A asma brônquica é uma doença inflamatória crônica das vias aéreas inferiores que resulta da interação entre fatores genéticos e ambientais.Teve como objetivo estudar o polimorfismo Arg16Gly e Gln27Glu do Gene &#946;2-ADR e a sensibilização fúngica associada ao controle e gravidade da asma. Trata-se de um estudo observacional analítico caso controle em portadores de asma, assistidos no Programa de Assistência ao Paciente Asmático do Hospital Universitário Presidente Dutra (PAPA-HUPD). Foram incluídos no estudo 83 pacientes com asma brônquica e 46 não asmáticos como controles. Os participantes coletaram duas amostra de 5ml de sangue, para genotipagem do gene &#946;2AR-16 e &#946;2AR-27 por PCR-RFLP e teste de sensibilização Elisa específico para fungos. Os dados de controle foram obtidos através do Teste de Controle da Asma (ACT) e os dados clínicos dos prontuários. As análises de polimorfismo não apresentaram associação com o estado de controle da asma para o gene &#946;2-ADR-16 e &#946;2-ADR-27. Entre asmáticos e não asmáticos foi observado diferença estatisticamente significante (p<0,05) com maior expressão do alelo Glu (74%) entre os não asmáticos. O homozigoto Glu/Glu também foi mais frequentes entre os não asmáticos, sugerindo que o alelo Glu-27 pode estar associado ao risco diminuído para asma. Quanto à sensibilização fúngica, não houve associação significante com os genótipos estudados. O estudo mostrou que, asmáticos graves são mais sensibilizados que não asmáticos e asmáticos moderados. Não houve diferença estatisticamente significante entre controle da asma e sensibilização fúngica, no entanto houve associação significativa com a gravidade. Associações isoladas entre sensibilização fúngica e asma, assim como entre polimorfismo e asma ficou evidente neste estudo. / Asthma is a chronic inflammatory disease of the lower airways, and is a result of the interaction between genetic and environmental factors. Aimed to study polymorphism and Arg16Gly Gln27Glu Gene &#946;2-ADR and fungal sensitization associated with asthma severity and control. It is an observational, analytic case-control study involving asthmatic subjects of the Assistance Program to the Asthmatic Patient - APAP, in the Presidente Dutra University Hospital, Maranhão, Brazil. Eighty-three asthmatic patients and 46 non-asthmatic controls were included in the study. PCR-RFLP genotyping of the &#946;2AR-16 and &#946;2AR-27 genes, and fungal-specific enzyme-linked immunosorbent assay (ELISA) were made in two 5 ml blood samples collected from the participants. Control data were gathered from the Asthma Control Questionnaire (ACQ) and clinical data from the medical records. The analysis of the polymorphism has not demonstrated association between the asthma control status and the &#946;2AR-16 and &#946;2AR-27 genes. There was statistically significant difference (p < 0,05) between asthmatics and non-asthmatics, with higher expression (74%) of the Glu allele in non-asthmatic subjects. The Glu/Glu homozygote was also more frequent between non-asthmatics, and it suggests that the Glu-27 allele might be associated with a lower risk to develop asthma. Regarding fungal sensitization, there wasn't significant association with the studied genotypes. The study demonstrated that severe asthmatics are more sensitized than non-asthmatics and moderate asthmatics. There wasn't statistically significant difference between asthma control and fungal sensitization; nevertheless, there was significant association with the severity level. Isolated associations between fungal sensitization and asthma, as well as associations between polymorphisms and asthma were evident in this study.

A asma brônquica é uma doença inflamatória crônica das vias aéreas inferiores que resulta da interação entre fatores genéticos e ambientais.Teve como objetivo estudar o polimorfismo Arg16Gly e Gln27Glu do Gene &#946;2-ADR e a sensibilização fúngica associada ao controle e gravidade da asma. Trata-se de um estudo observacional analítico caso controle em portadores de asma, assistidos no Programa de Assistência ao Paciente Asmático do Hospital Universitário Presidente Dutra (PAPA-HUPD). Foram incluídos no estudo 83 pacientes com asma brônquica e 46 não asmáticos como controles. Os participantes coletaram duas amostra de 5ml de sangue, para genotipagem do gene &#946;2AR-16 e &#946;2AR-27 por PCR-RFLP e teste de sensibilização Elisa específico para fungos. Os dados de controle foram obtidos através do Teste de Controle da Asma (ACT) e os dados clínicos dos prontuários. As análises de polimorfismo não apresentaram associação com o estado de controle da asma para o gene &#946;2-ADR-16 e &#946;2-ADR-27. Entre asmáticos e não asmáticos foi observado diferença estatisticamente significante (p<0,05) com maior expressão do alelo Glu (74%) entre os não asmáticos. O homozigoto Glu/Glu também foi mais frequentes entre os não asmáticos, sugerindo que o alelo Glu-27 pode estar associado ao risco diminuído para asma. Quanto à sensibilização fúngica, não houve associação significante com os genótipos estudados. O estudo mostrou que, asmáticos graves são mais sensibilizados que não asmáticos e asmáticos moderados. Não houve diferença estatisticamente significante entre controle da asma e sensibilização fúngica, no entanto houve associação significativa com a gravidade. Associações isoladas entre sensibilização fúngica e asma, assim como entre polimorfismo e asma ficou evidente neste estudo. / Asthma is a chronic inflammatory disease of the lower airways, and is a result of the interaction between genetic and environmental factors. Aimed to study polymorphism and Arg16Gly Gln27Glu Gene &#946;2-ADR and fungal sensitization associated with asthma severity and control. It is an observational, analytic case-control study involving asthmatic subjects of the Assistance Program to the Asthmatic Patient - APAP, in the Presidente Dutra University Hospital, Maranhão, Brazil. Eighty-three asthmatic patients and 46 non-asthmatic controls were included in the study. PCR-RFLP genotyping of the &#946;2AR-16 and &#946;2AR-27 genes, and fungal-specific enzyme-linked immunosorbent assay (ELISA) were made in two 5 ml blood samples collected from the participants. Control data were gathered from the Asthma Control Questionnaire (ACQ) and clinical data from the medical records. The analysis of the polymorphism has not demonstrated association between the asthma control status and the &#946;2AR-16 and &#946;2AR-27 genes. There was statistically significant difference (p < 0,05) between asthmatics and non-asthmatics, with higher expression (74%) of the Glu allele in non-asthmatic subjects. The Glu/Glu homozygote was also more frequent between non-asthmatics, and it suggests that the Glu-27 allele might be associated with a lower risk to develop asthma. Regarding fungal sensitization, there wasn't significant association with the studied genotypes. The study demonstrated that severe asthmatics are more sensitized than non-asthmatics and moderate asthmatics. There wasn't statistically significant difference between asthma control and fungal sensitization; nevertheless, there was significant association with the severity level. Isolated associations between fungal sensitization and asthma, as well as associations between polymorphisms and asthma were evident in this study.

The ADR Agreement allows to reduce the accidents of cars, transporting the dangerous goods. It determines how to pack, manipulate and transport the dangerous goods. It says how often the drivers have to be trained and what they should do when the accident happens.

This work deals with the specifics of relations between entities in the negotiation and implementation of international transport of goods. Since he is currently the most common way of transport of goods in Central Europe freight road transport of goods, the text is mainly dedicated to this issue. The underlying code for the obligations in this respect, the Convention CMR, which is devoted to a large part of the work. In other parts of the work is also introduced to the TIR Convention, the ADR Agreement concerning the international carriage of dangerous goods and the ATP Agreement, which defines the requirements for the transport of perishable foodstuffs. In the end, understand that INCOTERMS clauses with international trade and international transport of goods is closely related.

Medicines and vaccines have revolutionized disease prevention and treatment, offering numerous benefits. However, they also raise concerns about Adverse Drug Reactions (ADRs), which can have severe consequences. Summaries of Product Characteristics (SmPCs), provided by the European Medicines Agency (EMA), and Structured Product Labelings (SPLs), provided by the Food and Drug Administration (FDA), are valuable sources of information on drug-ADR relations. Understanding these relations is crucial as it contributes to establishing labeled datasets for known ADRs and advancing statistical assessment methods. Uppsala Monitoring Centre (UMC) has developed a text mining pipeline to extract known ADRs from SPLs. While the pipeline works effectively with SPLs, it faces challenges with SmPCs provided in PDF format. This study explores extending the scanner component of the pipeline by utilizing Python PDF extraction libraries to extract text from SmPCs and fine-tuning domain-specific pre-trained BERT-based models for Named Entity Recognition (NER), which is a Natural Language Processing (NLP) task, aiming to identify known ADRs from SmPCs. The investigation finds pypdfium2 [1] to be the optimal Python PDF extraction library, and fine-tuned PubMedBERT—a domain-specific language model pre-training from scratch [2]—for the NER task achieves the best performance in identifying ADRs from SmPCs. The model's performance, evaluated using entity-level evaluation metrics including Exact, Covering, and Overlap match metrics, achieves F1-scores of 0.9138, 0.9268, and 0.9671, respectively, indicating significantly good performance. Consequently, the extension model investigated in this study will be integrated into the existing pipeline by UMC professionals.

SUMMARY: MEDIATION OF COMMERCIAL DISPUTES - DOMESTIC AND INTERNATIONAL PERSPECTIVES Dr. Martin Svatoš This paper addresses the mediation and its use in the both domestic and international commercial disputes. The milieu that serves as a source of the problems to be resolved during mediation is a specific one. It demands quick, cost-effective and confidential resolution of complicated disputes involving several parties. In general, this cannot be granted by the traditional ways of dispute resolution - litigation and arbitration. Mediation is regarded as a cost-effective and quick extrajudicial resolution of disputes in civil and commercial matters through processes tailored to the needs of the parties. On the other hand, there are several legal and legal-related issues that have to be discussed. And thus, the question that remains to be answered is: Is mediation really as effective as it is told? And in the case of a positive answer - why it is not the most commonly used dispute resolution procedure? The main goal of this thesis is to answer these queries. Its first part focuses on the issue of mediation in general. Quite surprisingly, there is no exact definition of mediation neither in the legal acts, nor in the opinion of the ADR experts. In contrast, plenty of definition can be found after short...

Cette thèse porte sur la recherche et l'amélioration de cryoréfrigérateurs à désaimantation adiabatique (ADR) pour la gamme 4 K - 50 mK. Ce refroidissement à 50 mK permettra de répondre aux besoins de réfrigération des détecteurs les plus sensibles envisagés pour les instruments des missions d'astrophysique. Ce réfrigérateur doit être efficace et de masse optimisée.Les axes clefs de ce travail sont la mise au point d’une méthode d’identification de réfrigérants magnétiques de haute performance et l'étude d’interrupteurs thermiques efficaces. Parmi les matériaux étudiés, le YbGG (Yb3Ga5O12) a été identifié comme un excellent réfrigérant potentiel pour la gamme 1.5 K - 0.4 K, confirmé par sa caractérisation expérimentale. Le travail sur les interrupteurs thermiques à gaz d'échange a permis de supprimer ou de réduire de façon importante des effets de courts-circuits thermiques transitoires parasites, lesquels apparaissent dans les conditions particulières d’utilisation de ce type de cryocooler. Finalement, un démonstrateur de cryoréfrigérateur constitué de 3 étages d’ADR en série, adapté pour les besoins des futures missions spatiales, a été dimensionné et fabriqué. / Highly sensitive detectors required for astrophysics missions demand temperatures of about 50 mK to operate with the targeted sensitivity. This PhD work is dedicated on the research and development of Adiabatic Demagnetization Refrigerators (ADR) for space in the 4 K - 50 mK range. In particular, this cryocooler is required to be efficient with optimized mass.The key points of this work are the development of a method allowing the identification of highly efficient paramagnetic materials and the improvement of thermal heat switches. Among the material studied, YbGG (Yb3Ga5O12) was identified to have a great potential as a magnetic refrigerant in the 1.5 K - 0.4 K range, which was confirmed by its characterization. Transient thermal short circuits may appear on the gas-gap thermal switches under the working conditions of this cryocooler. This study allowed us to suppress or to considerably attenuate this effect. Finally, a cryocooler prototype consisting of 3 ADR stages was designed and built.

This dissertation is focused on transportation of hazardous substances and on procedures of units of integrated emergency system during a traffic accident. It covers issues such as valid legislature, drivers´ training, obligatory documents, compulsory spares and checking of vehicle by the Police of the Czech Republic. The cooperation of units of the integrated emergency system / firefighters, policemen, emergency healht care/ starts as a common action at the very moment all rescue and protection units arrive at the place of the trafic accident of a vehicle transportating hazardous substance. Main attention is paid to the police work. The empirical part is relating to the research of knowledge in the field of transportation of hazardous substances through the use of the questionnarie . It is divided into three parts. The first part of the questionnarie contains collected basic information about the informants. The second part is focused on general knowledge about transportation of hazardous substances. The third part is aimed to the knowledge of procedures and activities at the place of accident. The conclusion of this dissertation mentions some of the accident advised forms of how to improve the transportation of hazardous substance by land and the preparatin of procedure of the Police of the Czech Republic in joint operations.

The thesis ``Causes of Accident Occurrence in Transporting Dangerous Substances{\crq}q is aimed at the topic of road accidents in transport of dangerous substances, which is one of its inseparable parts on which extra stress is placed and cannot be classified as common transport. Road transport of dangerous substances is subject to the European Agreement concerning the International Carriage of Dangerous Goods by Road (ADR). Although the safety of road transport of dangerous goods is broadly secured in the sense of ADR there are still numerous factors affecting the transport course itself, which may lead to a road accident. Road accidents of vehicles transporting dangerous goods often involve leaks of dangerous substances and subsequent threat to human lives and health, damage on environment and property. This is why transport of dangerous substances definitely belongs to activities with higher risk rate. The fact that the time and place of accident occurrence cannot be determined in advance even escalates the danger. The thesis is aimed at surveying the situation in the field of causes of accident occurrence in transporting dangerous substances, discovering the level of awareness of the problems of dangerous substance transport and the causes of road accidents among traffic participants and proposing concrete preventive measures. Quantitative research was performed to gain information necessary to confirm my hypotheses. Secondary analysis of the data from the Police of the Czech Republic archives was used as the method for confirmation of hypotheses. A questionnaire survey was used for determination of the level of awareness among traffic participants. The hypotheses set in the thesis, that the causes of accident occurrence in transporting dangerous substances have direct influence on accident frequency and common road traffic participants do not have sufficient knowledge of the problems of dangerous substance transport have been confirmed.

Rapporten handlar om tidrapportering för konsulter och hur den kan kunna underlättas. Tidrapportering är ett måste för alla personer som arbetar i konsultbranschen. I dagens samhälle finns det problem med tidrapportering då anställda anser att det är ansträngande och ser det som extra arbete. Det är en utmaning för företag att lyckas med att få sina anställda att rapportera korrekt. Om rapporteringen inte sker på ett korrekt sätt kan detta få stora ekonomiska konsekvenser. Syftet med rapporten är att underlätta tidrapporteringen för konsulter. Detta genom att utveckla en mobil IT-artefakt. Applikationen som utvecklas ska fungera som ett stöd till tidrapportering och målet är att användaren ska interagera med applikationen så lite som möjligt. Artefakten som utvecklas är en mobilapplikation som använder sig av mobilens GPS-funktion. Action Design Research (ADR) är forskningsmetoden som används för att genomföra detta arbete. Denna rapport bygger på ett case i samarbete med konsultföretaget Knowit. Resultatet utmynnar i en IT-artefakt och 10 designprinciper om hur utvecklandet av en sådan applikation kan gå tillväga. / This thesis handles the area around time reporting within the consulting field and how it can be facilitated. Time reporting is a must for every employee in the consulting business. In today’s society, a problem exists as the employees sees this to be a demanding extra chore. To manage employees to execute this is a challenge for every business. If this is not done correctly, the business can face huge economic consequences. The purpose with this thesis is to facilitate time reporting for consultants. This will be done by developing a Mobile IT-Artifact. The application which will be developed will serve as a support for time reporting and its goal is to minimize the human-computer interaction. The artefact that will be developed uses the phones build in GPS function to achieve this. Action Design Research (ADR) is the research method used to complete the development of the artifact and the thesis. This thesis is built around a case in cooperation with the consulting company Knowit. The result of this essay will generate an IT-artifact along with 10 design principles which provides guidelines on how to develop a system of similar character