In this thesis, suggestion of appropriate excavation and support systems and selection of rock mass strength parameters for the determination of these systems were carried out for the &Ccedil / ubukbeli Tunnel in Antalya. &Ccedil / ubukbeli Tunnel is a twin tube flute shaped tunnel with 1985 m length, 12 m width, 10 m height and maximum overburden thickness of 130 m. The tunnel area consists of limestone, clayey limestone, claystone, marl and siltsone. Rock mass classification systems are used for evaluation of rock mass characteristics and estimation of strength parameters. Selection of appropriate numerical method and software tool, namely Phase2, is accomplished after an extensive literature survey. The rock mass was divided into sections according to the RMR, Q, NATM and GSI classification systems along the tunnel and excavation and support systems were determined empirically along these sections. Thereafter, geomechanical parameters (i.e. modulus of deformation Em, Hoek-Brown material constants m and s etc.) were selected based on these classification systems. Finite element analysis was carried out as the final step of the design in order to investigate deformations and stress concentrations around the tunnel, analyze interaction of support systems with excavated rock masses and verify and check the validity of empirically determined excavation and support systems. As the result of design studies accomplished along tunnel route, B1, B2, B3 and C2 type rock classes are assumed to be faced during construction of &Ccedil / ubukbeli Tunnel and appropriate excavation and support systems are proposed for these rock classes.

This study proposes an approach for land degradation assessment for an abandoned coal mine by using geospatial information technologies. The land degradation assessment focuses on two major changes: topographical and Land Use and Land Cover (LULC). For this purpose, stereo aerial photos, Worldview-1, Landsat and ASTER images, Terrestrial Laser Scanning (TLS) data, Global Positioning System (GPS) data, and ancillary maps were used for abandoned Ovacik surface coal mine. Volume of excavations and fillings, drainage network deviations, and slope instabilities were the investigated topographical disturbances by comparison of the Digital Elevation Models (DEM) for pre- and post-mining stages. Using aerial photos and Worldview-1 satellite image, LULC maps were prepared based on the same time period. Then areal extent and spatial pattern of the LULC change was calculated and mapped by post classification comparison method. The results of land degradation assessment show that there was a significant topographical disturbance and LULC change in the research area. Particularly, three dump areas with a total volume of 2,334,878 m3 were identified by DEM subtraction. It was found that stream network around the primary dump site shifted towards south with a maximum displacement of 60m. Slope analysis reveals that slopes higher that 60 degrees were mainly observed in excavation area with 81 percent. LULC change study showed that the forest area decreased an amount of 106,485 m2 from 1951 to 2008. However / by means of the forestation efforts in dump sites, an amount of 106,012 m2 forest land was recovered.

Overburden stripping is one of the essential activities in open-cast mines before starting the ore production. Due to the economic advantages, dragline is a widely utilized machinery in the overburden excavation. These earthmovers carry out the earthmoving process with dragging, hoisting and dumping actions of the bucket. Dragline excavator&rsquo / s efficiency is critically important, since poor performance of a dragline in the mine site directly affects the total efficiency of ore production. Therefore, productivity studies about dragline should be directed to decrease cycle time and increase payload, with avoiding catastrophic failure. In this regard, determination of stress distribution on the front-end components of dragline is meaningful to detect the external factors against dragline operation. In order to provide insight into the dragline bucket-formation interaction and stress distribution on the bucket, this research studies the simulation of horizontally moving dragline bucket where passive earth forces of the formation create resistance to the movement. Within the scope of simulation, (i) solid models of dragline bucket and the rigging mechanism were created in the Computer-Aided Drawing (CAD) environment, (ii) the model was transferred to the Finite-Element Analysis (FEA) software, (iii) two different case studies were simulated in the FEA virtual environment. One of the cases handled the stress investigation on the dragline bucket at the first interaction with the formation, while the other focused on the stress formations on a moving dragline bucket. Simulation results showed that overloading conditions occurred on bottom edges of the bucket lip for the first case, and drag hitch part and digging teeth for the second case. Moreover, a sensitivity analysis was carried out to measure the effects of formation specification changes on the stress values on the bucket. The analysis showed that stress values on the bucket elements were most sensitive to internal friction angle and least sensitive to density. Consequently, this thesis study discusses stress and deformation components on the dragline bucket during the interaction with formation. Since there is not enough number of research studies in the literature about the stress investigation on a moving dragline bucket, this thesis study is expected to provide benefit to understand the basis of dragline bucket actions.

<p>We showed previously that histone deacetylase (HDAC) inhibition with MS-275 in the context of boosting oncolytic immunotherapy can drive heightened antitumor responses, leading to increased survival in mouse intracranial melanoma models. However, it is currently unclear how the co-administration of MS-275 directly impacts tumor growth. Here, we investigated the role of MS-275 in preventing the outgrowth of antigen-deficient tumor variants as a result of suboptimal treatment protocols. By adoptively transferring tumor antigen-specific memory T cells (Tm) that were expanded <em>in vivo</em> with recombinant Vesicular Stomatitis Virus (VSV-gp33), we observed complete regression of 5-day old, intradermal B16-gp33 tumors (B16-F10 overexpressing the LCMV GP33-41 epitope); however, the tumors relapsed within a month of treatment. Relapsing tumor explants were able to grow in mice that were prophylactically immunized with recombinant Adenovirus (Ad-gp33), indicating that the tumor could no longer be recognized. Strikingly however, there was zero tumor recurrence if MS-275 was co-administered with Tm and VSV-gp33, suggesting that MS-275 may prevent the emergence and/or escape of antigen loss variants. Such a benefit is lost if the administration of the drug is delayed as little as five days post VSV treatment, suggesting that its synergistic effects coincide with early immune responses and oncolytic activity. Furthermore, transplantation studies of relapsing tumor explants showed that combination treatment was unable to provide tumor protection, confirming that the mechanisms by which MS-275 prevents tumor recurrence are unlikely through direct up-regulation of antigen presentation in low- or non-antigen-expressing variants <em>in vivo</em>. Indeed, CD4 depletion in the absence of MS-275 resulted in sustained tumor regression, implying that immunoregulatory cells such as CD4+ Treg play a prominent role in sustaining tumor regression. Moreover, MS-275 modulates the phenotypic status of tumor-infiltrating MDSCs toward the differentiation of inflammatory macrophages. Taken together, the data suggests that combination therapy with HDACi with oncolytic immunotherapy mediates a synergized immune attack against the tumor through subversion of immunomodulatory mechanisms.</p> / Master of Science in Medical Sciences (MSMS)

EINLEITUNG: Die externe Stabilisierung von Venengrafts soll die Scherkräfte auf die Venenwand vermindern und dadurch die Ausbildung einer Neointimaproliferation reduzieren. In experimentellen Modellen wurde diese Hypothese im Kurzzeitversuch überprüft. Es fanden sich in diesem Zeitraum widersprüchliche Ergebnisse. Ziel unserer Untersuchung war es, in einem neuen Modell der arterialisierten segmentalen Vena-jugularis-Transposition auf die infrarenale Aorta den Einfluss einer externen Fibrinkleberstabilisierung auf die Neointimabildung des Venengrafts im Langzeitversuch darzustellen. MATERIAL UND METHODEN: Männlichen Wistar-Ratten wurden Segmente der Vena jugularis entnommen und in Flussrichtung, nach Entfernen eines Aortensegmentes, in die infrarenale Aorta eingebracht. Somit entspricht dieses einem Venenbypassmodell mit komplett arterialisiertem Venengraft. Vor

Ventilation is a critical task in underground mining operation. Lack of a good ventilation system causes accumulation of harmful gases, explosions, and even fatalities. A proper ventilation system provides adequate fresh air to miners for a safe and comfortable working environment. Fans, which provide air flow to different faces of a mine, have great impact in ventilation systems. Thus, selection of appropriate fans for a mine is the acute task. Unsuitable selection of a fan decreases safety and production rate, which increases capital and operational costs. Moreover, pitch angle of fans&rsquo / blades plays an important role in fan&rsquo / s efficiency. Therefore, selection of a fan and its pitch angle, which yields the maximum efficiency, is an emerging issue for an efficient mine ventilation. The main objective of this research study is to provide a decision making methodology for the selection of a main fan and its appropriate pitch angle for efficient mine ventilation. Nowadays, analytical hierarchy process as multi criteria decision making is used, and it yields outputs based on pairwise comparison. On the other hand, Fuzzy Logic as a soft computing method was combined with analytical hierarchy process and combined model did not yield appropriate results / because Fuzzy AHP increased uncertainty ratio in this study. However, fuzzy analytical hierarchy process might be inapplicable when it faces with vague and complex data set. Soft computing methods can be utilized for complicated situations. One of the soft computing methods is a Neuro-Fuzzy algorithm which is used in classification and DM issues. This study has two phases: i) selection of an appropriate fan using Analytical Hierarchy Process (AHP) and Fuzzy Analytical Hierarchy Process (Fuzzy AHP) and ii) selection of an appropriate pitch angle using Neuro-Fuzzy algorithm and Fuzzy AHP method. This study showed that AHP can be effectively utilized for main fan selection. It performs better than Fuzzy AHP because FAHP contains more expertise and makes problems more complex for evaluating. When FAHP and Neuro-Fuzzy is compared for pitch angle selection, both methodologies yielded the same results. Therefore, utilization of Neuro-Fuzzy in situation with complicated and vague data will be applicable.

Made available in DSpace on 2016-06-02T19:52:13Z (GMT). No. of bitstreams: 1 DissAC.pdf: 1825602 bytes, checksum: 66578e867a58642d29d296cfb15d5fc3 (MD5) Previous issue date: 2005-12-05 / The steady growth of the fruit juices sector is a significant factor strengthening the Brazilian economy; the richness of the tropical fruits, the quality of juices they are processed into and the luring presentation to consumers expanded the internal market and helped conquer demanding markets abroad. All this happened as a result of meeting stringent and assorted requirements, since food fruit juices included quality and safety are a must today. The purpose of this paper is to present a proposal to integrate management systems involving quality, good manufacturing practices and related legal requirements, as well as HACCP, in a small fruit juices company in the State of São Paulo. The proposal includes integrated cost-effective actions to implement the various standards. The research carried out concludes that the integration of management systems involving quality, good manufacturing practices and related legal requirements, as well as HACCP, is feasible. A relationship matrix of the respective requirements was designed during the research, which allowed conducting an initial joint and revealing assessment to evaluate the degree of fulfillment of those requirements. Bearing in mind the company´s scenario where the research was performed and the first application of this Integrated Management System took place, the proposal was not totally implemented. The necessity was perceived to test the Integrated Management System and monitor its operation in other food sector companies, thus not only evaluating the consistency of the proposal but also its flexibility to meet local specific requirements and detect improvement opportunities. / O crescimento do setor de produção de sucos de frutas vem contribuindo ao fortalecimento da economia brasileira; a rica variedade de frutas tropicais, a diversidade de formas de apresentação e a qualidade dos sucos ampliaram o mercado interno e conquistaram mercados externos, atendendo exigências cada vez mais rígidas. As empresas do setor estão submetidas a crescentes exigências de qualidade e segurança de seus produtos. O objetivo deste trabalho é apresentar uma proposta para integrar os sistemas de gestão da qualidade, das boas práticas de fabricação e requisitos legais correlatos, bem como da APPCC, em uma pequena empresa de sucos de frutas situada no interior do Estado de São Paulo, submetida às crescentes exigências dos clientes. A proposta inclui ações integradas contribuindo para racionalizar os recursos aplicados ao processo de adequação aos diferentes referenciais normativos. O trabalho conclui que é viável a integração dos sistemas de gestão da qualidade, das boas práticas de fabricação e requisitos legais correlatos e da APPCC. A matriz de correspondência entre requisitos respectivos, desenhada durante a pesquisa realizada, permitiu a avaliação conjunta do grau de atendimento dos mesmos, facilitando o processo de implementação a partir dos resultados obtidos. Tendo em vista o cenário da empresa em que foi desenvolvida a pesquisa e realizada a primeira aplicação da proposta do Sistema Integrado de Gestão, não foi possível implementar a proposta integralmente. Foi percebida a necessidade de testar sua implementação e operação em outras empresas do setor de alimentos, para avaliar não só a consistência da mesma, senão também sua flexibilidade para se ajustar às especificidades locais e detectar oportunidades de melhoria. Palavras-chave: qualidade do alimento, segurança do alimento, BPF, ISO 9001 (2000) e APPCC, Resolução ANVISA RDC 275/01, indústria de sucos, sistema integrado de gestão.

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