We consider the problem of secure communications in a Gaussian two-way relay network where two nodes exchange confidential messages only via an untrusted relay. The relay is assumed to be honest but curious, i.e., an eavesdropper that conforms to the system rules and applies the intended relaying scheme. We analyze the achievable secrecy rates by applying network coding on the physical layer or the network layer and compare the results in terms of complexity, overhead, and efficiency. Further, we discuss the advantages and disadvantages of the respective approaches.

No description available.

An AC system’s voltage unbalance by a fundamental frequency negative sequence system is usually the main cause for the emission of non-characteristic harmonics by current source converters as used in conventional HVDC systems. This emission takes place on both sides of each 12-pulse converter. On the DC side mainly a 2nd harmonic voltage appears driving a 2nd harmonic current. The magnitude of this harmonic current can exceed the magnitudes of the characteristic harmonics even if no low order resonance exists. Further non-characteristic harmonics generated by the converter under such unbalanced supply voltage conditions have frequencies with a frequency distance to the characteristic harmonics of 2 times the fundamental frequency. The main technical drawbacks are the unintended coupling between both AC systems and the risk of thyristor over-stresses by DC current discontinuities at low power transfer levels. On both AC sides the largest 2 non-characteristic current harmonics generated by a 12-pulse HVDC converter under unbalanced supply voltage conditions are a negative sequence system of the fundamental harmonic and a positive sequence system of the 3rd harmonic. Also on the AC sides further harmonics are emitted by the converter with a order number distance of 2 to the orders of the characteristic harmonics. However, in practical AC system operation special attention has to be paid to the 3rd harmonic distortion level, in particular when low order resonance appears between the system impedance and the impedance of the converter station AC filters. In order to avoid the above mentioned problems, large smoothing reactors and sometimes large blocking filters are installed on the DC side and the voltage distortion on the AC sides is reduced by AC filters. However, these filters require an expensive high component rating if they are tuned to the 2nd or 3rd harmonic respectively. The work shows that a modification of the valve firing can reduce the levels of the 2nd and 3rd harmonic without investment into additional primary equipment. Furthermore, this offers the chance to reduce the minimum power transfer level since also the risk of an intermittent DC current can be reduced. A corresponding algorithm and a control strategy are proposed. However, the calculation of an appropriate firing pattern requires a detailed modelling of the processes within the converters, especially the formation of the harmonics and the harmonic transfer between AC and DC sides. The work proposes a component vector model for the calculation of the harmonics. This model assumes that each harmonic consists of a first component representing the ideal conversion process, a 2nd component representing the impact of different commutation angles and in the case of the modified firing a 3rd component considering the impact of the intended non-equidistant firing. The work shows, that the harmonic component vectors resulting from voltage unbalance and from firing modulation can be treated separately and superimposed linearly. The calculation of the harmonic component vectors is performed applying the method of switching functions. For the consideration of the commutation and firing angle differences the modelling of switching functions based on differential impulses is proposed. However, especially an accurate representation of the above mentioned 2nd component vector requires a correct calculation of the commutation angles and their valve-specific differences. The investigations of this work have revealed that the conventional method of calculating the commutation angles – assuming an ideal smoothed DC current - may not produce results of sufficient accuracy. This is especially true in the case of a high ripple of the DC current, e.g. smoothed with a small smoothing reactor. A small smoothing reactor is typical for HVDC back-to-back applications. Therefore a new analytical method for the calculation of the commutation angles has been developed which in particular considers the typical pulse form of the DC current and additionally the impacts of the voltage unbalance and of the proposed modification of the firing on the ripple shape of the DC current. Moreover, as this analytical method requires the instantaneous values of the DC current at the instants of valve firing, a further analytical method for the calculation of these discrete current values has been developed. The equations are valid under the same conditions as the new ones for calculation of the commutation angles, i.e. resistive-inductive AC system fundamental frequency impedances, any degree of DC current smoothing between ideal smoothing and a ripple at the limit for current discontinuities. Symmetrical conditions, supply voltage unbalances and non-equidistant firing as proposed are applied. It is shown that, using this method, also the discrete values of the DC current at the end of the commutation intervals can be determined. In practice one of these discrete current values indicates the minimum value during one period of the fundamental frequency. This offers the chance for a more exact analytical determination of the limit for the appearance of DC current discontinuities. For typical parameters of a back-to-back installation the new methods and the new analytical equations have been compared with simulation results showing excellent correlation for typical voltage unbalances of not more than 1...2% and firing angle differences of not more than 2.5°. This verification is performed for the harmonics, the commutation angles and the discrete values of the DC current at the firing instants as well.

Symbiosis between bacteria and single celled eukaryotes, such as ciliates and amoebae, is a widespread phenomenon. In the past years, the number of species characterizations of symbiotic bacteria, has constantly grown. Especially members of the order Rickettsiales (Alphaproteobacteria), which comprises obligate intracellular human and animal pathogens as well as other non-pathogenic intracellular species, got into the focus. However, biodiversity of both, protists and associated bacterial symbionts, is still largely underestimated. Thus, I hypothesised that different kind of bacteria occur naturally in the ciliate Paramecium, that paramecia can serve as potential reservoir for human and animal pathogens, and that the species distribution of Paramecium and its endosymbionts shows geographical patterns. In the present thesis, I provide data on the distribution and diversity of Paramecium species and their endosymbionts isolated from freshwater and brackish habitats from North and South America. The most frequent species were Paramecium biaurelia, Paramecium caudatum and Paramecium multimicronucleatum for the North American samples as well as P. multimicronucleatum and Paramecium calkinsi for the South American samples indicating geographical differences in the species distribution of Paramecium between the two continents. Monoclonal cultures were screened for the presence of endosymbionts by fluorescence in situ hybridization (FISH) using universal and specific probes. I detected bacterial endosymbionts belonging to different taxa of Rickettsiales sensu lato in Paramecium-cultures isolated from eight different habitats. Moreover, I characterized the four novel endosymbiont species “Candidatus Fokinia solitaria”, “Candidatus Fokinia cryptica”, “Candidatus Bealeia paramacronuclearis” and “Candidatus Jurandia parameciophila”, respectively, presenting detailed descriptions. Thus, I did not only detect various bacterial symbionts in different host species from two continents, but I also identified bacteria related to human and animal pathogens. Moreover, phylogenetic information provided by the four novel bacterial species helped me to revise the taxonomic organisation of the order Rickettsiales, which I split into the two orders Rickettsiales sensu stricto and Holosporales ord. nov. The importance and severity of a symbiosis for its host can be estimated, among others, by studying the symbionts transmission modes. Most host-symbiont systems in nature show a mixed mode of transmission, even if one transmission type occurs only rarely. Moreover, evolution of exclusively vertically or horizontally transmitted symbionts is scarce. However, circumstances for horizontal transmission of many symbiont species so far described as vertically transmitted, are completely unknown and still need to be revealed. Therefore, I assumed that both, vector organisms and environmental stress, can trigger horizontal transmission. I performed different sets of infection experiments using vector organisms and environmental stress factors as driving forces to trigger horizontal transmission. In experiments focused on vector-induced transmission, I was not able to confirm vector properties of Holospora towards Caedibacter, as described towards food bacteria. However, I rarely observed vector-independent horizontal transmission of Caedibacter taeniospiralis towards symbiont-free Paramecium species. The here tested genotypes of C. taeniospiralis might still take advantage of additional horizontal transmission, even if it occurs rarely. In addition, I tested the effect of salinity and temperature stress on the transmission of the recently described bacterial symbionts “Candidatus Megaira polyxenophila” and “Ca. Bealeia paramacronuclearis” as potentially interesting representatives. The involved symbiont and host genotypes differed in their response to the induced environmental stress. Results of horizontal transmission turned out to be ambiguous. While temperature stress did not show any effect on transmission, salinity stress could possibly induce horizontal transmission of “Ca. Megaira polyxenophila” at slightly increased salinity concentrations in regard to normal conditions indicating the significance of environmental stress for the selection of the preferred transmission mode. / Symbiosen zwischen Bakterien und einzelligen Eukaryoten wie Ciliaten und Amöben sind weitverbreit. In den vergangenen Jahren stieg die Anzahl der Artbeschreibungen symbiotisch lebender Bakterien stetig an. Besonders Vertreter der Ordnung Rickettsiales (Alphaproteobacteria), welche obligat intrazelluläre Menschen- und Tierpathogene sowie andere nicht-pathogene, intrazelluläre Arten beinhaltet, rückten in den Fokus. Die Biodiversität von Protisten und mit ihnen assoziierte, bakterielle Symbionten wird jedoch weitestgehend unterschätzt. Daher untersuchte ich, welche verschiedenen Bakterienarten im Ciliaten Paramecium vorkommen, ob Paramecien als potentielles Reservoir für menschen- und tierpathogene Bakterien dienen können und ob die Artverbreitung von Paramecium und seiner Symbionten geographische Muster aufweist. In der vorliegenden Arbeit, präsentiere ich Verbreitungs- und Diversitätsdaten von Paramecium-Arten sowie deren Endosymbionten, welche aus nord- und südamerikanischen Süß- und Brackwasserproben isoliert wurden. Die am häufigsten erfassten Arten in nordamerikanischen Proben waren Paramecium biaurelia, Paramecium caudatum und Paramecium multimicronucleatum, sowie P. multimicronucleatum und Paramecium calkinsi in südamerikanischen Proben. Die identifizierten Arten weisen auf geographische Unterschiede in der Artverteilung der beiden Kontinente hin. Monoklonale Massenkulturen wurden unter Verwendung universeller und spezifischer Sonden mittels Fluoreszenz in situ Hybridisierung auf das Vorhandensein von Endosymbionten überprüft. Dabei entdeckte ich bakterielle Endosymbionten verschiedener Rickettsiales sensu lato-Vertreter in Paramecienkulturen aus acht verschiedenen Habitaten. Darüber hinaus charakterisierte ich die vier neuen Endosymbiontenarten “Candidatus Fokinia solitaria”, “Candidatus Fokinia cryptica”, “Candidatus Bealeia paramacronuclearis” und “Candidatus Jurandia parameciophila” und lieferte detaillierte Artbeschreibungen. Somit erfasste ich nicht nur verschiedene Symbionten in unterschiedlichen Paramecium-Arten der beiden Kontinente, sondern identifizierte auch Bakterien, welche nahe mit relevanten Pathogenen verwandt sind. Die phylogenetischen Informationen, die mir diese vier neuen Bakterienarten lieferten, halfen mir die taxonomische Organisation der Ordnung Rickettsiales zu revidieren, welche ich in die zwei Ordnungen Rickettsiales sensu stricto und Holosporales ord. nov. aufspaltete. Die Bedeutung einer Symbiose für seinen Wirt kann unter anderem durch die Erforschung der Übertragungswege abgeschätzt werden. Die meisten natürlichen Wirt-Symbionten-Systeme zeigen gemischte Übertragungswege, auch wenn eine der Übertragungsarten nur wenig genutzt wird. Ferner tritt eine Evolution hin zu sich ausschließlich vertikal oder horizontal übertragenden Symbionten selten auf. Die Bedingungen, unter denen eine horizontale Übertragung der meisten sich als vertikal übertragend beschriebenen Symbionten stattfindet, sind unbekannt und müssen nach wie vor untersucht werden. Deshalb legte ich meiner Arbeit die Annahme zugrunde, dass sowohl Vektororganisen als auch Umweltstress eine horizontale Übertragung begünstigen können. Ich führte verschiedene Infektionsexperimente durch, in denen ich die Effekte von Vektororganismen und verschiedener abiotischer Stressfaktoren als potenzielle Auslöser für eine horizontale Übertragung untersuchte. In den Experimenten, die sich mit einer Vektor-induzierten Übertragung beschäftigten, konnte ich keine möglichen Vektoreigenschaften von Holospora gegenüber Caedibacter nachweisen, wie sie gegenüber Futterbakterien bekannt sind. In seltenen Fällen beobachtete ich jedoch eine Vektor-unabhängige, horizontale Übertragung von Caedibacter taeniospiralis auf Symbionten-freie Paramecium-Arten. Die hier getesteten C. taeniospiralis-Genotypen sind möglicherweise immer noch dazu in der Lage, die Vorteile einer zusätzlichen horizontalen Übertragung zu nutzen. Zusätzlich testete ich die Effekte von Salz- und Temperaturstress auf die Übertragung der kürzlich beschriebenen, bakteriellen Symbionten “Candidatus Megaira polyxenophila” und “Ca. Bealeia paramacronuclearis” als potentiell interessante Vertreter. Die getesteten Symbionten- und Wirtsgenotypen unterschieden sich hinsichtlich ihrer Reaktion auf den ausgelösten abiotischen Stress. Die erzielten Ergebnisse zur horizontalen Übertragung erscheinen jedoch nicht eindeutig. Während Temperaturstress keine Effekte auf die Übertragung hatte, führte leichter Salzstress zu einer möglichen horizontalen Übertragung von “Ca. Megaira polyxenophila”, was auf die Bedeutung abiotischer Stressfaktoren bei der Wahl des bevorzugten Übertragungsweges hinweist. / Le simbiosi fra batteri ed eucarioti unicellulari, come i ciliati e le amebe, è un fenomeno molto diffuso. Negli anni passati, il numero di descrizioni di specie di batteri simbionti è cresciuto costantemente. In particolare, sono venuti alla ribalta i membri dell’ordine Rickettsiales (Alphaproteobacteria), che comprende patogeni intracellulari obbligati umani e di animali, oltre ad altre specie di batteri intracellulari non patogeni. Comunque, la biodiversità dei protisti e dei batteri simbionti a loro associati è ancora largamente sottostimata. Perciò, è stato ipotizzato che ci siano diversi tipi di batteri che vivono in associatione con il ciliato Paramecium in natura, che I parameci possano fungere da possibili serbatoi naturali per patogeni umani e animali, e che la distribuzione delle specie di Paramecium e dei suoi simbionti presenti dei pattern geografici. Nel presente lavoro di tesi, sono presentati dati sulla distribuzione e diversità di specie del genere Paramecium e dei loro batteri endosimbionti, isolate da ambienti dulciacquicoli e salmastri dal nordamerica e sudamerica. Le specie più frequenti sono state Paramecium biaurelia, Paramecium caudatum e Paramecium multimicronucleatum per i campioni nordamericani, e P. multimicronucleatum e Paramecium calkinsi per i campioni sudamericani, il che indica differenze geografiche nella distribuzione della specie di Paramecium fra I gue continenti. Colture monoclonali sono state saminate per la presenza di endosimbionti tramite ibridazione in situ a fluorescenza (FISH), impiegando sonde universali e specifiche. Sono stati rilevati batteri endosimbionti appartenenti a diversi taxa di Rickettsiales sensu lato in colture di paramecio isolate da otto diversi habitat. Inoltre, sono state caratterizzate quattro nuove specie di endosimbionti, rispettivamente, “Candidatus Fokinia solitaria”, “Candidatus Fokinia cryptica”, “Candidatus Bealeia paramacronuclearis” e “Candidatus Jurandia parameciophila”), fornendo descrizioni dettagliate. Perciò non solo sono stati caratterizzati diversi batteri simbionti in differenti specie di ospiti da due continenti, ma sono anche stati identificati batteri affini a patogeni umani e animali. I dati filogenetici forniti dalle quattro nuove specie mi hanno permesso di revisionare l’organizzazione tassonomica dell’ordine Rickettsiales, che è stato diviso nei due ordini Rickettsiales sensu stricto e Holosporales ord. nov. L’importanza e la severità di una simbiosi per l’ospite può essere stimata studiando le modalità di trasmissione del simbionte. La maggior parte dei sistemi ospite-simbionte in natura presentano una modalità mista di trasmissione, anche se una tipo di trasmissione avviene solo occasionalmente. Inoltre, l’evoluzione di simbionti trasmessi eclusivamente per via verticale o orizzontale è scarsa. Comunque, le circostanze per la trasmissione orizzontale di molti simbionti finora descritti come trasmessi orizzontalmente sono completamente sconosciute, e necessitano di essere rivelate. Perciò, è stato ipotizzato che sia organismi vettori che stress ambientali possano indurre la trasmissione orizzontali. Sono stati eseguiti diversi set di esperimenti di infezione, impiegando organismi vettori e fattori di stress ambientali come agenti che potessero indurre tramissione orizzontale. In esperimenti incentrati sulla trasmissione indotta da vettori, non è stato possibile confermare capacità di vettore da parte di Holospora nei confronti di Caedibacter, come invece descritto nei confronti di batteri a vita libera. Comunque, in rari casi è stata osservata trasmissione orizzontale di Caedibacter taeniospiralis verso specie di Paramecium indipendente dal vettore. I genotipi testati di C. taeniospiralis potrebbero comunque trarre un vantaggio dalla possibilità alternativa di trasmissione orizzontale, anche se questa avviene solo di rado. Inoltre, è stato testato l’effetto dello stress da salinità e temperatura sulla trasmissione dei batteri simbionti recentemente descritti “Candidatus Megaira polyxenophila” e “Ca. Bealeia paramacronuclearis” come rappresentanti potenzialmente interessanti. I genotipi coinvolti di ospiti e simbionti hanno risposto diversamente a fattori indotti di stress ambientale. I risultati sono stati ambigui in termini di trasmissione orizzontale. Mentre lo stress da temperatura non ha mostrato un effetto sulla trasmissione, è stata rilevata una possibile induzione della trasmissione di “Ca. Megaira polyxenophila” in presenza di basso stress salino rispetto alle condizioni normali, indicando l’importanza degli stress ambientali per la selezione della modalità di trasmissione.

We consider the problem of secure communications in a Gaussian two-way relay network where two nodes exchange confidential messages only via an untrusted relay. The relay is assumed to be honest but curious, i.e., an eavesdropper that conforms to the system rules and applies the intended relaying scheme. We analyze the achievable secrecy rates by applying network coding on the physical layer or the network layer and compare the results in terms of complexity, overhead, and efficiency. Further, we discuss the advantages and disadvantages of the respective approaches.

An AC system’s voltage unbalance by a fundamental frequency negative sequence system is usually the main cause for the emission of non-characteristic harmonics by current source converters as used in conventional HVDC systems. This emission takes place on both sides of each 12-pulse converter. On the DC side mainly a 2nd harmonic voltage appears driving a 2nd harmonic current. The magnitude of this harmonic current can exceed the magnitudes of the characteristic harmonics even if no low order resonance exists. Further non-characteristic harmonics generated by the converter under such unbalanced supply voltage conditions have frequencies with a frequency distance to the characteristic harmonics of 2 times the fundamental frequency. The main technical drawbacks are the unintended coupling between both AC systems and the risk of thyristor over-stresses by DC current discontinuities at low power transfer levels. On both AC sides the largest 2 non-characteristic current harmonics generated by a 12-pulse HVDC converter under unbalanced supply voltage conditions are a negative sequence system of the fundamental harmonic and a positive sequence system of the 3rd harmonic. Also on the AC sides further harmonics are emitted by the converter with a order number distance of 2 to the orders of the characteristic harmonics. However, in practical AC system operation special attention has to be paid to the 3rd harmonic distortion level, in particular when low order resonance appears between the system impedance and the impedance of the converter station AC filters. In order to avoid the above mentioned problems, large smoothing reactors and sometimes large blocking filters are installed on the DC side and the voltage distortion on the AC sides is reduced by AC filters. However, these filters require an expensive high component rating if they are tuned to the 2nd or 3rd harmonic respectively. The work shows that a modification of the valve firing can reduce the levels of the 2nd and 3rd harmonic without investment into additional primary equipment. Furthermore, this offers the chance to reduce the minimum power transfer level since also the risk of an intermittent DC current can be reduced. A corresponding algorithm and a control strategy are proposed. However, the calculation of an appropriate firing pattern requires a detailed modelling of the processes within the converters, especially the formation of the harmonics and the harmonic transfer between AC and DC sides. The work proposes a component vector model for the calculation of the harmonics. This model assumes that each harmonic consists of a first component representing the ideal conversion process, a 2nd component representing the impact of different commutation angles and in the case of the modified firing a 3rd component considering the impact of the intended non-equidistant firing. The work shows, that the harmonic component vectors resulting from voltage unbalance and from firing modulation can be treated separately and superimposed linearly. The calculation of the harmonic component vectors is performed applying the method of switching functions. For the consideration of the commutation and firing angle differences the modelling of switching functions based on differential impulses is proposed. However, especially an accurate representation of the above mentioned 2nd component vector requires a correct calculation of the commutation angles and their valve-specific differences. The investigations of this work have revealed that the conventional method of calculating the commutation angles – assuming an ideal smoothed DC current - may not produce results of sufficient accuracy. This is especially true in the case of a high ripple of the DC current, e.g. smoothed with a small smoothing reactor. A small smoothing reactor is typical for HVDC back-to-back applications. Therefore a new analytical method for the calculation of the commutation angles has been developed which in particular considers the typical pulse form of the DC current and additionally the impacts of the voltage unbalance and of the proposed modification of the firing on the ripple shape of the DC current. Moreover, as this analytical method requires the instantaneous values of the DC current at the instants of valve firing, a further analytical method for the calculation of these discrete current values has been developed. The equations are valid under the same conditions as the new ones for calculation of the commutation angles, i.e. resistive-inductive AC system fundamental frequency impedances, any degree of DC current smoothing between ideal smoothing and a ripple at the limit for current discontinuities. Symmetrical conditions, supply voltage unbalances and non-equidistant firing as proposed are applied. It is shown that, using this method, also the discrete values of the DC current at the end of the commutation intervals can be determined. In practice one of these discrete current values indicates the minimum value during one period of the fundamental frequency. This offers the chance for a more exact analytical determination of the limit for the appearance of DC current discontinuities. For typical parameters of a back-to-back installation the new methods and the new analytical equations have been compared with simulation results showing excellent correlation for typical voltage unbalances of not more than 1...2% and firing angle differences of not more than 2.5°. This verification is performed for the harmonics, the commutation angles and the discrete values of the DC current at the firing instants as well.:1 Einleitung und Ziel der Arbeit 1.1 Einführung in die Problematik 1.2 HGÜ-Systeme als Quelle von Strom- und Spannungsharmonischen 1.3 Netzspannungsunsymmetrien 1.4 Abgrenzung der betrachteten technischen Systeme 1.5 Beweggründe für die Betrachtung 1.6 Zielstellungen 2 Erkenntnisstand und Analyse der Aufgabenstellung 2.1 Harmonische 2.2 Aktive Kompensation von Harmonischen 2.3 Diskrete Werte des Zwischenkreisstromes am Beginn und Ende der Kommutierungsintervalle 2.4 Kommutierungswinkel 3 Grundlagen 3.1 Methodischer Ansatz 3.2 Allgemeine Voraussetzungen, Annahmen und Festlegungen 3.3 Maßgebliche Impedanzen für die Stromaufteilung 3.4 Maßgebliche Impedanz für die gleichstromseitigen Stromharmonischen 3.5 Leerlauf-Klemmenspannung des Stromrichters 3.6 Kommutierungsspannung 3.7 Nummerierungssystem der Ventile 3.8 Überlappungsformen der Kommutierungsintervalle 3.9 Komplexer Spannungsunsymmetriefaktor 3.10 Anwendung und Modifikation von Schaltfunktionen 3.11 Verifikation der Ergebnisse 4 Harmonische auf der Gleichstromseite 4.1 Bildungsgesetz 4.2 Charakteristische Harmonische 4.3 Nichtcharakteristische Harmonische infolge unsymmetrischer Netzspannungen 4.4 Nichtcharakteristische Harmonische infolge Ansteuermodifikation 5 Diskreter Wert des Zwischenkreisstromes im Zündzeitpunkt 5.1 Vorgehensweise 5.2 Lösungsansatz 5.3 Konstante Gegenspannung 5.4 Reale Gegenspannung des HGÜ-Stromrichters 5.5 Berücksichtigung von Resistanzen 5.6 Unsymmetrische Netzspannungen 5.7 Ansteuermodifikation 5.8 Unsymmetrische Netzspannungen und gleichzeitige Ansteuermodifikation 5.9 Ergebnisse 6 Kommutierungswinkel 6.1 Vorgehensweise 6.2 Konstante Gegenspannung 6.3 Reale Gegenspannung des HGÜ-Stromrichters 6.4 Berücksichtigung von Resistanzen 6.5 Unsymmetrische Netzspannungen 6.6 Ansteuermodifikation 6.7 Unsymmetrische Netzspannungen und gleichzeitige Ansteuermodifikation 6.8 Ergebnisse 7 Vertiefende Betrachtung der nichtcharakteristischen Harmonischen auf der Gleichstromseite 7.1 Vorbemerkungen 7.2 Unsymmetrische Netzspannungen 7.3 Ansteuermodifikation 7.4 Spannungsunsymmetrie und gleichzeitige Ansteuermodifikation 7.5 Ergebnisse 8 Harmonische auf der Netzseite 8.1 Bildungsgesetz 8.2 Charakteristische Harmonische 8.3 Nichtcharakteristische Harmonische 9 Betrachtungen zur aktiven Kompensation 9.1 Vorbemerkungen 9.2 Betrachtungsumfang 9.3 Grundlagen 9.4 Konzeptioneller Vorschlag für die Kompensation der 2. Stromharmonischen 9.5 Betrachtung der Drehstromseite 9.6 Vorschlag zur Weiterentwicklung des Konzeptes 9.7 Berechnungsbeispiel zur Kompensation der 2. Harmonischen im Zwischenkreis 9.8 Ergebnisse und Schlussfolgerungen 10 Zusammenfassung 11 Literatur 12 Formelzeichen und Abkürzungen 13 Anlagenverzeichnis

In the COVID-19 pandemic, children were considered to play a major role in SARS-CoV-2 transmission similar to influenza. Thus, mitigation measures have been focused on children, impacting their everyday life severely. Despite this, infectivity in this age group regarding SARS-CoV-2 is not yet clarified. We performed a serology study in households with confirmed SARS-CoV-2 infection to evaluate virus transmission with focus on children and adolescents. Between January and July 2021, 341 minors and 650 adults from 300 households with a confirmed index case participated in the FamilyCoviDD19-study including serological assessment for SARS-CoV-2 antibodies and a questionnaire on demographics, recent and ongoing symptoms, hygiene measures and comorbidities. 45 (16.3%) of all index cases were < 18 years old. Thereof, 55.6% reported COVID-19 associated symptoms, while nearly all adult index cases were symptomatic (94.8%). There was significantly less virus transmission by children and adolescents compared to adult index cases with a secondary attack rate of 0.29 vs. 0.54. With the caveat that the results do not necessarily apply to the Delta and Omicron variants, we conclude that children and adolescents are less susceptible for SARS-CoV-2 infection, more frequently show an asymptomatic course of disease and are less infective than adults.

Neuroligine (NL) sind vorwiegend postsynaptisch lokalisierte transmembrane Adhäsionsmoleküle, die in Wechselwirkung mit dem präsynaptisch lokalisierten Protein Neurexin eine wichtige Rolle in der Reifung und Funktion von Synapsen spielen. Es existieren verschiedene NL-Isoproteine (NL-1 – NL-4), die sich in ihrer Assoziation zu exzitatorischen und inhibitorischen Synapsen unterscheiden. Die funktionelle und klinische Relevanz der Neuroligine belegen beispielhaft Mutationen des Isotyps NL 4, welche mit neuropsychiatrischen Erkrankungen wie Autismus-Spektrum-Störungen assoziiert vorkommen. Anhand eines durch Ausschalten des human-orthologen NL-4-Gens generierten Mausmodells (NL 4 Knockout, NL 4 KO) konnte in vorhergehenden Studien die Bedeutung einer immunhistochemisch beobachteten Lokalisation von NL 4 an glycinergen Synapsen der Retina für die inhibitorische synaptische Übertragung nachgewiesen werden. Im Unterschied dazu konnte kein Zusammenhang zwischen einer in Schicht IV des Barrel-Kortex nachweisbaren Lokalisation von NL-4 mit inhibitorischen Synapsen hergestellt werden. Deshalb, und aufgrund der in Schicht IV dominierenden exzitatorischen Verschaltung von thalamischen Projektionen und den kolumnenassoziierten Rückverschaltungen aus dem Neokortex, lässt sich eine Interaktion von NL-4 mit exzitatorischen Synapsen in diesem Areal vermuten. Im Rahmen der vorliegenden Arbeit wurde anhand der NL-4-KO-Modellmaus der Frage nachgegangen, inwiefern NL-4 die exzitatorische synaptische Übertragung im Barrel-Kortex beeinflusst. Dafür wurden mit Hilfe der Patch-Clamp-Technik abgeleitete AMPA-Rezeptor-vermittelte exzitatorische postsynaptische Ströme (EPSC) von bedornten Sternzellen, Sternpyramiden- und Pyramidenzellen der Schicht IV ausgewertet und zwischen NL-4-Wildtyp- (NL 4-WT) und NL 4 KO-Neuronen verglichen. Dabei zeigten NL 4-KO-Neurone signifikant veränderte Parameter der EPSC-Kinetik. Die Abfallszeit war in NL 4 KO-Neuronen signifikant länger, das maximale Gefälle und die maximale Steigung signifikant flacher gegenüber NL-4-WT-Kontrollen. Diese Veränderungen sprechen für eine funktionelle Relevanz von NL-4 für die AMPA-Rezeptor-vermittelte synaptische Übertragung auf exzitatorische Neurone in Schicht IV des Barrel-Kortex. Das Muster der in NL-4-KO-Neuronen veränderten EPSC-Kinetik weist dabei auf eine Modulation der biophysikalischen AMPA-Rezeptoreigenschaften hin und könnte mit Veränderungen der synaptisch exprimierten AMPA-Rezeptor-TARP-Subtypen in Zusammenhang stehen, die über Proteine der postsynaptischen Dichte (wie PSD-95 und S SCAM) mit Neuroliginen interagieren.

Today, lead is used in various engineering applications due to its desirable tribological properties. However, the negative health and environmental impacts associated with lead have raised concerns and resulted in regulatory restrictions on its use. It is therefore nessessary to fnd lead-free materials that can provide similar or even better performance than the commonly used lead-containing alloys. Scania, currently uses leaded alloys for a number of gearbox components where sliding wear can be an issue. This study aims to evaluate the tribological properties of fve lead-free alternative materials and assess their suitability as replacement for the currently used material, Leaded Brass. The tests were conducted in a pin-on-disk setup under similar conditions of those found in Scania’s gearbox. The results showed that the friction and wear was similar between Copper Beryllium and Leaded Brass, which indicates that Copper Beryllium is a potential replacement. Additionally, Nedox and Aluminum Bronze (APS) demonstrated signifcantly superior wear resistance, exhibiting 97% less wear compared to Leaded Brass while maintaining similar friction levels. These results underscore the potential for implementing lead-free materials to enhance sustainability and performance in critical applications like gearbox components. / Idag används bly i olika tekniska tillämpningar på grund av dess önskvärda tribologiska egenskaper. Men de negativa hälso- och miljöeffekterna associerade med bly har väckt oro och resulterat i reglerande begränsningar för dess användning. Det är därför nödvändigt att hitta blyfria material som kan erbjuda liknande eller till och med bättre prestanda än de vanligt förekommande blyhaltiga legeringarna. Scania använder för närvarande blyhaltiga legeringar för ett antal växellådskomponenter där glidande slitage kan vara ett problem. Denna studie syftar till att utvärdera de tribologiska egenskaperna hos fem blyfria alternativa material och bedöma deras lämplighet som ersättning för det nuvarande materialet, blyhaltig mässing. Testerna utfördes i en pin-on-disk konfiguration under liknande förhållanden som de som återfinns i Scanias växellåda. Resultaten visade att friktionen och slitage var liknande mellan kopparberyllium och blyhaltig mässing, vilket tyder på att kopparberyllium är en potentiell ersättare. Dessutom visade Nedox och aluminiumbrons (APS) betydligt överlägsen slitagebeständighet, med 97% mindre slitage jämfört med blyhaltig mässing, samtidigt som båda materialen hade liknande friktionsnivåer. Dessa resultat visar potentialen som finns med att implementera blyfria material för att förbättra hållbarheten och prestandan i kritiska tillämpningar som växellådskomponenter. / Heutzutage wird Blei aufgrund seiner wünschenswerten tribologischen Eigenschaften in verschiedenen technischen Anwendungen verwendet. Jedoch haben die negativen gesundheitlichen und Umweltauswirkungen, die mit Blei verbunden sind, Bedenken hervorgerufen und zu regulatorischen Beschränkungen seiner Verwendung geführt. Daher ist es notwendig, bleifreie Materialien zu finden, die ähnliche oder sogar bessere Leistungen als die üblicherweise verwendeten bleihaltigen Legierungen bieten können. Scania verwendet derzeit bleihaltige Legierungen für eine Reihe von Getriebekomponenten, bei denen Gleitverschleiß auftreten kann. Das Ziel dieser Studie ist es, die tribologischen Eigenschaften von fünf bleifreien Alternativmaterialien zu bewerten und ihre Eignung als Ersatz für das derzeit verwendete Material, Bleihaltiges Messing, zu prüfen. Die Tests wurden in einem Pin-on-Disk-Aufbau unter ähnlichen Bedingungen wie in den Getrieben von Scania durchgeführt. Die Ergebnisse zeigten, dass Reibung und Verschleiß zwischen Kupferberyllium und Bleihaltigem Messing ähnlich waren, was darauf hinweist, dass Kupferberyllium ein potenzieller Ersatz sein könnte. Darüber hinaus wiesen Nedox und Aluminiumbronze (APS) eine signifikant überlegene Verschleißfestigkeit auf und zeigten 97 % weniger Verschleiß im Vergleich zu Bleihaltigem Messing bei gleichbleibendem Reibungsniveau. Diese Ergebnisse unterstreichen das Potenzial zur Implementierung von bleifreien Materialien, um die Nachhaltigkeit und Leistungsfähigkeit in kritischen Anwendungen wie Getriebekomponenten zu verbessern.

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