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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 9 of 9 (0.029 seconds)Spelling suggestions: "subject:"44.38 pharmakologie"" "subject:"44.38 farmakologie""
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen / Pharmacokinetics Of Doxorubicin: Interindividual Variability And Impact Of Genetic Polymorphisms In Transmembrane Carrier-SystemsWasser, Katrin 09 June 2008 (has links)
No description available.
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Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen / Relevance of genetic polymorphisms in Cytochrom-P450-2C9- and -3A5 for pharmacokinetics, effects and adverse effects of Delta-9-Tetrahydrocannabinol in healthy male and female volunteersPfeil, Johannes 02 January 2009 (has links)
No description available.
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Arzneimittelsicherheit in der Psychiatrie / Vergleich der schweren unerwünschten Arzneimittelwirkungen von Citalopram und Escitalopram / Comparison of the severe adverse drug reaction of citalopram versus escitalopram / Results of the German drug safety programme in psychiatry AMSPBauer, Kathrin 29 September 2010 (has links)
No description available.
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OCT1-mediated cellular drug uptake and interactions between drug transport and drug metabolism / OCT1-mediated cellular drug uptake and interactions between drug transport and drug metabolismSaadatmand, Ali Reza 25 October 2012 (has links)
No description available.
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Funktionelle und genetische Variabilität bei der zytotoxischen Wirkung von Nukleosid-Analoga / Functional and genetic variability in the cytotoxic action of nucleosid analoguesKuschel, Christian 16 May 2012 (has links)
No description available.
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Die Auswirkungen von 20-Hydroxyecdyson (β-Ecdyson) im Vergleich zu 17-β-Östradiol auf den Knochenaufbau und Knochenstoffwechsel der Ratte als Modell für die postmenopausale Osteoporose der Frau / Effects of 20-Hydroxyecdysone (β-Ecdysone) compared to Estradiol on the bone substance and bone metabolism in ovarectomized rats as a model for the osteoporosis in postmenopausal womenDettmer, Birthe 05 June 2012 (has links)
No description available.
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Beeinflussung der Frakturheilung und des Stoffwechsels des osteopenischen Knochens durch Hormone, Raloxifen und Bisphosphat im Rattentiermodell / Fracture healing and metabolism in osteoporotic bone treated with estrogen, raloxifene, alendronate and cimicifuga racemosaSchumann, Jakob 26 January 2010 (has links)
No description available.
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Development of a novel technology to engineer heart muscle for contractile and paracrine support in heart failureSoong, Poh Loong 23 October 2012 (has links)
The human heart has poor endogenous regeneration. If myocytes are lost due
to injury, the myocardium is unable to restore its myocyte content and instead
undergoes compensatory hypertrophy and remodeling. Cardiac tissue
engineering aims to recreate and provide functional myocardium that replaces
the injured myocardium. In this study, human engineered heart muscle (EHM)
from cardiomyogenically differentiated human embryonic stem cells was
generated. EHMs consisted of elongated, anisotropically organized
cardiomyocyte bundles and responded “physiologically” to increasing calcium
concentrations. To generate large myocardium capable of encompassing the
ventricles, a novel process to systematically upscale the dimensions of
engineered myocardium to a humanized Biological Ventricular Assisted Device
(hBioVAD) was introduced. The hBioVADs formed a “pouch-like” myocardium at
rabbit heart dimensions and were beating spontaneously. Further enhancement
by biomimetic pulsatile loading generated “more mature” myocardium.
Additional paracrine functionality was integrated by generating insulin-like
growth factor-1 (IGF-1) secreting fibroblasts for tissue engineering applications.
IGF-1 release induced higher levels of Akt phosphorylation and hypertrophy in
cardiomyocytes resulting in increased force generation of EHM. Finally,
feasibility of “paraBioVAD” (IGF-1 cell line and cardiomyocytes) implantation
was demonstrated in a healthy rat model. Histological observations
demonstrated engraftment on the heart and the presence of vascular structures.
In conclusion, a humanized “paraBioVAD” technology for mechanic and
paracrine heart support was developed. Future studies will assess its
therapeutic utility in heart failure
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Evaluation neuroprotektiver Strategien am Beispiel ausgewählter neurodegenerativer Erkrankungen: Amyotrophe Lateralsklerose und Alkoholabhängigkeit / Evaluating neuroprotective strategies in neurodegenerative diseases: amyotrophic lateral sclerosis and alcohol dependenceBartels, Claudia 02 May 2007 (has links)
No description available.
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