This paper is part of the practical bachelor’s thesis that is reporting the details of the process of creating a new website called Access: Hearing world. The website is aimed to provide information about new smartphone applications for the targeted group of users. These users consist of sign language speaking deaf and hearing impaired individuals. This paper illustrates the pilot study that gave the website its foundation and the information the website needed to take shape. Also included in the paper is that choices that were made during the process of the creation of the website and what methods were used along the way. The subliminal theory that were used during the entire process was human-computer interaction especially usability and user-friendliness. This was measured and analyzed with two analyzing methods, these were PACT and SWOT. / Denna rapport handlar om skapandeprocessen bakom en ny samlingssida för smartphoneapplikationer som är riktad till döva och hörselskadade. Denna webbsida ska kunna ge ny information om nya smartphoneapplikationer oavsett vilken plattform användarna nyttjar. Denna rapport tar upp förstudien som utfördes innan webbsidan skapades för att kartlägga behoven fanns. Den tar även upp själva utförandet av webbsidan och vilka val som gjordes under den processen. Resultatet som utgår från det test som gjordes kommer också att återges genom en PACT-analys. Därefter kommer webbsidan att diskuteras och utvärderas genom en SWOT-analys för att belysa det som är styrkan, svagheten, möjligheten och hoten med Access: Hearing world som webbsidan heter.

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II Lietuvos Seimas 1923 – 1926 m. Santrauka. Lietuva, 1918 m. paskelbusi nepriklausomybę, pasuko demokratijos keliu. Lietuvos piliečiai galėjo tiesiogiai rinkti atstovus į Seimą, kurie atstovavo jų interesus. Istorikai daugiau tyrė Steigiamojo Seimo veiklą, nes šis Seimas padėjo pamatus tolesniam teisinės valstybės gyvavimui, nemažai tirtas III Seimas dėl savo darbų ir prezidento A. Smetonos įvykdyto valstybės perversmo. II Seimas mažai susilaukė dėmesio, todėl istorikams lieka aktualu užpildyti parlamentarizmo tyrimuose spragas. Šio darbo tikslas – išanalizuoti II Seimo veiklą, nuveiktus darbus. Tikslui pasiekti keliami uždaviniai: 1. pateikti politinės situacijos II Seimo išvakarėse apžvalgą, 2. išanalizuoti II Seimo rinkimų eigą ir rezultatus, 3. pristatyti Seimo kiekybinius ir kokybinius rodiklius, bei 4. aptarti atliktus Seimo darbus vidaus (politinėje, kultūrinėje, ekonominėje ir tautinėje sferoje) ir užsienio politikoje. Pirmajame Seime (1922 – 1923 m.) iš 78 Seimo narių – 38 buvo krikščionys demokratai (pozicija), o kita dalis opozicinės frakcijos. Toks skaičius lėmė, kad opozicija ir pozicija negal���jo tinkamai dirbti. Opozicija ginčijo Respublikos prezidento, vyriausybės išrinkimo teisėtumą (legitimumą), nesutardavo svarbiais klausimais. Todėl prezidentas A. Stulginskis 1923 kovo 13 d. paleido I Seimą. 1923m. gegužės 12-13 d. įvyko rinkimai į Antrąjį Seimą, kurie parodė, kad šį kartą rinkėjai buvo aktyvesni. Antrajame Seime daugiausia vietų iškovojo krikščionių... [toliau žr. visą tekstą] / The second Seimas of the Republic of Lithuania 1923 - 1926 Raimundas Trinkūnas Summary Lithuania, declared its independency in 1918, turned to the democracy way. Lithuanians were able to elect representatives directly to Seimas, who represented their interests. Historians started studying more about Constituve Seimas work, because this Seimas put the base for the further life of the juridical state existence, the III Seimas was researched quite in an intensive way as well because of its works and the revolution carried out by the president A. Smetona. The II Seimas got quite little attention. Due to that, it is of present interest to historians to fill the gaps in the researches of parliamentarism. The aims of this work – to analyze the movement and achieved works of the II Seimas. These tasks are raised in order to reach the aim: 1) to produce the review of the II Seimas Eve political situation; 2) to analyze the II Seimas election course and results; 3) to present the quantitive and qualitive indexes of Seimas, and: 4) to discuss about Seimas achieved works in inner (political, cultural, economical and national sphere) and foreign policy. From the 78 Seimas members in the First Seimas (1922-1923) – 38 members were Christian Democrats (position), and the others were opposition fractions. Because of such a number, position and opposition couldn’t work in a proper way. The opposition argued about Republic president, state election legitimacy, and disagreed about important... [to full text]

Myotonic Dystrophy type 1 (DM1), the most common form of adult muscular dystrophy (~1:8000) currently has no effective treatment. In DM1, expansion of a tri-nucleotide repeat in the 3' UTR of the DMPK gene results in DMPK mRNA hairpin structures, aggregating as insoluble ribonuclear foci. The resulting mis-regulation of important splicing factors, causes the inclusion of fetal exons in dozens of transcripts that contribute to the disease phenotype. In order to identify novel gene targets and kinase signalling pathways for potential therapeutics we have performed a high-throughput RNAi. RNA foci were visualized and quantified by in-situ hybridization. From our screen, we have identified a novel gene, PACT, as a modulator of foci integrity and that PACT knockdown can induce MBNL1 protein levels. The identified signalling complex represents a valid target for DM1 therapeutics. Our data further emphasizes the utility of RNAi screens in identifying disease-associated genes.

There is a huge need for information when you arrive as an immigrant in a new country. The purpose of the study is to find out recommendations for an information portal for newly arrived immigrants in Sweden. First, a survey was conducted to the webmasters of relevant authorities online resources regarding their ways of considering the needs of immigrant users. The answers showed that the webmasters of the official websites showed interest in considering the needs of immigrants in their websites by including pages in different languages, but most of them considered this to be difficult, expensive and problematic. To know more about a particular user group, a survey, interviews and observations have been done. A survey to newly arrived immigrants showed that their ICT skills are comparable to the average of Swedish citizens. In spite of differences within the immigrant group, like age, gender and cultural factors, they also shared common characteristics. Most of the immigrants trusted Swedish websites and Swedish authorities websites as reliable information resources more than websites in their mother-tongue. Test-persons were faced with the task of finding information about the possibility to borrow money for furniture for the first home in Sweden, our observations showed that very few of the test-persons managed to find their way to the correct authority webpage (Studiemedels-nämnden). Most test-persons tried by using many ways to search for the information, but all except two gave up. None of the test-persons managed to find the pages that were translated to their mother-tongue. The study points out the need for a systematical approach to web information for newly arrived immigrants to help them with their integration process and benefit from Swedish e-government services. A central multilingual portal website should be the heart of this program. This approach can be introduced in SFI schools given that all SFI schools are supplied with computers.

Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-05-13T19:15:37Z No. of bitstreams: 1 Mariana Rocha Santos Costa.pdf: 682333 bytes, checksum: 376b940d62e35ad0fe0a259f571e47ae (MD5) / Approved for entry into archive by Rodrigo Meirelles(rodrigomei@ufba.br) on 2013-05-16T17:17:21Z (GMT) No. of bitstreams: 1 Mariana Rocha Santos Costa.pdf: 682333 bytes, checksum: 376b940d62e35ad0fe0a259f571e47ae (MD5) / Made available in DSpace on 2013-05-16T17:17:22Z (GMT). No. of bitstreams: 1 Mariana Rocha Santos Costa.pdf: 682333 bytes, checksum: 376b940d62e35ad0fe0a259f571e47ae (MD5) Previous issue date: 2010 / O presente trabalho tem como objetivo a discussão da representação literária do pacto fraterno e a forma como este se configura enquanto simbologia da aliança nacional. Tomando como ponto de partida o enredo bíblico de Esaú e Jacó, irmãos gêmeos que se digladiam no contexto familiar, pretende-se analisar de que forma os romances Esaú e Jacó, de Machado de Assis e Dois Irmãos, escrito por Milton Hatoum se apropriam desse motivo para comentar os conflitos nacionais, em épocas distintas da história do Brasil. Reflexões acerca da discórdia familiar, da figura do duplo enquanto inimigo primevo, das diversas acepções que o termo ‘nação’ abarca, bem como do papel que cada um dos personagens gêmeos desempenha no decorrer das tramas, são conduzidas pelo intuito de iluminar as relações possíveis entre os textos literários e a história. Este estudo focaliza a premissa de que uma sociedade apenas se estabelece através de pactos. Os romances ora analisados também ilustram a forma como os acontecimentos domésticos entram em conexão com o meio social. / Salvador

Made available in DSpace on 2014-06-11T19:29:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-12-07Bitstream added on 2014-06-13T20:59:03Z : No. of bitstreams: 1 santos_vf_me_assis.pdf: 663507 bytes, checksum: 86402c11b4a071a9b47705452a750f08 (MD5) / Esta pesquisa nasce da experiência de alguns anos de acompanhamento psicossocial a adolescentes que cometeram atos infracionais, cumprindo medida sócio-educativa de internação em uma das unidades da FEBEM, hoje chamada de Fundação CASA. Partindo da perplexidade diante do mundo entre grades e muralhas que o trabalho cotidiano desvela, este estudo vai tomando direção com a lapidação de sentimentos e com a incessante busca de sentido para as relações que o ‘outro’ mundo revela. A organização peculiar do grupo de internos, regida por códigos e regras trazidas das leis do ‘crime organizado’, cuja história e relações com a dinâmica dos adolescentes são traçadas, inclusive em suas peculiaridades institucionais, demanda o questionamento da ‘lei’ que nos fundamenta a viver em sociedade. Diante do trânsito constante entre vítimas e agressores, pacto edípico e pacto social aparecem com toda a contradição evidenciada nas histórias familiares e na cultura institucional criada por esses meninos – homens – vítimas – bandidos. A despeito das considerações do vivido durante esses anos de trabalho, especialmente em 2003, o material de análise é produzido por meio de entrevistas a três adolescentes, cuja investigação fora pautada nas relações do adolescente com sua família, com a lei social e com a lei do crime, fundamentada pela teoria e método psicanalíticos, via leitura do sentimento de pertença familiar exposto por cada um deles. Tendo como objetivo geral analisar a relação entre crime e violência com o sentido de lei introjetado pelo adolescente no decorrer de sua história, da qual faz sua leitura expondo o inconsciente familiar que fundamenta seu sentimento de pertença... / This research is based on the experience of some years of psychosocial accompaniment to adolescents that committed acts of infraction, accomplishing socio-educational measure of internment in the units of internment of former FEBEM, today called CASA Foundation. Considering the perplexity of the world’s view behind bars and walls that the daily work demonstrates, this study will be molded by the feelings and with the incessant sense pursuit of different kinds of relationships that the other world reveals. The peculiar organization of the interns' group, governed by codes and rules brought of the organized crime, whose history and relationship with the adolescents' dynamics are traced, besides in their institutional peculiarities, the questioning of the law that bases the living in society. Facing the constant transit between victims and aggressors, edipic pact and social pact appears controversial and evidenced in their family histories and in the institutional culture created by those boys - men - victims - thieves. In spite of the experience of those years of work, especially in 2003, the material was analyzed and produced through interviews at three adolescents that they were deprived of freedom, whose investigation was ruled in the adolescent's relationships with their family, with the social law and with the law of the crime, based by the theory and method psychoanalytic, through comprehension of the feeling of belongs exposed for the adolescents. Tends as general objective to analyze the relationship among crime and violence with the sense of law introjected for the adolescent in elapsing their familiar history, which makes their interpretation by exposing their family unconscious that bases their feeling of belonging, we analyzed the effect of the execution or breaking... (Complete abstract click electronic access below)

Myotonic Dystrophy type 1 (DM1), the most common form of adult muscular dystrophy (~1:8000) currently has no effective treatment. In DM1, expansion of a tri-nucleotide repeat in the 3' UTR of the DMPK gene results in DMPK mRNA hairpin structures, aggregating as insoluble ribonuclear foci. The resulting mis-regulation of important splicing factors, causes the inclusion of fetal exons in dozens of transcripts that contribute to the disease phenotype. In order to identify novel gene targets and kinase signalling pathways for potential therapeutics we have performed a high-throughput RNAi. RNA foci were visualized and quantified by in-situ hybridization. From our screen, we have identified a novel gene, PACT, as a modulator of foci integrity and that PACT knockdown can induce MBNL1 protein levels. The identified signalling complex represents a valid target for DM1 therapeutics. Our data further emphasizes the utility of RNAi screens in identifying disease-associated genes.

Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-04-14T19:38:44Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Saulo_Bezerra_Xavier_Dissertação.pdf: 784596 bytes, checksum: f2f09773e562b063c573910c1fa2752a (MD5) / Made available in DSpace on 2016-04-14T19:38:44Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Saulo_Bezerra_Xavier_Dissertação.pdf: 784596 bytes, checksum: f2f09773e562b063c573910c1fa2752a (MD5) Previous issue date: 2014-10-31 / O Pacto pela Saúde no Brasil foi implantado com o objetivo de qualificar o processo de descentralização e organização das gestões, e de os gestores assumirem o compromisso público dessa construção, com base nos princípios constitucionais, definindo prioridades, utilizando recursos com eficiência e melhorando a qualidade de saúde da população. Considerando a importância da adesão ao Pacto pela Saúde, o estudo busca responder se este compromisso pactuado pelos municípios de Pernambuco influenciou na melhoria do bem-estar social e da eficiência na gestão dos recursos. Portanto, o trabalho busca avaliar os efeitos da adesão ao Pacto pela Saúde sobre os gastos e indicadores de saúde dos municípios de Pernambuco. O método utilizado para avaliação dos dados foi o de Diferenças em Diferenças (DD), que permite comparar municípios em grupos homogêneos, com correção de contra factuais, e estimar o efeito do Pacto por meio de análise de regressão. O estudo foi desenvolvido em três modelos: o modelo 1 é utilizado na análise do grupo de todos os municípios do estado, e os modelos 2 e 3, na avaliação dos municípios que fazem parte de grupos homogêneos, segundo os critérios do Índice de Desempenho do SUS (IDSUS). O estudo revelou que, conforme o modelo 1, a adesão ao Pacto pela Saúde provocou efeitos sobre o aumento dos gastos absolutos e também nas despesas com recursos humanos, porém apresentou pequeno impacto sobre o bem-estar social, com relação positiva apenas na cobertura vacinal. O modelo 2 identifica efeito apenas sobre as variáveis de gastos em saúde e o modelo 3 mostra impacto positivo sobre as variáveis dos indicadores de cobertura vacinal e pré-natal, sem influência sobre as variáveis de gastos em saúde. O indicador de mortalidade infantil não sofreu influência em nenhum dos modelos avaliados. Diante do estudo, no estado de Pernambuco, o Pacto pela Saúde ainda busca consolidação como a grande política de descentralização e mudança na saúde da população / The Pact for Health in Brazil was implemented in order to qualify the process of decentralization and organization of efforts, and managers take the public commitment of this construction, based on constitutional principles, defining priorities, using resources efficiently and improving the quality population health. Considering the importance of adherence to the Pact for Health, the study seeks to answer is this commitment agreed by Pernambuco municipalities influenced the improvement of social welfare and efficiency in resource management. Therefore, the study sought to determine the effects of accession to the Covenant on health spending and health indicators of Pernambuco municipalities. The method used to evaluate the data was the differences in differences (DD), which allows you to compare municipalities in homogeneous groups, with correction of factual against, and estimate the effect of the Covenant by regression analysis. The study was conducted in three models: Model 1 is used to analyze the group of all municipalities in the state, and models 2 and 3, in the evaluation of the municipalities that are part of homogeneous groups, according to the Performance Index criteria SUS (IDSUS). The study found that, depending on the model 1, adherence to the Pact for Health caused effects on the increase in absolute spending and also in human resources expenditures, but had little impact on the social well-being, positive relationship only in immunization coverage. Model 2 identifies effect only on the variables of health expenditures and the 3 model shows positive impact on the variables of the immunization coverage indicators and prenatal without influence on health spending variables. The infant mortality indicator was not affected in any of the evaluated models. Before the study, in the state of Pernambuco, the Pact for Health still seeking consolidation as a great decentralization policy and change in population health.

Yes / Purpose – The objective of this study is to understand the budgetary role of national legislatures in Euro Area (EA) countries and to analyse implications for fiscal discipline. Design/methodology/approach – Building on the budget institutions literature, a legislative budgetary power index for all the 19 EA countries is constructed using OECD and European Commission data as well as data generated from questionnaires to national authorities. A two-way fixed effects panel data model is then used to assess the effect of legislative budgetary power on the budget balance in the EA during 2006-15. Findings - Overall, in the EA, formal legislative powers vis-à-vis the national budgetary process are weak but there is more legislative involvement in SGP procedures and legislative budgetary organisational capacity is generally quite good. In contrast to the traditional view in the budget institutions literature, our empirical findings show that strong legislative budgetary power does not necessarily result in larger budget deficits. Research limitations/implications – Data on legislative budgeting was available from different sources and timeseries data was very limited. Practical implications – There is scope to improve democratic legitimacy of the national budgetary process in the EA, without necessarily jeopardising fiscal discipline. Originality/value – The constructed legislative budgetary power index covers all the 19 EA countries and has a broad scope covering various novel institutional characteristics. The empirical analysis contributes to the scarce literature on the impact of legislative budgeting on fiscal discipline.