Thesis (D. Min.)--Erskine Theological Seminary, 2002. / Abstract. Includes bibliographical references (leaves 154-162).

Applied research project (D. Min.)--School of Theology and Missions, Oral Roberts University, 2005. / Includes abstract and vita. Includes bibliographical references (leaves 146-156).

Thesis (M. Ed.)--Lancaster Bible College, 2004. / Abstract. Includes bibliographical references (leaves 62-67).

Thesis (M.S.)--Springfield College, 2004. / Includes bibliographical references.

Thesis (M. Ed.)--Lancaster Bible College, 2004. / Abstract. Includes bibliographical references (leaves 62-67).

O nebivolol, um fármaco com quatro centros quirais, está disponível na clínica como mistura racêmica dos isômeros d-nebivolol (SRRR) e l-nebivolol (RSSS). A atividade -adrenérgica do nebivolol reside no isômero d-nebivolol, enquanto o l-nebivolol promove a liberação de óxido nítrico das células endoteliais. O nebivolol é eliminado por metabolismo dependente do CYP2D6. O estudo avalia a farmacocinética e a relação farmacocinética-farmacodinâmica (PK-PD) dos isômeros do nebivolol em voluntários sadios. Foram investigados 15 voluntários sadios (10 homens e 5 mulheres) fenotipados com metoprolol como metabolizadores extensivos (EM, n=13) ou metabolizadores lentos para o CYP2D6 (PM, n=2). Os voluntários sadios foram tratados com dose única oral de 10 mg de nebivolol racêmico. As amostras seriadas de sangue foram coletadas até 48 h após a administração do fármaco. Os isômeros do nebivolol foram resolvidos na coluna Chirobiotic® V e analisados nas amostras de plasma empregando LC-MS/MS. Os parâmetros farmacocinéticos foram calculados por modelo bicompartimental com lag time, empregando o programa WinNonLin. A farmacodinâmica do nebivolol foi avaliada empregando como parâmetro a variação da frequência cardíaca entre os períodos final e anterior ao teste de esforço isométrico durante 2 min utilizando o handgrip a 30% da contratilidade voluntária máxima. A análise PK-PD relacionando o efeito na variação da frequência cardíaca induzida pelo exercício isométrico com as concentrações plasmáticas do isômero d-nebivolol foi avaliada empregando o modelo Emax sigmóide inibitório. A disposição cinética do nebivolol é enantiosseletiva nos voluntários sadios EM, com razões isoméricas de AUCl/ AUCd de 1,41. Os valores de concentração plasmática máxima (1,46 vs 0,79 ng/mL), área sob a curva concentração plasmática versus tempo (6,45 vs 3,99 ng.h/mL), clearance aparente (774,51 vs 1252,70 L/h) e volume de distribuição aparente (10936 vs 19082 L) mostram diferenças com significância estatística (Teste de Wilcoxon, p<0,05) entre os isômeros l-nebivolol e d-nebivolol para os voluntários sadios EM. A disposição cinética do nebivolol não é enantiosseletiva nos voluntários sadios PM investigados, com razões isoméricas de AUCl/AUCd de 0,93 e 0,98. Os valores de clearance aparente obtidos para os voluntários PM (87-350 vs 81-344 L/h, respectivamente para o l-nebivolol e d-nebivolol) são menores do que para os EM (775 vs 1253 L/h). O modelo Emax sigmóide inibitório descreveu a análise PK-PD relacionando o efeito na variação da frequência cardíaca induzida pelo exercício isométrico com as concentrações plasmáticas do isômero d-nebivolol em voluntários sadios EM com valores de Emax de 4,47 bpm (IC 95% 1,37-7,57) e de EC50 de 222,16 pg/mL (IC 95% 96,29-540,60 pg/mL). / Nebivolol is a drug with four chiral centers. It is administered in clinical practice as a racemic mixture of the isomers d-nebivolol (SRRR) and l-nebivolol (RSSS). The - blocking activity of nebivolol is attributed to d-nebivolol, whereas l-nebivolol promotes the release of nitric oxide from endothelial cells. Nebivolol is eliminated by metabolism dependent on CYP2D6. The present study evaluates the pharmacokinetic and pharmacokinetic-pharmacodynamic (PK-PD) of nebivolol isomers in healthy volunteers (10 men and 5 women) phenotyped with metoprolol as extensive metabolisers (EM, n=13) or poor metabolisers for CYP2D6. The healthy volunteers receveid a single oral dose of 10mg of racemic nebivolol. Serial blood samples were collected from 0 to 48 h after the administration of nebivolol. The isomers of nebivolol were analyzed by LC-MS-MS on a Chirobiotic® V column and the pharmacokinetic parameters (bicompartment model, micro, lag time, first order) were calculated by the software Winnonlin. The pharmacodynamic of nebivolol was evaluated using the variation of heart rate as parameter between the end and one minute before the handgrip exercise. Thus, the patients were oriented to conduct the isometric exercise with handgrip for 2 min at 30% of their maximum voluntary contractility. The PK-PD analysis relating the effect on the variation of heart rate induced by the isometric exercise and the plasma concentrations of the isomer d-nebivolol were evaluated using the Inhibitory effect sigmoid Emax model. The kinetic disposition of nebivolol is enantioselective on healthy volunteers EM, with isomeric ratios of AUCl/ AUCd of 0,93 e 0,98. The values of maximum plasma concentration (1,46 vs 0,79 ng/mL), area under the concentration time curve (6,45 vs 3,99 ng.h/mL), apparent clearance(774,51 vs 1252,70 L/h) and volume of distribution (10936 vs 19082 L) show statistically significant differences (p<0.05, Wilcoxon test) between the isomers l-nebivolol and d-nebivolol for the healthy volunteers EM. The kinetic disposition of nebivolol is not enantioselective on the healthy volunteers PM investigated, with isomeric ratios of AUCl/ AUCd of 1,07. The values of apparent clearance obtained for the volunteers pm (87-350 vs 81-344 L/h, respectively to l-nebivolol and d-nebivolol) are smaller than that for EM (775 vs 1253 L/h). The Inhibitory effect sigmoid Emax model described the PK-PD analysis described the effect on the variation of heart rate induced by handgrip isometric exercise with the plasma concentrations of the isomer d-nebivolol in healthy volunteers EM with Emax values of 4,47 bpm (IC 95% 1,37-7,57) and EC50 of 222,16 pg/mL (IC 95% 96,29-540,60 pg/mL).

Peace Corps Volunteers spend 27 months working in developing countries around the world. They orchestrate and implement a myriad of projects in various fields, often entirely on their own. This paper aims to provide insights into how Peace Corps service affects volunteers' entrepreneurial leadership proclivities. To accomplish this a pre / post-test was administered to 74 Returned Peace Corps Volunteers participating in the Paul D. Coverdell Fellowship program at the University of Arizona. Respondents were surveyed to determine their proclivity toward using entrepreneurial strategies and their proclivity to be innovative. Service in the Peace Corps increased the Returned Peace Corps Volunteers' ability to hone their entrepreneurial strategies and innovate. The results showed an increase in the Returned Peace Corps Volunteers' entrepreneurial leadership proclivities after they had completed their service.

The aim of my diploma thesis is to analyze the motivation of volunteers at Greenpeace. The theoretical part offers a consistent overview of theoretical propositions related to the chosen topic. In the practical part an empirical survey focused on two target groups was conducted. One target group is made up by volunteers from the Czech subsidiary of the international Greenpeace organization and the other target group is the Czech public. The most important goal of the survey was to get deeper insight into the motives, expectations and satisfaction of volunteers at Greenpeace and those who are active in other comparable organizations. On the basis of collected information similarities and differences between both target groups were identified and recommendations for employees of the Czech subsidiary of Greenpeace regarding the further cooperation with volunteers were formulated.

L’objectif principal de la présente thèse est d’investiguer sur l’insertion sociale des personnes âgées dans les politiques publiques menées par l’État brésilien, dans les actions sociales réalisées par l’Église catholique, surtout dans les actions développées par les bénévoles de le Pastorale de la Personne Âgée à João Pessoa, capitale de l’Etat de Paraíba, située dans le nord-est du Brésil. Pour cela, nous avons opté pour une recherche empirique de nature qualitative. Nous avons utilisé comme instruments méthodologiques l’observation participante et l’entretien semi-directif. Deux catégories d’acteurs sociaux ont participé de la présente recherche : 20 personnes âgées qui participent à des activités du Centre de Productions Artistiques – Culturelles de la Personne Âgée, de João Pessoa; et 20 bénévoles de la Pastorale de la Personne Âgée de l’Archidiocèse de Paraíba. Les observations ont été réalisées entre les mois de septembre 2009 et février 2010. Les registres d’observations participantes ont été constitués à travers des réunions, des ateliers, des évènements culturels et loisirs dans le mentionné Centre de Production Artistique-Culturelle de la Personne Âgée et aussi aux moyens d’événements culturels et loisirs du Centre Social de Paroisse Notre Dame de la Conception à João Pessoa (Brésil). L’analyse menée dans le cadre de notre recherche se base sur des fondements théoriques dans le domaine de la sociologie, ainsi que dans les textes de lois brésiliennes et d’autres documents officiels concernant à l’insertion sociale des personnes âgées liées à l’Église catholique au Brésil. [etc.] / The main objective of this thesis is to investigate the social inclusion of elderly people within the public policies offered by the Brazilian government and the actions taken by the Catholic Church through the Pastoral of Elderly People in João Pessoa, Paraíba, Northeast of Brazil. For this, we chose a qualitative empirical research. We used as methodological tools, partici-pant observation and semi-direct interview. Two categories of social actors participated in this research: 20 seniors, who participate in the activities of the Center for Artistic Productions - cultural elderly in the city of João Pessoa, State of Paraíba, northeast of Brazil and 20 volun-teers from the Pastoral of Elderly People, in the Archdiocese of Paraíba . Observations were carried out between September 2009 and February 2010. Records of participatory observa-tions were made through meetings, workshops, cultural events and leisure center in Cultural-Artistic Production of the elderly and the pastoral center of the Immaculate Conception Parish in Joao Pessoa, Brazil. The analysis of our research is based on theoretical foundations in so-ciology, as well as texts of Brazilian laws and other official documents relating to social in-clusion. Results indicated that: the State, the Catholic Church and other institutions working with the elderly in Brazil must find new ways to support families, so they can stay in the family, allowing them to enjoy a pleasant place; the health of the elderly is poor, where the Brazilian SUS (Unified Health System) does not offer a quality service for the elderly; Brazil-ian public policies, designed to the elderly, in a theoretical point of view, are well structured, but in practice, do not favor the elderly; the pensions paid to the elderly, by the Brazilian state, does not guarantee their well-being and social; volunteers involved in the Pastoral of Elderly people , in the Catholic Church, are motivated by the pleasure of serving others. At the end of our investigation, we believe that Brazil is a country that has laws which are recog-nized around the world, but those, in practice, are not met. The social actions, developed by the Pastoral of Elderly People, of the Catholic Church in Brazil, help the social inclusion of elderly people in the society.

Service is a powerful tool for the development of youth. It transforms the young person from a passive recipient to an active provider. When combined with formal education, service becomes a method of learning known as "Service Learning." Service learning enables teachers to employ a variety of effective teaching strategies that emphasize student-centered, interactive, experiential education.