A técnica de análise de sobrevivência tem sido muito utilizada por pesquisadores na área de saúde. Neste trabalho foi usada uma distribuição em análise de sobrevivência recentemente estudada, chamada distribuição exponencial generalizada. Esta distribuição foi estudada sob todos os aspectos: para dados completos e censurados, sob a presençaa de covariáveis e considerando sua extensão para um modelo multivariado derivado de uma função cópula. Para exemplificação desta nova distribuição, foram utilizados dados reais de câncer (leucemia mielóide aguda e câncer gástrico) que possuem a presença de censuras e covariáveis. Os dados referentes ao câncer gástrico tem a particularidade de apresentar dois tempos de sobrevida, um relativo ao tempo global de sobrevida e o outro relativo ao tempo de sobrevida livre do evento, que foi utilizado para a aplicação do modelo multivariado. Foi realizada uma comparação com outras distribuições já utilizadas em análise de sobrevivência, como a distribuiçãoo Weibull e a Gama. Para a análise bayesiana adotamos diferentes distribuições a priori para os parâmetros. Foi utilizado, nas aplicações, métodos de simulação de MCMC (Monte Carlo em Cadeias de Markov) e o software Winbugs. / Survival analysis methods has been extensively used by health researchers. In this work it was proposed the use a survival analysis model recently studied, denoted as generalized exponential distribution. This distribution was studied in all respects: for complete data and censored, in the presence of covariates and considering its extension to a multivariate model derived from a copula function. To exemplify the use of these models, it was considered real cancer lifetime data (acute myeloid leukemia and gastric cancer) in presence of censored data and covariates. The assumed cancer gastric lifetime data has two survival responses, one related to the total lifetime of the patient and another one related to the time free of the disease, that is, multivariate data associated to each patient. In these applications there was considered a comparative study with standard existing lifetime distributions, as Weibull and gamma distributions.For a Bayesian analysis we assumed different prior distributions for the parameters of the model. For the simulation of samples of the joint posterior distribution of interest, we used standard MCMC (Markov Chain Monte Carlo) methods and the software Winbugs.

Os processos de decisão de Markov (Markov Decision Process - MDP) têm sido usados para resolução de problemas de tomada de decisão sequencial. Existem problemas em que lidar com os riscos do ambiente para obter um resultado confiável é mais importante do que maximizar o retorno médio esperado. MDPs que lidam com esse tipo de problemas são chamados de processos de decisão de Markov sensíveis a risco (Risk-Sensitive Markov Decision Process - RSMDP). Dentre as diversas variações de RSMDP, estão os trabalhos baseados em utilidade exponencial que utilizam um fator de risco, o qual modela a atitude a risco do agente e que pode ser propensa ou aversa. Os algoritmos existentes na literatura para resolver esse tipo de RSMDPs são ineficientes se comparados a outros algoritmos de MDP. Neste projeto, é apresentada uma solução que pode ser usada em problemas maiores, tanto por executar cálculos apenas em estados relevantes para atingir um conjunto de estados meta partindo de um estado inicial, quanto por permitir processamento de números com expoentes muito elevados para os ambientes computacionais atuais. Os experimentos realizados evidenciam que (i) o algoritmo proposto é mais eficiente, se comparado aos algoritmos estado-da-arte para RSMDPs; e (ii) o uso da técnica LogSumExp permite resolver o problema de trabalhar com expoentes muito elevados em RSMDPs. / Markov Decision Process (MDP) has been used very efficiently to solve sequential decision-making problems. There are problems where dealing with environmental risks to get a reliable result is more important than maximizing the expected average return. MDPs that deal with this type of problem are called risk-sensitive Markov decision processes (RSMDP). Among the several variations of RSMDP are the works based on exponential utility that use a risk factor, which models the agent\'s risk attitude that can be prone or averse. The algorithms in the literature to solve this type of RSMDPs are inefficient when compared to other MDP algorithms. In this project, a solution is presented that can be used in larger problems, either by performing calculations only in relevant states to reach a set of meta states starting from an initial state, or by allowing the processing of numbers with very high exponents for the current computational environments. The experiments show that (i) the proposed algorithm is more efficient when compared to state-of-the-art algorithms for RSMDPs; and (ii) the LogSumExp technique solves the problem of working with very large exponents in RSMDPs

Muitos equipamentos utilizados para quantificar substâncias, como toxinas em alimentos, freqüentemente apresentam deficiências para quantificar quantidades baixas. Em tais casos, geralmente indicam a ausência da substância quando esta existe, mas está abaixo de um valor pequeno \'ksi\' predeterminado, produzindo valores iguais a zero não necessariamente verdadeiros. Em outros casos, detectam a presença da substância, mas são incapazes de quantificá-la quando a quantidade da substância está entre \'ksai\' e um valor limiar \'tau\', conhecidos. Por outro lado, quantidades acima desse valor limiar são quantificadas de forma contínua, dando origem a uma variável aleatória contínua X cujo domínio pode ser escrito como a união dos intervalos, [ómicron, \"ksai\'), [\"ksai\', \'tau\' ] e (\'tau\', ?), sendo comum o excesso de valores iguais a zero. Neste trabalho, são propostos modelos que possibilitam discriminar a probabilidade de zeros verdadeiros, como o modelo de mistura com dois componentes, sendo um degenerado em zero e outro com distribuição contínua, sendo aqui consideradas as distribuições: exponencial, de Weibull e gama. Em seguida, para cada modelo, foram observadas suas características, propostos procedimentos para estimação de seus parâmetros e avaliados seus potenciais de ajuste por meio de métodos de simulação. Finalmente, a metodologia desenvolvida foi ilustrada por meio da modelagem de medidas de contaminação com aflatoxina B1, observadas em grãos de milho, de três subamostras de um lote de milho, analisados no Laboratório de Micotoxinas do Departamento de Agroindústria, Alimentos e Nutrição da ESALQ/USP. Como conclusões, na maioria dos casos, as simulações indicaram eficiência dos métodos propostos para as estimações dos parâmetros dos modelos, principalmente para a estimativa do parâmetro \'delta\' e do valor esperado, \'Epsilon\' (Y). A modelagem das medidas de aflatoxina, por sua vez, mostrou que os modelos propostos são adequados aos dados reais, sendo que o modelo de mistura com distribuição de Weibull, entretanto, ajustou-se melhor aos dados. / Much equipment used to quantify substances, such as toxins in foods, is unable to measure low amounts. In cases where the substance exists, but in an amount below a small fixed value \'ksi\' , the equipment usually indicates that the substance is not present, producing values equal to zero. In cases where the quantity is between \'\'ksi\' and a known threshold value \'tau\', it detects the presence of the substance but is unable to measure the amount. When the substance exists in amounts above the threshold value ?, it is measure continuously, giving rise to a continuous random variable X whose domain can be written as the union of intervals, [ómicron, \"ksai\'), [\"ksai\', \'tau\' ] and (\'tau\', ?), This random variable commonly has an excess of zero values. In this work we propose models that can detect the probability of true zero, such as the mixture model with two components, one being degenerate at zero and the other with continuous distribution, where we considered the distributions: exponential, Weibull and gamma. Then, for each model, its characteristics were observed, procedures for estimating its parameters were proposed and its potential for adjustment by simulation methods was evaluated. Finally, the methodology was illustrated by modeling measures of contamination with aflatoxin B1, detected in grains of corn from three sub-samples of a batch of corn analyzed at the laboratory of of Mycotoxins, Department of Agribusiness, Food and Nutrition ESALQ/USP. In conclusion, in the majority of cases the simulations indicated that the proposed methods are efficient in estimating the parameters of the models, in particular for estimating the parameter ? and the expected value, E(Y). The modeling of measures of aflatoxin, in turn, showed that the proposed models are appropriate for the actual data, however the mixture model with a Weibull distribution fits the data best.

ANOVA analysis is a classic tool for multiple comparisons and has been widely used in numerous disciplines due to its simplicity and convenience. The ANOVA procedure is designed to test if a number of different populations are all different. This is followed by usual multiple comparison tests to rank the populations. However, the probability of selecting the best population via ANOVA procedure does not guarantee the probability to be larger than some desired prespecified level. This lack of desirability of the ANOVA procedure was overcome by researchers in early 1950's by designing experiments with the goal of selecting the best population. In this dissertation, a single-stage procedure is introduced to partition k treatments into "good" and "bad" groups with respect to a control population assuming some key parameters are known. Next, the proposed partition procedure is genaralized for the case when the parameters are unknown and a purely-sequential procedure and a two-stage procedure are derived. Theoretical asymptotic properties, such as first order and second order properties, of the proposed procedures are derived to document the efficiency of the proposed procedures. These theoretical properties are studied via Monte Carlo simulations to document the performance of the procedures for small and moderate sample sizes.

Electronics for automotive needs to be able to handle different situations that can occur on the power line, such as high voltage transients. ISO16750 and ISO-7637 describes different pulses and tests a system needs to be able to handle. This report compares three different protection circuits that can output +5V and +12V built for low power devices. The circuits use different techniques for protection, one that uses TVS diodes, another that uses a voltage regulator IC with built in protection. The last protection uses P-channel MOSFET’s for protection. The circuits are compared against protection, price and leakage current. The most relevant transients to test a system against are decided to be pulse1, pulse 2a and load dump. A pulse generator consisting of a pulse shaping network and a common drain amplifier is used to create the test pulses. The result shows that all the circuits could protect against pulse 2a and load dump. However, all the circuits did fail against pulse 1 due to an undersized diode for negative voltage protection. The leakage current did not exceed 4µA for two of the circuits in the temperature interval of -40°C to +100°C. All the circuits started to have high leakage current when the temperature got up to +150°C. The price for the circuits didn’t differ that much, all the circuits cost below 3 US-dollar per circuit when making 10 000 circuits. The conclusions that could be made of the results are that all the circuits could protect against pulse 1, pulse 2a and load dump if correct diode is used for negative voltage protection. The protection that builds on Pchannel MOSFET’s should be the best choice for low power devices due to its low leakage current and potential for low cost. The disadvantage is the complexity and number of components needed for the circuit. The TVS diodes should be used if low complexity and low number of components is preferred. The disadvantage is that TVS diodes gets hot if a load dump is applied and the interval between stand-off voltage and maximum clamping voltage is quite high. The study also shows that there are cheaper solutions than using TVS diodes.

<p>In this thesis the double exponential jump-diffusion model is considered and the Laplace transform is used as a method for pricing both plain vanilla and path-dependent options. The evolution of the underlying stock prices are assumed to follow a double exponential jump-diffusion model. To invert the Laplace transform, the Euler algorithm is used. The thesis includes the programme code for European options and the application to the real data. The results show how the Kou model performs on the NASDAQ OMX Stockholm Market in the case of the SEB stock.</p>

In this thesis the double exponential jump-diffusion model is considered and the Laplace transform is used as a method for pricing both plain vanilla and path-dependent options. The evolution of the underlying stock prices are assumed to follow a double exponential jump-diffusion model. To invert the Laplace transform, the Euler algorithm is used. The thesis includes the programme code for European options and the application to the real data. The results show how the Kou model performs on the NASDAQ OMX Stockholm Market in the case of the SEB stock.

Disturbances introduced in wall-bounded flows can grow and lead to transition from laminar to turbulent flow. In order to reduce losses or enhance mixing in energy systems, a fundamental understanding of the flow stability and transition mechanism is important. In the present thesis, the stability, transition mechanism and early turbulent evolution of wall-bounded flows are studied. The stability is investigated by means of linear stability equations and the transition mechanism and turbulence are studied using direct numerical simulations. Three base flows are considered, the Falkner-Skan boundary layer, boundary layers subjected to wall suction and the Blasius wall jet. The stability with respect to the exponential growth of waves and the algebraic growth of optimal streaks is studied for the Falkner-Skan boundary layer. For the algebraic growth, the optimal initial location, where the optimal disturbance is introduced in the boundary layer, is found to move downstream with decreased pressure gradient. A unified transition prediction method incorporating the influences of pressure gradient and free-stream turbulence is suggested. The algebraic growth of streaks in boundary layers subjected to wall suction is calculated. It is found that the spatial analysis gives larger optimal growth than temporal theory. Furthermore, it is found that the optimal growth is larger if the suction begins a distance downstream of the leading edge. Thresholds for transition of periodic and localized disturbances as well as the spreading of turbulent spots in the asymptotic suction boundary layer are investigated for Reynolds number Re=500, 800 and 1200 based on the displacement thickness and the free-stream velocity. It is found that the threshold amplitude scales like Re^-1.05 for transition initiated by streamwise vortices and random noise, like Re^-1.3 for oblique transition and like Re^-1.5 for the localized disturbance. The turbulent spot is found to take a bullet-shaped form that becomes more distinct and increases its spreading rate for higher Reynolds number. The Blasius wall jet is matched to the measured flow in an experimental wall-jet facility. Both the linear and nonlinear regime of introduced waves and streaks are investigated and compared to measurements. It is demonstrated that the streaks play an important role in the breakdown process where they suppress pairing and enhance breakdown to turbulence. Furthermore, statistics from the early turbulent regime are analyzed and reveal a reasonable self-similar behavior, which is most pronounced with inner scaling in the near-wall region. / QC 20101025

Certain hydrogel forming de novo proteins that utilize different crosslinking methods are studied experimentally on a rheometer. The stress reaxation modulus of CRC, a telechelic, triblock protein, is shown to be that of a stretched exponential function with a value of β ≅ 0.5. The insertion of an integrin binding domain and changes in pH within the range 6.5–8.5 are shown not to significantly affect the resulting rheological behavior. A selective chemical crosslinker is used on CRC hydrogel systems and is shown to change the rheological behavior of the system to that of a combination of a chemically and physically crosslinked system. Chemically crosslinked hydrogels composed of W6, a wheat gluten-based protein, demonstrate a storage modulus weakly dependent on the angular frequency that is much greater than the loss modulus, with a modulus concentration dependence of c^9/4.

Certain hydrogel forming de novo proteins that utilize different crosslinking methods are studied experimentally on a rheometer. The stress reaxation modulus of CRC, a telechelic, triblock protein, is shown to be that of a stretched exponential function with a value of β ≅ 0.5. The insertion of an integrin binding domain and changes in pH within the range 6.5–8.5 are shown not to significantly affect the resulting rheological behavior. A selective chemical crosslinker is used on CRC hydrogel systems and is shown to change the rheological behavior of the system to that of a combination of a chemically and physically crosslinked system. Chemically crosslinked hydrogels composed of W6, a wheat gluten-based protein, demonstrate a storage modulus weakly dependent on the angular frequency that is much greater than the loss modulus, with a modulus concentration dependence of c^9/4.