La performance accrue des instruments dans une vaste gamme de longueur d'onde a montré qu'une grande partie des étoiles jeunes étaient entourées de matière sans doute répartie dans un disque. La détection de tels systèmes par imagerie directe est difficile du fait de la faible taille angulaire de ces objets, ainsi que de leur faible luminosité en comparaison avec l'étoile. Il semble aujourd'hui que près de 50 \% d'étoiles pré-séquence principale de faible masse, dites étoiles T Tauri, soient entourées d'un disque. Cette proportion est beaucoup moins évidente pour les étoiles plus massives, dites Herbig Ae, du fait de leur faible nombre et du faible nombre de détections directes.<br />Jusqu'à présent, seule l'interprétation de la distribution spectrale d'énergie (SED) de ces objets permettait d'inférer la structure géométrique des disques autour des étoiles Herbig Ae. Les modèles sont fortement dégénerés et il est primordial d'obtenir des images, seules preuves directes de la présence ou non de disque. <br />Cette thèse a permis de mettre en évidence l'apport de l'imagerie en infrarouge moyen pour lever une partie de la dégénérescence liée à l'interprétation de la SED et mieux contraindre, pour plusieurs objets, les paramètres des disques, comme le rayon externe minimal ou l'inclinaison. De plus, nous présentons un nouveau mode d'observation avec VISIR, l'instrument pour les observations en infrarouge moyen au VLT (ESO, Chili): le mode BURST. Ce mode permet d'atteindre la limite de résolution spatiale déterminée par la diffraction. Grâce à l'imagerie en infrarouge faite avec cet instrument, cette thèse a permis de déterminer, pour la première fois, la géométrie (structure évasée) d'un disque autour d'une étoile massive inférée au préalable par l'interprétation des SEDs.

Šis darbas skirtas kraštinių darinių moreninių gruntų konsolidacinių ir stiprumo savybių sąryšiui išstudijuoti(išnagrinėti). Gruntų bandiniai paimti iš gręžinių kerno. Gręžiniai išgręžti NPP eksploatacijos nutraukimo objekte. Atliktų bandymų rezultatai parodė, kad klasikinės gruntų mechanikos dėsniai moreninių gruntų stiprumo priklausomybė tinka statistiniame lygyje. Bandymai įrodė, kad moreninio priemolio stiprumas yra multifaktorinis parametras. Tokio grunto bandinių stiprumas priklauso ir nuo molio dalelių kiekio, ir nuo konsistencijos, ir nuo poringumo koeficiento sumažėjimo. Poringumo koeficientas mažėja, didėjant vertikaliai apkrovai. Todėl klasikinė Coulomb – Navier – Mohr‘s stiprumo lygtis yra komplikuota. / This work deals with consolidation and strength features relationship in marginal glacial soils. Soil samples were taken from boreholes core. Boreholes were drilled in Nuclear Power Plant at used nuclear fuel storage facility. The results of test show that the classical laws of soil mechanics of strength dependence in moraine soils are correct in statistical level. Tests prove that strength of moraine loam is multifactor parameter. The strength of that kind of soil depends on quantity of clay particles, consistence and porosity decrease. Porosity decreases when vertical load rises. Therefore classical Coulomb-Navier-Mohr's equation is complicated.

Thesis (M.A.)--Bowling Green State University, 2009. / Document formatted into pages; contains ix, 122 p. : ill. Includes bibliographical references.

Thesis (M.A.), Memorial University of Newfoundland, 1999. / Bibliography: p. 90-98.

Made available in DSpace on 2014-12-17T14:13:44Z (GMT). No. of bitstreams: 1 ArlineteSM_Dissert.pdf: 1812083 bytes, checksum: 376b552fc90bb11b8b551d6db7f2d45f (MD5) Previous issue date: 2009-08-26 / Desenvolvido no Parque das Dunas, segunda reserva ambiental urbana do Brasil, ocupando uma ?rea de 1.172,80 hectares, com caracter?stica de mata atl?ntica de dunas, situada numa faixa litor?nea na regi?o urbana do munic?pio de Natal (05? 46 S, 35? 12 W), o presente estudo, realizado durante os anos de 2004 a 2006, teve como objetivo identificar as esp?cies de culic?deos existentes no Parque das Dunas, capazes de transmitir arbov?rus, tendo em vista que em 2004 houve uma epizootia de saguis (Callitrix jacchus), que causou grande mortandade, sem defini??o do agente etiol?gico. No ano de 2004, foram pesquisados sete pontos no interior da mata, com instala??o de 20 armadilhas de ovitrampas e 20 de bambu para coleta dos imaturos. Para os adultos, durante quatro vezes por semana, foram usadas as armadilhas de Sannhon. Foram coletados 5.691 imaturos, sendo 839 Ae. aegypti, 3.184 Ae. albopictus e 1.668 Hg. leucocelaenus. A coleta dos adultos foi realizada de 2004 a 2006, etapa em que se recolheu 17.506 culic?deos adultos, sendo 17.244 Wy. bourrouli, 255 Ae. aegypti, 593 Ae. albopictus, 1.275 Hg. leucocelaenus, 294 Oc. scapularis, 05 Oc. taeniorynchus, 02 Oc. serratus e 3 Li. durhami. Para os imaturos houve correla??o significativa entre Ae. aegypti e umidade relativa do ar p = 0, 049 e pluviometria p = 0,00, Ae. albopictus apresentou correla??o significativa positiva com a pluviometria, enquanto Hg. leucocelaenus n?o apresentou nenhuma das vari?veis clim?ticas. Para os adultos, a an?lise de s?rie temporal aponta flutua??o sazonal significativa para Ae. aegypti (p = 0,003); Ae. albopictus (p = 0,04); Oc. scapularis (p = 0,008 ) e Hg. leucocelaenus (p = 0,003). Uma correla??o significativa negativa foi observada entre o n?mero de Ae. albopictus coletado e a temperatura (Corr= - 0,50, p = 0,01); isto ?, para cada 1?C a mais h? diminui??o de 7 esp?cimes. Este estudo teve a participa??o de uma equipe multidisciplinar: bi?logos, entomologistas, para confirma??o das esp?cies; t?cnicos de laborat?rio, para acompanhamento di?rio das larvas eclodidas das armadilhas de ovitrampas. Teve a importante colabora??o de profissionais da Funda??o Oswaldo Cruz FIOCRUZ/Rio de Janeiro, da Universidade de S?o Paulo USP para identifica??o do grupo Wyeomyia.

Teoricamente, o Alinhamento Estratégico pode ser obtido com um bom Gerenciamento de Processos de Negócio (BPM na sigla em inglês), porém a relação entre esses temas é, na maioria das vezes, assumida implicitamente e pouco elaborada, tornando-se difícil a visualização e vínculo entre as estratégias e os modelos de processos detalhados, sendo necessário empreender pesquisas na direção de uma união efetiva dos dois temas. O presente trabalho desenvolveu um metamodelo multinível, para ligar os objetivos estratégicos com os processos de negócio da organização através da modelagem de processos de negócio. O trabalho conceitual foi acrescido por uma ferramenta de suporte à modelagem que permite a geração de modelos com base no metamodelo multinível e também a representação dos modelos em diferentes formas de abstração. A abordagem foi aplicada em uma grande multinacional e posteriormente foi conduzida uma avaliação experimental no qual foram realizadas entrevistas com funcionários de diferentes níveis hierárquicos para validar a eficiência e eficácia do trabalho desenvolvido. Como resultado foi possível constatar não apenas a efetividade em alcançar os objetivos propostos como também a facilidade na utilização e compreensão da abordagem em níveis devido a simplicidade na representação dos elementos e seus possíveis relacionamentos / Theoretically, the Strategic Alignment can be accomplished with a good Business Process Management, but the relationship between these themes is, most often, implicitly assumed and little developed, making it difficult to visualize and link between the strategies and the models of detailed processes, being necessary to undertake research towards an effective union of the two themes. This study developed a multilevel metamodel for connecting strategic objectives with organizational business processes through modeling of business processes. The conceptual work was increased by a support tool for modeling that allows the generation of models based on multilevel metamodel and also the representation of models in different forms of abstraction. The approach was applied in a large multinational and was subsequently conducted an experimental evaluation in which interviews with employees from different hierarchical levels were performed to validate the efficiency and effectiveness of their work. As a result it was possible to not only the effectiveness in achieving the proposed objectives as well as the ease of use and understanding of the tiered approach because of the simplicity in the representation of the elements and their possible relationships

Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-02-15T17:10:47Z No. of bitstreams: 1 renatamendesdefreitas.pdf: 1082430 bytes, checksum: 17933c41d6c615bede876aefdcce85ef (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-02-26T12:27:10Z (GMT) No. of bitstreams: 1 renatamendesdefreitas.pdf: 1082430 bytes, checksum: 17933c41d6c615bede876aefdcce85ef (MD5) / Made available in DSpace on 2016-02-26T12:27:10Z (GMT). No. of bitstreams: 1 renatamendesdefreitas.pdf: 1082430 bytes, checksum: 17933c41d6c615bede876aefdcce85ef (MD5) Previous issue date: 2014-02-21 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / As Neoplasias Mieloproliferativas são originadas por uma proliferação clonal de um progenitor hematopoético. Descrita inicialmente em 1951 como “Doenças Mieloproliferativas” e reavaliada pela Organização Mundial da Saúde em 2011, as Neoplasias Mieloproliferativas agrupam a Policitemia Vera, Trombocitemia Essencial e Miefibrose Primária em um subgrupo chamado de BCR-ABL negativo. De acordo com a revisão dos critérios adotados para o diagnóstico das Neoplasias Mieloproliferativas a presença da mutação JAK2 V617F é considerada critério de maior importância para o diagnóstico do subgrupo BCR-ABL negativo representando um marcador clonal. A Policitemia Vera é principalmente diagnosticada por um aumento na massa eritrocitária independente de fator estimulante, aumento de leucócitos no sangue periférico, esplenomegalia e trombocitose. Ocorre, geralmente, em homens e mulheres com faixa etária de 60 anos, com incidência de 0,7 a 2,6/100.000 habitantes/ano. A mutação V617F no gene JAK2 produz uma proteína alterada que ativa constitutivamente a via JAK-STAT e outras vias downstream de modo que, as proteínas de ativação transcricional e transdutoras de sinal (STAT do inglês Signal Transducerand Activator of Transcription) são fosforiladas posteriormente impactando na expressão de genes envolvidos na regulação da apoptose e proteínas regulatórias, além de alterar a taxa de proliferação das células hematopoéticas. Neste trabalho foram selecionados 26 pacientes com Policitemia Vera, os quais foram atendidos na cidade de Juiz de Fora, Minas Gerais. Foram realizadas análises de mutações no gene JAK2 a partir do material genético isolado do sangue periférico. Os dados clínicos de cada paciente foram relacionados entre si e correlacionados com os dados moleculares. / Myeloproliferative neoplasms (MPN) are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as “Myeloproliferative Diseases” and reevaluated by the World Health Organization in 2011 (WHO, 2011), the Myeloproliferative Neoplasms gather the Polycythemia Vera, Essential Thrombocythemia and Primary Mielofibrose in a subgroup called negative BCR-ABL. According to WHO the revised diagnosis criteria for myeloproliferative neoplasms, the presence of JAK2 V617F mutation, is considered the most important criterion for the diagnosis of negative BCR-ABL subgroup representing a clonal marker. The Polycythemia Vera is primarily diagnosed by an independent stimulating factor in red cells mass increasing, followed by an increase of leukocytes in peripheral blood, spleen and thrombocytosis. It usually occurs in men and women of all age groups with higher incidence in 60-year-old patients ranging from 0.7 to 2.6/ 100.000 hab/year. The V617F mutation in the JAK2 gene produces an altered protein that activates constitutively the JAK-STAT pathway and other pathways downstream as a result the protein transcriptional activation and signal transduction (STAT) are subsequently phosphorylated causing impact in the expression of genes involved in regulation of apoptosis and regulatory proteins, as well as altering the rate of proliferation of hematopoietic cells. In this study 26 patients with Polycythemia Vera were selected in Juiz de Fora, Minas Gerais. The peripheral blood was used for genetic material isolation (JAK2 mutation). The clinical data of each patient were related to each other and correlated with the molecular data.

This research project aimed to develop a condition monitoring system for the final production quality of pharmaceutical tablets and detection capping and lamination during powder compression process using the acoustic emission (AE) method. Pharmaceutical tablet manufacturers obliged by regulatory bodies to test the tablet's physical properties such as hardness, dissolution and disintegration before the tablets are released to the market. Most of the existing methods and techniques for testing and monitoring these tablet's properties are performed at the tablet post-compression stage. Furthermore, these tests are destructive in nature. Early experimental investigations revealed that the AE energy that is generated during powder compression is directly proportional to the peak force that is required to crush the tablet, i. e. crushing strength. Further laboratory and industrial experimental investigation have been conducted to study the relationship between the AE signals and the compression conditions. Traditional AE signal features such as energy, count, peak amplitude, average signal level, event duration and rise time were recorded. AE data analysis with the aid of advanced classification algorithm, fuzzy C-mean clustering showed that the AE energy is a very useful parameter in tablet condition monitoring. It was found that the AE energy that is generated during powder compression is sensitive to the process and is directly proportional to the compression speed, particle size, homogeneity of mixture and the amount of material present. Also this AE signal is dependent upon the type of material used as the tablet filler. Acoustic emission has been shown to be a useful technique for characterising some of the complex physical changes which occur during tabletting. Capping and lamination are serious problems that are encountered during tabletting. A capped or laminated tablet is one which no longer retains its mechanical integrity and exhibit low strength characteristics. Capping and lamination can be caused by a number of factors such as excessive pressure, insufficient binder in the granules and poor material flowabilities. However, capping and lamination can also occur randomly and they are also dependent upon the material used in tabletting. It was possible to identify a capped or laminated tablet by monitoring the AE energy level during continuous on-line monitoring of tabletting. Capped tablets indicated by low level of AE energy. The proposed condition monitoring system aimed to set the AE energy threshold that could discriminate between capped and non-capped tablets. This was based upon statistical distributions of the AE energy values for both the capped and non-capped tablets. The system aims to minimise the rate of false alarms (indication of capping when in reality capping has not occurred) and the rate of missed detection (an indication of non capping, when in reality capping has occurred). A novel approach that employs both the AE method and the receiver operating characteristic (ROC) curve was proposed for the on-line detection of capping and lamination during tabletting. The proposed system employs AE energy as the discriminating parameter to detect between capped and non-capped tablets. The ROC curve was constructed from the area under the two distributions of both capped and non-capped tablet. This curve shows a trade-off between the probabilities of true detection rate and false alarm rate for capped and non-capped tablet. A two-graph receiver operating characteristic (ROC) curve was presented as a modification of the original ROC curve to enable an operator to directly select the desired energy threshold for tablet monitoring. This plot shows the ROC co-ordinate as a function of the threshold value over the entire threshold (AE energy) range for all test outcomes. An alternative way of deciding a threshold based on the slope of the ROC curve was also developed. The slope of the ROC curve represents the optimal operating point on the curve. It depends upon the penalties cost of capping and the prevalence of capping. Sets of guidelines have been outlined for decision making i.e. threshold setting. These guidelines take into account both the prevalence of capping in manufacturing and the cost associated with various outcomes of tablet formation. The proposed condition monitoring system also relates AE monitoring to non-AE measurement as it enable an operator predicting tablet hardness and disintegration form the AE energy, a relationship which was established in this research.

The evolution of protoplanetary disks is believed to be driven largely by angular momentum transport resulting from magnetized disk winds and turbulent viscosity. The ionization of the disk that is essential for these processes has been thought to be due to host star coronal X-rays but could also arise from energetic particles produced by coronal flares, or traveling shock waves, and advected by the stellar wind. We have performed test-particle numerical simulations of energetic protons propagating into a realistic T. Tauri stellar wind, including a superposed small-scale magnetostatic turbulence. The isotropic (Kolmogorov power spectrum) turbulent component is synthesized along the individual particle trajectories. We have investigated the energy range [0.1-10] GeV, consistent with expectations from Chandra X-ray observations of large flares on T. Tauri stars and recent indications by the Herschel Space Observatory of a significant contribution of energetic particles to the disk ionization of young stars. In contrast with a previous theoretical study finding a dominance of energetic particles over X-rays in the ionization throughout the disk, we find that the disk ionization is likely dominated by X-rays over much of its area, except within narrow regions where particles are channeled onto the disk by the strongly tangled and turbulent magnetic field. The radial thickness of such regions is 5 stellar radii close to the star and broadens with increasing radial distance. This likely continues out to large distances from the star (10 au or greater), where particles can be copiously advected and diffused by the turbulent wind.

Aims. The aim of this work is to constrain properties of the disk around the archetype FU Orionis object, FU Ori, with as good as similar to 25 au resolution. Methods. We resolved FU Ori at 29-37 GHz using the Karl G. Jansky Very Large Array (JVLA) in the A-array configuration, which provided the highest possible angular resolution to date at this frequency band (similar to 0 ''.07). We also performed complementary JVLA 8-10 GHz observations, Submillimeter Array (SMA) 224 GHz and 272 GHz observations, and compared these with archival Atacama Large Millimeter Array (ALMA) 346 GHz observations to obtain the spectral energy distributions (SEDs). Results. Our 8-10 GHz observations do not find evidence for the presence of thermal radio jets, and constrain the radio jet/wind flux to at least 90 times lower than the expected value from the previously reported bolometric luminosity-radio luminosity correlation. The emission at frequencies higher than 29 GHz may be dominated by the two spatially unresolved sources, which are located immediately around FU Ori and its companion FU Ori S, respectively. Their deconvolved radii at 33 GHz are only a few au, which is two orders of magnitude smaller in linear scale than the gaseous disk revealed by the previous Subaru-HiCIAO 1.6 mu m coronagraphic polarization imaging observations. We are struck by the fact that these two spatially compact sources contribute to over 50% of the observed fluxes at 224 GHz, 272 GHz, and 346 GHz. The 8-346 GHz SEDs of FU Ori and FU Ori S cannot be fit by constant spectral indices (over frequency), although we cannot rule out that it is due to the time variability of their (sub)millimeter fluxes. Conclusions. The more sophisticated models for SEDs considering the details of the observed spectral indices in the millimeter bands suggest that the >29 GHz emission is contributed by a combination of free-free emission from ionized gas and thermal emission from optically thick and optically thin dust components. We hypothesize that dust in the innermost parts of the disks (less than or similar to 0.1 au) has been sublimated, and thus the disks are no longer well shielded against the ionizing photons. The estimated overall gas and dust mass based on SED modeling, can be as high as a fraction of a solar mass, which is adequate for developing disk gravitational instability. Our present explanation for the observational data is that the massive inflow of gas and dust due to disk gravitational instability or interaction with a companion/intruder, was piled up at the few-au scale due to the development of a deadzone with negligible ionization. The piled up material subsequently triggered the thermal instability and the magnetorotational instability when the ionization fraction in the inner sub-au scale region exceeded a threshold value, leading to the high protostellar accretion rate.