Les produits de glycation avancée (AGEs) sont trouvés en excès dans le plasma et les tissus au cours du diabète, de l'insuffisance rénale et du vieillissement. Ils se forment aussi pendant la cuisson domestique et industrielle des aliments. Actuellement, la plus forte consommation de denrées alimentaires transformées contenant des quantités importantes des AGEs augmente le risque d'exposition de la population aux AGEs et à leurs effets biologiques. C'est ainsi que l'étude de la biodisponibilité des AGEs devient un sujet d'actualité dans la compréhension de la pathogenèse de certaines maladies chroniques, particulièrement le diabète. Deux études cliniques ont été menées dans le but d'étudier l'impact de l'ingestion des AGEs alimentaires sur les fluctuations des concentrations de ces mêmes molécules retrouvées dans les fluides biologiques des individus sains étudiés. Une première étude qui compare la teneur des AGEs ingérés à travers deux régimes alimentaires administré à 62 jeunes adultes. Une deuxième étude qui évalue la teneur en AGEs d'une alimentation basée sur du lait maternel ou du lait de formules infantiles donné à 161 bébés. La quantification de la carboxyméthyllysine (CML) et des AGEs fluorescents comme indicateurs de la réaction de Maillard a été effectuée dans les aliments administrés aux sujets de l'étude ainsi que dans leurs matrices biologiques : plasma, urine et fèces. Les résultats montrent qu'un régime contenant 2,5 fois moins de CML et 1,7 fois moins des AGEs fluorescents, en comparaison avec un régime courant ou standard, peut provoquer des baisses importantes de ces indicateurs dans le plasma, l'urine et la matière fécale des individus sains. Ces diminutions sont plus accentuées au niveau de l'excrétion urinaire. D'autre part, une plus forte présence de la CML dans le lait de formules infantiles correspond à une plus forte quantité de CML dans le plasma et dans l'urine des enfants ayant ingéré cet aliment, à la différence des enfants nourris avec le lait maternel, caractérisé par de faibles quantités de la CML. Chez les adultes soumis au régime bas en AGEs ainsi que les bébés nourris avec le lait maternel, les niveaux de certains paramètres métaboliques tels que le stress oxydatif, les antioxydants importants et des facteurs de l'inflammation cellulaire et systémique ont été normaux mais inférieurs à ceux des adultes et des enfants ayant ingéré de plus fortes quantités d'AGEs. Ces effets indiquent que de plus faibles quantités de produits de Maillard alimentaires pourraient avoir un impact sur la prévention des maladies chroniques. / Advanced Glycation End Products (AGEs) are found in excess in plasma and tissus during diabetes, renal diseases and aging. AGEs are known to form in foods during industrial processes or home cooking. Nowadays, an excessive intake of technologically transformed foods riches in AGEs, increase the risk of the population to their possible pathophysiological effects. In this contexte, the study of bioavailability of AGEs formed in foods may have a significant impact in understanding the pathogenesis of some chronic diseases as diabetes.Two clinical studies were conducted to study the impact of dietary intake of AGEs on fluctuating levels of these same molecules found in biological fluids of healthy individuals studied. A first study that compared the content of AGEs ingested through two diets administered to 62 young adults. A second study evaluates the AGE content of a diet based on breast milk or infant formula milk given to 161 babies. Quantification of CML and fluorescent AGEs as indicators of the Maillard reaction was performed in the food administered to the subjects and their biological matrices: plasma, urine and feces. The results show that a diet containing less than 2.5 times and 1.7 times of CML and fluorescent AGEs respectively, compared with a current or standard diet, can cause significant declines in these indicators in plasma, urine and fecal matter of healthy individuals. These decreases are more pronounced at the level of urinary excretion. A stronger presence of CML in the milk of infant formula is a higher amount of CML in plasma and urine of children who ingested this food, unlike the children fed with milk breast, characterized by low levels of CML. In adults subjected to diet low in AGEs and babies fed breast milk, the levels of some metabolic parameters such as oxidative stress, antioxidants and important factors of cellular and systemic inflammation, were lower than normal levels of adults and children who ingested higher amounts of AGEs. These effects indicate that lower amounts of dietary Maillard products could have an impact on chronic disease prevention

The thesis summarizes and subsequently describes and evaluates contemporary knowledge, development and structure of early medieval settlement in the northwestern part of the Czech Republic. Emphasis is placed on the spatial relation of settlements and burial grounds to local selected features of the natural environment, which is evaluated on the basis of graphical representation and statistical processing in individual periods of czech early Middle Ages. The spatial context and the distribution of the settlement in the landscape are also evaluated. Spatial settlement properties are processed into catalogs and are handled in GIS and statistical tools. The resulting model is rather of a general nature because it is the first comprehensive treatment of the early medieval settlement in this part of Bohemia and is thus discussed from a methodological point of view.

O objetivo desta pesquisa é analisar a imagem do casamento ao longo dos séculos XI e XII, a partir dos novos ideais reformadores da Igreja. A intenção é fazer um estudo comparativo das representações da literatura e dos novos ideais religiosos de casamento, que estavam sendo propostos pela Igreja aproximadamente no mesmo período, a partir de quatro documentos diferentes: o Decretum de Burchard de Worms, o Concordia discondantium canonum de Graciano, os três primeiros Concílios de Latrão e os decretais de Alexandre III, presentes no Líber Extra.. Como fontes literárias serão utilizadas as obras Eric et Enide, Cligès, Lancelot ou Le Chevalier de la Charrette, e Ivain ou Le Chevalier au Lion, todas de Chrétien de Troyes, autor do século XII. Houve transformações na constituição da doutrina do casamento nesse período? Se houve, é possível percebê-las também na literatura? Através destas comparações seria possível identificar como a sociedade era afetada por tais transformações? Estas são as perguntas que orientarão o estudo. / The goal of this research is to analyse the image of marriage throughout the 11th and 12th having the reforming ideals of the Church as the basis. The intention is to make a comparitive study of the literary representations and the new religious ideals for marriage proposed by the Church at the same period. Four documents will be used: the Decretum by Burchard de Worms, the Concordia discordantium canonum by Gratian, the first three Lateran Councils and the decretal letters of Alexandre III, found in the Liber Extra. The literary sources will be Eric et Enide, Cliges, Lancelot, and Ivain, all written by Chretien de Troyes, a 12th century author. Were there transformations in the marriage doctrine in this period? If there were, is it possible to see them in the literature? Could we identify how the society was affected by such transformations through a comparative study? These are some of the questions that will guide the present study.

黃健羒著. / 手稿本, 複本據手稿本影印. / 論文(神學學部神道學碩士)--香港中文大學硏究院. / 參考文獻: leaves 143-151. / Huang Jianfen zhu. / 論文撮要 --- p.ii / 謝詞 --- p.iv / 經文引述按語 --- p.v / 附表目錄 --- p.iii / Chapter 第一章 --- 導論 --- p.1 / Chapter 第二章 --- 教牧書信作者問題 --- p.9 / Chapter 二、一節 --- 作者問題的重要性 --- p.10 / Chapter 二、二節 --- 推斷作者是否保羅的途徑 --- p.14 / Chapter 二、三節 --- 總論 --- p.23 / Chapter 第三章 --- 使徒性教會的本質 --- p.26 / Chapter 三、一節 --- 初期教會信經 --- p.29 / Chapter 三、二節 --- 使徒傳統 --- p.34 / Chapter 三、三節 --- 承繼使徒傳統的準則 --- p.43 / Chapter 第四章 --- 受按立之牧職 --- p.52 / Chapter 四、一節 --- 初期教會之情況 --- p.53 / Chapter 四、二節 --- 牧職之涵義 --- p.58 / Chapter 四、三節 --- 按立之涵義 --- p.66 / Chapter 四、四節 --- 長老、監督及執事 --- p.76 / Chapter 第五章 --- 受按立牧職之重要功能─教導 --- p.86 / Chapter 五、一節 --- 教牧書新重視教導 --- p.89 / Chapter 五、二節 --- 藉教導保持使徒性 --- p.97 / Chapter 五、三節 --- 如何在今日教會中推行教導 --- p.108 / Chapter 第六章 --- 結論 --- p.116 / 畧字表 --- p.122 / 註釋 --- p.124 / 書目 --- p.143

A presente pesquisa propõe analisar, avaliar e validar o uso de ensaios de aderência açoconcreto para estimativa da resistência à compressão axial do concreto in loco nas primeiras idades em canteiros de obras, como alternativa ao controle de qualidade tradicional. Alguns pesquisadores propuseram a utilização de um ensaio de aderência modificado, que denominaram Appropriate Pull-Out Test (APULOT), como uma adaptação do método pullout test (POT) tradicional, normalizado pela norma EN12504-3. Para viabilizar o uso do ensaio APULOT como ensaio que possa ser implementado na prática do controle tecnológico do concreto em canteiros de obras e seja representativo da resistência in loco é necessário definir um padrão para o mesmo. O presente trabalho desenvolveu um molde específico para o ensaio, analisou a influência do processo da cura nos resultados da tensão máxima de aderência, estudou como a medição da maturidade no concreto pôde auxiliar na determinação do momento certo para fazer o ensaio de arrancamento e comparou resultados dos ensaios feitos em corpos de prova para teste de aderência com ensaios de arrancamento de barras de aço em painéis de concreto. Para tanto foram feitos nove concretagens empregando diferentes tamanhos e configurações de corpos de prova, ensaios de arrancamento, extrações de testemunhos de painéis de concreto, ensaios à compressão simples e medições de maturidade dos concretos empregados. Também se realizaram registros de temperatura ambiente e velocidade do vento na vizinhança dos painéis, buscando estabelecer relações entre a maturidade e as condições ambientais do canteiro. Os ensaios descritos anteriormente realizaram-se às idades de 3, 5, 7 e 28 dias. Os resultados obtidos mostram que, sob condições padronizadas de ensaio, existe ótima correlação entre a tensão máxima de aderência e a resistência à compressão do concreto e por tanto o ensaio de aderência pode ser utilizado para fazer uma estimativa da resistência à compressão do concreto in loco nas primeiras idades. / This research aims to analyze, evaluate and validate the use of steel-concrete bond tests to estimate the axial compression strength of in situ concrete at early ages on construction sites, as alternative to conventional strength control tests. Some researchers have proposed the use of a modified bond test, named Appropriate Pull-Out Test (APULOT), as an adaptation of the traditional pull-out test method (POT) standardized by the EN12504-3. To implement the APULOT as a strength control procedure for concrete on construction site, standardization is needed. This study developed a specific mold for the test; analyzed the influence of curing process on the results of the maximum bond stress; studied how measuring the maturity in the concrete could help to determine when is the right time to make the pull-out test; compared results of tests made on cores for testing the bond and pull-out tests on steel bars in concrete panels. Therefore, it have been made nine concrete events, pull-out tests using different sizes and configurations of cylindrical concret specimen, pull-out tests and extraction of cores from concrete panels, compressive test and maturity measurements of specific employees. Also, temperature and wind speed records have been performed in the panel´s sourrundings, seeking to establish relationships between maturity and ambiental conditions on construction site. The tests described above were carried out at 3, 5, 7 and 28 days. The results show that, under standardized test conditions, a correlation between the maximum bond stress and the concrete compression strength exists, and therefore, bond test can be used to estimate the in situ compression strength of the concrete in the first ages.

Cette étude entend poser le problème des violences dans le monde universitaire parisien du XIVe siècle jusqu’au milieu du XVe siècle. Le monde universitaire est compris comme l’ensemble des maîtres, des étudiants et des serviteurs attachés juridiquement au studium. Il s’agit d’analyser l’évolution du phénomène en tenant compte du contexte politique troublé lié à la guerre de Cent Ans, à la guerre civile et au Schisme. Cette thèse aspire à mettre en évidence que les violences étaient un phénomène significatif identitaire pour les gens de l’Université. L’étude des sources historiques variées allant des documents normatifs et des traités didactiques aux données judiciaires et aux chroniques, permet de révéler un large spectre des pratiques violentes touchant le monde du studium parisien. / This study intends to rase the problem of violence in Parisian university world from the XIVth to the middle of the XVth c. The university world in this work is understood as a totality of masters, students and servants who were legally linked to the studium. We propose to examine the evolution of the phenomenon taking account of the troubled character of the political context which was due to the Hundred Years War, the civil war and also to the Schism. This study aims at highlighting the phenomenon of violence as significant to the identity of the university population. The analysis of varied historical sources ranging from the normative documents and didactic treaties to judicial data and chronicles, allows to reveal a large range of violent practices concerning the world of the studium of Paris.

This dissertation examines how clerics in the Lombard and Carolingian Kingdom of Italy prosecuted disputes with each other. It argues for and explores two core features of the clerical legal culture of the kingdom. The first regards the judicial institutions that clerics exploited. While the late eleventh and twelfth centuries would see the elaboration of a coherent system of ecclesiastical justice centered on the papal court, distinct from secular judicial institutions, the situation in the early Middle Ages was radically different. Early medieval Italian clerics made recourse to a wide variety of judicial forums, including both "secular" ones such as the public courts and properly "ecclesiastical" ones such as church synods. The dissertation explores these judicial pathways--some of them well-trodden and enduring ones, others more ad hoc--and the ways clerics navigated between them. Second, this study demonstrates that many early medieval Italian clerics displayed considerable skill and sophistication in crafting and delivering legal arguments against each other. Those arguments frequently hinged on substantive appeal to canon law. This finding presents a challenge to a prevailing view in legal-historical scholarship which downplays or ignores practical legal expertise in the early Middle Ages and often dismisses the period itself as an "age without jurists." This dissertation instead argues for an early medieval clerical legal culture that scholars must take seriously as a prehistory to the well-known legal and judicial developments of the eleventh and twelfth centuries. This is the first study to explore in depth the diversity of judicial pathways exploited by clerics in early medieval Italy and the legal arguments they constructed. Proceeding on the basis of case studies, it traces the threads of ecclesiastical legal culture through several genres of sources: in addition to diplomatic sources such as judicial notices, papal bulls, imperial diplomas, and private charters, it also examines the evidence to be found in works of poetry, hagiography, and historiography, and in legal compilations. Among the ecclesiastical disputes that receive extended discussion are those between the bishops of Arezzo and Siena, between the patriarchs of Aquileia and Grado, between the abbots of Nonantola and neighboring bishops, and those within the diocese of Lucca.

The present study revises the chronology for the twelfth-century "artifex" Nicholaus, demonstrating that his career began just after c.1122 in Piacenza and ended in Verona c. 1164, not c. 1150 as often proposed. The first sculpted entranceway with the Nicholaus imprimatur was executed at the Sagra di San Michele. It is documented that Nicholaus was put in charge of supervising the construction and decoration of the new cathedral in Ferrara in 1135, including the western entranceway with his self-laudatory signature inscription. His activity here ended around 1150, at which time the interior of the cathedral was functional. In the early 1140s, members of the Nicholaus atelier and possibly the "artifex" himself crossed the Alps to execute certain sculptures at the imperial burial church at Königslutter. The signed Verona Cathedral entranceway was executed in the 1150s. Work at San Zeno began after 1164: the elegiac tone of two signature inscriptions here seems to indicate that Nicholaus died around this time. To determine the date of the Nicholaus Verona projects, given the lack of firm documentary evidence for their dating, because their subject matter could be associated with a known historical incident or situation and those dates fit with my stylistic evaluation as to the sculpture's date, I used the dates for these occurrences as the "termini post quem" for the project. Luigi Simeoni had proposed that the formation of the commune of Verona in 1135 is celebrated by the scene on the lunette at San Zeno depicting the patron saint of Verona signing blessing in the midst of the troops. This supported a date of 1138 for this work. However, my research into the relationship between Verona and various emperors led me to conclude that the image on the lunette at San Zeno actually memorializes the formation in 1164 of the Veronese League opposing Emperor Frederick Barbarossa. A second subject here, The Hunt of Theodoric, seems to have been chosen to insult Barbarossa, previously well received in Verona. The San Zeno frontispiece with Nicholaus's sculptures, the famous bronze doors, and the Wheel of Fortune window was assembled c.1200.

On Violence and Tyranny examines historiography as a vehicle for the production of a theory of tyrannicide in the aftermath of the murder of Pedro I de Castilla (1369). The thesis of this work is that by considering the royal chronicle as a vehicle and locus for political theorization, we can appreciate the formulation of a theory of tyrannicide as a medium for dynastic legitimation that is not reducible to political propaganda. Rather, it becomes a meditation about monarchy itself, the limits of power, and the underlying causes and consequences of political violence. The chronicle of the king Pedro's rule conceives an economy of violence coded in terms of saber (political wisdom), justice and the law, as a means to face the ideological, political, and social challenges that civil war and regicide pose to a community. I will focus on two fragments of the chronicle, a pair of letters attributed to a wise Moor that the chronicler chose to include in a second stage of his composition and that establish extra textual connections to other political genres such as the specula principum and political prophecy. Through them, I will explore how a theory of tyrannicide allows the chronicler to confront three major problems that regicide poses. First, how to explicate the dynastic break that king Pedro’s murder brought about, and minimize the discontinuity that the advent of a new, and illegitimate, dynasty (the Trastámaras) represented for a historical tradition that deeply valued the continuity of history. Second, how a theory of tyrannicide served to repair the broken ties provoked by the civil war. And third, how to represent that founding violence, the violence against a sovereign, to render it legitimate, but not available for anyone else to exploit.

In late medieval Europe, suspicions arose that minority groups wished to destroy the Christian majority by poisoning water sources. These suspicions caused the persecution of different minorities by rulers, nobles and officials in various parts of the continent during the fourteenth and fifteenth centuries. The best-known case of this kind of persecution was attacks perpetrated against Jewish communities in the German Empire between 1348 and 1350. At this time, the Black Death devastated the continent, and Jews were accused of intentionally spreading the disease by poisoning wells. A series of terrifying massacres ensued, destroying many of the major Jewish communities in Europe. This was not, however, the only case in which such charges led to persecution. In 1321, lepers in south-western France were accused of attempting to spread their particular illness by poisoning water sources. These accusations evolved to include the idea that the plot was initiated by Muslim rulers and aided by the Jews of France. As a consequence, both Jews and lepers suffered violent fates, from expulsion or isolation to execution by fire. Similar, albeit less widespread, cases can be traced up until the fifteenth century. Often Jews were the victims, but lepers, Muslims, paupers, mendicants and foreigners also fell victim to persecution justified by allegations of well poisoning. This dissertation presents a thorough analysis of the subject of well-poisoning accusations and describes why and how they were adopted in the late Middle Ages. The study describes the origins of this phenomenon, how it spread through medieval Europe and its eventual decline. It asserts that in order to explain this process, one must first understand the factors within medieval society, culture and politics that made the idea of a well-poisoning threat convincing. It shows that these accusations were created to justify and drive the persecution and marginalization of minorities. At the same time, it claims that well-poisoning accusations could not have caused such major political and social shifts unless contemporaries genuinely believed the charges were plausible, convincing and threatening.