas particulier du second; le deuxième contient les théorèmes et résultats principaux. Dans les deux articles, nous considérons la confluence de deux points singuliers réguliers en un point singulier irrégulier et nous étudions les conséquences de la divergence des solutions au point singulier irrégulier sur le comportement des solutions du système déployé. Pour ce faire, nous recouvrons un voisinage de l'origine (de manière ramifiée) dans l'espace du paramètre de déploiement $\epsilon$. La monodromie d'une base de solutions bien choisie est directement reliée aux matrices de Stokes déployées. Ces dernières donnent une interprétation géométrique aux matrices de Stokes, incluant le lien (existant au moins pour les cas génériques) entre la divergence des solutions à $\epsilon=0$ et la présence de solutions logarithmiques autour des points singuliers réguliers lors de la résonance. La monodromie d'intégrales premières de systèmes de Riccati correspondants est aussi interprétée en fonction des éléments des matrices de Stokes déployées. De plus, dans le second article, nous donnons le système complet d'invariants analytiques pour le déploiement de systèmes différentiels linéaires $x^2y'=A(x)y$ ayant une singularité irrégulière de rang de Poincaré $1$ à l'origine au-dessus d'un voisinage fixé $\mathbb{D}_r$ dans la variable $x$. Ce système est constitué d'une partie formelle, donnée par des polynômes, et d'une partie analytique, donnée par une classe d'équivalence de matrices de Stokes déployées. Pour chaque valeur du paramètre $\epsilon$ dans un secteur pointé à l'origine d'ouverture plus grande que $2\pi$, nous recouvrons l'espace de la variable, $\mathbb{D}_r$, avec deux secteurs et, au-dessus de chacun, nous choisissons une base de solutions du système déployé. Cette base sert à définir les matrices de Stokes déployées. Finalement, nous prouvons un théorème de réalisation des invariants qui satisfont une condition nécessaire et suffisante, identifiant ainsi l'ensemble des modules. / This thesis deals with the analytic classification of unfoldings of linear differential systems with an irregular singularity. It contains two papers related to this subject: the first paper presents results concerning the confluence of the hypergeometric equation and may be viewed as a particular case of the second one; the second paper contains the main theorems and results. In both papers, we study the confluence of two regular singular points into an irregular one and we give consequences of the divergence of solutions at the irregular singular point for the unfolded system. For this study, a full neighborhood of the origin is covered (in a ramified way) in the space of the unfolding parameter $\epsilon$. Monodromy of a well chosen basis of solutions around the regular singular points is directly linked to the unfolded Stokes matrices. These matrices give a complete geometric interpretation to the well-known Stokes matrices: this includes the link (existing at least for the generic cases) between the divergence of the solutions at $\epsilon=0$ and the presence of logarithmic terms in the solutions for resonant values of $\epsilon$. Monodromy of first integrals of related Riccati systems are also interpreted in terms of the elements of the unfolded Stokes matrices. The second paper goes further into the subject, giving the complete system of analytic invariants for the unfoldings of nonresonant linear differential systems $x^2y'=A(x)y$ with an irregular singularity of Poincaré rank $1$ at the origin over a fixed neighborhood $\mathbb{D}_r$ in the space of the variable $x$. It consists of a formal part, given by polynomials, and an analytic part, given by an equivalence class of unfolded Stokes matrices. For each parameter value $\epsilon$ taken in a sector pointed at the origin of opening larger than $2\pi$, we cover the space of the variable, $\mathbb{D}_r$, with two sectors and, over each of them, we construct a well chosen basis of solutions of the unfolded differential system. This basis is used to define the unfolded Stokes matrices. Finally, we give a realization theorem for the invariants satisfying a necessary and sufficient condition, thus identifying the set of modules.