Thesis advisor: Michael J. Naughton / Nanoscale biosensing devices improve and enable detection mechanisms by taking advantage of properties inherent to nanoscale structures. This thesis primarily describes the development, characterization and application of two such nanoscale structures. Namely, these two biosensing devices discussed herein are (1) an extended-core coaxial nanogap electrode array, the ‘ECC’ and (2) a plasmonic resonance optical filter array, the ‘plasmonic halo’. For the former project, I discuss the materials and processing considerations that were involved in the making of the ECC device, including the nanoscale fabrication, experimental apparatuses, and the chemical and biological materials involved. I summarize the ECC sensitivity that was superior to those of conventional detection methods and proof-of-concept bio-functionalization of the sensing device. For the latter project, I discuss the path of designing a biosensing device based on the plasmonic properties observed in the plasmonic halo, including the plasmonic structures, materials, fabrication, experimental equipment, and the biological materials and protocols. / Thesis (PhD) — Boston College, 2019. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Physics.

京都大学 / 新制・課程博士 / 博士(工学) / 甲第24147号 / 工博第5034号 / 新制||工||1786(附属図書館) / 京都大学大学院工学研究科電気工学専攻 / (主査)教授 篠原 真毅, 教授 小嶋 浩嗣, 教授 山本 衛 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

Rapid and robust characterization of large earthquakes in terms of their spatial extent and temporal duration is of high importance for disaster mitigation and early warning applications. Backtracking of seismic P-waves was successfully used by several authors to image the rupture process of the great Sumatra earthquake (26.12.2004) using short period and broadband arrays. We follow here an approach of Walker et al. to backtrack and stack broadband waveforms from global network stations using traveltimes for a global Earth model to obtain the overall spatio-temporal development of the energy radiation of large earthquakes in a quick and robust way. We present results for selected events with well studied source processes (Kokoxili 14.11.2001, Tokachi-Oki 25.09.2003, Nias 28.03.2005). Further, we apply the technique in a semi-real time fashion to broadband data of earthquakes with a broadband magnitude >= 7 (roughly corresponding to Mw 6.5). Processing is based on first automatic detection messages from the GEOFON extended virtual network (GEVN).

The use of wireless communication techniques and network centric topologies for portable communication networks and platforms makes it important to investigate new distributed beamforming techniques. Platforms such as micro air vehicles (MAVs), unattended ground sensors (UGSs), and unpiloted aerial vehicles (UAVs) can all benefit from advances in this area by enabling advantages in stealth, enhanced survivability, and maximum maneuverability. Collaborative beamforming is an example of a new technique to utilize these systems which uses a randomly distributed antenna array with a fitting phase coefficient for the elements. In this example, the radiated signal power of each element is coherently added in the far-field region of a specified target direction with net destructive interference occurring in all other regions to suppress sidelobe behavior. A wide variety of topologies can be used to confine geometrically these mobile random arrays for analysis. The distribution function for these topologies must be able to generalize the randomness within the geometry. Gaussian and Uniform distributions are investigated in this analysis, since they provide a way to calculate the statistically averaged beampattern for linear, planar (square and circular), and volumetric (cubical, cylindrical, and spherical) geometries. They are also of practical interest since the impact of array topology on the beampattern can typically be described in closed form. A rigorous analysis is presented first for disc-shaped topologies to motivate the discussion on random array properties and provide several new insights into their behavior. The analyses of volumetric geometries which are of interest to this work are drawn from this planar topology to provide a tractable and coherent discussion on the properties of more complex geometries. This analysis considers Normal and Gaussian distributed array element populations to derive the average beampattern, sidelobe behavior, beamwidth, and directivity. The beampattern is also examined in a similar manor for circular and spherical arrays with a truncated Gaussian distribution. A summary of the random array analysis and its results concludes this thesis.

This thesis is about protein profiling in blood-derived samples using suspension bead ar- rays built with protein affinity reagents, and the evaluation of binding characteristics and potential disease relation of such profiles. A central aim of the presented work was to discover and verify disease associated protein profiles in blood-derived samples such as serum or plasma. This was based on immobiliz- ing antigens or antibodies on color-coded beads for a multiplexed analysis. This concept generally allow for a dual multiplexing because hundreds of samples can be screened for hundreds of proteins in a miniaturized and parallelized fashion. At first, protein antigens were used to study humoral immune responses in cattle suffering from a mycoplasma infec- tion (Paper I). Here, the most immunogenic of the applied antigens were identified based on reactivity profiles from the infected cattle, and were combined into an antigen cocktail to serve as a diagnostic assay in a standard ELISA set-up. Next, antibodies and their em- ployment in assays with directly labeled human samples was initiated. This procedure was applied in a study of kidney disorders where screening of plasma resulted in the discovery of a biomarker candidate, fibulin-1 (Paper II). In parallel to the disease related applica- tions, systematic evaluations of the protein profiles were conducted. Protein profiles from 2,300 antibodies were classified on the bases of binding properties in relation to sample heating and stringent washing (Paper III). With a particular focus on heat dependent de- tectability, a method was developed to visualize those proteins that were captured to the beads in an immunoassay by using Western blotting (Paper IV). In conclusion, this thesis presents examples of the possibilities of comparative plasma profiling enabled by protein bead arrays. / <p>QC 20130208</p>

Fully efficient systolic arrays for the solution of Toeplitz matrices using Schur algorithm [1] have been obtained. By applying clustering mapping method [2], the complexity of the algorithm is 0(n) and it requires n/2 processing elements as opposed to n processing elements developed elsewhere [1]. The motivation of this thesis is to obtain efficient pipeline arrays by using the synthesis procedure to implement Toeplitz matrix solution. Furthermore, we will examine pipeline structures for the Toeplitz system factorization and back-substitution by obtaining clustering and Multi-Rate Array structures. These methods reduce the number of processing elements and enhance the computational speed. Comparison and advantage of these methods to other method will be presented. / Graduation date: 1992

The purpose of this research is to find ways to create an omnidirectional antenna with high directivity in the vertical plane. The investigation is based on computer simulation using the program CST 2011. The objective is a narrow-band antenna that is omnidirectional in the horizontal plane and has maximum achievable directivity for a fixed size. Three of the most promising antenna designs are selected based on the current state of antenna technology. Their maximum directivities are estimated by means of well known relations in antenna theory. It is shown that the most suitable design is an omnidirectional antenna in the form of a cylindrical dipole antenna array with an active central dipole. For this antenna, excitation by means of a radial traveling wave, with a phase velocity smaller than speed of the light, is possible. It is found that for a certain value of a moderating factor it is possible to obtain a directivity that is 2.5 – 3 dB larger than that of a dipole or a linear antenna with uniform excitation. The antenna structures are modeled to determine the number of dipoles, their dimensions and the spacing between them that maximizes the directivity.

The study is based on the acoustic data collected by horizontal line array (HLA) of Asian Seas International Acoustic Experiment (ASIAEX) in South China Sea of 2001. Beamforming was used to localize the sound sources during the experiment, such as explosive, to understand its correlation with position deviation from the array. According to previous studies, the horizontal line array has ambiguity in bearing identification, which was often resolved by maneuvering array¡¦s position, therefore it can also be concluded that the well understanding of array¡¦s position is the key to the accurate source localization. Due to the limitation of element spacing of array used in the experiment, 50 Hz is the highest frequency can be analyzed in the study, so the recorded explosive sounds were chosen for analysis. The numerical test of array has shown the width of main lobe in beamforming is reduced by the increasing total length of the array, and the energy in the side lobes would affect the accuracy of source bearing. During the experiment, the horizontal array was found, and proved indirectly by current measurement of acoustic Dopper current profiler, to be moved by tidal currents, so the deviation from the designed deploy position can be computed. The deviation was used to quantify the resolution effect on localization by the movement of array, and when there is a 10 m deviation, the width of main lobe would increase from 8¢X to 16¢X in the studied case. The experimental results match the simulations well, so it can provide a guideline in predicting the accuracy of underwater source localization when the movement of horizontal line array is possible. Key word: underwater source localization, horizontal line array, beamforming, position deviation, array resolution

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The work here presents a review of beam forming architectures. As an example, the author presents an 8x8 Butler Matrix passive beam forming network including the schematic, design/modeling, operation, and simulated results. The limiting factor in traditional beam formers has been the large size dictated by transmission line based couplers. By replacing these couplers with transformer-based couplers, the matrix size is reduced substantially allowing for on chip compact integration. In the example presented, the core area, including the antenna crossover, measures 0.82mm×0.39mm (0.48% the size of a branch line coupler at the same frequency). The simulated beam forming achieves a peak PNR of 17.1 dB and 15dB from 57 to 63GHz. At the 60GHz center frequency the average insertion loss is simulated to be 3.26dB. The 8x8 Butler Matrix feeds into an 8-element antenna array to show the array patterns with single beam and adjacent beam isolation.