Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The rapid spread of resistance against antimalarial drugs, especially chloroquine and pyrimethamine–sulphadoxine, emphasises the need for new alternatives or modification of existing drugs. Artemisinin–based combination therapies (ACT’s) with different targets prevent or delay the development of drug resistance and therefore have been adopted as first–line therapy by all endemic countries. Proguanil–dapsone, an antifolate combination is more active than pyrimethamine–sulphadoxine and is being considered as an alternative to pyrimethamine–sulphadoxine. Artesunate–proguanil–dapsone is a new ACT that has wellmatched pharmacokinetics and is relatively rapidly eliminated; therefore there is a reduced risk of exposure to any single compound and potentially a decreasing risk of resistance. A few studies have been done on a triple fixed–dose combination therapy for malaria treatment and such a combination for artesunate, proguanil and dapsone are not currently investigated, manufactured or distributed. The aim of this study was to develop a triple fixed–dose combination for artesunate, proguanil and dapsone. The formulation was developed in three phases; basic formulation development, employing factorial design to obtain two possible optimised formulations and evaluating the optimised formulations. During the formulation development the most suitable manufacturing procedure and excipients were selected. A full 24 factorial design (four factors at two levels) was used to obtain the optimised formulations. As end–points to identify the optimised formulations, weight variation, friability, crushing strength and disintegration of the tablets, were used. Statistical analysis (one way ANOVA) was used to identify optimal formulations. To identify any interaction between the active pharmaceutical ingredients (API’s) and the API’s and excipients, differential scanning calorimetry was done. Flow properties of the powder mixtures (of the optimised formulations) were characterised by means of angle of repose; critical orifice diameter (COD); bulk density and tapped density; and flow rate. Tablets of the two optimised powder formulations were compressed. The tablets were evaluated and characterised in terms of weight variation, friability, crushing strength, disintegration and dissolution behaviour. Initial formulation development indicated that wet granulation was the most suitable manufacturing method. The results from the factorial design indicated that different amounts (% w/w) of the lubricant and binder as well as two different fillers influenced the weight variation, crushing strength and disintegration statistically significant. Two formulations containing two different fillers (microcrystalline cellulose or Avicel® PH 101, and lactose or Granulac® 200) were found to be within specifications and ideal for manufacturing. Tablets prepared from the FA formulation (formulation containing Avicel® PH 101) complied with the standards and guidelines for weight variation, friability, crushing strength and disintegration as set by the British Pharmacopoeia (BP). Tablets had an average crushing strength of 121.56 ± 0.022 N. Tablets disintegrated within 52.00 seconds and a maximum weight loss of 0.68% occurred during the friability test. Weight variation of the tablets prepared from the FG formulation (formulation containing Granulac® 200) complied with the standards. Average crushing strength was 91.99 ± 6.008 N and the tablets disintegrated within 140.00 seconds. Percentage friability (1.024%) did not comply with the guideline of a percentage friability of less than 1%, however, no cracked or broken tablets were seen. Dissolution showed that 98, 93 and 94% of artesunate, proguanil and dapsone were respectively released (of the label value) within 15 minutes for the FA formulations. Release of artesunate, proguanil and dapsone for the FG formulation was 62, 85 and 92% for the same time period. The release of the three API’s (the FG formulation) increased to 78, 89 and 92%, respectively, after 45 minutes. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2012.

Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The rapid spread of resistance against antimalarial drugs, especially chloroquine and pyrimethamine–sulphadoxine, emphasises the need for new alternatives or modification of existing drugs. Artemisinin–based combination therapies (ACT’s) with different targets prevent or delay the development of drug resistance and therefore have been adopted as first–line therapy by all endemic countries. Proguanil–dapsone, an antifolate combination is more active than pyrimethamine–sulphadoxine and is being considered as an alternative to pyrimethamine–sulphadoxine. Artesunate–proguanil–dapsone is a new ACT that has wellmatched pharmacokinetics and is relatively rapidly eliminated; therefore there is a reduced risk of exposure to any single compound and potentially a decreasing risk of resistance. A few studies have been done on a triple fixed–dose combination therapy for malaria treatment and such a combination for artesunate, proguanil and dapsone are not currently investigated, manufactured or distributed. The aim of this study was to develop a triple fixed–dose combination for artesunate, proguanil and dapsone. The formulation was developed in three phases; basic formulation development, employing factorial design to obtain two possible optimised formulations and evaluating the optimised formulations. During the formulation development the most suitable manufacturing procedure and excipients were selected. A full 24 factorial design (four factors at two levels) was used to obtain the optimised formulations. As end–points to identify the optimised formulations, weight variation, friability, crushing strength and disintegration of the tablets, were used. Statistical analysis (one way ANOVA) was used to identify optimal formulations. To identify any interaction between the active pharmaceutical ingredients (API’s) and the API’s and excipients, differential scanning calorimetry was done. Flow properties of the powder mixtures (of the optimised formulations) were characterised by means of angle of repose; critical orifice diameter (COD); bulk density and tapped density; and flow rate. Tablets of the two optimised powder formulations were compressed. The tablets were evaluated and characterised in terms of weight variation, friability, crushing strength, disintegration and dissolution behaviour. Initial formulation development indicated that wet granulation was the most suitable manufacturing method. The results from the factorial design indicated that different amounts (% w/w) of the lubricant and binder as well as two different fillers influenced the weight variation, crushing strength and disintegration statistically significant. Two formulations containing two different fillers (microcrystalline cellulose or Avicel® PH 101, and lactose or Granulac® 200) were found to be within specifications and ideal for manufacturing. Tablets prepared from the FA formulation (formulation containing Avicel® PH 101) complied with the standards and guidelines for weight variation, friability, crushing strength and disintegration as set by the British Pharmacopoeia (BP). Tablets had an average crushing strength of 121.56 ± 0.022 N. Tablets disintegrated within 52.00 seconds and a maximum weight loss of 0.68% occurred during the friability test. Weight variation of the tablets prepared from the FG formulation (formulation containing Granulac® 200) complied with the standards. Average crushing strength was 91.99 ± 6.008 N and the tablets disintegrated within 140.00 seconds. Percentage friability (1.024%) did not comply with the guideline of a percentage friability of less than 1%, however, no cracked or broken tablets were seen. Dissolution showed that 98, 93 and 94% of artesunate, proguanil and dapsone were respectively released (of the label value) within 15 minutes for the FA formulations. Release of artesunate, proguanil and dapsone for the FG formulation was 62, 85 and 92% for the same time period. The release of the three API’s (the FG formulation) increased to 78, 89 and 92%, respectively, after 45 minutes. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2012.

The code observable of global navigation satellite systems (GNSS) is influenced by group delay variations (GDV) of transmitter and receiver antennas. For the Global Positioning System (GPS), the variations can sum up to 1 m in the ionosphere-free linear combination and thus can significantly affect precise code applications. The contribution of the GPS transmitters can amount to 0.8 m peak-to-peak over the entire nadir angle range. To verify the assumption of their time-invariance, we determined daily individual satellite GDV for GPS transmitter antennas over a period of more than two years. Dual-frequency observations of globally distributed reference stations and their multipath combination form the basis for our analysis. The resulting GPS GDV are stable on the level of a few centimeters for C1, P2, and for the ionosphere-free linear combination. Our study reveals that the inconsistencies of the GDV of space vehicle number (SVN) 55 with respect to earlier studies are not caused by temporal instabilities, but are rather related to receiver properties.

The code observable of global navigation satellite systems (GNSS) is influenced by group delay variations (GDV) of transmitter and receiver antennas. For the Global Positioning System (GPS), the variations can sum up to 1 m in the ionosphere-free linear combination and thus can significantly affect precise code applications. The contribution of the GPS transmitters can amount to 0.8 m peak-to-peak over the entire nadir angle range. To verify the assumption of their time-invariance, we determined daily individual satellite GDV for GPS transmitter antennas over a period of more than two years. Dual-frequency observations of globally distributed reference stations and their multipath combination form the basis for our analysis. The resulting GPS GDV are stable on the level of a few centimeters for C1, P2, and for the ionosphere-free linear combination. Our study reveals that the inconsistencies of the GDV of space vehicle number (SVN) 55 with respect to earlier studies are not caused by temporal instabilities, but are rather related to receiver properties.

Multifunktionella aspekter och flerdimensionella problem öppnar upp för användandet av geografiska informationssystem (GIS) vid beslutsfattande. Ett användningsområde i GIS är möjligheten att ta fram lämpliga områden, det innebär områden där flera lämpliga aspekter stämmer överens med varandra. Denna typ av lämplighetsanalys påverkas i hög grad av författaren samt beroende på analysmetod vilket i sin tur påverkar beslutsfattande. Denna studie syftar till att undersöka hur de val författaren gör påverkar metoden samt vilka konsekvenser det får för beslutsprocessen. Utifrån tidigare forskning har två analysmetoder identifierats, Analytic Hierarchy Process (AHP) och Weighted Linear Combination (WLC). För att kunna jämföra de två metoderna tar studien stöd i en exempelstudie från Linköpings tätort. Utifrån denna studie går det att se att författaren påverkar resultatet av kriterier och viktning men där det skiljer sig olika mycket mellan de två analysmetoderna AHP och WLC. AHP och WLC har både styrkor och svagheter som gör dem lämpliga för denna sorts studie. / Multifunctional aspects and multidimensional problems open up the use of geographic information systems (GIS) in decision-making. One area of ​​use in GIS is the site selection, the site selection combines areas with several suitable aspects. This type of suitability analysis is greatly influenced by the author and depending on the analysis method, which in turn affects decision-making. This study aims to investigate how the choices the author makes affect the method and what consequences it has for the decision-making process. Based on previous research, two analysis methods have been identified, Analytic Hierarchy Process (AHP) and Weighted Linear Combination (WLC). In order to compare the two methods, the study is supported by an example study from Linköping City. Based on this study, it can be seen that the author influences the results of criteria and weighting. However the two analysis methods AHP and WLC affect the study in different ways. AHP and WLC both have strengths and weaknesses that make them suitable for site selection studies.

South Africa’s electricity supply is under pressure. Mining is one of South Africa’s largest electricity consumers with electricity-intensive services such as compressed air, cooling, ventilation, etc. More than 40% of mine electricity consumption is used for cooling and ventilation. There is a need to reduce the operational cost on a mine as electricity prices are set to increase at least 2% above South Africa’s inflation target. The mine-cooling and ventilation system was investigated for energy cost-saving. No clear energy and cost-saving strategy for the entire mine-cooling and ventilation system was found. Projects are implemented ad hoc and scattered throughout the system. A strategy is needed to help realise the total saving available on the entire mine-cooling and ventilation system. An implementation strategy for load-management and energy-saving projects on a mine-cooling and ventilation system was developed. A peak clip project on the surface BAC was developed and added to the strategy. The resultant strategy attains all savings throughout the entire mine-cooling and ventilation system. A peak clip project on the surface BAC of a typical mine results in an annual saving of R1.4 million. Implementing this new project on other mines could save R11 million annually. Implementing the sequenced combination of cooperative projects on a typical mine results in a saving of R30 million. That is a saving of 38% on the ventilation and cooling cost and 16% on the total mine electricity bill. / PhD (Mechanical Engineering), North-West University, Potchefstroom Campus, 2014

South Africa’s electricity supply is under pressure. Mining is one of South Africa’s largest electricity consumers with electricity-intensive services such as compressed air, cooling, ventilation, etc. More than 40% of mine electricity consumption is used for cooling and ventilation. There is a need to reduce the operational cost on a mine as electricity prices are set to increase at least 2% above South Africa’s inflation target. The mine-cooling and ventilation system was investigated for energy cost-saving. No clear energy and cost-saving strategy for the entire mine-cooling and ventilation system was found. Projects are implemented ad hoc and scattered throughout the system. A strategy is needed to help realise the total saving available on the entire mine-cooling and ventilation system. An implementation strategy for load-management and energy-saving projects on a mine-cooling and ventilation system was developed. A peak clip project on the surface BAC was developed and added to the strategy. The resultant strategy attains all savings throughout the entire mine-cooling and ventilation system. A peak clip project on the surface BAC of a typical mine results in an annual saving of R1.4 million. Implementing this new project on other mines could save R11 million annually. Implementing the sequenced combination of cooperative projects on a typical mine results in a saving of R30 million. That is a saving of 38% on the ventilation and cooling cost and 16% on the total mine electricity bill. / PhD (Mechanical Engineering), North-West University, Potchefstroom Campus, 2014

Thesis (MSc)--Stellenbosch University, 2011. / ENGLISH ABSTRACT: An off-line signature verification system attempts to authenticate the identity of an individual by examining his/her handwritten signature, after it has been successfully extracted from, for example, a cheque, a debit or credit card transaction slip, or any other legal document. The questioned signature is typically compared to a model trained from known positive samples, after which the system attempts to label said signature as genuine or fraudulent. Classifier fusion is the process of combining individual classifiers, in order to construct a single classifier that is more accurate, albeit computationally more complex, than its constituent parts. A combined classifier therefore consists of an ensemble of base classifiers that are combined using a specific fusion strategy. In this dissertation a novel off-line signature verification system, using a multi-hypothesis approach and classifier fusion, is proposed. Each base classifier is constructed from a hidden Markov model (HMM) that is trained from features extracted from local regions of the signature (local features), as well as from the signature as a whole (global features). To achieve this, each signature is zoned into a number of overlapping circular retinas, from which said features are extracted by implementing the discrete Radon transform. A global retina, that encompasses the entire signature, is also considered. Since the proposed system attempts to detect high-quality (skilled) forgeries, it is unreasonable to assume that samples of these forgeries will be available for each new writer (client) enrolled into the system. The system is therefore constrained in the sense that only positive training samples, obtained from each writer during enrolment, are available. It is however reasonable to assume that both positive and negative samples are available for a representative subset of so-called guinea-pig writers (for example, bank employees). These signatures constitute a convenient optimisation set that is used to select the most proficient ensemble. A signature, that is claimed to belong to a legitimate client (member of the general public), is therefore rejected or accepted based on the majority vote decision of the base classifiers within the most proficient ensemble. When evaluated on a data set containing high-quality imitations, the inclusion of local features, together with classifier combination, significantly increases system performance. An equal error rate of 8.6% is achieved, which compares favorably to an achieved equal error rate of 12.9% (an improvement of 33.3%) when only global features are considered. Since there is no standard international off-line signature verification data set available, most systems proposed in the literature are evaluated on data sets that differ from the one employed in this dissertation. A direct comparison of results is therefore not possible. However, since the proposed system utilises significantly different features and/or modelling techniques than those employed in the above-mentioned systems, it is very likely that a superior combined system can be obtained by combining the proposed system with any of the aforementioned systems. Furthermore, when evaluated on the same data set, the proposed system is shown to be significantly superior to three other systems recently proposed in the literature. / AFRIKAANSE OPSOMMING: Die doel van ’n statiese handtekening-verifikasiestelsel is om die identiteit van ’n individu te bekragtig deur sy/haar handgeskrewe handtekening te analiseer, nadat dit suksesvol vanaf byvoorbeeld ’n tjek,’n debiet- of kredietkaattransaksiestrokie, of enige ander wettige dokument onttrek is. Die bevraagtekende handtekening word tipies vergelyk met ’n model wat afgerig is met bekende positiewe voorbeelde, waarna die stelsel poog om die handtekening as eg of vervals te klassifiseer. Klassifiseerder-fusie is die proses waardeer individuele klassifiseerders gekombineer word, ten einde ’n enkele klassifiseerder te konstrueer, wat meer akkuraat, maar meer berekeningsintensief as sy samestellende dele is. ’n Gekombineerde klassifiseerder bestaan derhalwe uit ’n ensemble van basis-klassifiseerders, wat gekombineer word met behulp van ’n spesifieke fusie-strategie. In hierdie projek word ’n nuwe statiese handtekening-verifikasiestelsel, wat van ’n multi-hipotese benadering en klassifiseerder-fusie gebruik maak, voorgestel. Elke basis-klassifiseerder word vanuit ’n verskuilde Markov-model (HMM) gekonstrueer, wat afgerig word met kenmerke wat vanuit lokale gebiede in die handtekening (lokale kenmerke), sowel as vanuit die handtekening in geheel (globale kenmerke), onttrek is. Ten einde dit te bewerkstellig, word elke handtekening in ’n aantal oorvleulende sirkulêre retinas gesoneer, waaruit kenmerke onttrek word deur die diskrete Radon-transform te implementeer. ’n Globale retina, wat die hele handtekening in beslag neem, word ook beskou. Aangesien die voorgestelde stelsel poog om hoë-kwaliteit vervalsings op te spoor, is dit onredelik om te verwag dat voorbeelde van hierdie handtekeninge beskikbaar sal wees vir elke nuwe skrywer (kliënt) wat vir die stelsel registreer. Die stelsel is derhalwe beperk in die sin dat slegs positiewe afrigvoorbeelde, wat bekom is van elke skrywer tydens registrasie, beskikbaar is. Dit is egter redelik om aan te neem dat beide positiewe en negatiewe voorbeelde beskikbaar sal wees vir ’n verteenwoordigende subversameling van sogenaamde proefkonynskrywers, byvoorbeeld bankpersoneel. Hierdie handtekeninge verteenwoordig ’n gereieflike optimeringstel, wat gebruik kan word om die mees bekwame ensemble te selekteer. ’n Handtekening, wat na bewering aan ’n wettige kliënt (lid van die algemene publiek) behoort, word dus verwerp of aanvaar op grond van die meerderheidstem-besluit van die basis-klassifiseerders in die mees bekwame ensemble. Wanneer die voorgestelde stelsel op ’n datastel, wat hoë-kwaliteit vervalsings bevat, ge-evalueer word, verhoog die insluiting van lokale kenmerke en klassifiseerder-fusie die prestasie van die stelsel beduidend. ’n Gelyke foutkoers van 8.6% word behaal, wat gunstig vergelyk met ’n gelyke foutkoers van 12.9% (’n verbetering van 33.3%) wanneer slegs globale kenmerke gebruik word. Aangesien daar geen standard internasionale statiese handtekening-verifikasiestelsel bestaan nie, word die meeste stelsels, wat in die literatuur voorgestel word, op ander datastelle ge-evalueer as die datastel wat in dié projek gebruik word. ’n Direkte vergelyking van resultate is dus nie moontlik nie. Desnieteenstaande, aangesien die voorgestelde stelsel beduidend ander kenmerke en/of modeleringstegnieke as dié wat in bogenoemde stelsels ingespan word gebruik, is dit hoogs waarskynlik dat ’n superieure gekombineerde stelsel verkry kan word deur die voorgestelde stelsel met enige van bogenoemde stelsels te kombineer. Voorts word aangetoon dat, wanneer op dieselfde datastel geevalueerword, die voorgestelde stelstel beduidend beter vaar as drie ander stelsels wat onlangs in die literatuur voorgestel is.

近年來，電腦技術突飛猛進，其功能及成本效益與往昔相比，真是不可同日而語。電 腦容量大、速度快、計算精確已成為會計資訊處理不可或缺的輔助工具。然傳統會計 觀念、程序限制了電腦功能的發揮。本研究是引用事件方法之會計觀念與觀連式資料 庫技術加以整合。由於會計觀念與電腦技術緊密結合，使得事件會計資訊系統充分運 用電腦的功能，並克服不少傳統會計資訊系統的缺失。文中將一一討論事件方法、資 料統一整合、關連式資料庫的觀念；並以簡易製造業為例，說明事件資訊系統的設計 及操作；最後，將專章討論事件會計資訊系統在內部管理決策中所發揮的功能。

Large variations in writing styles and difficulties in segmenting cursive words are the main reasons for handwritten cursive words recognition for being such a challenging task. An Indian postal document reading system based on a segmentation-free context based stochastic model is presented. The originality of the work resides on a combination of high-level perceptual features with the low-level pixel information considered by the former model and a pruning strategy in the Viterbi decoding to reduce the recognition time. While the low-level information can be easily extracted from the analyzed form, the discriminative power of such information has some limits as describes the shape with less precision. For that reason, we have considered in the framework of an analytical approach, using an implicit segmentation, the implant of high-level information reduced to a lower level. This enrichment can be perceived as a weight at pixel level, assigning an importance to each analyzed pixel based on their perceptual properties. The challenge is to combine the different type of features considering a certain dependence between them. To reduce the decoding time in the Viterbi search, a cumulative threshold mechanism is proposed in a flat lexicon representation. Instead of using a trie representation where the common prefix parts are shared we propose a threshold mechanism in the flat lexicon where based just on a partial Viterbi analysis, we can prune a model and stop the further processing. The cumulative thresholds are based on matching scores calculated at each letter level, allowing a certain dynamic and elasticity to the model. As we are interested in a complete postal address recognition system, we have also focused our attention on digit recognition, proposing different neural and stochastic solutions. To increase the accuracy and robustness of the classifiers a combination scheme is also proposed. The results obtained on different datasets written on Latin and Bengali scripts have shown the interest of the method and the recognition module developed will be integrated in a generic system for the Indian postal automation.