Orientador: Guilherme Antonio Moreira de Barros / Resumo: A Síndrome Dolorosa Miofascial (SDM) é considerada um importante problema de saúde pública, podendo, muitas vezes, ser incapacitante e de difícil tratamento. Considerando que, atualmente, o tratamento da SDM é pouco eficaz para o controle da dor, verificamos a necessidade do estudo de novas técnicas e da comparação com as técnicas já existentes. O presente estudo teve como objetivo comparar técnicas de eletroestimulação intramuscular com a técnica de agulhamento seco para o tratamento dessa enfermidade musculoesquelética. Foram estudados 90 pacientes divididos em três grupos. O primeiro grupo foi tratado com agulhamento seco em pontos de gatilhos (PGs), o segundo grupo com eletroestimulação intramuscular de PGs e o terceiro grupo foi tratado com eletroestimulação de pontos motores (PMs) pertencentes ao músculo acometido e/ou o nervo responsável pela inervação desse músculo. O músculo utilizado foi a porção superior do trapézio que é inervado pelo nervo acessório espinal. Foram realizadas sete sessões de tratamento em cada grupo e todos foram avaliados antes e após o término do mesmo. Não houve diferença estatisticamente significativa nos escores de dor da Escala Verbal Numérica (EVN) entre os grupos estudados, apesar de todas as intervenções terem se mostrado eficazes para o tratamento da dor miofascial do músculo trapézio. / Abstract: Myofascial Pain Syndrome (SDM) is considered an important public health problem and can often be disabling and difficult to treat. Considering that, currently, the treatment of SDM is not very effective for pain control, we verified the need to study new techniques and to compare them with existing techniques. The present study aimed to compare intramuscular electrostimulation techniques with the dry needling technique for the treatment of this musculoskeletal disease. Ninety patients were studied, divided into three groups. The first group was treated with dry needles at trigger points (PGs), the second group with intramuscular electrostimulation of PGs and the third group was treated with electrostimulation of motor points (PMs) belonging to the affected muscle and / or the nerve responsible for innervation of that muscle. The muscle used was the upper portion of the trapezius, which is innervated by the spinal accessory nerve. Seven treatment sessions were carried out in each group and all were evaluated before and after the end of the same. There was no statistically significant difference in pain scores on the Numerical Verbal Scale (EVN) between the groups studied, although all interventions have been shown to be effective for the treatment of trapezius muscle myofascial pain. / Doutor

Traditional Chinese Medicine (TCM) has been common practice for many years, and part of the treatment plan of several million patients in the world. This includes areas such as Great Britain, USA, Germany, the Netherlands, Ireland, Switzerland and China. However, its possibilities in the territory of the Czech Republic are limited and insufficiently mapped (the area of practicing TCM for non-medical education practitioners). The thesis analyzes the current situation of doctors and practitioners applying TCM in the territory of the Czech Republic compared to other countries where TCM has been successfully established within the health system for many years. It also aims to find out how doctors and practitioners advocate their focus, what reasons they present for treatment with the TCM and how they deal with the criticism of their colleagues from the West. The work will include findings on why conventional physicians are heading towards Eastern medicine. Due to the debate of the topic, the thesis will continue to deal with the legislative anchoring of TCM in the laws of the Czech Republic and the world. The theoretical part of the thesis presents basic concepts related to the history and philosophy of the TCM. It also describes methods of diagnostics, treatment and pillars that the TCM supports...

This dissertation investigates to use and increase existing vibrancy to revitalize an urban environment. The urban response is to consolidate existing functions within Rua De Bagamoyo, as a night- life precinct through the introduction of gaming as an extension of the existing night- life activity. The architectural response is to focus on a building that houses a casino and facility for prostitutes that challenges the private-public relationships of place by extending the street into the built form and the form into the street through a series of threshold spaces that explore the notions of visual and physical access. / Dissertation (MArch(Prof))--University of Pretoria, 2011. / Architecture / unrestricted

Sowohl in der Human- als auch in der Veterinärmedizin existieren mittlerweile zahlreiche Therapieverfahren, die immer öfter komplementär zur Schulmedizin eingesetzt werden. Zu den in der Tiermedizin besonders häufig angewandten Verfahren zählen die Neuraltherapie und die Akupunktur. Aber auch die Transkutane Elektrische Nerven Stimulation (TENS) und die Stimulation myofaszialer Triggerpunkte werden zu den segmentalen Therapiemethoden gerechnet. Die Linderung chronischer Schmerzzustände steht beim Einsatz dieser Verfahren im Vordergrund. Muskuloskelettale Erkrankungen der Lendenwirbelsäule und Lendenregion sowie der Gliedmaßen stellen beim Hund eine häufige Indikation für den Einsatz eines neuraltherapeutischen Verfahrens dar. In diesem Zusammenhang wird die Regio lumbalis des Hundes sehr häufig für eine Therapie herangezogen. Die Wirkung einer neuraltherapeutischen Behandlung wird in diesem Bereich segmental über die Spinalnerven vermittelt. Ziel der vorliegenden Dissertation war es, die Regio lumbalis des Hundes insbesondere im Hinblick auf das Innervationsmuster der Hautnerven detailliert darzustellen. Die erhobenen Befunde sollten einen Beitrag zum besseren Verständnis der Wirkmechanismen der verschiedenen Therapietechniken leisten. Außerdem sollte nach einem möglichen morphologischen Korrelat zu den in der TCM definierten Akupunkturpunkten gesucht werden. Zu diesem Zweck wurden der Verlauf und die Verzweigung der Nerven des Lendenbereiches von n=12 formalinfixierten Hunden beginnend von der dorsalen Medianlinie dargestellt. Eine fotografische Dokumentation fand in drei Schichten statt: im Bereich der Fascia thoracolumbalis (a), auf Niveau der langen Rückenmuskulatur (b) und über den Procc. transversi (c). Des Weiteren wurde bei n=2 Tieren eine Präparation des subkutanen Innervationsmusters vorgenommen. Um die präparatorischen Ergebnisse interindividuell vergleichen zu können, wurden sog. Kaudalverschiebungsindizes entwickelt und für die einzelnen Spinalnerven berechnet. Spinalnerven, welche die Haut der Regio lumbalis innervierten, stammten aus den Rückenmarkssegmenten Th12 bis L5. Nervi cutanei der Dorsaläste besaßen alle Hunde, bei n=7 Tieren beteiligten sich auch Hautäste von Rr. ventrales aus den Segmenten L3 bis L5 an der Innervation des dorsalen Lendenbereiches. Die Anzahl der Hautnervenäste variierte individuell zwischen drei und sieben, wobei die Nerven bei den Tieren mit einer geringeren Anzahl aus den weiter kranial gelegenen Segmenten stammten. Der Verlauf, die Verzweigung sowie der Perforation der Nervi cutanei durch die Fascia thoracolumbalis zeigten eine sehr hohe individuelle Variabilität. Im Bereich der langen Rückenmuskulatur wurde dagegen ein vergleichbares und segmental regelmäßiges Innervationsmuster angetroffen. Bei der Präparation der subkutanen Nervenverläufe fiel ein sehr irreguläres und segmental nicht nachvollziehbares Muster auf. Bei allen untersuchten Hunden zeigten die Dorsaläste der Spinalnerven eine Kaudalverschiebung um mindestens eine Wirbelkörperlänge. Die in der vorliegenden Arbeit eingeführten Kaudalverschiebungsindizes ermöglichen einen interindividuellen Vergleich des Verlaufes der Spinalnerven der Regio lumbalis. Durch die errechneten Indizes ist eine graphische Darstellung und aussagekräftige Interpretation der morphologischen Ergebnisse gegeben. Die zum Teil hohe interindividuelle Variation im Innervationsmuster der Hautnerven des Lendenbereiches in den oberflächlichen Körperschichten lässt den Schluss zu, dass die Hautareale des Lendenbereiches nicht bei jedem Tier von demselben Spinalnerven innerviert werden. Das bedeutet, dass die Dermatome bei verschiedenen Individuen nicht identisch sind. Des Weiteren schließt die unterschiedliche Lokalisation der Nerven und ihrer Durchtrittstellen durch die Fascia thoracolumbalis ein morphologisches Korrelat zu den in der TCM festgelegten Akupunkturpunkten aus. Die bei allen Hunden regelmäßige Anordnung der Spinalnerven auf Niveau der langen Rückenmuskulatur deutet vielmehr darauf hin, dass ein in der Körperperipherie gesetzter Reiz unabhängig von einer genauen Punktlokalisation einen segmental in das Rückenmark vermittelten Effekt bei einer neuraltherapeutischen Behandlung zur Folge hat. Für eine erfolgreiche Therapie sind daher die profunde Kenntnis der Segmentanatomie sowie der neuroanatomischen Verschaltungswege unbedingt erforderlich. In Zukunft sollte mehr Augenmerk auf individuelle Unterschiede im Innervationsmuster gelegt werden, da diese einen möglichen Grund für die individuell variable oder auch ausbleibende Wirkung bei einer neuraltherapeutischen Behandlung darstellen können.

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This study showed that state laws and policies constrain the locational preferences of alternative health care providers to varying degrees, depending on the particular profession and level of legal status. Three separate surveys were conducted, focusing on acupuncturists, chiropractors and homeopaths in Maryland, Virginia, North Carolina, and the District of Columbia. The acupuncture findings revealed intraprofessional divisions that lead to a strong influence of legal constraints on the locational behavior of non-MD acupuncturists. Results from the chiropractic survey reflected an established profession with a less pronounced, but moderate, influence of state laws and policies on location and mobility. The homeopathy findings, while based on a much smaller sample, did not reveal a strong relationship between legal constraints and spatial characteristics, except in the extreme case of North Carolina's recent prohibition. This study also postulated a model to explain the progression of alternative health care professions toward legitimation. The variables of public acceptance and legal constraints on location were plotted on the model to identify particular levels of progression. The importance of this research is highlighted by impending health care reforms, the need for access to professional health services, skyrocketing biomedical costs, and the documented utilization of alternative health care in this country. / Master of Science

研究背景：便秘被過往的研究確認為世界各地老年人的一個常見健康問題，尤其是居住在安老院的長者。香港一項人口普查亦指出便秘也是香港老年人的一個常見健康問題。便秘對長者的生理、心理和社會功能等各方面都產生不良影響。此外，醫療體制亦因處理便秘及其衍生的健康問題而面對沉重的負擔。目前所採用的常規方案是生活模式改變及使用軟便劑，但兩者均未能有效地紓緩便秘的徵狀。由於香港老齡人口持續增長，便秘將會是一個具有潛在持續性的老年健康問題，故尋找一個能有效地紓緩便秘徵狀的方案甚為迫切。耳穴療法是一項普及的中醫療法，亦屬於互補療法。過往在中國進行的研究顯示，耳穴療法能有效地治療便秘，惟此等療效尚未被確實。耳穴療法應是一個對處理便秘具有潛在療效的治療方案。現時，香港尚未有研究評價耳穴療法對處理便秘的療效。 / 研究目的：本研究旨在評價耳穴療法的互補療效，對安老院內的長者便秘徵狀及便秘相關的健康生活品質的干預效果。 / 研究方法：本研究是一個採取混合研究法的臨床研究。先進行化研究，評價耳穴療法對安老院內長者的便秘徵狀及便秘相關的健康生活品質的互補療效；接著進行質化研究，探討面談者對接受耳穴療法的經驗及感受。量化研究是一個隨機對照及雙盲的研究。安老院內的院友被取錄為參與者後，便隨機地獲分配一個研究組別。本研究共有三個研究組別，每名組員分別接受一個預定的干預措施，包括磁珠耳貼療法 (干預組)，王不留行籽耳貼療法 (對照A組) 及耳貼療法 (對照B組)，干預措施是在七個選定的耳穴上進行耳穴療法，共維持十天。研究指標包括便秘徵狀及便秘相關的健康生活品質。此等研究指標分別在干預前 (基線資料)、十天後 (干預措施結束) 和二十天後 (干預措施結束後十天) 進行資料蒐集。統計推斷方法是採用廣義估計方程模型檢驗組間和組內在便秘徵狀及便秘相關的健康生活品質之差異。質化研究的面談者必須是完成整個研究過程的干預組組員，並在量化檢驗的便秘徵狀指標中取得最高分及最低分的各四位組員。透過個別面談，探討面談者對接受耳穴療法以處理便秘的經驗及感受。 / 研究結果：本研究共有99名參與者。祇有90名參與者接受干預措施 (干預組=31；對照A組=28；對照B組=31)，其中的81名參與者完成整個療程 (干預組=29；對照A組=25；對照B組=27)。本研究結果顯示耳穴療法在十天 (p=0.016)及二十天 (p=0.016) 的研究時期內，便秘相關的健康生活品質中的滿意度在干預組及對照A組間有顯著的差異 (十天及二十天均是p=0.016)。然而，本研究證實磁珠耳貼療法能顯著地紓緩便秘徵狀 (十天：p=0.013；二十天：p<0.001)，提升與便秘相關的健康生活品質 (十天：p=0.005；二十天：p<0.001)，並於三個研究組別中取得最大的療效。此外，質化研究結果顯示，耳穴療法確是一項安全及具認受性的療法，適用於安老院內的院友，可作為處理便秘的治療方案。 / 研究結論：本研究是香港首個通過隨機對照的臨床研究，以評價耳穴療法對處理便秘的互補療效。研究結果顯示磁珠耳貼療法對安老院內的院友具有正向的臨床價值：磁珠耳貼療法能紓緩便秘徵狀及提升便秘相關的健康生活品質；安老院內的院友認為耳穴療法是一項安全及具認受性的療法；對住在安老院內年長的中國人而言，耳穴療法是一項與其文化相關的照護方式。本研究就處理安老院內院友的便秘問題為護理專業提供了有關耳穴療法的新知，並作為日後於護理實務及護理研究方面的參考和方向。 / Background: Constipation has been identified in previous studies as a worldwide health problem among elderly people, especially those living in residential care homes (RCHs). Similarly, constipation is also reported as a common health problem among elderly people in Hong Kong in a local population survey. Constipation adversely affects the biopsychosocial well-being of elderly people. In addition, heavy burden has been imposed on the health care system in dealing with constipation and its related health problems. Constipation is currently managed by laxatives and lifestyle modification. However, constipation is not effectively relieved by these two management strategies. In Hong Kong, the aging population is seen to have an increasing trend. Constipation will then be a potentially expanding health problem among elderly people. All these data indicate an urgent need for effective alternatives to manage this health problem. Auriculotherapy is one popular treatment modality in Chinese medicine, which is also a form of complementary therapy. Previous studies conducted in Mainland China reported promising results in managing constipation with auriculotherapy, although its effectiveness was not affirmed. Auriculotherapy appears to be a promising management strategy for constipation. Until now, no study has been conducted in Hong Kong to evaluate the effectiveness of auriculotherapy in managing constipation. / Aim: The current study aims to evaluate the complementary effects of auriculotherapy in relieving constipation symptoms and in promoting disease-specific health-related quality of life (HRQOL) among elderly RCH residents. / Methods: The present study is a clinical trial that adopts the mixed-method design. A randomized placebo-controlled trial was first conducted to evaluate the complementary effects of auriculotherapy in relieving symptoms of constipation and in promoting disease-specific HRQOL in elderly RCH residents. After the completion of the randomized placebo-controlled trial, the qualitative approach was conducted to explore the participants’ experience and perceptions on the use and complementary effects of auriculotherapy with magnetic pellets in managing constipation. The randomized placebo-controlled trial was a double-blind study. The participants were recruited from elderly RCH residents and then randomly assigned to one of the three study groups. The participants received the assigned intervention, namely, auriculotherapy using auricular plaster with magnetic pellet (experimental group), auriculotherapy using auricular plaster with Semen Vaccariae (placebo-controlled group A), or auriculotherapy using only auricular plaster (placebo-controlled group B). Auriculotherapy was applied onto seven selected auricular acupoints for 10 days. Two outcome variables, namely, constipation symptoms and disease-specific HRQOL, were measured before the implementation of intervention (baseline), on Day 10 (at the completion of the intervention), and on Day 20 (at the 10th-day follow-up after the intervention). The generalized estimating equation model was adopted to evaluate the between-group and within-group differences in the complementary effects of auriculotherapy on constipation symptoms and disease-specific HRQOL. In the qualitative approach, the informants were recruited from participants of the experimental group who had successfully completed the study with mean scores in constipation symptoms at the top- or bottom-four ranking. The informants were individually interviewed to explore their experience and perceptions on the use and complementary effects of auriculotherapy in managing constipation. / Results: Ninety-nine participants were recruited in the study. Ninety participants received the intervention as assigned, and eventually, 81 participants completed the intervention. When the interaction effects of time and group were simultaneously considered, statistical significant differences were only found in the satisfaction subscale of the disease-specific HRQOL between the experimental group and placebo-controlled group A on both Day 10 (p=0.016) and Day 20 (p=0.016). For the experimental group, significant time effects were found in constipation symptoms (Day 10：p=0.013; Day 20：p<0.001) and disease-specific HRQOL (Day 10：p=0.005; Day 20：p<0.001) after receiving auriculotherapy. Most importantly, the participants who received auriculotherapy with magnetic pellets showed the greatest improvement in constipation symptoms and disease-specific HRQOL after the intervention compared with the two placebo-controlled groups. The qualitative findings further revealed that auriculotherapy is a safe, well-accepted therapy in managing constipation among elderly RCH residents. / Conclusion: The current study is the first known randomized placebo-controlled trial that evaluates the complementary effects of auriculotherapy in managing constipation in Hong Kong. The current findings indicate positive clinical value of auriculotherapy with magnetic pellets in managing constipation in elderly RCH residents. Auriculotherapy with magnetic pellets was found to provide favourable therapeutic effects in relieving constipation symptoms and in promoting disease-specific HRQOL among elderly RCH residents. This therapy is also considered by elderly people as a safe and acceptable therapy with minimal side effects. In addition, auriculotherapy is considered as a culturally relevant care modality for Chinese elderly RCH residents. The current study contributes new knowledge to nursing for future reference and directions in both nursing practice and nursing research with regard to the complementary effects of auriculotherapy in managing constipation among elderly RCH residents. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Li, Mei Kuen. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2012. / Includes bibliographical references (leaves 273-305). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract and appendixes also in Chinese. / Chapter CHAPTER 1 --- INTRODUCTION / Introduction --- p.1 / Background of the study --- p.2 / Aim and significances of the study --- p.6 / Overview of the thesis --- p.6 / Chapter CHAPTER 2 --- LITERATURE REVIEW / Introduction --- p.8 / Constipation: Potentially expanding health problem in elderly population --- p.9 / Prevalence of constipation --- p.9 / Definition of constipation --- p.11 / Physiology and pathophysiology of defecation --- p.13 / Effects of constipation --- p.15 / Adverse individual health consequences --- p.15 / Economic burden in health care system --- p.18 / Contributory factors for constipation --- p.20 / Roles of nurses in managing constipation in current practice --- p.22 / Cautious use of laxatives --- p.24 / Lifestyle modification --- p.24 / Promoting dietary fiber intake --- p.25 / Encouraging oral fluid intake --- p.26 / Promoting physical activity --- p.26 / Integration of complementary therapy into nursing practice in managing constipation --- p.28 / Auriculotherapy --- p.30 / Historical overview of auriculotherapy --- p.30 / Conceptual framework of auriculotherapy --- p.31 / Approaches of auriculotherapy --- p.36 / Mechanism of auriculotherapy --- p.37 / Clinical applications of auriculotherapy in managing constipation --- p.39 / Complementary effects of auriculotherapy in managing constipation: Review of previous studies --- p.41 / Subject characteristics --- p.41 / Intervention protocol --- p.45 / Therapeutic outcome criteria and effectiveness --- p.50 / Strengths and limitations of the reviewed studies --- p.56 / Recommendations for future studies --- p.59 / Significances of the current study --- p.60 / Summary --- p.61 / Chapter CHAPTER 3 --- METHODS / Introduction --- p.63 / Overview of study design --- p.65 / Mixed-method study design --- p.66 / Quantitative approach --- p.66 / Qualitative approach --- p.68 / Research aim and objectives --- p.68 / Research aim --- p.68 / Research objectives --- p.68 / Null hypotheses --- p.69 / Operational definitions --- p.71 / Rationale of the study design --- p.73 / Rationale for adopting the mixed-method design --- p.73 / Rationale for adopting the randomized controlled trial design --- p.75 / Rationale for adopting double-blindness --- p.75 / Rationale for adopting random assignment --- p.76 / Rationale for adopting a pretest and repeated post-test design --- p.78 / Rationale for recruiting placebo-controlled groups --- p.79 / Quantitative approach --- p.81 / Sample --- p.81 / Accessible population --- p.81 / Sampling method and selection of participants --- p.82 / Sample size determination --- p.85 / Experimental intervention --- p.87 / Content of the experimental intervention --- p.87 / Integrity of experimental intervention --- p.92 / Qualification of the intervener --- p.92 / Consistency of implementation of intervention --- p.93 / Compliance of the participants to study instructions --- p.84 / Data collection --- p.95 / Study Instruments and records --- p.95 / Patient Assessment of Constipation Symptom Questionnaire (Cantonese Chinese for Hong Kong) (PAC-SYM) --- p.96 / Patient Assessment of Constipation Quality of Life Questionnaire (Cantonese Chinese for Hong Kong) (PAC-QOL) --- p.97 / Abbreviated Mental Test (Hong Kong version; AMT) --- p.98 / Physical Activity Questionnaire (Hong Kong version; PAQ) --- p.98 / Screening for eligibility of the participant --- p.99 / Demographic and Clinical Data Sheet --- p.99 / Assessment of Clinical Syndrome of Constipation --- p.99 / Assessment of oral intake of Fruits and Vegetables (AFV) --- p.100 / Bowel Movement Record (BMR) --- p.100 / Drug Administration Record (DAR) --- p.101 / Data collection procedure --- p.101 / Qualitative approach --- p.104 / Rationale for adopting criterion sampling --- p.105 / Pilot Study --- p.106 / Feasibility of the sampling method --- p.107 / Feasibility of the data collection instruments and procedure --- p.107 / Feasibility of implementation of the study intervention --- p.108 / Characteristics of the pilot sample --- p.109 / Sample size recalculation --- p.113 / Appropriateness of the interview guide --- p.114 / Recommendations for the main study --- p.115 / Data Analysis --- p.115 / Quantitative data --- p.115 / Assessment of accuracy of data entry --- p.116 / Description of sample characteristics --- p.117 / Assessment of homogeneity of the study groups --- p.117 / Detection of the intervention effect --- p.118 / Justification for choosing parametric statistical tests over non-parametric statistical tests --- p.118 / Adoption of the Generalized Estimating Equations (GEE) model --- p.119 / Rationale for adopting the GEE model --- p.119 / Choosing the appropriate link function and working correlation matrix --- p.121 / Control of possible covariates in data analysis --- p.123 / Qualitative data --- p.124 / Ethical considerations --- p.125 / Principle of respect for persons --- p.126 / Principle of beneficence --- p.127 / Principle of justice --- p.128 / Summary --- p.129 / Chapter CHAPTER 4 --- RESULTS / Introduction --- p.132 / Recruitment and characteristics of participants --- p.133 / Recruitment of participants --- p.133 / Characteristics of the participants --- p.137 / Characteristics of the study sample and homogeneity among study groups --- p.140 / Characteristics of the study sample --- p.141 / Homogeneity of the characteristics of participants who received and those who did not receive the intervention in the study --- p.145 / Homogeneity of the characteristics of participants in the experimental and the placebo-controlled groups --- p.145 / Complementary effects of auriculotherapy in managing constipation --- p.149 / Adopting the GEE model --- p.152 / Checking the missing data --- p.152 / Identifying the covariates --- p.152 / Choosing the appropriate link function --- p.153 / Choosing the appropriate working correlation matrix --- p.160 / Complementary effects of auriculotherapy on constipation symptoms and disease-specific HRQOL --- p.160 / Complementary effects of auriculotherapy on constipation symptoms --- p.161 / Constipation symptoms (PAC-SYM) --- p.161 / Subscales of constipation symptoms --- p.165 / Abdominal symptoms subscale --- p.165 / Rectal symptoms subscale --- p.168 / Stool symptoms subscale --- p.172 / Summary of the complementary effects of auriculotherapy on constipation symptoms --- p.175 / Complementary effects of auriculotherapy on disease-specific HRQOL --- p.177 / Disease-specific HRQOL (PAC-QOL) --- p.177 / Subscales of disease-specific HRQOL --- p.181 / Physical discomfort subscale --- p.181 / Psychosocial discomfort subscale --- p.185 / Worries and concerns subscale --- p.186 / Satisfaction subscale --- p.190 / Summary of the complementary effects of auriculotherapy on disease-specific HRQOL --- p.193 / Effect size calculation --- p.196 / Findings revealed from study records --- p.197 / Monitoring of the intervention dose --- p.198 / Change of bowel movement pattern --- p.198 / Change in drug administration --- p.200 / Reporting of side effects associated with auriculotherapy --- p.202 / Reporting of unexpected beneficial effects after receiving auriculotherapy --- p.202 / Qualitative findings revealed from interview --- p.203 / Recruitment of informants --- p.203 / Characteristics of the informants --- p.204 / Qualitative findings --- p.207 / Benefits of auriculotherapy in managing constipation --- p.208 / Minor discomforts associated with auriculotherapy --- p.210 / Life as usual with the use of auriculotherapy --- p.210 / Willingness to adopt and recommend auriculotherapy to others --- p.213 / Summary of the qualitative findings --- p.214 / Summary --- p.215 / Chapter CHAPTER 5 --- DISCUSSION / Introduction --- p.217 / Profile of participants --- p.217 / Demographic and clinical characteristics of the participants --- p.218 / Baselines outcome variables of the participants --- p.224 / Clinical value of auriculotherapy with magnetic pellets in managing constipation --- p.226 / Summary of the key findings --- p.226 / Complementary effects in relieving constipation symptoms and in promoting disease-specific HRQOL --- p.228 / Safe and well-accepted intervention --- p.236 / Culturally relevant care modality --- p.239 / Challenges associated with recruiting elderly participants --- p.241 / Strengths and limitations of the current study --- p.246 / Strengths of the study --- p.246 / Limitations of the study --- p.253 / Summary --- p.257 / Chapter CHAPTER 6 --- CONCLUSION / Introduction --- p.258 / Contribution of new knowledge to nursing --- p.258 / Implications for nursing practice --- p.259 / Clinical application of auriculotherapy in nursing practice --- p.261 / Strategies to promote integration of auriculotherapy into nursing practice --- p.263 / Implications for nursing research --- p.266 / Recommendations for further studies --- p.268 / Conclusion of the whole study --- p.269 / REFERENCES (ENGLISH) --- p.273 / REFERENCES (CHINESE) --- p.303

Introdução: Este estudo foi realizado com o intuito de avaliar efeitos da acupuntura sobre os pacientes com asma leve e moderada persistentes com o uso de beta-2 agonista ou corticoide inalatório. Métodos e casuística: Trata-se de um estudo prospectivo, duplo-cego, randomizado e cruzado com dois braços. Os 74 pacientes com diagnóstico de asma leve/moderada, de acordo com a classificação de GINA 2002/2003, foram divididos em dois grupos, sendo 31 do Grupo I, e 43 do Grupo II inicialmente. Foram realizadas consultas médicas e exames que incluíram espirometria, citologia de escarro induzido, NO expirado, preenchimento de escala de sintoma, questionários de qualidade de vida de asma e de SF 36, e realização de peak-flow, dependendo da Fase do protocolo. A Fase I constituiu-se dos exames pré-intervenção. Na Fase II, foram realizadas 10 sessões de Acupuntura Real no Grupo I e 10 sessões de Acupuntura Sham no Grupo II, na Fase III, houve 4 semana de washout, na Fase IV, houve a troca de técnicas de acupuntura, sendo uma sessão por semana e, na Fase V, realização dos exames. Resultados: Não há diferença nos critérios de avaliação no pré-tratamento entre dois grupos, com exceção de maior celularidade inflamatória no Grupo II. No entanto, houve uma redução significativa de eosinófilos (p = 0,035) e neutrófilos (p = 0,047), e aumento de macrófagos (p = 0,001), melhora da medida de volume do peak-flow (p = 0,01) na fase IV do Grupo II. No Grupo I, na avaliação de escala de sintomas diária, havia menor uso de medicação de resgate (p = 0,043) na Fase II, e, depois de receber a Acupuntura Sham na Fase IV, havia menos tosse (p = 0,007), menos chiado (p = 0,037), menos dispneia (p < 0,001) e menor uso de medicação de resgate (p < 0,001). No Grupo II, após receber o tratamento com a Acupuntura Sham na Fase II, houve diminuição de tosse (p = 0,037), de chiado (p = 0,013) e de dispneia (p = 0,014), e, na Fase IV, havia menos tosse (p = 0,040), sibilos (p = 0,012), dispneia (p < 0,001) e menos despertares noturnos (p = 0,009). Nos questionários de qualidade de vida de asma e de SF 36, foram encontrados alguns aspectos de melhora significantes na Acupuntura Sham dos dois grupos em relação à Fase I, mas os resultados da Acupuntura Real tiveram maiores índices de melhora em relação aos resultados da Acupuntura Sham nos dois grupos. Mas não há diferença significativa entre os dois na qualidade de vida de SF 36. Entretanto, não houve alteração de avaliação de espirometria e de óxido nítrico expirado. Conclusão: Este estudo demonstrou que o uso de Acupuntura Real num grupo de pacientes com a celularidade mais inflamatória teve melhor resultados de sintomas diários, tais como dispneia e despertar noturno, de medida de volume de peak-flow matutina, e de avaliação de qualidade de vida em asma e SF36, além da diminuição quantitativa de neutrófilos e de eosinófilos, com aumento de macrófagos, que justificam os efeitos anti-inflamatórios e imunitários. A acupuntura é uma terapia segura, não havendo nenhum efeito colateral observado neste projeto que possa interferir com a vida cotidiana e pode ser de grande auxílio no alívio de sintomas, com melhora de qualidade de vida e, possivelmente, pode ter uma ação na modulação do processo inflamatório de vias aéreas / Introduction: This survey has been conducted in order to evaluate the effects of acupuncture in patients with persistent mild and moderate asthma (according to GINA criteria 2003), using beta agonist and/or inhaled glucocorticoid. Methods and patients: This is a prospective, double blinded, randomized and cross-over study with two branches: 74 patients diagnosed with mild and moderate asthma were divided into two groups: Group I with 31, initiating with real acupuncture and Group II, starting with sham acupuncture. Medical interview and laboratory tests including spirometry, induced sputum citology, exhaled NO measurement, quality of life questionnaire (SF-36 and QQL), besides, daily symptom scores and measurement of peak-flow were performed, in the beginning of the study, and in the end of each phase of treatment. Phase I: laboratory tests and other qualitative measurements. There were 10 real acupuncture weekly sessions to Group I and 10 sham acupuncture sessions to Group II in Phase II. On the other hand, in the Phase IV, there was an exchange between Group I and Group II, which was receiving real acupuncture started to receive sham, and vice-versa, the number of sessions remained the same (10 weekly sessions). Phase III, during the interval between Phase II and Phase IV, there was an interval of 4 weeks of washout. Phase V: laboratory tests and other qualitative measurements. Results: There was no difference beween both the groups in all criteria of evaluation pré treatment, with only na exception: in the Group II there was large inflammatory cell counts. However, there was a significant reduction in eosinophils (p = 0.035) and neutrophils (p = 0.047), and increase of macrophages (p = 0.001), improved peak-flow measurement in the morning (p = 0.01) in Group II (started with sham) in Phase IV. In Daily Symptons Score, there was a significant reduction in use of rescue medication (p = 0.043) in Group I (real acupuncture) in Phase II and after received sham acupuncture (Phase IV), there were less cough (p = 0.007), less wheezing (p = 0.037), less dyspnea (p < 0.001) e less use of rescue medication (p < 0.001). In Group II, after received sham (Phase II), there were less cough (p = 0.037), less wheezing (p = 0.013) and less dyspnea (p = 0.014). In Phase IV, less cough (p = 0.040), wheezing (p = 0.012), dyspnea (p < 0.001) and less nocturnal awakening (p = 0.009). In the questionnaires of quality of life SF-36 and QQL, several domains were found to be improved after received sham acupuncture in both groups, comparing phase II against phase I, but the results found after received real acupuncture were better than sham in both groups. Although there was no statistic difference between both groups. However, there was no difference in exhaled NO and spirometry measurement. Conclusion: This survey demonstrated that the use of real acupuncture in a group of patients with large inflammatory cells counts could have contributed to reduce symptoms, improve quality of life, improved peak-flow measurement in the morning and reduced inflammatory cells count in induced sputum, therefore, acupuncture is a safe healing techniques, presented no adverse effects observed in this study, and could of great help in treatment of patients with mild and moderate asthma

Introdução: Este estudo foi realizado com o intuito de avaliar efeitos da acupuntura sobre os pacientes com asma leve e moderada persistentes com o uso de beta-2 agonista ou corticoide inalatório. Métodos e casuística: Trata-se de um estudo prospectivo, duplo-cego, randomizado e cruzado com dois braços. Os 74 pacientes com diagnóstico de asma leve/moderada, de acordo com a classificação de GINA 2002/2003, foram divididos em dois grupos, sendo 31 do Grupo I, e 43 do Grupo II inicialmente. Foram realizadas consultas médicas e exames que incluíram espirometria, citologia de escarro induzido, NO expirado, preenchimento de escala de sintoma, questionários de qualidade de vida de asma e de SF 36, e realização de peak-flow, dependendo da Fase do protocolo. A Fase I constituiu-se dos exames pré-intervenção. Na Fase II, foram realizadas 10 sessões de Acupuntura Real no Grupo I e 10 sessões de Acupuntura Sham no Grupo II, na Fase III, houve 4 semana de washout, na Fase IV, houve a troca de técnicas de acupuntura, sendo uma sessão por semana e, na Fase V, realização dos exames. Resultados: Não há diferença nos critérios de avaliação no pré-tratamento entre dois grupos, com exceção de maior celularidade inflamatória no Grupo II. No entanto, houve uma redução significativa de eosinófilos (p = 0,035) e neutrófilos (p = 0,047), e aumento de macrófagos (p = 0,001), melhora da medida de volume do peak-flow (p = 0,01) na fase IV do Grupo II. No Grupo I, na avaliação de escala de sintomas diária, havia menor uso de medicação de resgate (p = 0,043) na Fase II, e, depois de receber a Acupuntura Sham na Fase IV, havia menos tosse (p = 0,007), menos chiado (p = 0,037), menos dispneia (p < 0,001) e menor uso de medicação de resgate (p < 0,001). No Grupo II, após receber o tratamento com a Acupuntura Sham na Fase II, houve diminuição de tosse (p = 0,037), de chiado (p = 0,013) e de dispneia (p = 0,014), e, na Fase IV, havia menos tosse (p = 0,040), sibilos (p = 0,012), dispneia (p < 0,001) e menos despertares noturnos (p = 0,009). Nos questionários de qualidade de vida de asma e de SF 36, foram encontrados alguns aspectos de melhora significantes na Acupuntura Sham dos dois grupos em relação à Fase I, mas os resultados da Acupuntura Real tiveram maiores índices de melhora em relação aos resultados da Acupuntura Sham nos dois grupos. Mas não há diferença significativa entre os dois na qualidade de vida de SF 36. Entretanto, não houve alteração de avaliação de espirometria e de óxido nítrico expirado. Conclusão: Este estudo demonstrou que o uso de Acupuntura Real num grupo de pacientes com a celularidade mais inflamatória teve melhor resultados de sintomas diários, tais como dispneia e despertar noturno, de medida de volume de peak-flow matutina, e de avaliação de qualidade de vida em asma e SF36, além da diminuição quantitativa de neutrófilos e de eosinófilos, com aumento de macrófagos, que justificam os efeitos anti-inflamatórios e imunitários. A acupuntura é uma terapia segura, não havendo nenhum efeito colateral observado neste projeto que possa interferir com a vida cotidiana e pode ser de grande auxílio no alívio de sintomas, com melhora de qualidade de vida e, possivelmente, pode ter uma ação na modulação do processo inflamatório de vias aéreas / Introduction: This survey has been conducted in order to evaluate the effects of acupuncture in patients with persistent mild and moderate asthma (according to GINA criteria 2003), using beta agonist and/or inhaled glucocorticoid. Methods and patients: This is a prospective, double blinded, randomized and cross-over study with two branches: 74 patients diagnosed with mild and moderate asthma were divided into two groups: Group I with 31, initiating with real acupuncture and Group II, starting with sham acupuncture. Medical interview and laboratory tests including spirometry, induced sputum citology, exhaled NO measurement, quality of life questionnaire (SF-36 and QQL), besides, daily symptom scores and measurement of peak-flow were performed, in the beginning of the study, and in the end of each phase of treatment. Phase I: laboratory tests and other qualitative measurements. There were 10 real acupuncture weekly sessions to Group I and 10 sham acupuncture sessions to Group II in Phase II. On the other hand, in the Phase IV, there was an exchange between Group I and Group II, which was receiving real acupuncture started to receive sham, and vice-versa, the number of sessions remained the same (10 weekly sessions). Phase III, during the interval between Phase II and Phase IV, there was an interval of 4 weeks of washout. Phase V: laboratory tests and other qualitative measurements. Results: There was no difference beween both the groups in all criteria of evaluation pré treatment, with only na exception: in the Group II there was large inflammatory cell counts. However, there was a significant reduction in eosinophils (p = 0.035) and neutrophils (p = 0.047), and increase of macrophages (p = 0.001), improved peak-flow measurement in the morning (p = 0.01) in Group II (started with sham) in Phase IV. In Daily Symptons Score, there was a significant reduction in use of rescue medication (p = 0.043) in Group I (real acupuncture) in Phase II and after received sham acupuncture (Phase IV), there were less cough (p = 0.007), less wheezing (p = 0.037), less dyspnea (p < 0.001) e less use of rescue medication (p < 0.001). In Group II, after received sham (Phase II), there were less cough (p = 0.037), less wheezing (p = 0.013) and less dyspnea (p = 0.014). In Phase IV, less cough (p = 0.040), wheezing (p = 0.012), dyspnea (p < 0.001) and less nocturnal awakening (p = 0.009). In the questionnaires of quality of life SF-36 and QQL, several domains were found to be improved after received sham acupuncture in both groups, comparing phase II against phase I, but the results found after received real acupuncture were better than sham in both groups. Although there was no statistic difference between both groups. However, there was no difference in exhaled NO and spirometry measurement. Conclusion: This survey demonstrated that the use of real acupuncture in a group of patients with large inflammatory cells counts could have contributed to reduce symptoms, improve quality of life, improved peak-flow measurement in the morning and reduced inflammatory cells count in induced sputum, therefore, acupuncture is a safe healing techniques, presented no adverse effects observed in this study, and could of great help in treatment of patients with mild and moderate asthma

Introdução: A equipe de Enfermagem em hospitais tem sido exposta a ambientes de trabalho estressantes, submetidos, muitas vezes, à condições de trabalho precárias, com baixa qualidade de vida. A auriculoterapia chinesa apresentou eficácia em estudo preliminar para redução de estresse com um protocolo escolhido com base na Medicina Tradicional Chinesa(MTC) e este Ensaio Clínico se propôs a avaliar a eficácia e o alcance da técnica quando é aplicada com e sem protocolo fechado. Objetivos: Descrever e investigar os níveis de estresse da equipe de Enfermagem do Hospital Samaritano; Comparar a eficácia da auriculoterapia chinesa realizada com e sem protocolo, descrever os principais diagnósticos de MTC para estresse e a eficácia dos pontos escolhidos. Material e Método: Na primeira fase, 484 profissionais responderam a um questionário de dados sócio-demográficos e à Lista de Sintomas de Stress de Vasconcellos(LSS). Foram incluídos aqueles com pontuação entre 37 a 119 pontos (médio e alto estresse). Randomizaram-se 213 pessoas em 3 grupos (controle, grupo protocolo e grupo sem protocolo); 175 finalizaram o tratamento de 12 sessões de auriculoterapia com agulha semipermanente, duas vezes por semana, por seis semanas. O protocolo de pontos utilizado foi: ponto Rim, Tronco Cerebral, Shenmen e Yang do Fígado 1 e 2. Os instrumentos de Coleta de dados no Ensaio Clínico foram a LSS, o Inventário de Sintomas de Stress da Lipp (ISSL), o Instrumento de Qualidade de Vida (SF36v2), uma Ficha de diagnósticos de MTC. O período de coleta foi de novembro de 2011 a julho de 2012 e sete acupunturistas participaram do estudo. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa da EEUSP e do Hospital. Resultados: Na primeira fase, a pontuação média de estresse de 484 profissionais foi de 45,92 (nível médio). Os que apresentaram níveis mais elevados de estresse foram: as enfermeiras (p=0,012), profissionais do turno da manhã (p=0,022) e sujeitos com doenças auto referidas (p=0,001). Na segunda fase, os dois grupos de intervenção obtiveram diferenças estatísticas significativas quando comparadas ao grupo controle (p<0,05), com efeito superior para o grupo sem protocolo segundo a LSS no pós-tratamento e follow-up. Quanto ao ISSL, houve melhores resultados para o grupo sem protocolo para a fase de resistência/quase exaustão e domínio psicológico da fase de alerta. Quanto ao SF36v2, houve diferença estatística (p<0,05) somente para o grupo sem protocolo quanto ao domínio físico no follow-up. No domínio mental, ambos os grupos de intervenção obtiveram resultados positivos(p<0,05), com ligeira superioridade para o grupo sem protocolo quanto ao índice d de Cohen. Os principais diagnósticos de MTC foram: Estagnação de Qi e Xue nos meridianos tendino-musculares, Calor de Estômago e Subida de Yang do Fígado, Estagnação de Qi do Fígado, Distúrbio de Shen, Deficiência de Yin do Rim, Deficiência de Qi e Xue do Baço-Pâncreas. Os pontos mais utilizados foram os cinco pontos do protocolo somados a Estômago, Baço e pontos de dor. Conclusão: o grupo sem protocolo obteve melhores resultados para redução de estresse e melhoria de qualidade de vida, demonstrando que a auriculoterapia chinesa quando feita de forma individualizada / Introduction: Hospitals Nursing Team have been exposed to highly stressful work environment and submitted many times to precarious work conditions and thus low quality of life. Chinese auricular therapy has presented efficiency in a preliminary study to reduce stress by a selected protocol based on Chinese Traditional Medicine (MTC). This Clinical Trial is proposed to evaluate the effectiveness and reach of the technique whenever this is applied with or without a closed protocol. Objectives: Describe and investigate the stress levels of Samaritano Hospitals Nursing Team; Compare the effectiveness of Chinese Auricular Therapy performed with or without protocol; Describe the main diagnosis of MTC for stress and efficiency of the selected points. Material and Method: On the first phase, 484 professionals answered to a questionnaire containing demographic social data and to the Vasconcelos List of Stress Symptoms (LSS). Those ones with score between 37 and 119 points (average and high stress) were included. 213 people were randomized in 3 groups (control, protocol group and group without protocol); 175 ended a 12-session auricular therapy treatment with semi-permanent ear needles twice a week for six weeks. The scoring protocol used was: Kidney point, Brain stern point, Shenmen and Yang of the Liver 1 and 2. The instruments for the data collection in the Clinical Trial were LSS, Lipp Stress Symptoms Inventory (ISSL), Instrument of Life Quality (SF36v2), MTC diagnosis chart. The period of data collection was between November 2011 and July 2012 and seven acupuncturists participated in the trial. This study was approved by the School and Hospital Ethical Committee on Clinical Trial. Results: On the first phase, the average scoring of stress was of 45,92 (average level of stress). The professionals that presented higher stress levels were: nurses (p=0,012), morning shift professionals (p=0,022) and subjects with self-referred diseases (p=0,001). On the second phase, the two intervention groups presented differences once compared with the control group (p<0,05), with higher effect in the group without protocol according to LSS in the after treatment and follow-up. Regarding ISSL, there were better results to without protocol group for resistance/quasi-exhaustion phase and physical domain of alert phase. In relation to SF36v2, there was statistics difference (p<0,05) only for the group without protocol in connection with physical dominance during follow-up. In mental dominance, both of intervention groups presented positive results (p<0,05), with an slight superior effect for the group without protocol as per Cohens index. The main MTC diagnosis was: Qi stagnation and Xue in the tendino-muscular meridians, Stomach Heat and Rising of Yang of the Liver, Qi stagnation of the Liver, Shen Disturbs, Kidney Yin Deficiency, Qi deficiency and Xue of Spleen-Pancreas. The mostly used points were the five ones of the protocol plus Stomach, Spleen and pain points. Conclusion: the group without protocol presented the best results for stress reduction and improvement of life quality, demonstrating that Chinese auricular therapy made in a personalized way broaden the reach of the technique.