In the United States, one in every 100 adults is confined to a correctional facility. Approximately 60% of inmates have an alcohol use disorder (AUD). When compared to the general population, inmates are twice as likely to have AUD. As they are unable to readily access alcohol, inmates entering a correctional facility with AUD are at high risk for the lethal alcohol withdrawal syndrome (AWS). AWS is preventable and yet correctional nurses process new inmates without an evidence-based clinical practice guideline (CPG) to assess for AUD, the prerequisite for AWS. The purpose of this project was to develop an evidence-based CPG with implementation algorithm to guide the inmate assessment for AUD. The ACE star model of knowledge transformation guided the project, the AGREE II was used to develop the CPG, and the Delphi technique was used to evaluate the final CPG with algorithm. Nationally, 20 correctional health experts were identified and asked to participate in the Delphi expert panel, although 11 experts agreed to participate only 9 completed the evaluation. The experts were correctional health experts, nurses and physicians, from different regions of the United States. The resulting CPG satisfied all 23-items of the AGREE II. Through 2 Delphi panel rounds, all participants recommended the CPG with minor modifications (6 experts recommended as presented while the 3 recommended with modifications). At the project conclusion, all 9 experts agreed the CPG will help improve the identification, referral, and management of inmates with AUD. This project contributes to positive social change as the CPG addresses a serious problem, AUD with possible AWS, in a vulnerable population. The CPG may be generalizable for use in other correctional facilities.

Physicians encounter significant difficulty when faced with decisions related to withdrawal of life-sustaining therapy (WLST) in patients with devastating brain injury (DBI). The complexity of this decision-making process is multifactorial, including practitioner- and patient-specific variables, as well as surrogate decision-maker bias, inaccuracies in scoring systems, and inconsistencies in guidelines endorsed by professional societies; these issues all contribute to the significant uncertainty of these situations and variability in treatment paradigm. Solutions are complex; however, analyzing WLST with an urban bioethical lens — which emphasizes the principles of solidarity, agency, and social justice — can enhance physicians’ ability to navigate this uncertainty and ensure that potential solutions are patient-centered. / Urban Bioethics

Research shows that strong CSR practices have a positive impact on organizational commitment which is crucial when employees are faced with negative events in the organization. Therefore, it is crucial for organizations to adopt CSR practices to retain engaged employees as they are less likely to engage in behaviors disadvantageous to the organization when negative events occur. However, some organizations face difficulties balancing efficiency with sustainable practices and respond to the pressures of CSR by adhering to or actively resisting it. The aim of this study is to explore what employee withdrawal behaviors can be associated with organizations’ strategic responses to CSR. We operationalize this aim by conducting ten semi-structured interviews studying what behaviors employees adopt in reaction to events in the Swedish fast fashion industry. An analytical framework has been created and applied to the findings based on previous research on employee withdrawal behavior and organizations’ strategic responses to institutional pressures. The findings indicate that there is a higher likelihood amongst committed employees to potentially engage in withdrawal behaviors the more organizations actively resisted CSR as a practice. A new dimension of withdrawal behavior is added to complement previous research to ultimately provide inspiration for future research.

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This study examined the impact of perceived economic hardship on family processes and children's socially withdrawn (reticent) behaviors in Romania. The sample consisted of 121 Romanian mothers and fathers of 4-5 year old children, as well as children's kindergarten teachers. Drawing on Conger and colleagues' family stress model of economic hardship, the associations among mothers' and fathers' ratings of economic hardship, depression, marital conflict, psychologically controlling parenting, and teacher ratings of child social withdrawal were analyzed. Structural equation modeling using AMOS 7.0 was used to test the model. Findings generally support earlier studies with European American families, as well as research with families outside of the U.S. Results indicate that higher perceptions of economic hardship related to increases in marital conflict. Mothers' and fathers' depression also associated positively with marital conflict. Marital conflict related to psychologically controlling parenting and mediated the effects of parents' depression on psychological control. Psychological control, in turn, associated positively with children's socially withdrawn (reticent) behaviors. Multiple group analysis indicated that the models for boys (N = 61) and girls (N = 60) were significantly different. Further analyses indicated that for boys, psychologically controlling parenting did not predict reticence. For girls, only fathers' psychological control predicted reticence. Significant links were additionally found for girls between economic hardship and fathers' depression, and between fathers' depression and psychologically controlling parenting.

This study assessed the influence of language on the ability of children identified as being at risk for internalizing behavior disorders to successfully participate in a social skills intervention program. Fourth and fifth grade students participated in Strong Kids: A Social and Emotional Learning Curriculum in Grades 4-8, a program which promotes emotional resiliency. The Clinical Evaluation of Language Fundamentals-Fourth Edition (CELF-4) and Children's Communication Checklist-Second Edition (CCC-2) were both completed to obtain a global language score and pragmatic language score. The Teacher's Report Form (TRF), a shortened 10-item version of the Internalizing Student Symptom Scale (ISSC), and a 20-item knowledge based assessment relating to the Strong Kids curriculum were completed prior to and after the intervention. These behavioral assessments were administered in order to determine improvement in academic performance, adaptive functioning, and behavioral/emotional problems with relation to language functioning. It was found that children with higher general language abilities made significantly positive improvements with regard to withdrawal than children with lower general language abilities on measures taken prior to and directly after the Strong Kids curriculum. Additionally, the ISSC revealed that children with lower general language abilities rated themselves as having significantly more positive changes in behavior than children with higher general language abilities on measures taken prior to and six weeks following the Strong Kids curriculum. Pragmatic functioning, determined by the CCC-2, was not associated with significant behavioral improvements between children with high and low pragmatic language skills.

Using a two-wave APIM Structural Equation Model, this study investigated how husband and wife attachment styles predict husband and wife covert relational aggression one year later with husband and wife shame as potential moderating variables. Data was taken from 308 married couples in waves three and four of the Flourishing Families project using self-report and partner report of spouse questionnaires. Findings showed that an individual's attachment insecurity predicts their use of relational aggression. Wives' relational aggression is predicted by an increase in husbands' relational aggression. An increase in wives' insecure attachment had less of an impact on husbands' relationally aggressive behavior. Shame predicts the use of relational aggression. Shame moderates some of the actor and partner relationships, showing that in certain cases, as shame increases the relationship between attachment strategy and relational aggression also increases. Clinicians are advised to assess and treat partners as a couple as one partner's attachment and shame may affect the other's behavior, and those high in shame and insecure attachment are more likely to use covert relational aggression.

Catharanthine is derived from the Catharanthus roseus plant and is an analog to ibogaine, a drug that reduces opioid and alcohol withdrawal symptoms and decreases drug self-administration in both animals and humans. Catharanthine has promise to be an alternative pharmacological treatment for addiction without the adverse side effects associated with ibogaine. The objective of this study was to evaluate catharanthine’s effects on dopamine (DA) transmission in the mesolimbic DA system as well as determine its effects on both ethanol withdrawal induced anxiety and drug-seeking behaviors in mice. We hypothesized that catharanthine would inhibit evoked DA release in the nucleus accumbens (NAc) while also reducing anxiety and drug seeking behaviors in mice. We found that superfusion of catharanthine (1-100 µM) to mouse brain slices significantly inhibits evoked DA release in the NAc of the striatum in a dose dependent manner, while also slowing DA reuptake through inhibition of the dopamine transporter (DAT), measured using fast-scan cyclic voltammetry (FSCV). We also found that intraperitoneal administration of catharanthine in live mice significantly increases extracellular DA, measured via microdialysis with electrochemical detection. Catharanthine inhibition of evoked DA release was significantly reduced by the non-selective nAChR antagonist mecamylamine, the α4 nAChR antagonist dihydro-β-erythroidine hydrobromide (DhβE) and the α6 nAChR antagonist α-conotoxin MII, suggesting that catharanthine inhibits α4 and α6 nAChRs in the NAc. Iontophoresis and in-vivo data indicates that catharanthine slows DA reuptake and increases extracellular DA in the NAc through partial inhibition of DATs. Catharanthine also blocked increases in anxiety-like behavior during ethanol withdrawal in mice in the elevated plus maze. Lastly, preliminary data suggests that catharanthine increases both water and ethanol drinking in a 24-hour two-bottle choice drinking paradigm, which was contrary to our hypothesis.

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No description available.