No / The S-xanthenyl (Xan) group was demonstrated to have potential as a convenient protecting group for 1-thiosugars in the synthesis of thioglycosides. Easily introduced by reaction of a 1-thiosugar with 9-hydroxyxanthene in the presence of catalytic TFA, the S-Xan group is compatible with a wide range of functionalities and protecting groups.

L’utilisation du babeurre pour la formulation alimentaire est limitée à cause de la capacité de rétention d’eau importante de ses phospholipides. L’objectif de ce projet était de développer une nouvelle approche de valorisation des constituants du babeurre. Ce sous-produit de l’industrie laitière est riche en composants d’intérêts qui ont des propriétés nutritionnelles, santés, et fonctionnelles prometteuses comme les constituants de la membrane de globule de matière grasse (MFGM) et les phospholipides. Les deux principaux procédés de production d’agrégats protéiques laitiers ont été combinés donnant un traitement thermique intensif à pH acide des protéines du lactosérum en présence des constituants du babeurre. Les résultats ont d’abord montré qu’il était possible de substituer différentes proportions de protéines du lactosérum par des protéines du babeurre et que la présence des constituants du babeurre entrainait la formation d’agrégats protéiques variés avec une capacité de rétention d’eau plus faible. Les résultats ont révélé que des agrégats protéiques étaient préformés lors de la préparation des babeurres incluant les protéines du lactosérum, les caséines et les protéines de la MFGM. Les phospholipides sont intégrés aux agrégats par l’intermédiaire de la MFGM à des températures faibles (65°C) alors qu’ils semblent s’associer directement avec les protéines à des températures plus élevées ( 80°C). Par la suite, les agrégats du babeurre agissent à titre de noyau d’agrégation pour les protéines issues du lactosérum. Le type d’interactions formées entre les protéines a un impact significatif sur les propriétés physiques et fonctionnelles des agrégats. En dernier lieu, il a été possible d’utiliser ces agrégats variés pour la production de yaourt ferme. Les agrégats lactosérum:babeurre ont agi à titre d’agent passif plutôt que d’agent actif mais des interactions entre les agrégats et les protéines du lait écrémé ont été observées. Ces associations seraient initiées par les groupements thiols libres des agrégats présents avant le chauffage. Cependant, la mise en solution de la poudre d’agrégats doit être strictement contrôlée. Ce projet propose une nouvelle approche pour l’utilisation du babeurre ainsi qu’une meilleure compréhension du comportement à la chaleur de ses constituants. / The use of buttermilk in food formulation is limited due to the extensive water-holding capacity of its phospholipids. The goal of this project was to develop a new approach for the valorization of buttermilk’s constituents. This by-product is rich in valuable components with promising nutritional, healthy, and functional properties such as the milk fat globule membrane (MFGM) constituents, the phospholipids. The two main processes of production of dairy aggregates have been combined resulting of the intensive heat-denaturation of whey proteins at low pH (4.6) in presence of proteins from buttermilk. First, results showed that it was possible to substitute whey proteins by different levels of buttermilk proteins in the process and that the presence of buttermilk constituents led to the formation of mixed aggregates with new functional properties such as a low water-holding capacity. Results revealed that aggregates are pre-formed during the preparation of the buttermilk concentrates involving whey proteins, casein, and MFGM proteins. Phospholipids are integrated to the aggregates through the MFGM at low temperature (65°C), but seem to directly interact with the proteins at higher temperatures ( 80°C). These pre-formed aggregates from buttermilk can act as aggregation nucleus for the proteins from whey. The types of interactions that occur between the proteins significantly affected the properties of the aggregates such as their water-holding capacity, their size, and the solubility of the powder. Finally, it was possible to use the mixed aggregates in the production of set-type yogurt. Whey:buttermilk aggregates were acting more like a passive than a reactive filler, but some possible interactions with the proteins from the skim milk were observed due to the high concentration of thiol groups of the aggregates before heating. However, the dispersibility of the powder must be strictly controlled. Overall, this project proposed a new approach for the use of buttermilk and allowed a better understanding of the thermal behavior of its constituents.

This thesis examines the extent to which, and the reasons why, the government of Malaysia provides educational opportunities for children and young people who are being detained in the closed (penal) institutions on orders under section 91 (1) (f) and section 97 of the Child Act, 2001. This thesis presents a detailed analysis of the driving factor(s) that motivate the government of Malaysia in formulating and implementing policy and law in regards to providing educational opportunities for such young people. The thesis, therefore, examines the conceptualization by the Malaysia Prisons Department of children‟s rights, particularly their rights to education and offender rehabilitation. Analysis reveals that, educational rights in Malaysia have such priority because education is seen generally as the way to socialize (all) young people and to improve human capital and economic potential in Malaysia. Consequently, rehabilitation in Malaysian penal institutions is conceptualized almost entirely as education. The thesis argues that the Malaysian government has been using children‟s rights to education and also offender rehabilitation to improve the process of socialization of young people in prisons institutions to enable them to contribute to the achievement of the national goals.

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-07-14T11:15:55Z No. of bitstreams: 1 472158 - Texto Completo.pdf: 751305 bytes, checksum: ffdde5def01a98e514b77df168284466 (MD5) / Made available in DSpace on 2015-07-14T11:15:55Z (GMT). No. of bitstreams: 1 472158 - Texto Completo.pdf: 751305 bytes, checksum: ffdde5def01a98e514b77df168284466 (MD5) Previous issue date: 2013-01-04 / This paper seeks to shed some light on a few semantic and syntactic issues concerning aspectual post-verbal particles. Besides having directional meanings or forming idiomatic combinations, the particles associated with verbs in the structures known as particle verbs, phrasal verbs, or verb-particle constructions, can also convey aspectual meanings, namely, continuative aspect, a new subcategory of imperfective aspect proposed by Brinton (2009), and telicity, a notion pertaining to accomplishments, one of the kinds of situations proposed by Vendler (1957). Continuative aspect portrays a situation as continuing in time instead of ending; the post-verbal particles which can add continuativity to the situation they are inserted in are on, along, and away. Telicity is a feature that situations have if they have a definite, intrinsic endpoint; the particles which can add a telos to situations are up, down, out, off, through, over, and away. These aspectual notions might be accompanied by some other related meaning, which arises upon the combination of verb and particle. On the telic group, up is the particle which has the purest telic meaning; its correspondent in the continuative group is on. In addition, if we apply the notion of productivity in the sense of Jackendoff (2002) to them, we can conclude that telic up and continuative on and away are productive, in that their combination with verbs can be built online, and the outputs need not be listed in the lexicon.The remaining particles in both groups are, in turn, semiproductive; this means that, even though there is some regularity in their combination with verbs, those cannot be built online and need to be individually listed in the lexicon. These structures also pose a challenge to syntax; not only aspectual, but all particle verbs have syntactic characteristics, such as particle shift, which are difficult to explain in syntactic theory. The two most commonly adopted attempts are the complex head and the small clause analyses, but neither of them is sufficient to explain all the peculiarities in the syntactic behavior of verb-particle constructions. Jackendoff (2002) proposes that, if binary branching were dropped, it would be possible to propose a theory in which the relations that the particle has with the verb and with the DP complement did not have precedence over one another, which seems to be the main reason behind the difficulty in describing the syntactic structure of particle verbs. Furthermore, a few particularities in the syntactic influence of some aspectual particles on the verbs raise even more questions on the syntax of verb-particle constructions. / Este trabalho pretende esclarecer algumas quest?es sem?nticas e sint?ticas sobre part?culas p?s-verbais aspectuais. Al?m de apresentar significados direcionais ou idiom?ticos, as part?culas associadas a verbos nas estruturas chamadas particle verbs, phrasal verbs ou verb-particle constructions tamb?m podem ter sentidos aspectuais; s?o eles continuatividade, uma subdivis?o do imperfectivo proposta por Brinton (2009), e telicidade, uma no??o dos accomplishments, uma das categorias de Vendler (1957). O aspecto continuativo demonstra a situa??o continuando no tempo em vez de terminar; as part?culas que podem adicionar continuatividade ?s situa??es s?o on, along e away. Telicidade ? uma caracter?stica das situa??es que possuem um ponto final intr?nseco; as part?culas que podem dar um telos ?s situa??es s?o up, down, out, off, through, over e away. Estas no??es podem vir acompanhadas de algum outro significado relacionado na combina??o entre verbo e part?cula. No grupo t?lico, up ? a part?cula que possui o significado mais puro de telicidade; sua correspondente no grupo continuativo ? on. Al?m disso, se aplicarmos a no??o de produtividade de Jackendoff (2002), concluiremos que up, e tamb?m as continuativas on e away, s?o produtivas, pois as combina??es entre elas e os verbos podem ser constru?das no momento da fala, sem necessidade de serem listadas no l?xico.O restante das part?culas nos dois grupos s?o, por sua vez, semiprodutivas; isso significa que, embora haja certa regularidade nas combina??es com os verbos, estas n?o podem ser constru?das no momento da fala e precisam ser listadas individualmente no l?xico. Estas estruturas ainda representam um desafio para a sintaxe; n?o apenas os particle verbs aspectuais, mas todos eles, possuem caracter?sticas, como o particle shift, que s?o dif?ceis de explicar na teoria sint?tica. As duas tentativas mais adotadas s?o as chamadas complex head e small clause analyses, por?m, nenhuma das duas ? suficiente para explicar todas as peculiaridades do comportamento sint?tico das verb-particle constructions. Jackendoff (2002) prop?e que, se a ramifica??o bin?ria fosse descartada, seria poss?vel propor uma teoria em que as rela??es da part?cula com o verbo e com o complemento DP n?o tivessem preced?ncia uma sobre a outra, o que parece ser a principal raz?o por tr?s da dificuldade em descrever a estrutura sint?tica dos particle verbs. Ademais, algumas particularidades na influ?ncia sint?tica de algumas part?culas aspectuais nos verbos levantam ainda mais perguntas a respeito da sintaxe de verb-particle constructions.

<p>The aim of this paper is to examine how mid-level executive officers within Swedish Police respond to subordinates autonomous behaviour, mainly according to Lipsky´s theory on street-level bureaucracy. Questions focused on are:</p><p>1. Which personnel related obstacles, are preventing the executive officers?</p><p>2. How do executive officers counter obstacles?</p><p>3. If possible, based on the result of the study, which are the conclusions about existing countermeasures?</p><p>The papers´ aim is not to suggest which obstacles should be removed, nor if countermeasures are good/bad. Main aim is to identify how obstacles are countered. Theory and method are built on framework of Case Study. The method is built on theoretic examination of obstacles to examine concepts´ size and then interviews to confirm the obstacles and identify countermeasures. Conclusion of the first question is that obstacles are omnipresent in the governmental and societal systems. Conclusion of the second question is that obstacles are countered by friendly approach and to ally oneself to staff and personnel. Conclusion of the last question is that a mid-level executive through his allying enhances some behaviour, as long as more-wanted behaviours are produced with quality. This has effect upon society when combating crime, but is probably not likely to measure effectively.</p>

Thesis (M.A.)--Trinity Evangelical Divinity School, 2003. / Abstract. Includes bibliographical references (leaves 164-168).

No description available.

Prions are self-perpetuating and, in most cases, aggregation-prone protein isoforms that transmit neurodegenerative diseases in mammals and control heritable traits in yeast. Prion conversion requires a very high level of identity of the interacting protein sequences. Decreased transmission of the prion state between divergent proteins is termed "species barrier" and was thought to occur due to the inability of divergent prion proteins to co-aggregate. Species barrier can be overcome in cross-species infections, for example from "mad cows" to humans. We studied the counterparts of yeast prion protein Sup35, originated from three different species of the Saccharomyces sensu stricto group and exhibiting the range of prion domain divergence that overlaps with the range of divergence observed among distant mammalian species. Heterologous Sup35 proteins co-aggregated in S. cerevisiae cells. However, in vivo cross-species prion conversion was decreased and in vitro polymerization was cross-inhibited in at least some heterologous combinations, thus demonstrating the existence of prion species barrier. Our data suggests that species-specificity of prion transmission is controlled at the level of conformational transition rather than co-aggregation. We have shown the Sup35 prion domain is sufficient for the species barrier among the S. sensu stricto species, and constructed SUP35 chimeric prion domains, combining the subregions of various origins Our data demonstrated in different cross-species combinations, different modules of prion domain play a crucial role in the controlling of species-specificity of prion transmission. One essential amino acid position has been identified in S. cerevisiae and S. paradoxus system. Our data support a model suggesting that identity of the short amyloidogenic sequences is crucial for the species barrier. Sup35 originated from three different species of the S. sensu stricto group were capable of forming a prion in S. cerevisiae. However, it was not known whether they are capable of generating and maintaining the prion state in the homologous cell environment. We have constructed the S. paradoxus and S. bayanus strains with appropriate markers, and we were able to demonstrate de novo [PSI+] formation in S. paradoxus but not in S. bayanus. Our data show that [PSI+] formation is not a unique property of S. cerevisiae.

Children benefit in many ways from play. Play provides children with an excellent way to express their feelings and conceptions of the world in which they live. Play also provides a forum in which researchers can capture, understand and interpret children's voices and views. Like many countries around the world, Vietnam is currently reforming their early childhood education curriculum to provide a play-based, child centred and outcomes focused approach to early childhood education. In order to capture children's interest and promote child initiated and directed learning, educators and policy makers need to consider how children interpret their personal play lives. This study presents data from children's programs in nine kindergartens and cultural programs in Hanoi and Ho Chi Minh City. Children's drawings and stories were collected to document young children's conceptions of play in Vietnam at the turn of the millennium. Through these 353 drawings and stories, key themes in the children's play lives were identified. The purpose of this study is to examine children's views about play. What do they like to play? How do they define play? How are young Vietnam's children's conceptions of their play influenced by cultural attitudes and expectations? In addition, the study proposes some new play-based, child centred and outcomes focused approaches to curriculum development for Vietnamese early childhood programs.

Zugl.: Frankfurt am Main, Univ., Diss., 2006