INTRODUÇÃO: A ressonância magnética (RM) e artro-ressonância magnética (artro-RM) vêm sendo rotineiramente empregadas para o estudo das estruturas ligamentares do tornozelo. Os processos talares posterior e lateral constituem locais de várias inserções ligamentares, sendo algumas praticamente desconhecidas e não demonstradas por métodos de imagem. OBJETIVOS: Demonstrar o papel da artro-RM combinada do tornozelo e da articulação subtalar posterior para avaliação dos ligamentos dos processos posterior e lateral do tálus, caracterizar o melhor plano de imagem por RM para análise ligamentar, e correlacionar os aspectos por imagem com aqueles provenientes da análise anatômica e histológica. MÉTODOS: Radiografia e imagem por RM foram inicialmente realizadas em dez tornozelos de cadáveres. Artro-RM do tornozelo e da articulação subtalar posterior seguidas de análise anátomo-histológica foram então realizadas para permitir uma melhor avaliação dos ligamentos dos processos posterior e lateral do tálus. RESULTADOS: Em todos os espécimes, a artro-RM permitiu uma melhor caracterização das estruturas ligamentares. Os ligamentos talocalcâneo lateral e medial foram melhor avaliados nos planos axial e coronal, respectivamente. O plano axial foi o melhor para visualizar o ligamento fibulotalocalcâneo, e o plano sagital foi o melhor para a avaliação do ligamento talocalcâneo posterior. Os ligamentos talofibular anterior e posterior, e o ligamento tibiotalar posterior (porções superficial e profunda) foram melhor demonstrados no plano axial. A correlação anátomo-histológica mostrou os locais das inserções ligamentares. CONCLUSÃO: A artro-RM combinada do tornozelo e da articulação subtalar posterior possibilitou a caracterização das inserções ligamentares nos processos talares posterior e lateral, incluindo os ligamentos talocalcâneo posterior, medial e lateral, e fibulotalocalcâneo. A RM e artro-RM com correlação anatômica mostrou o melhor plano para análise destes ligamentos. O estudo histológico confirmou os locais das inserções ligamentares. / INTRODUCTION: MR imaging and MR arthrography have been routinely used in the ankle ligaments study. The posterior and lateral talar processes are sites of many ligaments insertions, some of which are practically unknown and not shown in imaging methods. OBJECTIVES: To demonstrate the role for combined ankle and posterior subtalar MR arthrography in the assessment of the ligaments of the posterior and lateral talar processes, to establish the best MR imaging plane to analyze the ligaments, and correlate the imaging aspects with those delineated through anatomic inspection and histologic analysis. METHODS: Routine radiography and MR imaging were initially performed in ten cadaveric ankles. Ankle and posterior subtalar MR arthrography, followed by anatomic and histologic analysis, was then performed to allow better assessment of the ligaments of the lateral and posterior talar processes. RESULTS: In all specimens, MR arthrography provided better delineation of the ligaments structures. The lateral talocalcaneal and medial talocalcaneal ligaments were best seen in the axial and coronal planes, respectively. The axial plane was best to visualize the fibulotalocalcaneal ligament, and the sagittal MR plane was best for evaluating the posterior talocalcaneal ligament. The anterior and posterior talofibular ligaments, and posterior tibiotalar ligament (superficial and deep portions) were best demonstrated in the axial plane. Histologic analysis was correlated to anatomic sectioning and showed the attachment sites of these ligaments. CONCLUSION: Combined ankle and posterior subtalar MR arthrography allowed the characterization of the ligaments attaching to the posterior and lateral talar processes, including the posterior, lateral and medial talocalcaneal and fibulotalocalcaneal ligaments. Anatomic correlation with MR and MR arthrography showed the best plane to analyze these ligaments. Histologic study confirmed the insertions of these ligaments.

OBJETIVO: avaliar a histomorfometria do endométrio na fase lútea de mulheres férteis e inférteis. MÉTODOS: foram triadas 40 pacientes, 30 inférteis e 10 férteis, em seguimento na Clínica Ginecológica do HC-FMUSP, que concordaram em participar deste estudo. Foi realizada avaliação ultrassonográfica seriada a partir da menstruação, para determinação da ovulação. Na fase lútea as pacientes eram submetidas à histeroscopia. Foram excluídas 14 pacientes sendo 12 por falta durante a avaliação ultrassonográfica e 2 pela presença de pólipos. A casuística foi composta por 6 controles férteis, que foram comparadas a 20 casos inférteis (endometriose-8, causa tubo-peritoneal-5, causa masculina-5, sem causa aparente-2). Na histeroscopia foram coletadas duas biópsias dirigidas (sistema de Bettocchi) da parede posterior (terço distal), e da parede anterior (terço médio), e uma biópsia aspirativa com Pipelle. Foram avaliados parâmetros histomorfométricos endometriais. RESULTADOS: as duas formas de biópsia foram apropriadas para análise endometrial; a dirigida coletou menor área tecidual, porém sem sangue. Nenhum paciente fértil apresentou heterogeneidade endometrial (atraso de fase em algum sítio); isto ocorreu em 7 (35%) das inférteis (p=0,11). Foi diagnosticada endometrite em 2 (10%) casos. CONCLUSÃO: não foram observadas diferenças histomorfométricas entre o endométrio de mulheres férteis e inférteis na fase lútea. Parte das pacientes inférteis mostrou heterogeneidade endometrial e endometrite. A biópsia dirigida, assim como a aspirativa, foi adequada ao estudo endometrial na fase lútea / Objective: to evaluate the endometrial histomorphometry of fertile and infertile women during their luteal period. Methods: 40 female patients- 30 infertile and 10 fertile- who were being followed-up at the Gynecological Clinic at the Hospital das Clinicas (HC),-Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), agreed to participate in the study. Serial ultra sonograms, starting from their menstrual period, were performed to identify their ovulation. In the luteal phase the patients underwent hysteroscopy. From the initial sample, 14 patients were excluded from the study, 12 of whom for being absent during scheduled ultra sonograms and 2 for presenting polyps. The final sample thus consisted of 6 fertile females (control subjects) who were compared to 20 patients with infertility, categorized as follows: 8 due to endometriosis, 5 due to peritoneal tube conditions, 5 due to male infertility, and 2 with no apparent cause. During the hysteroscopy 2 directed biopsies (Bettocchis System) of the posterior wall (distal third section) and of the anterior wall (medial third) were performed, as well as Pipelle sampling. Endometrial histomorpholometric parameters were evaluated. Results: the two forms of endometrial sampling performed were appropriate for the endometrial analysis. The directed biopsy collected tissue from a smaller area, but it had no blood. None of the fertile patients presented endometrial heterogeneity, i.e., phase delay in any site. In contrast, this occurred in 7(35%) of the infertile females (p=0.11). Endometritis was diagnosed in 2 (10%) of the cases. Conclusions: no histomorphometric differences were observed in the endometrium of the fertile and infertile female patients during their luteal phase. About a third of infertile cases (35%) displayed endometrial heterogeneity and a small percentage of which (10%) had endometritis. Both the directed biopsy and Pipelle sampling were found satisfactory for studies of endometrium during the luteal phase

This thesis considers the prevalence and spatial distribution of Salmonella serovars amongst wild endemic lizards on offshore islands around the coast of New Zealand. The mean test prevalence of faecal excretion of Salmonella was 4.7%. Skinks (Scincidae) were more likely (8.5%) to be carriers of Salmonella than geckos (1.6%). Each island was host to between one and three Salmonella serovars that were not found on any other islands in this study. Two exceptions were Salmonella Bousso and Salmonella Mana which were found on two islands within the same geographical area. Based on the findings of this study, different islands are likely to be hosts to different Salmonella serovars which could have implications for future translocations of native lizards. I also assessed the prevalence and spatial distribution of faecal excretion of Salmonella, Aeromonas and Hafnia alvei within Mana Island. The prevalence of Salmonella on Mana Island was estimated at 5.8%. Salmonella was found predominantly in skinks (10.0%) and less often in geckos (4.1%). H. alvei was found at a prevalence of 1.9%. No Aeromonas species were cultured from any of the cloacal swabs, suggesting that the 95% confidence interval for the true prevalence is 0-3%. Each site sampled in this study was host to one or more unique serovar of Salmonella not found at any of the other sites. The results of this study indicate that Salmonella serovars may become established within populations of lizards and is not spread between them. This may be due to a lack of dispersal of lizards between sites, raising important considerations for the translocation of native lizards. I investigated the prevalence of faecal excretion of Salmonella, H. alvei and Aeromonas by New Zealand native lizards from two captive populations. The mean prevalence of faecal excretion of Salmonella in the captive lizards sampled was 11.5%. There was a higher prevalence of Salmonella within captive population A (22.0%) than in population B (3.6%). No Aeromonas was cultured from any of the lizards. H. alvei was found at a prevalence of 5.2%. The prevalence of Salmonella and H. alvei was significantly higher in captive lizards than in wild populations. Captive lizards may, therefore, not be appropriate founders for new populations of wild lizards. Finally I assessed the different efficiencies of two media and two temperatures in isolating six Salmonella serovars from a reptilian source. All serovars grew equally well at 37°C and 27°C. For most serovars XLD agar was the more successful media than MacConkey agar but the success of different culture media depended on the serovar being cultured. Because lizards are frequently host to a wide range of Salmonella serovars, screening samples using multiple microbiological methods is likely to give the best chance of isolating all Salmonella serovars present.

This thesis covers broad topics concerning limb growth and development and their effects on locomotion in the brown kiwi (Apteryx mantelli). I begin by describing the morphological features of a collection of unknown-age wild kiwi embryos from early development to point of hatch. Using these features, I assign developmental stages to each embryo and compare the progress of development to the same-staged ostrich and chicken embryos. Measurements of the hindlimb, bill and crown-rump length are used to develop an aging scheme based on comparisons with the ostrich and the chicken. The ostrich model and chicken model create age predictions for the unknown aged kiwi embryos. One kiwi embryo was of known age and both models gave identical predictions for this marker embryo, but gave differing predictions for all other kiwi embryos. Using captive-reared kiwi chicks, I characterise hindlimb, bill and bodyweight growth from the time of hatch to 3 months of age. Growth patterns are very linear within this time period for all measurements but bodyweight. Female kiwi hatch with longer bills than males, but the growth of both sexes converges by the end of the 3-month period. Growth of bodyweight in the males slows earlier than in females. Bodyweight and bill length were then compared to a wild population of kiwi. Captive-reared chicks were found to hatch with shorter bills than the wild birds and to increase in bodyweight at a faster rate than wild birds. Rapid weight gain has been implicated in developmental limb deformities in other precocial and long-legged birds and has the potential to produce similar results in captive kiwi. I further studied the movement of the hindlimb during locomotion in two adults and one juvenile kiwi by filming them while they were walking on a treadmill. Kinematic parameters were measured from the video recordings and compared to overground parameters from another study. Similarity between the treadmill and overground locomotor parameters validates the use of a treadmill in studying kiwi locomotion. None of the birds achieved the theoretical transition from a walk to a run at a duty factor of 0.5. After normalising for size, the juvenile showed a longer stride length and lower stride frequency with increasing speed than the adults. Lateral head oscillations were observed during the stride cycle, which I propose having a sensory function as well as a biomechanical one.

Objetivo: Estudar as alterações morfométricas da retina de ratos expostos agudamente à fumaça de cigarro. Métodos: Em um estudo experimental, controlado, mascarado, foram utilizados 24 ratos Wistar machos (8 semanas de idade), sendo metade deles expostos por duas horas contínuas à fumaça de cigarro em uma câmara de inalação e a outra metade exposta a ar comprimido como grupo controle. A fumaça foi aspirada diretamente do cigarro utilizando um sistema venturi, e conduzida para a câmara. A concentração de monóxido de carbono no interior da câmara de inalação foi mantida em uma faixa constante de 45 a 55 partes por milhão, monitorada eletronicamente no interior do recipiente. Os ratos foram sacrificados imediatamente após a inalação e nos momentos 24 e 48 horas após exposição. Os olhos foram enucleados e analisados por meio da morfometria em microscópio óptico, por examinador mascarado. Resultados: Foram identificadas regiões da retina do grupo exposto que sofreram redução das estimativas morfométricas em comparação ao grupo controle, com significância estatística correspondendo às regiões dos fotorreceptores, camada nuclear interna e plexiforme interna 48 horas após a exposição. Comparando os grupos expostos entre si houve uma redução progressiva nas estimativas morfométricas das camadas retinianas com o aumento do intervalo entre o término da exposição e o sacrifício, de forma estatisticamente significante na camada nuclear interna. Conclusão: As retinas dos ratos expostos agudamente à fumaça de cigarro sofreram uma redução nas estimativas morfométricas, com uma tendência a redução progressiva nas estimativas no decorrer das primeiras 48 horas após exposição / Objective: To evaluate morphometric alterations of the retina, from rats acutely exposed do cigarette smoking. Methods: In an experimental, prospective, masked study with 24 male Wistar rats (8 weeks old), half of them were exposed during two hours continually to cigarette smoking inside an intoxicating chamber, while the other half exposed to compressed air. The smoke was aspirated directly from cigarette, using a venturi system, and conducted to the chamber. The carbon monoxide concentration was constantly kept in between 45 to 55 parts per million, electronically monitored inside de chamber. The rats were sacrificed immediately after the inhalation, 24 and 48 hours after exposition. The eyes were enucleated and analyzed trough morphometry, in an optical microscope, by a masked examiner. Results: It was identified regions of the retina in the experimental group that suffered a reduction in the morphometric estimates, comparing to control group, with statistical significance, corresponding to the photoreceptor layer, the inner nuclear and inner plexiform layers, 48 hours after exposure. Comparing the exposed groups between themselves, there was a progressive reduction in the morphometric estimates of retinal layers after an increase in time between finishing the exposure and sacrifice, with statistical significance in inner nuclear layer. Conclusion: The retina of rats acutely exposed to cigarette smoke suffered a reduction in the morphometric estimates, with a tendency to progressive reduction in the estimates during the initial 48 hours after exposure

A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic activity and alters intrafol1icular steroid hormone levels. In a series of four experiments, the morphology of oocytes and embryos retrieved from immature rats, treated with either a low or high dose of PMSG, and mature, cycling rats was compared to determine whether a superovulatory dose of PMSG has an adverse effect on oocyte maturation and subsequent fertilization and embryonic development in immature rats. Morphological criteria for the assessment of intraoviductal oocyte aging were established in the first experiment. During intraoviductal aging, progressive morphological changes directed by the intrinsic developmental program of the oocyte were observed. Further alterations in morphology were attributed to abnormalities of cytoskeletal function. In the second experiment, no difference in morphology was observed between oocytes retrieved from immature rats treated with either 4 or 40 IU PMSG. When compared with mature rats, changes attributable to cytoskeletal instability were observed in aged oocytes from immature rats treated with both doses of PMSG. This was concluded to be a manifestation of altered intrafollicular oocyte maturation as a result of the administration of exogenous gonadotrophin. In the third and fourth experiments, delayed fertilization and a significant reduction in fertilization rate were observed in superovulated, immature rats. The major cause of fertilization failure was determined to be intraoviductal oocyte aging. A significant increase in abnormal embryos was observed as a result of parthenogenetic activation of the aged oocytes. Abnormal, fertilized embryos retrieved from the superovulated group were concluded to be the manifestation of delayed fertilization. In conclusion, the major effect of a superovulatory dose of PMSG on oocyte fertilizability and embryonic development was intraoviductal oocyte aging and delayed fertilization. Changes attributed to altered intrafol1icular maturation were manifested during oocyte aging in immature rats treated with either the low or high dose of PMSG. / Medicine, Faculty of / Obstetrics and Gynaecology, Department of / Graduate

Univerzita Karlova v Praze Přírodovědecká fakulta Studijní program: Filosofie a dějiny přírodních věd MUDr. Jan Hrudka Nádory v dějinném a kulturním kontextu v novověku Tumours in historical and social context in the modern period Disertační práce Školitel / Supervisor: Prof. RNDr. Stanislav Komárek, Dr. Praha, 2017 SUMMARY: The PhD thesis called Tumours in historical and social context in the modern period is an attempt to describe a change of medical thinking in modern period; science and medicine turns from antique humoral pathology, explaining all diseases as an imbalance of the four body humours, to pathological anatomy and experimental physiology. In the point of view of pathological anatomy, the viscera of diseased person are no more "screen" or "mirror" of the disease, but it becomes directly the "stage" or "theatre" of the acting disease. This shift in the thought may be labelled as movement from humoralism to localism or ontologism; the disease isn't just abnormal amount of some natural juice any more, but becomes new original entity. This change undergoes the understanding of tumours and cancerous disease as well. Instead of antique understanding tumours as precipitates of black bile, the cell theory occurs in the 19th century. This theory explains tumours as a mass of cells undergoing excessive...

Os objetivos deste estudo foram obter medidas antropométricas faciais, a medida interincisiva máxima e proporções faciais em crianças, verificar se há diferença estatisticamente significativa entre as médias das medidas e proporções faciais, segundo idade e sexo, comparar a distância do canto externo do olho ao cheilion do lado direito com o lado esquerdo da face e comparar as médias das medidas antropométricas faciais desta amostra com os padrões de normalidade para crianças norte-americanas. Participaram 254 crianças, 117 do sexo masculino e 137 do sexo feminino, com idades entre 7,0 e 11,11 anos, leucodermas, em dentição mista, sem queixas fonoaudiológicas e/ou histórico de tratamento fonoaudiológico prévio e/ou atual. As medidas antropométricas faciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face e distância entre o canto externo do olho e o cheilion no lado direito e esquerdo da face. As proporções faciais obtidas foram as estabelecidas entre o lábio superior e o lábio inferior, entre o terço superior da face e o terço médio da face e entre o terço médio da face e o terço inferior da face. O instrumento utilizado foi o paquímetro digital marca Starrett Série 727. Os resultados mostraram que, para o lábio superior e para o filtro, não houve diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. Nas demais medidas faciais, observou-se diferença estatisticamente significativa entre as médias, segundo idade. Na maioria das medidas faciais, as meninas apresentaram médias inferiores às obtidas para os meninos. As proporções faciais não apresentaram diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. As médias da distância entre o canto externo do olho e o cheilion no lado direito da face foram estatisticamente maiores do que as médias dessa distância no lado esquerdo da face. Os resultados obtidos nesta amostra para o lábio superior, o lábio inferior e o terço inferior da face encontram-se abaixo das médias descritas para as crianças norte-americanas. Os resultados desta amostra, referentes ao filtro, coincidem com as médias descritas para as crianças norte-americanas. / The purposes of this study were to obtain anthropometric facial measurements, the maximum distance between incisors and facial proportions in children, to verify if there is statistically significant difference among the averages of the facial measurements and proportions, according age and sex, to compare the distance from the exocanthion to the cheilion of the right side that of the left side of the face and to compare the averages of the anthropometric facial measurements of this sample with the North American norms. 254 children participated, 117 male and 137 female, with ages ranging from 7,0 to 11,11 years, leukoderm, in mixed dentition period, with no history of speech and swallowing disorders or treatment. The collected anthropometric facial measurements were upper lip, lower lip, philtrum, upper face, middle face, lower face and the distance from the exocanthion to the cheilion of each side of the face. The collected facial proportions were between the upper lip and lower lip, between the upper face and middle face and between middle face and lower face. The used instrument was the electronic digital sliding caliper Starrett Series 727. The results showed that there was no statistically significant difference among averages according age, in both sexes, to the upper lip and to the philtrum. In others facial measurements, statistically significant difference among averages according age was observed. In the majority of facial measurements, girls showed lower averages than boys. The facial proportions did not show statistically significant difference among averages according to age, in both sexes. The averages of the distance from the exocanthion to the cheilion in right side of the face were statistically higher than the averages of the distance from the exocanthion to the cheilion in left side of the face. The results of this sample referring to upper lip, lower lip and lower face were lower than the North American norms for children. The results of this sample referring the philtrum were the same as the North American norms for children.

A avaliação da morfologia orofacial sob o enfoque antroposcópico, bem como a mensuração das estruturas orofaciais, é importante aspecto do exame fonoaudiológico, contribuindo para a determinação do diagnóstico, do planejamento terapêutico e do prognóstico dos indivíduos com respiração oral. Os objetivos desta tese foram: 1. descrever as características posturais e morfológicas dos órgãos fonoarticulatórios de crianças respiradoras orais, segundo a idade; 2. descrever as medidas e proporções orofaciais de crianças respiradoras orais, segundo a idade e; 3. comparar as medidas e proporções orofaciais de crianças respiradoras orais com as medidas e proporções orofaciais de crianças sem queixas fonoaudiológicas, segundo a idade. A tese encontra-se dividida em três estudos: Estudo I -Características posturais e morfológicas dos órgãos fonoarticulatórios de crianças respiradoras orais: enfoque antroposcópico; Estudo II - Medidas e proporções orofaciais de crianças respiradoras orais; e Estudo III -Comparação entre medidas e proporções orofaciais de crianças respiradoras orais e de crianças sem queixas fonoaudiológicas. Participaram dos estudos 100 crianças, de ambos os sexos, com idades entre sete anos e 11 anos e 11 meses, leucodermas, em dentição mista, com diagnóstico de respiração oral. No Estudo III, o grupo controle foi composto de 254 crianças, de ambos os sexos, na faixa etária entre sete anos e 11 anos e 11 meses, leucodermas, em dentição mista e sem queixas fonoaudiológicas. As características posturais e morfológicas dos órgãos fonoarticulatórios das crianças respiradoras orais pesquisadas no Estudo I foram posição habitual de lábios e de língua, possibilidade de vedamento labial, hiperfunção do músculo mentual durante a oclusão labial, mordida e morfologia do lábio inferior, das bochechas e do palato duro, por meio da antroposcopia. Os resultados indicaram que os aspectos mais comuns na amostra foram posição habitual de lábios entreaberta, posição habitual de língua no assoalho oral, possibilidade de vedamento labial, hiperfunção do músculo mentual durante a oclusão dos lábios, mordida alterada, lábio inferior com eversão, simetria de bochechas e palato duro alterado. Nos Estudos II e III, as crianças foram submetidas à avaliação antropométrica, sendo que as medidas orofaciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face, lados da face e distância interincisiva máxima. O instrumento utilizado foi o paquímetro eletrônico digital marca Starrett Série 727. Os resultados do Estudo II evidenciaram que não houve diferença estatisticamente entre a maioria das médias das medidas e proporções orofaciais de crianças respiradoras orais, segundo a idade. Os resultados do Estudo III mostraram que para algumas medidas e proporções orofaciais houve diferença estatística entre as duas populações estudadas. Conclui-se, ao analisar os três estudos, que as alterações antroposcópicas parecem ser mais evidentes nos respiradores orais do que as alterações antropométricas. Por fim, tem-se que a antropometria mostra-se útil na avaliação fonoaudiológica, complementando o julgamento visual com medidas quantitativas. / The evaluation of the orofacial morphology made by anthroposcopic approach, as well as the measurement of orofacial structures, is an important aspect from the speech-language pathology assessment that contributes to determination of diagnosis, management and prognosis of mouth breathing individuals. The purposes of this thesis were: 1. to describe the postural and morphologic characteristics of the stomatognathic system of mouth breathing children, according to age; 2. to describe the orofacial measurements and proportions of mouth breathing children, according to age and; 3. to compare the orofacial measurements and proportions of mouth breathing children to those of children with no history of speech-language pathology disorders, according to age. The thesis is divided in three studies: Study I - Postural and morphologic characteristics of the stomatognathic system of mouth breathing children: anthroposcopic approach; Study II - Orofacial measurements and proportions of mouth breathing children; and Study III - Comparation between measurements and proportions of mouth breathing children and children with no history of speech-language pathology disorders. 100 children participated in the studies, of both sexes, with ages ranging from seven to 11 years and 11 months, leukoderms, in mixed dentition period, with mouth breathing diagnosis. In Study III, the control group was comprised of 254 children, of both sexes, with ages ranging from seven to 11 years and 11 months, leukoderms, in mixed dentition period, with no history of speech-language pathology disorders. The postural and morphologic characteristics of the stomatognathic system of mouth breathing children researched in Study I were labial and lingual resting position, possibility of labial occlusion, mentalis muscle hyperfunction during labial occlusion, bite and morphology of lower lip, cheeks and hard palate, observed by anthroposcopy approach. The results indicated that the most common aspects in the sample were half-open lips in resting position, tongue lowered on the mouth\'s floor in resting position, possibility of labial occlusion, mentalis muscle hyperfunction during labial occlusion, alteration of the bite, labioverted, symmetry of the cheeks and alteration of the hard palate. In Studies II and III, the children were submitted to anthropometric assessment and the orofacial measurements obtained were upper lip, lower lip, philtrum, upper face, middle face, lower face, sides of the face and maximum interincisal distance. The instrument used was the electronic digital sliding caliper Starrett Series 727. The results of Study II showed that there was no statistically difference between the most of averages of the orofacial measurements and proportions of mouth breathing children, according to ages. The results of Study III showed that in some orofacial measurements and proportions there was statistically difference between the two studied populations. In analysis of the three studies, it can be concluded that the anthroposcopic alterations seems to be more evident in mouth breathers than anthropometric alterations. Finally, the anthropometry shows useful in speech-language pathology assessment and supplements visual judgment with quantitative measurements.

Os objetivos deste estudo foram obter medidas antropométricas faciais, a medida interincisiva máxima e proporções faciais em crianças, verificar se há diferença estatisticamente significativa entre as médias das medidas e proporções faciais, segundo idade e sexo, comparar a distância do canto externo do olho ao cheilion do lado direito com o lado esquerdo da face e comparar as médias das medidas antropométricas faciais desta amostra com os padrões de normalidade para crianças norte-americanas. Participaram 254 crianças, 117 do sexo masculino e 137 do sexo feminino, com idades entre 7,0 e 11,11 anos, leucodermas, em dentição mista, sem queixas fonoaudiológicas e/ou histórico de tratamento fonoaudiológico prévio e/ou atual. As medidas antropométricas faciais obtidas foram lábio superior, lábio inferior, filtro, terço superior da face, terço médio da face, terço inferior da face e distância entre o canto externo do olho e o cheilion no lado direito e esquerdo da face. As proporções faciais obtidas foram as estabelecidas entre o lábio superior e o lábio inferior, entre o terço superior da face e o terço médio da face e entre o terço médio da face e o terço inferior da face. O instrumento utilizado foi o paquímetro digital marca Starrett Série 727. Os resultados mostraram que, para o lábio superior e para o filtro, não houve diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. Nas demais medidas faciais, observou-se diferença estatisticamente significativa entre as médias, segundo idade. Na maioria das medidas faciais, as meninas apresentaram médias inferiores às obtidas para os meninos. As proporções faciais não apresentaram diferença estatisticamente significativa entre as médias segundo idade, em ambos os sexos. As médias da distância entre o canto externo do olho e o cheilion no lado direito da face foram estatisticamente maiores do que as médias dessa distância no lado esquerdo da face. Os resultados obtidos nesta amostra para o lábio superior, o lábio inferior e o terço inferior da face encontram-se abaixo das médias descritas para as crianças norte-americanas. Os resultados desta amostra, referentes ao filtro, coincidem com as médias descritas para as crianças norte-americanas. / The purposes of this study were to obtain anthropometric facial measurements, the maximum distance between incisors and facial proportions in children, to verify if there is statistically significant difference among the averages of the facial measurements and proportions, according age and sex, to compare the distance from the exocanthion to the cheilion of the right side that of the left side of the face and to compare the averages of the anthropometric facial measurements of this sample with the North American norms. 254 children participated, 117 male and 137 female, with ages ranging from 7,0 to 11,11 years, leukoderm, in mixed dentition period, with no history of speech and swallowing disorders or treatment. The collected anthropometric facial measurements were upper lip, lower lip, philtrum, upper face, middle face, lower face and the distance from the exocanthion to the cheilion of each side of the face. The collected facial proportions were between the upper lip and lower lip, between the upper face and middle face and between middle face and lower face. The used instrument was the electronic digital sliding caliper Starrett Series 727. The results showed that there was no statistically significant difference among averages according age, in both sexes, to the upper lip and to the philtrum. In others facial measurements, statistically significant difference among averages according age was observed. In the majority of facial measurements, girls showed lower averages than boys. The facial proportions did not show statistically significant difference among averages according to age, in both sexes. The averages of the distance from the exocanthion to the cheilion in right side of the face were statistically higher than the averages of the distance from the exocanthion to the cheilion in left side of the face. The results of this sample referring to upper lip, lower lip and lower face were lower than the North American norms for children. The results of this sample referring the philtrum were the same as the North American norms for children.