in English Title: Development of legal regulation of drug related crimes The thesis analyzes current criminal legislation in the area of drug-related crimes, compares it with previously effective legislation and outlines ambiguities in interpretation of selected legal terms. Increased attention is paid to legislative changes of the past five years which determine the current situation and future legislative development. The author predominantly focuses on problematic issues and challenged provisions related to the discussed topic which she then examines in detail. In order to provide the reader with a full picture of the topic, opinions of academic and professional authorities are presented. Furthermore, judicial practice of mainly Supreme Court is emphasized, as it plays a key role in interpretation of law. Alongside currently applicable court rulings, obsolete judicature is also quoted in order to help the reader understand the background of the legislation and especially its previous precipitous development. The thesis is divided in five chapters. The first chapter introduces the reader into the topic of addictive substances and defines relevant legal terminology. The second chapter deals with the current legislation in the area of narcotic and psychotropic substances in international, European...

The objective of my thesis is to deepen and expand research on my thesis I tried to prove or disprove the link between social status in the classroom and student use of cannabis. For research, I chose a sample of 21 students cook waiter field. In my thesis expand my research, because I want to prove whether the result is unique to college or is a general phenomenon among high school students. For the purposes of my research, I added one class schools, two gymnazium school classes, because this children are considered elite, and finally two classes of business school and for this reason that this type of education is visited the largest number of students. In my research I used combination od three methods. sociometric research, selected questions from the ESPAD questionnaire and interviews with selected students. Based on the research showed that the visible difference in the relation between social status and cannabis use at each school. The largest is in the school and the smallest is in the gymnazium.. This fact seems to me very interesting and I think that the fact this could work to solve this serious problem. In the theoretical part explains how to use the above methods, the effects and the influence of cannabis on humans. Keywords: Sociometry - cannabis - the status of the student -...

The aim of this study is to, in view of theories about deviance and social control, examine how cannabis users are experiencing and relating to their own use and the society’s perception on this use. Qualitative interviews with six users or former users of cannabis were performed.  Sociological concepts of deviance and normality, social control, roles, role distance and stigma were used to analyze the results. The study shows that the cannabis users experience deficiencies in the Swedish drug policy. They feel like the picture of cannabis as a dangerous substance is unanimous in society and that it is not accepted to question it. They also believe that issues related to narcotics are being handled inadequately in Sweden and that this may lead to people suffering from addiction not seeking help. The cannabis users in this study also felt like other people perceived them as addicts and junkies, while the users themselves separated use and abuse. Lastly, we discovered three different strategies to deal with the attitudes and norms in society. These strategies were: resistance and questioning, hidden use and secretiveness, adapting social circle and adoption of different roles.

Submitted in fulfillment of the requirement for the degree of Doctor of Philosophy in the Faculty of Health Sciences at the University of the Witwatersrand, Johannesburg / Renewed interest in cannabinoid compounds arose since the discovery of the endocannabinoid system in the early 1990’s and its role in mediating the body’s energy balance. The aim of this study was to investigate the effect of an organic Cannabis sativa (hereafter referred to as C. sativa) extract on β-cell secretory function using an in vivo diet-induced obese rat model and an in vitro isolated rat pancreatic islet model and to determine the associated molecular changes within the pancreatic tissue. Materials and methods: Diet-induced obese Wistar rats and rats fed on standard pellets were subcutaneously injected, over a 28 day period, with an organic C. sativa extract or the vehicle (1% Tween 80® in saline). The effect of diet and treatment was evaluated using the intraperitoneal glucose tolerance tests (IPGTTs) and quantitative polymerase chain reaction (qPCR) analysis on rat pancreata. In vitro studies were conducted using isolated rat islets exposed to 11.1 (representative of normoglycemic conditions) and 33.3 mM glucose levels (representative of hyperglycemic conditions) over a 24-(D1; acute) and 96-hour (D4; chronic) period, and treated with C. sativa extract containing an equivalent of 2.5 (T1) and 5 ng/mL (T2) tetrahydrocannabinol (THC). Glucose-stimulated insulin secretion (GSIS), immunohistocytochemistry for apoptosis and proliferation detection and western blotting for detection of cannabinoid receptor type 1 (CB1), CB2 receptors and specific transduction factors were undertaken. Antagonist studies were conducted using AM251 (A1) and AM630 (A2) to block CB1 and CB2, respectively, to determine the role of cannabinoid receptors in insulin secretion. Results: The overall increase in body weight in the experimental groups occurred at a significantly slower rate than the control groups (P < 0.01), irrespective of diet. In the lean group, the area under the curve for glucose (AUCg) was significantly higher compared to the diet-induced obese group (P < 0.001), while C. sativa treatment significantly improved the AUCg in the lean rats (P < 0.05). The cafeteria diet did not induce hyperglycemia and insulin resistance in the obese rats and C. sativa treatment maintained a plasma glycemic profile similar to the obese control rats. The lower AUCg values in the obese group may, in part, be due to the inclusion of milk products (shown to be beneficial in reducing diabetes) in the cafeteria diet. qPCR analysis showed that the cafeteria diet induced down-regulation of the following genes in the obese control group, relative to lean controls: UCP2 (P < 0.01), c-MYC (P < 0.05) and FLIP (P < 0.05), and upregulation of CB1 (P < 0.01), GLUT2 (P < 0.001), UCP2 (P < 0.001) and PKB (P < 0.05), relative to the obese control group, while c-MYC levels were down-regulated (P < 0.05), relative to the lean control group. In the in vitro study, results showed C. sativa treatment decreased chronic insulin secretion in islets cultured under normoglycemic condition for D1 (P < 0.05), but not for D4. In islets cultured under hyperglycemic conditions, C. sativa treatment for the D4 period showed a significant increase in their chronic insulin secretion (HD4T1, P = 0.07; HD4T2, P < 0.001), increase in basal insulin secretion (HD4T1, P < 0.001; HD4T2, P < 0.001), increase in GSIS (HD4T1, P < 0.05; HD4T2, P < 0.001), reduction in glucose-stimulated:basal insulin production (HD4T1, P < 0.05; HD4T2, P < 0.05), reduction in insulin content (HD4T1, P < 0.001), increase in the percentage basal : content ratio (HD4T1, P < 0.001; HD4T2, P < 0.01) and increase in the percentage GSIS : content ratio (HD4T1, P < 0.001; HD4T2, P < 0.05), relative to ND4C islets. In antagonist studies, A2 preconditioning did not affect suppress the stimulatory effect of C. sativa treatment on chronic insulin secretion under normo- and hyperglycemic conditions, relative to the NC and HC islets, respectively. qPCR studies showed that C. sativa exposure induced a 2.2-fold increase in CB1 gene expression, relative to normoglycemic control islets (P < 0.05), while c-MYC and FLIP expression was significantly reduced by 12% (ND4T1, P < 0.05) and 37% (HD4T1, P < 0.05), respectively. C. sativa treatment also induced increased secretion of anti-inflammatory cytokines/chemokines under hyperglycemic conditions. Conclusion: These results suggest that C. sativa protects pancreatic islets against the negative effects of obesity (in vivo studies) and hyperglycemia (in vitro studies). In light of these findings, further investigation into the potential of C. sativa as a complementary therapeutic agent in the treatment of the deleterious effects of hyperglycemia in diabetic patients is warranted. In addition, the significant effect of C. sativa treatment on adipose tissue in experimental rats needs further investigation to determine how the cannabinoids affect the mechanisms of adipogenesis and lipolysis in diet-induced obesity. Keywords: Diet-Induced Obesity, Cannabinoids, C. sativa, THC, β-cell, AM251, AM630.

Submitted by PPG Odontologia (odontologia-pg@pucrs.br) on 2018-03-15T18:13:31Z No. of bitstreams: 1 MARIANA_KLEIN_DIS.pdf: 2818382 bytes, checksum: 8bd8dc12dea147fdea294b9c63661941 (MD5) / Approved for entry into archive by Tatiana Lopes (tatiana.lopes@pucrs.br) on 2018-03-28T11:55:01Z (GMT) No. of bitstreams: 1 MARIANA_KLEIN_DIS.pdf: 2818382 bytes, checksum: 8bd8dc12dea147fdea294b9c63661941 (MD5) / Made available in DSpace on 2018-03-28T11:59:45Z (GMT). No. of bitstreams: 1 MARIANA_KLEIN_DIS.pdf: 2818382 bytes, checksum: 8bd8dc12dea147fdea294b9c63661941 (MD5) Previous issue date: 2018-01-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Ulcerative lesions are some of the most common injuries of the oral mucosa. Damage to the epithelial barrier results in discomfort, which may interfere with oral hygiene, chewing, swallowing and speech. The management of these lesions basically aims to optimize and accelerate tissue repair, in addition to reducing its symptomatology. However, there is no option considered gold standard for the treatment of traumatic mouth ulcers. Cannabidiol (CBD) is the main non-psychomimetic component of Cannabis sativa. It exerts potent antiinflammatory, antioxidant and analgesic effects when tested in various pathological conditions. The present dissertation is structured in the form of 2 scientific papers. The first article consists of a literature review to evaluate the different mechanisms of action of CBD that may be involved in the repair of ulcerative lesions, suggesting that this drug is promising for the treatment of oral inflammatory disorders. The second article is a report of an experimental study conducted in an animal model, to assess the effect of 5 and 10 mg/kg CBD on the repair of an ulcerative lesion induced on the ventral tongue of 60 Wistar rats after 3 and 7 days. Treatment with CBD decreased inflammatory scores after 3 days (p < 0.05), but was unable to clinically influence the size of ulcerative lesions. Thus, it is concluded that CBD has an inflammation modulating effect and may represent a promising alternative in the management of oral wounds. / As les?es ulceradas correspondem ?s enfermidades mais frequentes da mucosa bucal. O dano ? barreira epitelial resulta em desconforto, podendo interferir na higiene oral, mastiga??o, degluti??o e fala. O manejo dessas les?es objetiva basicamente otimizar e acelerar o reparo tecidual, al?m de diminuir a sintomatologia dolorosa. No entanto, n?o est? dispon?vel atualmente uma alternativa considerada o padr?o-ouro para o tratamento das ?lceras traum?ticas bucais. O canabidiol (CBD) ? o principal componente n?o-psicomim?tico da Cannabis sativa e desempenha potentes efeitos anti-inflamat?rios, antioxidantes e analg?sicos em diversas condi??es patol?gicas. A presente disserta??o est? estruturada na forma de 2 artigos cient?ficos. O primeiro consiste em uma revis?o de literatura, cujo objetivo foi avaliar os diferentes mecanismos de a??o do CBD que possam estar envolvidos no reparo de les?es ulceradas traum?ticas, sugerindo o car?ter promissor desta droga na terapia de dist?rbios inflamat?rios orais. O segundo trata de um estudo experimental desenvolvido em modelo animal, com objetivo de avaliar cl?nica e histologicamente o efeito da administra??o intraperitoneal do CBD, nas doses de 5 e 10 mg/kg, por 3 e 7 dias, no reparo de les?o ulcerada induzida no ventre lingual de 60 ratos Wistar. O tratamento com CBD foi capaz de diminuir os escores inflamat?rios das les?es ap?s 3 dias (p < 0,05), contudo n?o foi suficiente para interferir no tempo de cicatriza??o das ?lceras. Dessa forma, concluiu-se que o CBD ? capaz de modular o processo inflamat?rio em les?es ulceradas orais, podendo representar uma alternativa promissora no manejo dessa condi??o.

Submitted by William Justo Figueiro (williamjf) on 2015-06-15T22:51:58Z No. of bitstreams: 1 17.pdf: 23802324 bytes, checksum: 8005f41c1cffc71f7faca250bc920a4d (MD5) / Made available in DSpace on 2015-06-15T22:51:58Z (GMT). No. of bitstreams: 1 17.pdf: 23802324 bytes, checksum: 8005f41c1cffc71f7faca250bc920a4d (MD5) Previous issue date: 2013-11-28 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / UFPI - Universidade Federal do PIAUI / Este estudo, realizado a partir da percepção da existência de um discurso favorável à legalização do uso medicinal e recreativo da Cannabis sativa, nas atividades jornalísticas e culturais, produzido em uma nova ambiência semiótica que se articula com diversos campos do saber, como os da medicina, da antropologia, do direito, da indústria, da moda e das artes; procura compreender como os discursos antiproibicionistas foram historicamente restritos às bordas dos sistemas de comunicação, e de que modo as mobilizações discursivas que se opõem à proibição ou criminalização da Cannabis sativa, materializadas em diferentes plataformas midiáticas, constituem acontecimentos jornalísticos, que semioses acionam e que tensões de sentidos desencadeiam. Foram estudados textos jornalísticos, letras de músicas, vídeos e fotos contendo posicionamentos antiproibicionistas, e postagens de usuários no fórum de debates Growroom, sobre a organização das “marchas da maconha” de São Paulo, em 2011. / This study, developed from the perception of the existence of a speech favorable at the legalization of recreational and medicinal use of Cannabis sativa in journalistic and cultural activities, produced in a new ambience semiotics that articulates with several disciplines, such as medicine, anthropology, law, industry, fashion and arts, seeks to understand how discourses prohibitionist historically are restricted to the edges of the communication systems, and how the discursive mobilizations who oppose to prohibition or criminalization of Cannabis sativa, materialized in different media platforms constitute journalistic events, what semiosis and tension of senses are triggered. We studied newspaper articles, lyrics, videos and photos with anti-prohibitionist placements and postings of users on the Growroom discussion forum about the organization of the "marijuana marches" of São Paulo, in 2011.

A Cannabis sativa L. é a droga de abuso de uso proscrito mais consumida no mundo. O consumo desta droga por condutores de veículo automotor está associado com o aumento do risco de acidentes de trânsito, com o aumento da gravidade e com o aumento das taxas de mortalidade. O objetivo deste trabalho foi propor métodos analíticos aplicáveis à rotina laboratorial forense para monitoramento do consumo de canábis por condutores. Para tanto, foi utilizada como metodologia a extração líquido-líquido seguida de análise por cromatografia em fase gasosa acoplada a detector de massas para pesquisa de canabinoides em matrizes biológicas como sangue total (ST) e fluido oral (FO). A análise de 11-nor-9-carbóxi-delta9-THC (THC-COOH) em amostras de ST por cromatografia gasosa envolve a derivatização desta molécula e, consequentemente, do THC extraído desta matriz (quando presente), uma vez que ambos estão presentes no mesmo extrato, constituindo mais uma etapa analítica e que requer maior controle das condições de reação. Por outro lado, a detecção de THC em FO pode ser realizada sem a realização desta etapa, o que constitui uma vantagem analítica. A determinação de THC-COOH e THC em ST não demonstrou repetibilidade, o que inviabilizou as análises qualitativas e quantitativas nesta matriz. A detecção de THC em FO se mostrou uma análise simples e passível de validação, porém com limite de detecção (200ng/mL) acima do recomendado pelas guias forenses internacionais (2 ng/mL). A metodologia analítica desenvolvida se mostrou compatível com aplicação na análise confirmatória em casos de intoxicação aguda pelo consumo de canábis, demonstrando a necessidade de utilização de técnicas de concentração de amostras como extração em fase sólida ou microextração em fase sólida, para obtenção de menores limites de detecção, podendo assim ser aplicado na rotina laboratorial para o monitoramento do uso frequente de canábis, e não apenas em casos de intoxicação aguda. Além disso, foi realizada uma abordagem sobre a interpretação da detecção de THC em diferentes matrizes biológicas. / Cannabis sativa L. is the illegal drug of abuse most consumed in the world. The consumption of this drug by motor vehicle drivers is associated with an increased risk of traffic accidents, increased severity and increased mortality rates. The objective of this work was to propose analytical methods applicable to forensic laboratories to verify the consumption of cannabis by drivers. Liquid-liquid extraction followed by gas chromatography (GC) coupled to mass spectrometry (MS) detector has been applied to cannabinoid analysis in biological samples such as whole blood (WB) and oral fluid (OF). The analysis of 11-nor-9-carboxy-delta9-THC (THC-COOH) in WB by GC required the derivatization of this molecule and also involved the derivatization of THC since both were extracted from the same sample. The derivatization constitutes another analytical step, which requires greater control of the reaction conditions. Fortunately, the detection of only THC in OF can be done without performing this step. The determination of THC-COOH and THC in WB did not demonstrate repeatability, which impaired the qualitative and quantitative analyzes in this matrix. The detection of THC in OF proved to be a simple analysis, that could be validated, but the limit of detection (200ng/mL) was higher than the recommended by the international forensic guides (2 ng/mL). The chromatographic method developed was compatible with the application of a confirmatory analysis in acute cannabis intoxication, demonstrating the need to use techniques of samples concentration such as SPE or SPME, in order to obtain lower limits of detection, thus being able to be applied in the laboratory routine for the monitoring of the frequent use of cannabis, and not only in cases of acute intoxication. In addition, it was made an approach of THC detection in different biological matrices.

Though the drug remains illegal at the federal level, in recent years states and localities have increasingly liberalized their marijuana laws in order to generate tax revenue and save resources on marijuana law enforcement. Many states have adopted some form of medical marijuana and/or marijuana decriminalization laws, and as of 2017, Washington, Colorado, Maine, California, Oregon, Massachusetts, Nevada, Alaska, and the District of Columbia have all legalized marijuana for recreational use. In 2016 recreational marijuana generated over $1.8 billion in sales. Hence, studying marijuana reforms and the policies and outcomes of early recreational marijuana adopters is an important area of research. However, perhaps due to the fact that legalized recreational cannabis is a recent phenomenon, a scarcity of research exists on the impacts of recreational cannabis legalization and the efficacy and efficiency of cannabis regulation. This dissertation aims to fill this gap, using the Washington recreational marijuana market as the primary setting to study cannabis legalization in the United States. Of first order importance in the regulation of sin goods such as cannabis is quantifying the value of the marginal damages of negative externalities. Hence, Chapter 1 (co-authored with Lin Tian) explores the impact of marijuana dispensary location on neighborhood property values, exploiting plausibly exogenous variation in marijuana retailer location. Policymakers and advocates have long expressed concerns that the positive effects of the legalization--e.g., increases in tax revenue--are well spread spatially, but the negative effects are highly localized through channels such as crime. Hence, we use changes in property values to measure individuals' willingness to pay to avoid localized externalities caused by the arrival of marijuana dispensaries. Our key identification strategy is to compare changes in housing sales around winners and losers in a lottery for recreational marijuana retail licenses. (Due to location restrictions, license applicants were required to provide an address of where they would like to locate.) Hence, we have the locations of both actual entrants and potential entrants, which provides a natural difference-in-differences set-up. Using data from King County, Washington, we find an almost 2.4% decrease in the value of properties within a 0.5 mile radius of an entrant, a $9,400 decline in median property values. The aforementioned retail license lottery was used to distribute licenses due to a license quota. Retail license quotas are often used by states to regulate entry into sin goods markets as quotas can restrict consumption by decreasing access and by reducing competition (and, therefore, increasing markups). However, license quotas also create allocative inefficiency. For example, license quotas are often based on the population of a city or county. Hence, licenses are not necessarily allocated to the areas where they offer the highest marginal benefit. Moreover, as seen in the case of the Washington recreational marijuana market, licenses are often distributed via lottery, meaning that in the absence of an efficiency secondary market for licenses, the license recipients are not necessarily the most efficient potential entrants. This allocative inefficiency is generated by heterogeneity in firms and consumers. Therefore, in Chapter 2, I develop a model of demand and firm pricing in order to investigate firm-level heterogeneity and inefficiency. Demand is differentiated by geography and incorporates consumer demographics. I estimate this demand model using data on firm sales from Washington. Utilizing the estimates and firm pricing model, I back out a non-parametric distribution of firm variable costs. These variable costs differ by product and firm and provide a measure of firm inefficiency. I find that variable costs have lower inventory turnover; hence, randomly choosing entrants in a lottery could be a large contributor to allocative inefficiency. Chapter 3 explores the sources of allocative inefficiency in license distribution in the Washington recreational marijuana market. A difficulty in studying the welfare effects of license quotas is finding credible counterfactuals of unrestricted entry. Therefore, I take a structural approach: I first develop a three stage model that endogenizes firm entry and incorporates the spatial demand and pricing model discussed in Chapter 2. Using the estimates of the demand and pricing model, I estimate firms' fixed costs and use data on locations of those potential entrants that did not win Washington's retail license lottery to simulate counterfactual entry patterns. I find that allowing firms to enter freely at Washington's current marijuana tax rate increases total surplus by 21.5% relative to a baseline simulation of Washington's license quota regime. Geographic misallocation and random allocation of licenses account for 6.6\% and 65.9\% of this difference, respectively. Moreover, as the primary objective of these quotas is to mitigate the negative externalities of marijuana consumption, I study alternative state tax policies that directly control for the marginal damages of marijuana consumption. Free entry with tax rates that keep the quantity of marijuana or THC consumed equal to baseline consumption increases welfare by 6.9% and 11.7%, respectively. I also explore the possibility of heterogeneous marginal damages of consumption across geography, backing out the non-uniform sales tax across geography that is consistent with Washington's license quota policy. Free entry with a non-uniform sales tax increases efficiency by over 7% relative to the baseline simulation of license quotas due to improvements in license allocation.

Detection of evolutionarily conserved pathogen motifs by pattern recognition receptors (PRRs), particularly on dendritic cells (DCs), is crucial for adequate immune responses. Defects in DC function are known to be associated with inflammatory bowel disease (IBD). The endocannabinoid system (ECS) is the system through which exocannabinoids such as Δ⁹-tetrahydrocannabinol and cannabidiol signal. Regarding inflammation, cannabinoids generally exert anti-inflammatory effects, including on experimental colitis. However, most work has been performed in animal models and less is known about the function of this system in human immune cells, particularly DCs. Monoacylglycerol lipase (MGLL) is the key enzyme for hydrolysis of the endocannabinoid 2-arachidonoylglycerol, and a member of the serine hydrolase enzyme superfamily. This thesis defines the activity of serine hydrolase enzymes for the first time in human DCs upon stimulation by NOD2/TLR2 ligands using activity-based protein profiling (ABPP). MGLL is shown to be ubiquitously upregulated upon stimulation of DCs and in monocyte-derived macrophages. Through pharmacological inhibition studies, MGLL is demonstrated to regulate cellular and secreted lipids, not limited to endocannabinoids. However, overall DC function is independent of this enzyme suggesting that the effects of lipid modulation may be on bystander cells. Challenging the current literature, MGLL inhibition with a novel inhibitor worsens murine Citrobacter rodentium colitis. Finally, ABPP demonstrates a rich serine hydrolome in colonic tissue from human IBD with many enzymes previously undefined in this disease. Gene expression of ECS components suggests the enzymes ABHD12 and DAGLα/β may be potential markers of field change in IBD.

Les procédés industriels de transformation des grandes productions végétales génèrent des quantités importantes de coproduits qui peuvent très souvent trouver une valorisation en tant que sources de molécules à valeur ajoutée pour l'agrochimie. Les travaux de thèse se polarisent sur une matière première originale : le chanvre (Cannabis sativa L.), plante riche en une lignine particulière, de caractéristiques différentes de celle du bois et beaucoup plus accessible. Le procédé de défibrage du chanvre (Cannabis sativa L.) génère 30% de fibres pour 70% de co-produits lignocellulosiques : chènevotte (50%) et poudre organique (20%) lesquels ont été étudiés ici comme sources potentielles d'acides hydroxycinnamiques (AHC) tels que les acides férulique (AF) et p-coumarique (ApC). Leur répartition structurale dans la matrice lignocellulosique a été évaluée analytiquement par hydrolyses séquencées. L'AF est majoritairement éthérifié à la structure lignocellulosique, et ce pour les deux matières, tandis que l'ApC est principalement sous forme estérifiée dans la poudre organique et lie en proportions équivalentes par des liaisons ester et éther dans la chènevotte. Le fractionnement des coproduits du chanvre pour l'obtention d'extraits et raffinats performants en acides phénoliques a été étudié par extraction assistée par micro-ondes et extraction thermo-mécano-chimique en extrudeur bi-vis. Ces méthodes ont toutes deux permis d'intensifier l'extraction des AHC. Pour la chènevotte, un solvant hydro-alcoolique alcalin conduit aux rendements optimaux en ApC en réacteur micro-ondes et en AF par extrusion bi-vis tandis que, pour la poudre organique, ce même solvant est le plus efficace pour extraire les deux acides phénoliques par extrusion bi-vis. L'enrichissement en AHC des extraits par adsorption sur différents solides microporeux a été étudié. La zéolithe *BEA (beta) a démontré un fort potentiel tant pour l'adsorption d'AHC de solutions modèles que pour ceux contenus dans les extraits issus des schémas de fractionnement. / The industrial transformation of common cultivated crops generates significant amounts of by-products that can often be valorized as a source of value- added molecules for biochemistry. The present work focuses on an original raw material: hemp (Cannabis sativa L.), rich in a particularly, more accessible, lignin having different characteristics than that of wood. Hemp defibering process (Cannabis sativa L.) generates 30% fibers and 70% lignocellulosic by-products: hemp shives (50%) and hemp dust (20%) which were studied in this work as a potential source of hydroxycinnamic acids (HCA) such as ferulic (FA) and p-coumaric (pCA) acids. Their structural distribution in the lignocellulosic matrix was analytically evaluated by multistage hydrolysis. FA is mostly etherified to the lignocellulosic structure, while pCA is mainly esterified in hemp dust and equally bound through ester and ether linkages in hemp shives. Biorefinery of hemp by-products, to obtain extracts and raffinates which are rich in phenolic acids, was studied by using microwave-assisted extraction and thermo-mechano-chemical extraction using twin-screw extruder. Both methods have helped to intensify the extraction of HCA. For hemp shives, alkaline-hydro alcoholic solvent lead to the optimum yields of pCA by microwave extraction and of FA by twin-screw extrusion, while for hemp dust, the same solvent is the most effective for the extraction of both phenolic acids using twin-screw extraction. The enrichment of HCA extracts by adsorption on different microporous solids has been investigated. The zeolite *BEA (beta) showed a high potential of HCA adsorption from both model solutions and extracts obtained from fractionation.