abstract: Bioimpedance measurements have been long used for monitoring tissue ischemia and blood flow. This research employs implantable microelectronic devices to measure impedance chronically as a potential way to monitor the progress of peripheral vascular disease (PVD). Ultrasonically powered implantable microdevices previously developed for the purposes of neuroelectric vasodilation for therapeutic treatment of PVD were found to also allow a secondary function of tissue bioimpedance monitoring. Having no structural differences between devices used for neurostimulation and impedance measurements, there is a potential for double functionality and closed loop control of the neurostimulation performed by these types of microimplants. The proposed technique involves actuation of the implantable microdevices using a frequency-swept amplitude modulated continuous waveform ultrasound and remote monitoring of induced tissue current. The design has been investigated using simulations, ex vivo testing, and preliminary animal experiments. Obtained results have demonstrated the ability of ultrasonically powered neurostimulators to be sensitive to the impedance changes of tissue surrounding the device and wirelessly report impedance spectra. Present work suggests the potential feasibility of wireless tissue impedance measurements for PVD applications as a complement to neurostimulation. / Dissertation/Thesis / Masters Thesis Bioengineering 2015

Wireless power transfer (WPT) is the key enabler for a myriad of applications, from low-power RFIDs, and wireless sensors, to wirelessly charged electric vehicles, and even massive power transmission from space solar cells. One of the major challenges in designing implantable biomedical devices is the size and lifetime of the battery. Thus, replacing the battery with a miniaturized wireless power receiver (WPRx) facilitates designing sustainable biomedical implants in smaller volumes for sentient medical applications. In the first part of this dissertation, we propose a miniaturized, fully integrated, wirelessly powered implantable sensor with on-chip antenna, designed and implemented in a standard 0.18μm CMOS process. As a batteryless device, it can be implanted once inside the body with no need for further invasive surgeries to replace batteries. The proposed single-chip solution is designed for intraocular pressure monitoring (IOPM), and can serve as a sustainable platform for implantable devices or IoT nodes. A custom setup is developed to test the chip in a saline solution with electrical properties similar to those of the aqueous humor of the eye. The proposed chip, in this eye-like setup, is wirelessly charged to 1V from a 5W transmitter 3cm away from the chip. In the second part, we propose a self-biased, differential rectifier with enhanced efficiency over an extended range of input power. A prototype is designed for the medical implant communication service (MICS) band at 433MHz. It demonstrates an efficiency improvement of more than 40% in the rectifier power conversion efficiency (PCE) and a dynamic range extension of more than 50% relative to the conventional cross-coupled rectifier. A sensitivity of -15.2dBm input power for 1V output voltage and a peak PCE of 65% are achieved for a 50k load. In the third part, we propose a wide-range, differential RF-to-DC power converter using an adaptive, self-biasing technique. The proposed architecture doubles the dynamic range of conventional rectifiers. Unlike the continuously self-biased rectifier proposed in the second part, this adaptive rectifier extends the dynamic range while maintaining both the high PCE peak and the sensitivity advantage of the conventional cross-coupled scheme, and can operates in the GHz range.

This research has its basis in developments within the field of inductive powering and wireless power transfer, WPT, and more specifically one the branch within this field, which is called magnetic resonance coupling. This principle enables efficient power transfer from a transmitting unit to a receiving unit at a distance of some times the unit diameter. The developments within magnetic resonant coupling are together with the possibilities and challenges of today’s smart textile industry the starting point to investigate a novel textile-based product concept for WPT by combining both technologies. Multiple textile samples, consisting of cotton and electrically conductive copper yarns, were produced by weaving technique, additional assembling of electronic components were performed manually and several measurements were carried out to investigate the sample characteristics and the sample performance in terms of power transfer. The produced samples showed to behave similarly to conventional inductors and were able to transfer power over some distance.

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<p dir="ltr">Decades of semiconductor technology scaling and breakthroughs in communication technology have miniaturized computing, embedding it everywhere, enabling the development of smart things connected to the internet, forming the Internet of Things. Further miniaturization of devices has led to an exponential increase in the number of devices in and around the body in the last decade, forming a subset of IoT which is increasingly becoming popular as the Internet of Bodies (IoB). The gradual shift from the current form of human-electronics coexistence to human-electronics cooperation, is the vision of Internet of Bodies (IoB). This vision of a connected future with devices in and around our body talking to each other to assist their day-to-day functions demands energy efficient means of communication. Electro-Quasistatic Human Body Communication (EQS-HBC) has been proposed as an exciting alternative to traditional Radio Frequency based methodologies for communicating data around the body. In this dissertation, we expand the boundaries of wearable and implantable IoB nodes using Electro-Quasistatic Human Body Communication and Powering by developing advanced channel models and demonstrating novel applications.</p><p dir="ltr">Leveraging the advanced channel models developed for wearable EQS-HBC, we demonstrate wearable applications like ToSCom which extend the use cases of touchscreens to beyond touch detection and location to enable high-speed communication strictly through touch. We further demonstrate an application of EQS Resonant Human Body Powering to demonstrate Step-to-Charge, allowing mW-scale wireless power transfer to wearable devices. With increasing connected implanted healthcare devices becoming a part of the IoB space, we benchmark RF-based technologies for In-Body to Out-of-Body (IBOB) communication using novel in-vivo experiments. We then explore EQS-HBC in the realm of IBOB communication using advanced channel modeling, revealing its potential for low-power and physically secure data transfer from implantable devices to wearable nodes on the body, demonstrating its potential in extending the battery life span of implantable nodes. Finally, an overview of the potential of IoB devices is analyzed with the use of EQS-HBC where we propose a human-inspired distributed network of IoB nodes which brings us a step closer to the potential for perpetually operable devices in and around the body.</p>