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Thesis aims to analyze some auxological aspects of menarche in a sample of peripubertal school-aged Prague girls. Sample PRAHA 2012 consists of 293 girls from Prague within the age ranging from 11,00 - 14,99 years. Ascertained median age of menarche 12,4 years is significantly lower (p = 0,0004) than median of Prague population - 13,04 years, respectively lower than median age of menarche of Czech population - 13,00 years according to data from the last national anthropological survey (CAV 2001). Our investigation suggests a "break off" in long-term stagnation age of menarche (minus 0,6 year) at least in a urban population in Czech Republic. According to our findings deceleration age of menarche wasn't accompanied by increase of average body height or other nutritional characteristics (body weight, BMI, arm circumference, thickness of skinfolds) in comparison with actual pediatrics standards. Though, there is a clearly evidence that participant's body composition affected age of menarche. A comparison of premenarcheal (n = 139) and postmenarcheal (n = 154) girls of the same age showed statistically significant elevated values in body weight (42,5 kg, 47,6 kg vs 56,3 kg, 54,1 kg), BMI (17,6 kg/mš, 18,3kg/mš vs 21,3 kg/mš, 20,7 kg/mš) and percentage of body fat (19,4%, 19,7% vs 24,5% a 23,1%) at...

Dentre os problemas da universidade pública hoje está o da ampliação desmedida de publicações científicas com o intuito de colocar o Brasil no rol dos melhores países em ciência e tecnologia sem um correspondente aumento na qualidade do que se produz. Em consequência, o aumento de nossa produção tem transformado o caráter de autarquia da instituição acadêmica e parece ser prejudicial à universidade, conduzindo-a de um estado de instituição social a outro de mera organização social. Nesta esteira, poderíamos quem sabe afirmar que o Sistema Qualis, da Capes, surge como um controle externo sobre o que se tem feito e produzido no ensino superior público e que apesar de seu acolhimento como regulador e hierarquizador da produção científica nacional por meio da publicação de periódicos, aparentemente sua aplicação não tem sido isenta de controvérsias. Parece-nos que há uma dissociação entre o que prega o discurso oficial por meio do Qualis e a realidade científica das universidades públicas, de vez que este tem ditado como o meio científico deve ajustar sua produção para atender uma demanda de progresso científico que deverá crescer em competência e excelência acadêmicas, obtendo-se assim, supostamente, qualidade. Por isso, propomos analisar os critérios utilizados pelo Sistema Qualis para a caracterização da excelência da produção acadêmica brasileira. / Among the public university problems today there is the out of measure enlargement of scientific publications with the purpose of inserting Brazil in the roll of the best countries in science and technology, without the corresponding increase in its publications quality. As a result, the increase of our production has been transforming the autarchy character and it seems to be harmful to university, conducting it from a state of social institution to another of simple social organization. On this course, we could assert that the Qualis System from Capes, arises as an external control over what has been done and produced in the public superior education and besides its welcoming as regulator and hierarchical organizer of the national scientific production by means of publication of periodicals, apparently its application has not been free from controversies. It seems that there is dissociation between what the official discourse preaches through Qualis and the scientific reality in public universities, since this system has been dictating how the scientific circle should adjust its production to supply a scientific progress demand, which should grow in academic competency and excellence, thus supposedly obtaining quality. For this reason, we propose to analyze what Qualis criteria understands by quality in the context of Brazilian academic production.

Marsílio de Pádua (1280-1343), um importante pensador político medieval, escreveu o Defensor pacis, sua obra principal, em 1324. Nela, discutiu os principais conflitos de sua época e tentou assegurar a supremacia de poder do imperador, ameaçada naquele momento, ao menos no plano teórico, pelo papado que pretendia que o império proviesse do papa e arrogava-se o direito de designar, controlar e julgar o imperador. Para fazer tal análise, o paduano afirmou que se serviria de métodos corretos elaborados pela razão e apoiados em proposições bem estabelecidas e evidentes por si mesmas. Este trabalho de mestrado discutiu a ascensão histórica do papado, bem como as alternativas encontradas por Marsílio para constituir poder civil laico. Para isso, analisamos sua teoria conciliar e sua idéia de delegação e representação do poder. / Marsilius of Padua (1280-1343), an important political thinker of de Middle Ages, wrote the Defensor pacis, his most important work, in 1324. In there, he discussed the main conflicts of the period, and tried to assure the supremacy for the power of the emperor, menaced, at that moment, at least in theoretical level, by the papacy, who pretended that the empire came from the pope, and took itself the right to chose, control, and judge the emperor. In order to do such analysis the thinker said that he would be served by correct methods founded in reason and supported by solid and evident propositions. This work discussed the historical rise of papacy, as well as the alternatives found by Marsilius in order to build the laic civil government. For, well do an analysis of his counciliar theory, and his idea of delegation and power representation.

O requisito fundamental na seleção do par doador-receptor em Transplantes de Medula Óssea (TMO) é regido pelo sistema do Complexo Principal de Histocompatibilidade, ou seja, pelos mecanismos imunológicos mediados pelas moléculas dos Antígenos Leucocitários Humanos (HLA). No entanto as incompatibilidades HLA, podem influenciar de forma negativa ou positiva os resultados dos transplantes, através da Doença do Enxerto versus Hospedeiro e o efeito do enxerto versus Leucemia (EvL) respectivamente. Ainda é desconhecido o impacto do locus HLA-DPB1* neste contexto. Assim o presente projeto tem como objetivo a avaliação do impacto do HLA-DPB1* em transplantes de pacientes consanguíneos e a ocorrência de DECH. Para a tal finalidade, tipificamos o locus em questão utilizando a metodologia PCR-SSO, onde após a reação de amplificação da cadeia pela polimerase, realizamos a hibridização com uma sequência específica de oligonucleotídeos para tipificação do Loco HLA-DPB1*. Foram analisadas 826 amostras, sendo 413 pares de receptores e seus respectivos doadores familiares, submetidos a Transplantes de Células Tronco Hematopoiéticas, realizados na Unidade de Transplante de Medula Óssea de Curitiba da Universidade Federal do Paraná e da Faculdade de Medicina de Ribeirão Preto- USP. Observou-se que a presença de incompatibilidades HLA-DPB1* aumentam a chance dos receptores desenvolverem a doença do enxerto versus hospedeiro aguda, em graus mais graves. Assim, concluímos que a avaliação deste loco pode prevenir esta doença, e caso não haja outro doador, alerta o clínico quanto à utilização de medidas profiláticas. / The key requirement in the selection of the receptor-donor pair for bone marrow transplant is is defined by the Major Histocompatibility Complex, or by immunologic mechanisms mediated by molecules of the Human Leukocyte Antigens (HLA). However the post transplant complications due to HLA mismatches, as Graft versus Host Disease (GVHD) and graft failure are fundamental to the success of these transplants. Still unknown is the impact of loci HLA DPB1*, so this project aims to assess the impact of HLA - DPB1* in transplant patients consanguineous and assessing the impact of incompatibilities in HLA - DPB1 * GVHD. For this purpose, analyzed the loco in question using the PCR-SSO method, where after the amplification reaction polymerase chain, we performed hybridization with a sequence -specific primers for typing of HLA - DPB1* Loco. We analyzed 826 samples, 413 pairs of recipients and their respective donors, patients undergoing Hematopoietic Stem Cell Transplants performed in the Unit for Bone Marrow Transplantation in Curitiba, Federal University of Paraná and the Faculty of Medicine of Ribeirão Preto - USP. It was observed that the presence of mismatches HLA- DPB1* increase the chance of recipients develop chronic graft versus host disease, in more severe degrees. Thus, we conclude that the evaluation of this loci can prevent this disease and if no other donors alert the clinician to the use of prophylactic measures.

A presente tese se propõe a avaliar os avanços e recuos do denominado Regime Internacional para Atrocidades (RIA), focando-se sobremaneira no seu principal desdobramento normativo e institucional: o Tribunal Penal Internacional (TPI). Tais avanços e recuos não podem ser analisados somente a partir de qualificações políticas pragmáticas ou de princípios morais cosmopolitas reconhecidos pelo Tribunal, mas sim a partir da existência de um conflito de valores exposto na construção e consolidação do regime em questão: justiça versus paz, bem como da necessidade de superá-lo. É esse conflito entre a justiça internacional, interpretada de modo cosmopolita, e também pelo viés restrito do paradigma jurídico de enforcement dos direitos humanos, e a paz, interpretada como a ausência de conflito direto, bem como a consequente necessidade de arbitrá-lo, que nos permitirá fazer recomendações sobre o que se deve fazer para implementar um RIA realmente efetivo no sentido de livrar a humanidade das violações de direitos humanos que se qualificam como atrocidades, considerando as particularidades de contextos transicionais e ampliando a prestação de contas. A estratégia recomendada pela tese é a da combinação de uma justiça judicializada, que se traduz no TPI, com outros mecanismos de justiça transicional. Ademais, uma atuação do TPI sensível às vítimas e às atividades de peacebuilding é parte fundamental dessa estratégia. Os casos sob a investigação do TPI serão trazidos à tona na presente tese no sentido de ilustrar alguns aspectos do argumento principal nela estruturado. / This thesis aims to evaluate advances and shortcomings concerning the so-called International Atrocities Regime (IAR), focusing on its main normative and institutional achievement: the International Criminal Court (ICC). Such advances and shortcomings cannot be analised either exclusively through pragmatic political qualifications or through cosmopolitan moral principles embraced by the Court. Instead, we initially sustain the existence of a conflict of values apparent in the building up and consolidation of the above mentioned regime: the justice versus peace dilemma and the necessity of overcoming it. It is this dilemma between international justice, interpreted according to both a cosmopolitan perspective and a judicial paradigm of human rights enforcement, and peace, interpreted as the absence of direct conflict, and simultaneously the urgent need of managing this conflitct of value that will allow us to make some normative recommendations about what is to be done in order to implemente an effective IAR. By effectiveness, we mean both the prevention of humanity from suffering gross human rights violations qualified as atrocities, considering the particularities involved in transitional contexts, and the promotion of accountability. The strategy recommended by the thesis is the combination of a judicialized justice, translated into ICC practices, with other transitional justice mechanisms. In addition, an ICC performance sensible to victims and peacebuilding activities is a fundamental aspect of such a strategy. In this sense, the cases under ICC investigation will be mobilized in order to illustrate some aspects of the main argument structured in the thesis.

Marsílio de Pádua (1280-1343), um importante pensador político medieval, escreveu o Defensor pacis, sua obra principal, em 1324. Nela, discutiu os principais conflitos de sua época e tentou assegurar a supremacia de poder do imperador, ameaçada naquele momento, ao menos no plano teórico, pelo papado que pretendia que o império proviesse do papa e arrogava-se o direito de designar, controlar e julgar o imperador. Para fazer tal análise, o paduano afirmou que se serviria de métodos corretos elaborados pela razão e apoiados em proposições bem estabelecidas e evidentes por si mesmas. Este trabalho de mestrado discutiu a ascensão histórica do papado, bem como as alternativas encontradas por Marsílio para constituir poder civil laico. Para isso, analisamos sua teoria conciliar e sua idéia de delegação e representação do poder. / Marsilius of Padua (1280-1343), an important political thinker of de Middle Ages, wrote the Defensor pacis, his most important work, in 1324. In there, he discussed the main conflicts of the period, and tried to assure the supremacy for the power of the emperor, menaced, at that moment, at least in theoretical level, by the papacy, who pretended that the empire came from the pope, and took itself the right to chose, control, and judge the emperor. In order to do such analysis the thinker said that he would be served by correct methods founded in reason and supported by solid and evident propositions. This work discussed the historical rise of papacy, as well as the alternatives found by Marsilius in order to build the laic civil government. For, well do an analysis of his counciliar theory, and his idea of delegation and power representation.

Dentre os problemas da universidade pública hoje está o da ampliação desmedida de publicações científicas com o intuito de colocar o Brasil no rol dos melhores países em ciência e tecnologia sem um correspondente aumento na qualidade do que se produz. Em consequência, o aumento de nossa produção tem transformado o caráter de autarquia da instituição acadêmica e parece ser prejudicial à universidade, conduzindo-a de um estado de instituição social a outro de mera organização social. Nesta esteira, poderíamos quem sabe afirmar que o Sistema Qualis, da Capes, surge como um controle externo sobre o que se tem feito e produzido no ensino superior público e que apesar de seu acolhimento como regulador e hierarquizador da produção científica nacional por meio da publicação de periódicos, aparentemente sua aplicação não tem sido isenta de controvérsias. Parece-nos que há uma dissociação entre o que prega o discurso oficial por meio do Qualis e a realidade científica das universidades públicas, de vez que este tem ditado como o meio científico deve ajustar sua produção para atender uma demanda de progresso científico que deverá crescer em competência e excelência acadêmicas, obtendo-se assim, supostamente, qualidade. Por isso, propomos analisar os critérios utilizados pelo Sistema Qualis para a caracterização da excelência da produção acadêmica brasileira. / Among the public university problems today there is the out of measure enlargement of scientific publications with the purpose of inserting Brazil in the roll of the best countries in science and technology, without the corresponding increase in its publications quality. As a result, the increase of our production has been transforming the autarchy character and it seems to be harmful to university, conducting it from a state of social institution to another of simple social organization. On this course, we could assert that the Qualis System from Capes, arises as an external control over what has been done and produced in the public superior education and besides its welcoming as regulator and hierarchical organizer of the national scientific production by means of publication of periodicals, apparently its application has not been free from controversies. It seems that there is dissociation between what the official discourse preaches through Qualis and the scientific reality in public universities, since this system has been dictating how the scientific circle should adjust its production to supply a scientific progress demand, which should grow in academic competency and excellence, thus supposedly obtaining quality. For this reason, we propose to analyze what Qualis criteria understands by quality in the context of Brazilian academic production.

This thesis aims to re-analyze the early twentieth century modern architecture, with in the frame work of posthumanism. Referring to the materialist and socioconstructive architecture of Hannes Meyer, the study proposes a shift from humanist ways of production and reception to posthumanism, where the centrality of human in the productive processes of both art and life is questioned. With this respect, the thesis proposes a historical continuity with the post 1960&amp / #8217 / s posthumanist involvement of the postmodern architecture with the early twentieth century modern architecture. Moreover, it is argued that the ideal of modern architecture&amp / #8217 / s break with tradition could be realized through a move towards posthumanism referring posthumanist shift occurred in the avant-garde modernism. Within this framework the thesis, via proposing the book by Michael Hays: Modernism and the Posthumanist Subject: The Architecture of Hannes Meyer and Ludwig Hilberseimer as a pretext, argues that the modern architecture&amp / #8217 / s ideal of break with tradition is realized through the Neue Sachlichkeit architecture of Hannes Meyer within which the architectural production is integrated with the social and productive determinants of life.

abstract: The e-Retail industry has grown rapidly over the last few years and is projected to continue its upward trend as consumers shift from traditional channels to online channels. In March 2010, Forrester Research forecasted that online retail sales will grow by 10% a year for the next 5 years and e-Retail sales will amount to $249 billion by 2014. With intense competition for market share and profits, information systems and technology (IST) sourcing decisions are becoming increasingly important to e-Retail firms to support continued growth and market responsiveness. There are several aspects for e-Retailers to consider when formulating its IST sourcing strategy. Whether to choose make versus buy for technology assets and services has been addressed in both strategy and IS literature (Handfield et al. 1999, Leiblein et al. 2002, Wade and Hulland, 2004). Then there is the follow-up question of selecting a best-of-breed strategy or tighter partnership with a select group of vendors (Clemons et al. 1993, Kauffman and Tsai 2009). Few studies have looked at IST sourcing or proposed models and frameworks for evaluating IST sourcing decisions (Saarinen and Vepsalainen, 1994). Furthermore, these existing studies mainly address the antecedents of the decisions but not so much on their performance effects (Kauffman and Tsai 2009; Smith et al., 1998). The goal of this study is to extend the knowledge of IST sourcing for e-Retailers, a topic which has received limited attention (Kishore et al., 2004), by addressing a core problem: How should an e-Retailer develop and implement its IST sourcing strategy to accommodate the increase in consumer demand and IT complexity but still achieve high performance? The study introduces two theoretical models to examine organizational factors that influence an e-Retailer's IST sourcing strategies of make versus buy and partnership versus best-of-breed. The proposed models are tested using a panel data set of 307 e-Retail firms over the period of 2006 to 2010. The study opens up the black box of internal firm operations by introducing a granular view of IST sourcing decisions at both the value chain and e-Commerce architecture levels and examining the performance impacts of these strategic choices. This in-depth look at IST sourcing has yet to be explored in the literature. / Dissertation/Thesis / Ph.D. Information Management 2012