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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 9 of 9 (0.05 seconds)Spelling suggestions: "subject:"MED 351 pharmakologie"" "subject:"MED 351 farmakologie""
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Bedeutung genetischer Polymorphismen in den Genen des Transportproteins SLC6A14, des Leptinrezeptors, des Adiponektins und des Adiponektin-Rezeptors für das Risiko, unter Antipsychotikatherapie Übergewicht zu erleiden / Effects of genetic polymorphisms in the genes of the transport protein SLC6A14, the leptin receptor, adiponectin and the adiponectin receptor on the risk to suffer from obesity during antipsychotic therapyTorno, Ernst-Christian 13 March 2012 (has links)
No description available.
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Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen / Pharmacokinetics Of Doxorubicin: Interindividual Variability And Impact Of Genetic Polymorphisms In Transmembrane Carrier-SystemsWasser, Katrin 09 June 2008 (has links)
No description available.
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Einfluss des Renin-Angiotensin-Systems auf die menschliche Erythropoetinproduktion unter normoxischen Bedingungen und nach Stimulation durch Fenoterol / Influence of the renin-angiotensin-system on the humen erythopoietin production under normoxic conditions and after stimulation by fenoterolSchenck, Tim 09 November 2010 (has links)
No description available.
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Pharmakogenetik des Zytostatikums Melphalan: Charakterisierung des Membrantransportes / Pharmacogenetics of the cytostatic drug melphalan:Characterization of the membrane transportKühne, Annett 28 April 2008 (has links)
No description available.
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Entwicklung von Substraten und Inhibitoren pharmakologisch relevanter Proteintargets / Development of substrates and inhibitors of pharmacologically relevant protein targetsRiester, Daniel 25 January 2005 (has links)
No description available.
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Molecular mechanisms of the effect of the mood stabilizer lithium on cAMP-induced CREB transcriptional activity / Untersuchung des molekularen Mechanismus der Wirkung des Phasenprophylaktikums Lithium auf die cAMP-induzierte CRE/CREB-vermittelte GentranskriptionHeinrich, Annette 28 April 2009 (has links)
No description available.
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Tryptamines as Ligands and Modulators of the Serotonin 5‑HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens / Tryptamine als Liganden und Modulatoren des 5‑HT2A Serotonin-Rezeptors und die Isolierung von Aeruginascin aus dem halluzinogenen Pilz Inocybe aeruginascensJensen, Niels 04 November 2004 (has links)
No description available.
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Development of a novel technology to engineer heart muscle for contractile and paracrine support in heart failureSoong, Poh Loong 23 October 2012 (has links)
The human heart has poor endogenous regeneration. If myocytes are lost due
to injury, the myocardium is unable to restore its myocyte content and instead
undergoes compensatory hypertrophy and remodeling. Cardiac tissue
engineering aims to recreate and provide functional myocardium that replaces
the injured myocardium. In this study, human engineered heart muscle (EHM)
from cardiomyogenically differentiated human embryonic stem cells was
generated. EHMs consisted of elongated, anisotropically organized
cardiomyocyte bundles and responded “physiologically” to increasing calcium
concentrations. To generate large myocardium capable of encompassing the
ventricles, a novel process to systematically upscale the dimensions of
engineered myocardium to a humanized Biological Ventricular Assisted Device
(hBioVAD) was introduced. The hBioVADs formed a “pouch-like” myocardium at
rabbit heart dimensions and were beating spontaneously. Further enhancement
by biomimetic pulsatile loading generated “more mature” myocardium.
Additional paracrine functionality was integrated by generating insulin-like
growth factor-1 (IGF-1) secreting fibroblasts for tissue engineering applications.
IGF-1 release induced higher levels of Akt phosphorylation and hypertrophy in
cardiomyocytes resulting in increased force generation of EHM. Finally,
feasibility of “paraBioVAD” (IGF-1 cell line and cardiomyocytes) implantation
was demonstrated in a healthy rat model. Histological observations
demonstrated engraftment on the heart and the presence of vascular structures.
In conclusion, a humanized “paraBioVAD” technology for mechanic and
paracrine heart support was developed. Future studies will assess its
therapeutic utility in heart failure
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Evaluation neuroprotektiver Strategien am Beispiel ausgewählter neurodegenerativer Erkrankungen: Amyotrophe Lateralsklerose und Alkoholabhängigkeit / Evaluating neuroprotective strategies in neurodegenerative diseases: amyotrophic lateral sclerosis and alcohol dependenceBartels, Claudia 02 May 2007 (has links)
No description available.
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