O fenômeno do congestionamento, decorrente do rápido aumento da demanda por todos os meios de transporte só tende a se agravar, já que sistemas de transporte (vistos como um todo) têm um grande impacto na economia mundial. No caso do transporte veicular em particular, é notório que a demanda por mobilidade é uma das características da nossa sociedade. O impacto direto e indireto dos congestionamentos em áreas urbanas e interurbanas é imenso, e precisam ser avaliados adequadamente para que seus efeitos sejam pelo menos minorados. Esta dissertação apresenta o AVNET, uma modelagem baseada em agentes para avali- ação do balanceamento de carga em redes de tráfego veicular, capaz de investigar micros- copicamente a interação entre oferta, demanda e as particularidades do comportamento dos motoristas, aqui tratados como agentes autônomos capazes de perceber o estado do ambiente e se adaptar a ele utilizando replanejamento heurístico. O principal objetivo do AVNET é investigar a interação entre a percepção que o agente possui do tráfego e a consequente adaptação através da mudança de rota durante a viagem. De forma cíclica, o AVNET propõe que o estado do ambiente influencia na percepção do agente, e a ação do agente influencia no estado do ambiente. As medidas de balanceamento de carga visam avaliar o desempenho do ponto de vista do motorista, ao invés de abordar a avaliação do ponto de vista da rede como algumas abordagens tradicionalmente propõe. Experimentos foram realizados a partir da variação nas condições de oferta - utili- zando uma rede com topologia em estilo de grade e uma abstração de algumas vias arte- riais da cidade de Porto Alegre/RS - variação nas condições de demanda - o tipo de dis- tribuição e número de viagens - e dos tipos de agentes utilizados. Os resultados ajudam a responder como será o balanceamento de carga de redes de tráfego veicular conforme as condições de oferta e demanda do ambiente, e de percepção/ação dos agentes. / The phenomenon of congestion, due to the rapid increase in demand for all means of transport is only going to worsen, since systems transport (seen as a whole) have a major impact on the world economy. In the case of vehicular transport in particular, it is clear that the demand for mobility is a characteristic of our society. The direct and indirect impact of congestion in urban and long distance is immense, and must be properly evaluated for their effects are at least mitigated. This dissertation presents the AVNET, an agent-basead modelling to evaluate load bal- ancing in networks of vehicular traffic, able to microscopically investigate the interaction between supply, demand and the peculiarities of the behavior of drivers, here treated as autonomous agents, capable to perceive the state of the environment and adapt to it using heuristic redesign. The main goal of AVNET is to investigate the interaction between the perception that the agent has the traffic and the consequent adaptation by changing the route during the trip. Cyclically, the AVNET propose that the state of the environment influences the perception of the agent and the agent’s action influences the state of the environment. Experiments were performed from the variation in supply conditions - using a network grid topology and an abstraction of some arterial roads in the city of Porto Alegre/RS - changes in demand conditions - the type of distribution and number of trips - and the types of agents used. The results will help answer how the balancing network load of vehicular traffic as conditions of supply and demand of the environment, and perception / action agents.

O fenômeno do congestionamento, decorrente do rápido aumento da demanda por todos os meios de transporte só tende a se agravar, já que sistemas de transporte (vistos como um todo) têm um grande impacto na economia mundial. No caso do transporte veicular em particular, é notório que a demanda por mobilidade é uma das características da nossa sociedade. O impacto direto e indireto dos congestionamentos em áreas urbanas e interurbanas é imenso, e precisam ser avaliados adequadamente para que seus efeitos sejam pelo menos minorados. Esta dissertação apresenta o AVNET, uma modelagem baseada em agentes para avali- ação do balanceamento de carga em redes de tráfego veicular, capaz de investigar micros- copicamente a interação entre oferta, demanda e as particularidades do comportamento dos motoristas, aqui tratados como agentes autônomos capazes de perceber o estado do ambiente e se adaptar a ele utilizando replanejamento heurístico. O principal objetivo do AVNET é investigar a interação entre a percepção que o agente possui do tráfego e a consequente adaptação através da mudança de rota durante a viagem. De forma cíclica, o AVNET propõe que o estado do ambiente influencia na percepção do agente, e a ação do agente influencia no estado do ambiente. As medidas de balanceamento de carga visam avaliar o desempenho do ponto de vista do motorista, ao invés de abordar a avaliação do ponto de vista da rede como algumas abordagens tradicionalmente propõe. Experimentos foram realizados a partir da variação nas condições de oferta - utili- zando uma rede com topologia em estilo de grade e uma abstração de algumas vias arte- riais da cidade de Porto Alegre/RS - variação nas condições de demanda - o tipo de dis- tribuição e número de viagens - e dos tipos de agentes utilizados. Os resultados ajudam a responder como será o balanceamento de carga de redes de tráfego veicular conforme as condições de oferta e demanda do ambiente, e de percepção/ação dos agentes. / The phenomenon of congestion, due to the rapid increase in demand for all means of transport is only going to worsen, since systems transport (seen as a whole) have a major impact on the world economy. In the case of vehicular transport in particular, it is clear that the demand for mobility is a characteristic of our society. The direct and indirect impact of congestion in urban and long distance is immense, and must be properly evaluated for their effects are at least mitigated. This dissertation presents the AVNET, an agent-basead modelling to evaluate load bal- ancing in networks of vehicular traffic, able to microscopically investigate the interaction between supply, demand and the peculiarities of the behavior of drivers, here treated as autonomous agents, capable to perceive the state of the environment and adapt to it using heuristic redesign. The main goal of AVNET is to investigate the interaction between the perception that the agent has the traffic and the consequent adaptation by changing the route during the trip. Cyclically, the AVNET propose that the state of the environment influences the perception of the agent and the agent’s action influences the state of the environment. Experiments were performed from the variation in supply conditions - using a network grid topology and an abstraction of some arterial roads in the city of Porto Alegre/RS - changes in demand conditions - the type of distribution and number of trips - and the types of agents used. The results will help answer how the balancing network load of vehicular traffic as conditions of supply and demand of the environment, and perception / action agents.

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Organizations, once established, tend not to change, typically going obsolete as society continues to evolve. This makes adaptability an important issue. Organizational members must make sense to each other, or coordination suffers. They must also make sense to environmental actors, or the organization will not achieve the support it needs to survive. This sense-making is a process of institutionalization, of constructing a shared understanding of the organization's enterprise, business and environment. When environmental actors adopt new priorities, ideas and modes of thinking, organizations must develop a new understanding of reality or go obsolete. To stay adaptable, organizations needs to contain competing perspectives. But the pressures to conform and to coordinate make it difficult for established organizations to adapt, trapped by the very benefits of increased efficiency. Using an agent-based model of organizational institutionalization, I show that an organization's adaptability is highly dependent on structural elements that affect the member interaction frequencies, and that organizations that leverage the strength of weak ties between member groups can maintain adaptability. The effects of changes to any of these elements are decidedly non-linear, however, which helps explain why it is difficult to design effective organizations. Organizational structure is one part of a tri-partite framework of institutional development in organizations and of organizational adaptability, where the other two parts are the individual characteristics of the members and the content of the organizational culture.

Un système logistique est une composante essentielle d'un système spatial dans lequel les acteurs s'organisent autour d'infrastructures pour faire circuler des flux (de marchandises, d'information et financier) sur un territoire. L'organisation logistique globale résulte d'un processus auto-organisé et distribué de la part des acteurs. Ce travail vise à comprendre, à de multiples échelles, comment des acteurs autonomes et très hétérogènes (dans leurs modes de fonctionnements et dans leurs objectifs), s'organisent collectivement autour des infrastructures à leurs dispositions pour gérer des flux soumis à un ensemble de contraintes (temporelles, spatiales,...). On propose ici un modèle orienté agent permettant de simuler les processus de création et d'organisation des flux liés à la logistique sur un territoire. Le modèle prévoit de décrire l'interface entre les flux internationaux et les flux urbains afin de comprendre comment les dynamiques portuaires et urbaines cohabitent au sein du système. Le modèle intègre une dynamique structurelle et organisationnelle grâce aux graphes dynamiques afin de représenter l'évolution du système. Le modèle permet ainsi aux agents de s'adapter, comme dans la réalité, à des perturbations du système. / A logistic system is an essential component of a spatial system. Actors are organised around infrastructures in order to move different kinds of flow (of goods, of information, or financial) over a territory. The logistic organisation comes from an auto-organised and distributed process from the actors. This works aims to understand, at different scales, how autonomous and heterogeneous actors (according to their goals and methods to take decisions) are collectively organised around infrastructures to manage different kinds of flow, and despite numerous constraints (temporal, spatial,...). We propose an agent-based model which allows to simulate the processes to create and organise logistic flow over a territory. The model describes an interface between international and urban flow in order to understand how the port and urban dynamics work together. The model integrates a structural and organisational dynamics thanks to dynamic graphs in order to represent the evolution of this kind of system. Thus, the agents can adapt themselves to system's perturbations as in the reality.

Cancer is a complex illness that affects millions of people every year. Amongst the most frequently encountered variants of this illness are solid tumours. The growth of solid tumours depends on a large number of factors such as oxygen concentration, cell reproduction, cell movement, cell death, and vascular environment. The aim of this thesis is to provide further insight in the interconnections between these factors by means of numerical simulations. We present a multiscale model for tumor growth by coupling a microscopic, agent-based model for normal and tumor cells with macroscopic mean-field models for oxygen and extracellular concentrations. We assume the cell movement to be dominated by Brownian motion. The temporal and spatial evolution of the oxygen concentration is governed by a reaction-diffusion equation that mimics a balance law.To complement this macroscopic oxygen evolution with microscopic information, we propose a lattice-free approach that extends the vascular distribution of oxygen. We employ a Markov chain to estimate the sprout probability of new vessels. The extension of the new vessels is modeled by enhancing the agent-based cell model with chemotactic sensitivity. Our results include finite-volume discretizations of the resulting partial differential equations and suitable approaches to approximate the stochastic differential equations governing the agent-based motion. We provide a simulation framework that evaluates the effect of the various parameters on, for instance, the spread of oxygen. We also show results of numerical experiments where we allow new vessels to sprout, i.e. we explore angiogenesis. In the case of a static vasculature, we simulate the full multiscale model using a coupled stochastic/deterministic discretization approach which is able to reduce variance at least for a chosen computable indicator, leading to improved efficiency and a potential increased reliability on models of this type.

Metapolybia wasps live in small societies (around one hundred adults) and rear their young in nests they construct on flat surfaces from plant materials. For processing nest paper, they must gather plant materials and process it into pulp with water. The water is collected by water foragers and is transferred to pulp foragers indirectly via a "common stomach." The common stomach, or social crop, is formed by generalist wasps called laborers. These wasps can engage in water exchange, store water in their crops, and may become specialist foragers or builders. We provide an alternative model for regulating task partitioning in construction behavior by using an agent based modeling framework parameterized by our field observations. Our model predicts that assessing colony needs via individual interactions with the common stomach leads to a robust regulation of task partitioning in construction behavior. By using perturbation experiments in our simulations, we show that this emergent task allocation is able to dynamically adapt to perturbations of the environment and to changes in colony-level demands or population structure. The robustness of our model stems from the fact that the common stomach is both a strong buffer and a source of several feedback mechanisms that affect the individual wasps. We show that both the efficiency and the task fidelity of these colonies are dependent upon colony size. We also demonstrate that the emergence of specialist wasps (individuals with high task fidelity) does not require any special initial conditions or reinforcement at the individual level, but it is rather a consequence of colony-level workflow stability. Our model closely mimics the behavior of Metapolybia wasps, demonstrating that a regulation mechanism based on simple pair-wise interactions through a common stomach is a plausible hypothesis for the organization of collective behavior.

Forager honey bees exhibit a robust time memory, based on an endogenous circadian clock, enabling them to schedule their flights to coincide with the nectar presentation of known food sources. They retain this time memory for several consecutive days even in the absence of nectar rewards. Recent work has identified 2 classes of forager: "persistent" foragers that reconnoiter a known food source to ascertain its status and "reticent" foragers that apparently wait in the hive for a waggle dance confirming source availability. Surprisingly, a foraging group contains 40-90% persistent foragers, depending on experience at the source. What is the benefit in sending so many foragers to investigate a source when only a few foragers are required to reactivate the entire group? We used an agent-based software model to test the energetics underlying several different ratios of persistent and reticent individuals in the foraging group while varying 6 ecological factors: forager group size, source distance, source sucrose concentration, source availability in hours, number of days the source is known to the colony, and the rate at which new unemployed foragers appear on the dance floor. Our model demonstrates 2 primary explanations. First, a large number of persistent foragers are needed to ensure that at least some foragers will reconnoiter their source early in its availability, thus enabling the group to effectively exploit the source. Second, the cost of a reconnaissance flight is negligible compared with even a single successful foraging trip.

The Southern Swedish hospital region is the home of nearly 2 million people, inwhich 5,684 individuals were diagnosed by stroke during 2016, according tostatistics from the hospitals in the region. With this large number ofstroke-diagnosed patients across the region, an effective stroke transport policy isinevitably important to provide fast treatment for these patients.In this thesis, we developed an agent-based simulation model for evaluating theperformance of transport logistics policies. We followed the Design ScienceResearch methodology in order to design and develop the model. Using the model,we assessed two transport logistics policies for the Southern Swedish hospitalregion. We used a synthetic set of stroke patients, which we generated using Montecarlo simulation, for the processes of developing the model and assessing our twostroke transport logistics policies.We argue that the assessment of transport logistics policies is important for theability to improve the planning process, for example, when choosing hospital fordiagnosis of patients showing stroke symptoms. The optimization of the strokelogistics process aims to ensure the quality and operational efficiency of the hospitalsector as well as to increase the chance of survival of stroke patients.

The question how a least-cost spatial allocation of sustainable electricity infrastructure may look like using different decision-making procedures (markets, different kinds of land-use and grid regulations) has not yet been analysed explicitly. We measure the sustainability of emerging energy landscapes providing power from renewable energy sources (RES) by an overall welfare function also comprising all kinds of space-related disutilities, i.e. spatial externalities - be they site-specific or related to the distance to a residential area (consumer centre). The presented agent-based model (ABM) concept aims at assessing different policy scenarios to govern the land-use for energetic purposes under the constraint of ensuring the electricity supply for a virtual landscape with RES. To derive optimal spatial allocation an agent-based modelling approach is implemented, which includes a virtual landscape, three settlements as demand centres and profit-oriented producers of renewable power. For the design of the electricity grid and the calculation of grid-related reinforcement costs a load-flow model is applied, being also able to map grid externalities during the RES expansion in space. The model allows RES producers to choose profit-maximising cells for plant installations until the given demand for power of the virtual landscape is met. Different policy scenarios allocate particular costs to agents (e.g. grid reinforcement costs, spatial externalities) or restrict the land-use with respect to ecological or social restraints. Furthermore, consumer centres have the possibility to follow own particular regional strategies, to increase their individual benefit. The overall efficiency of allocation (total cost level) as well as the distributional fairness (regional net costs) are evaluated for the policy scenarios and the regional strategies.