A dissertation submitted to the Faculty Of Education in partial fulfillment of the requirements for the Degree of Masters in Educational Psychology in the Department of Educational Psychology & Special Needs Education at the University Of Zululand, 2018 / The study sought to explore and examine experiences of parents with regard to the education of their autistic children in special schools. Previous studies in this area looked at the inclusion of autistic children and focused on educators’ attitudes or perceptions. Thus this study intended to get parents’ perspectives, their ideas and views about the education of their children with autism spectrum disorder in special schools. To find out if they are satisfied, and explore what seem to be the concerns and challenges, the study adopted a qualitative case study design. Data were generated from nine mothers who had children attending special schools. They were purposively sampled from three special schools for children with intellectual impairment. Semi-structured interviews were conducted with mothers regarding their views and concerns about the education of their autistic children. A thematic content analysis was used to extract common themes from the collected data. Major findings were that most parents were happy and satisfied with the education of their children, though some lacked understanding and thorough knowledge about autism and special education. Parents raised concerns about lack of therapists in special schools when their ASD children need the intervention of speech and language therapists and occupational therapists. It was also found that parents struggle to access preprimary education for their children. It is recommended that special schools create forums where parents have a platform to voice their opinions and concerns. In conclusion, the study was able to give insight into parents’ experiences, views and concerns with regard to the education of autistic children. Knowing parents’ concerns and opinions may help improve the provision of education for autistic children. With the recent release of the Draft on National Strategy for Autism (September, 2017), perhaps parents’ hope for improvement in provision of education for autistic children might be realized

The number of children being diagnosed with Autism Spectrum Disorder (ASD), an impairment that affects an individual’s social-communication abilities and behavior, is currently 1 in 68. An estimated 50,000 students who have ASD are reaching adulthood and exiting secondary education annually―a phenomenon known as the Autism Tsunami. There is a lack of services available to support this wave of young adults with ASD to be self-sustaining, contributing members of their communities. This is evidenced by the 37% of adults in their early 20s, who have ASD, and who have never worked or attended any postsecondary educational program. Due to the lack of appropriate accommodations in many of these programs, there is a low rate of completion for those who enroll. With an increase in positive educational outcomes in K-12 education, there are a burgeoning number of individuals holding the diagnosis of ASD able to enroll in postsecondary education at IHEs. For these students, the predicament of attending an IHE may pose unique challenges despite their ability to complete academic work. There is an ever-increasing need to support individuals with ASD while they attend IHEs, however there is a scant amount of emerging literature on this topic. This exploratory case study was conducted to gain an in-depth understanding of the ways in which Nathan, a student with ASD, was supported while he attended North Coast University (NCU), with the intent to inform further research, and affect the practice of service providers who work with students with ASD who are attending IHEs. The results of this study yielded an in-depth understanding of how NCU Disability Service providers, David and Richard, and Nathan’s mother, Sandy, supported him as he attended NCU, and of his lived experience of support. The Interactional Model of Disability, a model that views disability as caused by both the individual’s impairment and external environmental influences, was used as the theoretical lens in this study. The findings of this study are as follows. Although Nathan has incredible perseverance and academic ability, without support he would not have had the same level of success. The early proactive, nonacademic approach to supporting students with ASD used by NCU was instrumental in Nathan’s success and in helping him to become more independent. Coaching an intervention used as part of the NCU approach was highly effective for Nathan. David and Richard’s dedication to positive student outcomes played a role in Nathan’s success. Support from his mom was essential, but needed to be invisible. The ubiquitous nature of the issue of disclosure of disability emerged, as well as how Nathan experiences ASD.

Autism or autism spectrum disorder (ASD) is a multifaceted neurological condition that impairs social interaction, communication and behaviour. The current increase in the prevalence of ASD is alarming. A large population of parents is left searching for answers regarding their child’s developmental delays. Once their child has been diagnosed, they have to deal with the challenge of raising such a child. Parenting a child with ASD is particularly challenging for mothers as it has been reported that they struggle with poor health and wellbeing as well as high stress levels. Literature has also shown that the maternal interaction style impacts the prognosis for the child’s development, again highlighting the importance of the mother’s wellbeing. Several studies refer to the severe impact of ASD on the family as a unit, yet the unique challenges that mothers face are often overlooked. To address the wellbeing of these mothers, it is necessary to understand their experiences of their child’s diagnosis with ASD. This qualitative phenomenological study explored and described mothers’ experiences of their child’s diagnosis with ASD by using the Process-Person-Context-Time model from Bronfenbrenner’s bioecological theory as a framework. Unstructured interviews with seven mothers were conducted, voice recorded and transcribed. Data was analysed using thematic content analysis. Findings revealed four interrelated themes: 1) the mother’s experience of the interactions and relationships within her immediate family (Proximal Process), 2) the mother’s experience of her internal and external characteristics and resources (Person), 3) the mother’s experience of her environment (Context), and 4) the mother’s experience of the journey through time (Time). Bronfenbrenner’s theory in its matured form also proved to be of value in understanding these mothers’ daily lives and challenges. The key findings provide valuable insight that may inform professionals who develop support programmes aimed at mothers with ASD children or that may guide such professionals’ therapeutic interventions with mothers with ASD children. / MSW, North-West University, Potchefstroom Campus, 2015

Autism or autism spectrum disorder (ASD) is a multifaceted neurological condition that impairs social interaction, communication and behaviour. The current increase in the prevalence of ASD is alarming. A large population of parents is left searching for answers regarding their child’s developmental delays. Once their child has been diagnosed, they have to deal with the challenge of raising such a child. Parenting a child with ASD is particularly challenging for mothers as it has been reported that they struggle with poor health and wellbeing as well as high stress levels. Literature has also shown that the maternal interaction style impacts the prognosis for the child’s development, again highlighting the importance of the mother’s wellbeing. Several studies refer to the severe impact of ASD on the family as a unit, yet the unique challenges that mothers face are often overlooked. To address the wellbeing of these mothers, it is necessary to understand their experiences of their child’s diagnosis with ASD. This qualitative phenomenological study explored and described mothers’ experiences of their child’s diagnosis with ASD by using the Process-Person-Context-Time model from Bronfenbrenner’s bioecological theory as a framework. Unstructured interviews with seven mothers were conducted, voice recorded and transcribed. Data was analysed using thematic content analysis. Findings revealed four interrelated themes: 1) the mother’s experience of the interactions and relationships within her immediate family (Proximal Process), 2) the mother’s experience of her internal and external characteristics and resources (Person), 3) the mother’s experience of her environment (Context), and 4) the mother’s experience of the journey through time (Time). Bronfenbrenner’s theory in its matured form also proved to be of value in understanding these mothers’ daily lives and challenges. The key findings provide valuable insight that may inform professionals who develop support programmes aimed at mothers with ASD children or that may guide such professionals’ therapeutic interventions with mothers with ASD children. / MSW, North-West University, Potchefstroom Campus, 2015

Play is an important contributor to children’s development: it reflects, reinforces, and results in development (Johnson, Christie, Wardle, 2005). However, the tools available to support planning and measurement of play are not sufficiently detailed or focused on children with autism and severe learning difficulties (SLD). Play for children with autism is consistently identified as restrictive and repetitive. Although extensive research examines symbolic play, the content and structure of functional play, which is considered a valuable precursor of symbolic play, is rarely the subject of focused research (Williams, 2003; Lifter, Foster-Sanda, Arzamarski, Briesch, & McClure, 2011). Given the developmental potential that play presents, the aim of this study was to examine the functional play presented by children with autism and SLD, with a view to designing a play framework that enables teachers to support functional play development in the classroom. A pragmatic mixed methods approach was adopted across a three-stage study in three schools. Study 1 provides the background for creating a functional play framework, while Study 2 focuses on the creation of the framework through objective observations of the play activity of a total of 27 children with autism and SLD, as well as interviews with nine classroom teachers. Study 3 was a process of trialling the framework in two schools and collaborating with eight teachers to finalise the functional play framework, in particular by considering its usability. Data collected across the three studies provided a description of functional play that suggests it is more complex than traditionally defined. Four key areas of functional play were identified: interacting with one object; interacting with two (or more) objects; interacting with self; and interacting with the environment. Additionally, 12 subcategories were established as components related to functional play. Teachers reported that they could use the framework to baseline play, set targets and measure play progression for children with autism and SLD. The framework was also identified as a tool that supports classroom management and continuing professional development. The proposed framework facilitates the identification of small increments of progress and extends on other available play frameworks. By developing detailed descriptions of the play that children with autism and SLD present, the framework provides a greater ability to identify precise deficits and, more specifically, to target support in the area of play. Additionally, the collaborative approach with classroom teachers provides diverse viewpoints but also begins to merge the gap between researchers and practitioners in order to ensure a useful resource. Recommendations for further descriptive accounts, greater involvement of classroom professionals in the development of resources and additional trials of the framework are acknowledged.

The author examined current literature supporting the use of innovative, music-based interventions to support young children with autism spectrum disorder and other developmental disabilities engage in the things that they want, need, and desire to do. The author introduced Song-based Interventions for Navigating Gains in Occupational Therapy (SING-OT), as an innovative, music-based educational intervention program designed to support the engagement, participation, and performance needs of young children with disabilities. SING-OT uses an evidenced-supported, client-centered, and interests and strengths-driven approach. This proposed multi-phase program focuses on improving knowledge on the literature connecting evidence to song-based interventions and providing access to uniquely composed, occupation-inspired songs, that support children’s performance and participation needs. Additionally, conducting an initial feasibility study that assesses the effectiveness of task completion in a common personal hygiene and grooming task within the preschool setting was recommended. Future developments extend to improving caregiver health and wellness outcomes through training opportunities. The author provided a comprehensive program evaluation plan that highlights key stakeholders, a proposal for a single-subject study design, and implications of the program. The SING-OT program can be utilized as (1) an additional intervention tool for practicing occupational therapy practitioners and other professionals, (2) an avenue for interprofessional collaboration, and (3) a vehicle for improving the occupational performance outcomes among young children with disabilities.

Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders that affects about 1% of the worldwide population and has a strong genetic component. Stereotyped behavior and restricted interests, as well as problems of social interaction and communication characterize ASD. Moreover, in 10% of cases, ASD occurs as a secondary condition in addition to a syndrome, such as Phelan-McDermid syndrome (PMS), which is associated with a great clinical variability. Among genetic factors, copy number variations (CNVs) are one of the most important. However, the clinical significance of many CNVs remains nuclear and there is an underrepresentation of small CNVs associated with ASD in the literature. In this context, this project aimed to 1) characterize large and small CNVs in Brazilian patients with ASD using an array-CGH previously customized in our laboratory. 2) Clinically and genetically describe a cohort of Brazilian patients with PMS, as well as to determine the frequency of this syndrome among Brazilian patients with ASD and other neurodevelopmental disorders. In result, we 1) further validated the customized array-CGH, 2) provided additional evidence of association with ASD for 27 candidate genes, 3) described 15 CNVs never reported in the literature in association with this disorder, 4) presented evidence that around 70% of CNVs found in our cohort are not polymorphism of our population and 5) reinforced the idea of shared molecular pathways among different neurodevelopmental disorders. In addition, we described for the first time a Brazilian cohort of patients with PMS and contributed to the molecular and clinical characterization of this syndrome. We also provided additional evidence of genotype-phenotype association with regard to the presence of renal problems and speech status in patients with PMS and estimated the frequency of this syndrome among Brazilian patients with ASD and intellectual disability (syndromic or not). With these results, we hope to contribute to better understand the ASD and PMS etiology, especially in our population / O Transtorno do Espectro Autista (TEA) corresponde ao um grupo heterogêneo de alterações no neurodesenvolvimento que afeta cerca de 1% da população mundial e apresenta um forte componente genético. O TEA é caracterizado pela presença de comportamento estereotipado e interesses restritos, além de problemas de interação social e comunicação. Além disso, em 10% dos casos, o TEA ocorre como uma condição secundária somada a uma síndrome. Um exemplo é a síndrome de Phelan-McDermid (PMS), associada a uma grande variabilidade clínica. Dentre os fatores genéticos, as variações no número de cópias (CNVs) são um dos mais importantes. No entanto, o significado clínico de muitas CNVs permanece incerto, além de haver juma sub-representação de CNVs pequenas associadas ao TEA na literatura. Dentro deste contexto, este projeto teve como objetivos 1) caracterizar CNVs grandes e pequenas em pacientes brasileiros com TEA utilizando uma lâmina de array-CGH previamente customizada no Laboratório de Genética do Desenvolvimento - USP. 2) descrever clínica e geneticamente uma casuística de pacientes brasileiros com PMS, bem como determinar a frequência desta síndrome em pacientes com TEA e com outras alterações de neurodesenvolvimento. Como resultados, nós 1) validamos a lâmina customizada, 2) fornecemos evidencia adicional de associação com o TEA para 27 genes, 3) descrevemos 15 CNVs nunca reportadas em associação com o transtorno 4) apresentamos evidências de que cerca de 70% das CNVs encontradas em nossa coorte não são polimorfismo de nossa população e 5) reforçamos a ideia de vias moleculares compartilhadas entre diferentes alterações do neurodesenvolvimento. Além disso, descrevemos pela primeira vez uma casuística brasileira de pacientes com PMS e contribuímos para a síndrome. Fornecemos evidência adicional de associação genótipo-fenótipo no que diz respeito à presença de problemas renais e status de fala em pacientes com PMS e estimamos a frequência da síndrome entre pacientes brasileiros com TEA e com deficiência intelectual (sindrômica ou não). Com estes resultados, esperamos ter contribuído para o entendimento da etiologia tanto do TEA, quanto da PMS, sobretudo na nossa população

Submitted by Fabricia Fialho Reginato (fabriciar) on 2015-07-31T00:53:02Z No. of bitstreams: 1 CristianeCabral.pdf: 4377433 bytes, checksum: b789cb978bdbdc0ed65df7402acbe999 (MD5) / Made available in DSpace on 2015-07-31T00:53:02Z (GMT). No. of bitstreams: 1 CristianeCabral.pdf: 4377433 bytes, checksum: b789cb978bdbdc0ed65df7402acbe999 (MD5) Previous issue date: 2014-08 / UNISINOS - Universidade do Vale do Rio dos Sinos / A presente dissertação teve como objetivo investigar a relação entre a família e a escola frente ao processo de inclusão escolar de crianças com Transtorno do Espectro Autista (TEA). Ela encontra-se composta por dois estudos organizados no formato de artigos. O primeiro deles apresenta uma revisão sistemática da literatura nacional e internacional sobre a inclusão escolar de crianças com TEA, atentando para o período e periódico da publicação, os temas investigados e as escolhas metodológicas. Foram analisados 25 estudos nacionais, publicados entre 1998 e 2014, localizados nas bases LILACS, BVS, SCIELO e Portal de Periódicos da CAPES, que consideram os temas: a escola frente ao processo de inclusão da criança com TEA, formação e atuação do professor na inclusão escolar, formação e atuação do psicólogo no âmbito da inclusão escolar e inclusão e desenvolvimento da criança com TEA no contexto escolar. Também foram considerados 92 estudos internacionais, localizados nas bases EBSCOhost e Medline, publicados entre 1993 e 2013, cujos temas de investigação foram agrupados em: a escola frente ao processo de inclusão escolar, capacitação e atuação do professor na inclusão escolar, instrumentos de avaliação do processo de ensino-aprendizagem no contexto da inclusão escolar, intervenções para inclusão social e desenvolvimento da aprendizagem, família e processo de inclusão escolar, inclusão e desenvolvimento da criança com TEA no contexto escolar. Quanto aos aspectos metodológicos, a maioria dos estudos localizados caracterizou-se como empírico e de abordagem qualitativa. O segundo estudo, por sua vez, teve como objetivo investigar a relação entre a família da criança com TEA e a escola de ensino regular, a relação entre a família da criança com TEA e a professora e a relação entre a professora e a criança com TEA. Trata-se de uma pesquisa qualitativa, de caráter exploratório e transversal, da qual participaram mães, pais e professoras de quatro crianças com diagnóstico de TEA. As mães responderam o Questionário sobre os Dados Sociodemográficos da Família e a Ficha de Dados sobre o Transtorno do Espectro Autista, além da Entrevista sobre a Inclusão Escolar de seu/sua filho/a com TEA, assim como os pais. As professoras responderam a uma Entrevista sobre seu Trabalho com Crianças com TEA. A análise de conteúdo revelou que a relação entre os pais, as professoras e a escola ocorre, muitas vezes, a partir de uma situação problema com a criança no contexto escolar. Além disso, percebeu-se que poucas escolas trocam informações e conhecimento com os pais de forma sistemática. Espera-se que ambos os estudos contribuam como fonte de informação teórica e empírica aos profissionais da educação e saúde que trabalham com inclusão de crianças com TEA, para que possam refletir e fortalecer suas práticas na busca de uma relação mais próxima entre família e escola, visando potencializar o desenvolvimento destas crianças. / The purpose of this dissertation is to investigate the relationship between the family and the school in relation to the process of school inclusion for children with Autism Spectrum Disorder (ASD). The first of the two articles that comprise this study presents a systematic review of the national and international literature on the inclusion of children with ASD, covering the period and the journal of the publishing, the themes investigated, and the methodological choices. The 25 national-based studies, taken from LILACS, BVS, SCIELO and CAPES Portal databases, published between 1998 and 2014 cover the following themes: the school and the process of inclusion of children with ASD, the formation of teachers and their attitude towards the school inclusion, the formation of psychologists and their attitude towards school inclusion, and the inclusion and development of children with ASD in the school context. Additionally, 92 international studies, located in the EBSCOhost and Medline databases, published between 1993 and 2013, were considered. The studies were grouped by investigation theme as follows: the school and the school inclusion process, development and behavior of teachers faced with school inclusion, evaluation instruments for the teaching-learning process in the context of school inclusion, interventions for social inclusion and development of learning, family and the process of school inclusion, inclusion and development of children with ASD in the school context. In terms of methodological aspects, most of the studies located are characterized as empirical and of a qualitative approach. The second study looks into the relationship between the family of a child with ASD and the regular school, the relationship between the family of a child with ASD and the female teacher, and the relationship between the female teacher and the child with ASD. It is a qualitative research, exploratory and transversal in nature, in which mothers, fathers and teachers of four children with ASD diagnose participated. Both mothers and fathers responded the Family Socio-demographic Data Questionnaire and the Autism Spectrum Disorder Data Sheet and an interview about the school inclusion of their child with ASD. The teachers were interviewed about their work with children with ASD. The content analysis showed that the relationship between the parents, the teachers and the school is often triggered by a problem situation involving the child in the school context. It was also observed that few schools exchange information and knowledge with parents on a systematic basis. It is hoped that both studies will contribute as a source of theoretical and empirical information to education and health professionals working with the inclusion of children with ASD so that they will reflect on, and improve their practices resulting in a closer relationship between the family and the school with better development of those children.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-06-18T20:35:03Z No. of bitstreams: 1 GiseleEduardodeOliveiraSilvaDissertacao2018.pdf: 1661361 bytes, checksum: 22eba59d2a319e6a60fcfb072b430263 (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-06-18T20:35:44Z (GMT) No. of bitstreams: 1 GiseleEduardodeOliveiraSilvaDissertacao2018.pdf: 1661361 bytes, checksum: 22eba59d2a319e6a60fcfb072b430263 (MD5) / Made available in DSpace on 2018-06-18T20:35:44Z (GMT). No. of bitstreams: 1 GiseleEduardodeOliveiraSilvaDissertacao2018.pdf: 1661361 bytes, checksum: 22eba59d2a319e6a60fcfb072b430263 (MD5) Previous issue date: 2018-02-23 / In the last decades, several international movements have appeared in favor of a more inclusive and less segregator system of education. In Brazil, inclusion was influenced by ideals of education from Europe and the United States. In relation to rights for students with Autism Spectrum Disorder (ASD), the Berenice Piana Law presents a significant support figure in the process of inclusion of this audience, the specialized companion, as long as their need is proven. In the Federal District (FD), this support is provided by a teaching assistant which is a Volunteer Social Educator (VSE). Considering the VSE as a support for the educational inclusion of the student with ASD leads to the need to reflect on pedagogical policies and practices directed at them, due to the challenges education faces. Moreover, it is debatable whether the rights of these students are being guaranteed, since not even the federal legislation guarantees the profile of this aid figure. This being true, the scarcity of research related to the VSE in the realm of educational inclusion is detected. From a broader perspective, this research investigates the inclusive process of students with ASD in reverse integration classes of mainstream school, to discover relevant aspects about the role of volunteer social educator, order to promote the educational inclusion of this public. The research aimed to investigate whether the volunteer social educator's role in the classroom in the process of including the student with ASD contributes to the success of their school performance or corroborates a veiled exclusion. The methodology used was exploratory qualitative research. It is a multiple cases study with one unit of analysis. The sources of evidence used were document analysis, observations and interviews. The research participants were two teachers, two VSE, a director and an educational counselor from two mainstream schools of the FD public school system in which they studied children with ASD in reverse integration classes accompanied by VSE. Exclusion processes were identified in both cases, although the importance of this educational support is acknowledged. The research revealed the necessity of continuous work in relation to the formation of the VSE. The way in which district legislation is supplying the specialized companion, to which the TEA student is entitled, has not been sufficient to guarantee the right to learn from the whole individual formation perspective. / Nas últimas décadas, surgiram vários movimentos internacionais em prol de um sistema de ensino mais inclusivo e menos segregativo. No Brasil, a inclusão sofreu influências de ideais de educação advindas da Europa e dos Estados Unidos da América. Em relação aos direitos voltados aos estudantes com Transtorno do Espectro Autista (TEA), a Lei Berenice Piana apresenta uma figura de apoio significativa no processo de inclusão desse público, o acompanhante especializado, desde que a sua necessidade seja comprovada. No Distrito Federal (DF), esse apoio é suprido pelo Educador Social Voluntário (ESV). Ao se considerar o ESV como apoio à inclusão educacional do estudante com TEA leva à necessidade de refletir sobre políticas e práticas pedagógicas a ele direcionadas, em virtude dos desafios colocados à educação. Além disso, é discutível se os direitos desses estudantes estão sendo garantidos, posto que nem mesmo a legislação federal garante o do perfil dessa figura de auxílio. Diante disso, e constatada a escassez de pesquisas relacionadas ao ESV no âmbito da inclusão educacional, numa perspectiva mais abrangente, esta pesquisa investiga o processo inclusivo de estudantes com TEA em turmas de integração inversa de escola regular, para descobrir aspectos relevantes sobre o papel do educador social voluntário, a fim de promover a inclusão educacional desse público. A pesquisa teve por objetivo investigar se a atuação do educador social voluntário, em sala de aula, no processo de inclusão do estudante com TEA, contribui para o êxito de seu desempenho escolar ou corrobora uma exclusão velada. A metodologia utilizada foi a pesquisa qualitativa exploratória. Trata-se de um estudo de casos múltiplos com uma unidade de análise. As fontes de evidência utilizadas foram análise documental, observações e entrevistas. Os participantes da pesquisa foram dois professores, duas ESV, uma diretora e uma orientadora educacional de duas escolas regulares da rede pública de ensino do DF nas quais estudavam crianças com TEA em turmas de integração inversa acompanhados por ESV. Processos excludentes foram identificados nos dois casos, ainda que reconhecida a importância desse apoio educacional. A pesquisa concluiu ser necessário um trabalho contínuo de formação em relação ao ESV. A maneira como a legislação distrital está suprindo o acompanhante especializado, a que o estudante com TEA tem direito, não tem sido suficiente para garantir os direitos de aprendizagem da perspectiva da formação integral.

Activation of the maternal immune system and resultant maternal cytokine expression due to prenatal infection has been implicated as a significant contributor to the pathology of neuropsychiatric and neurodevelopmental disorders such as schizophrenia and Autism Spectrum Disorder (ASD). Increased maternal interleukin-6 (IL-6) expression, observed clinically and in animal models of prenatal infection, and resultant activation of key signaling pathways, has been shown to be a biological indicator of pathology, and a central component of the pathological mechanism. In animal models of prenatal infection and clinically in pregnancy disorders hallmarked by immunological irregularities and increased IL-6 expression, inhibition of IL-6 has been shown to reduce pathological symptoms both maternally and in the exposed offspring. This study aims to demonstrate the ability of IL-6 expression, resulting from prenatal infection, to induce neuropathological and behavioral outcomes that mirror clinical observations seen in disorders such as ASD. More importantly, it shows how flavones luteolin and diosmin, a subclass of the flavonoid family, through inhibition of IL-6 mediated activation of Signal Transducer and Activator of Transcription-3 (Stat3) can reduce these pathologies both in vitro and in vivo. Evidence suggests that flavonoids, a polyphenolic class of naturally occurring plant secondary metabolites, are potent anti-inflammatory agents that can attenuate the expression of cytokines such as IL-6, possibly through the modulation of tyrosine kinase activity. They have been shown to have significant therapeutic potential in disorders hallmarked by increased inflammation or disruptions in immune regulation, such as neurodegenerative disorders and certain cancers. Members such as diosmin have also been shown to be safe during pregnancy, and are currently utilized in the treatment of certain vascular disorders associated with pregnancy. In vitro work undertaken in this study showed that co-administration of luteolin with IL-6 in neural stem cells (NSC) was able to attenuate pathological outcomes induced by IL-6 including aberrant proliferation, over expression of astroglial marker, glial fibrillary acidic protein (GFAP) and changes in cellular morphology. In vivo studies involving luteolin and diosmin further confirmed the therapeutic efficacy of these compounds as similar attenuation of IL-6 mediated maternal and fetal pro-inflammatory cytokine expression and abnormal behaviors in prenatally exposed offspring was observed. Mechanistically, these effects were mediated through inhibition of Stat3 activation although other pathways activated by IL-6 were modulated by flavone co-treatment. Flavonoid treatment during periods of prenatal infection may prove to be a therapeutic intervention for the resultant pathological outcomes seen in offspring through attenuation of the maternal and fetal immune response to infection as well as modulation of signaling pathways in the fetal brain. These compounds may prove therapeutically efficacious for the application in perinatal conditions hallmarked by increased inflammation during pregnancy.