INTRODUÇÃO: A plastia valvar mitral é o tratamento de escolha para a correção da insuficiência mitral mixomatosa. Estudos ecocardiográficos tridimensionais demonstram que a plastia mitral com implante de anéis protéticos altera a morfologia e a função do anel valvar mitral, porém a literatura é escassa em relação ao comportamento do anel mitral após a plastia mitral sem utilização de anéis protéticos. OBJETIVO: Analisar a morfologia e a função cardíaca de indivíduos submetidos à plastia valvar mitral pela técnica de Duplo Teflon, através da ecocardiografia tridimensional em tempo real. CASUÍSTICA: Foram incluídos 14 pacientes portadores de insuficiência mitral secundária a degeneração mixomatosa, que foram submetidos à plastia valvar mitral pela técnica de Duplo Teflon. Destes, 10 pacientes eram do sexo masculino e a idade média foi de 61,3 ± 11,2 anos. Em relação à classe funcional, 13 pacientes encontravam-se em classe III ou IV no período pré-operatório. Na análise ecocardiográfica pré-operatória, o valor médio do volume diastólico final do ventrículo esquerdo foi 156,57 ± 46,61ml, e a fração de ejeção do ventrículo esquerdo variou de 38 a 68%, com média de 57,93 ± 6,67%. O valor médio do anel mitral posterior foi 6,97 ± 0,13 cm. MÉTODOS: Os pacientes foram avaliados nos períodos pré-operatório, pós-operatório imediato (POI), 6 meses e 1 ano após a plastia mitral. A ecocardiografia tridimensional avaliou a morfologia do anel mitral através das medidas do anel anterior e posterior, dos diâmetros transversos e da área valvar. A função anular foi avaliada pela relação entre as áreas valvares internas durante a sístole e diástole. Foram avaliados os volumes e a função do átrio e do ventrículo esquerdos. Foi utilizado teste de análise de variância de medidas repetidas para o estudo estatístico, sendo considerado estatisticamente significante p < 0,05. RESULTADOS: O anel mitral posterior demonstrou uma redução significativa (p<0,001) no POI, que manteve-se estável durante o estudo. Não houve variação significativa na área valvar durante o estudo. Houve uma redução significativa nos diâmetros ântero-posterior e médio-lateral no POI (p<0,001), porém houve um aumento significativo no diâmetro médio-lateral entre POI e 1 ano. A fração de variação do anel mitral durante o ciclo cardíaco, ao longo do estudo, variou entre 30,92 e 35,75%, não havendo diferença estatisticamente significante. A análise dos volumes sistólicos, atrial e ventricular, demonstrou uma redução volumétrica significativa entre POI e 1 ano (p=0,028 e p=0,020, respectivamente). Entre o pré-operatório e 1 ano, houve uma redução média de 19,9% e 15,4% nos volumes atrial e ventricular, respectivamente. Os volumes diastólicos atrial e ventricular apresentaram uma redução significativa no POI (p<0,001 e p=0,024, respectivamente), permanecendo estáveis ao longo do estudo. Houve aumento na fração de ejeção do átrio esquerdo após 6 meses (p<0,001), porém não houve variação na função ventricular esquerda. CONCLUSÕES: A plastia mitral com a anuloplastia segmentar pela técnica do Duplo Teflon reduziu o anel posterior da valva mitral, que permaneceu estável no período de um ano. A variação da área anular mitral durante o ciclo cardíaco permaneceu estável durante o estudo. Além disso, houve um remodelamento reverso atrial e ventricular esquerdo, associado à melhora na função do átrio esquerdo / INTRODUCTION: Mitral valve repair is the treatment of choice to correct mixomatous mitral insufficiency. Tridimensional echocardiography studies demonstrate that mitral repair using prosthetic ring implant modifies mitral valve annulus morphology and function, although the literature related to mitral valve annulus behavior after mitral repair without use of prosthetic rings is scarce. OBJECTIVE: Analyze cardiac morphology and function using real time tridimensional echocardiography in individuals submitted to mitral valve repair with Double Teflon technique. CASUISTIC: Were included 14 patients with mitral valve insufficiency secondary to mixomatous degeneration that were submitted to mitral valve repair with the Double Teflon technique. Of them, 10 patients were male and the mean age was 61.3 ± 11.2 years. According to preoperatively functional class, 13 patients were in class III or IV. In preoperative echocardiographic analysis, the mean value of left ventricle end diastolic volume was 156.57 ± 46.61ml, and the left ventricle ejection fraction ranged between 38 and 68%, with average of 57.93 ± 6.67%. The mean value of the posterior annulus was 6.97 ± 0.13 cm. METHODS: Patients were evaluated in preoperative period, immediate postoperative period, 6 months and 1 year after mitral repair. Tridimensional echocardiography evaluated mitral annulus morphology by anterior and posterior measurements, transverse diameters and valve area. The annular function was evaluated through the ratio between internal valve areas during systole and diastole. Were evaluated left atrial and ventricle volumes and function. Statistic analysis was made by repeated measures ANOVA test and was considered statistically significant p < 0.05. RESULTS: Posterior mitral annulus demonstrated a significant reduction in immediate postoperative period (p<0.001), remaining stable during the study. There was no significant variation in valve area during the study. There was a significant reduction in anteroposterior and mediolateral diameters in the immediate postoperative period (p<0.001), although there was a significant increase in mediolateral diameter between immediate postoperative period and 1 year. Annular area variation over the cardiac cycle during the study ranged between 30.92 and 35.75%, without statistic significance. The analysis of systolic volumes, atrial and ventricular, demonstrated a significant volumetric reduction between immediate postoperative period and 1 year (p=0.028 and p=0.020, respectively). Between preoperative period and 1 year, there was a mean reduction in atrial and ventricle volumes of 19.9% and 15.4%, respectively. Atrial and ventricle diastolic volumes presented a significant reduction in immediate postoperative period (p<0.001 and p=0.024, respectively), remaining stable during the study. There was an increase in left atrial ejection fraction after 6 months (p<0.001), although there was no significant variation in left ventricle ejection fraction. CONCLUSIONS: Mitral valve repair with segmentar annuloplasty with the Double Teflon technique reduced the posterior mitral annulus, which remained stable in 1 year period. The variation in mitral annulus area during cardiac cycle remained stable during the study. Furthermore, there was a left atrial and ventricle reverse remodeling, associated with an improvement in left atrial function

Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2017-04-20T13:29:23Z No. of bitstreams: 1 2016 - Rafael Veloso Patr?cio.pdf: 9711857 bytes, checksum: 5f7e5b198769c9a633040fd42126df03 (MD5) / Made available in DSpace on 2017-04-20T13:29:23Z (GMT). No. of bitstreams: 1 2016 - Rafael Veloso Patr?cio.pdf: 9711857 bytes, checksum: 5f7e5b198769c9a633040fd42126df03 (MD5) Previous issue date: 2016-08-24 / Funda??o de Apoio a Pesquisa Cient?fica e Tecnol?gica da UFRRJ-FAPUR / Controling of downhole pressure is essential for a safety process of oil well drilling. In a permeable formation, fluids from reservoir come into the annulus region (wellbore) when the downhole pressure is below pore pressure, featuring a disorder called kick. Literature reports some mathematical models developed to predict the behavior of the wellbore in presence of gas kick, however, there are few works reporting control and experiments. By this reason, it was built an experimental plant in order to study system?s behavior during fluid inlet (gas) from reservoir to annulus, and then, sought to develop a control strategy able to mitigate this disorder, without shut-in the well. A strategy with reconfiguration of the control law feedback?feedforward was designed to reject disturbance (gas inlet in the annular), to ensure the drilling within the operating window. Parallelly,simulation studies were developed which are: the construction of mathematical model, validated by the employment of the experimental unit, and the implementation of control based on reconfiguration of control law. / O controle da press?o anular de fundo ? fundamental para que a perfura??o de po?os de petr?leo seja feita de forma segura. Em uma forma??o perme?vel, fluidos do reservat?rio migram para a regi?o anular quando a press?o anular de fundo est? abaixo da press?o de poros, caracterizando o dist?rbio denominado kick. A literatura reporta alguns modelos matem?ticos desenvolvidos para prever o comportamento do po?o na presen?a de kick de g?s, por?m poucos s?o os trabalhos abordando controle e experimentos. A partir desta motiva??o, foi constru?do uma planta experimental para estudar o comportamento do sistema durante a entrada de fluido (g?s) do reservat?rio no anular, e assim, buscou-se desenvolver uma estrat?gia de controle que mitigue tal dist?rbio sem a necessidade do fechamento total do po?o. Uma estrat?gia com reconfigura??o da lei de controle feedback?feedforward foi desenvolvida para rejeitar a perturba??o (entrada de g?s no anular), visando assegurar a perfura??o dentro da janela operacional. Paralelamente, foram desenvolvidos estudos de simula??o quais sejam: a constru??o de um modelo matem?tico, validado empregando-se a unidade experimental, e a implanta??o de controle baseado em reconfigura??o da lei de controle

La presente tesis aborda problemas de optimización y obtención de desigualdades óptimas dentro de la Geometría Convexa. En concreto, se recogen las propiedades conocidas del anillo mínimo asociado a un cuerpo convexo plano y se estudian algunas propiedades nuevas que ayudan a conocer mejor la relación entre ambos. Se estudian con detalle las desigualdades geométricas existentes entre el anillo mínimo de un cuerpo convexo y las magnitudes geométricas clásicas, a saber, área, perímetro, circunradio, inradio, anchura mínima y diámetro, obteniendo en cada caso los conjuntos extremales. Se estudian con detalle propiedades que relacionan el anillo mínimo de un cuerpo convexo con su circunradio por un lado, y su inradio por otros. Se consideran fijos anillo mínimo y circunradio y se presentan las desigualdades óptimas que realcionan estas magnitudes con las restantes, describiendo los conjuntos extremales. Finalmente se realiza algo similar pero considerando fijos, esta vez, el anillo mínimo y el inradio. / This thesis aims to deal with the optimization problems and how to obtain the optimal inequalities within the Convex Geometry. It aims to treat with the already known properties of the minimal annulus associated to a plane convex body; we are also to study some new properties that help us know the relationship between both of them. The geometrical inequalities existing between the minimal annulus of a convex body and the classical geometrical measures are studied in detail. These measures are the area, the perimeter, the circumradius, the inradius, the minimal width and the diameter, and we will obtain in each case the extremal sets. We will study in detail those properties relating the minimal annulus of a convex body with its circumradius first and its inradius later. We will consider as fixed the minimal annulus and the cicumradius, and the optimal inequalities that relate those measures with the remaining one will be represented by describing the extremal sets. Finally, we will do something similar but considering as fixed the minimal annulus and the inradius.

Inspired by work of Hubery [Hub] and Fomin, Shapiro and Thurston [FST06] related to cluster algebras, we construct a bijection between certain curves on a cylinder and the string modules over a path algebra of type Ãn. We show that under this bijection irreducible maps and the Auslander-Reiten translation have a geometric interpretation. Furthermore we prove that the dimension of extension groups can be expressed in terms of intersection numbers. Finally we explain the connection to cluster algebras and apply our results to describe the exchange graph in type Ãn. / Angeregt durch Arbeiten zu Cluster-Algebren von Hubery [Hub] und Fomin, Shapiro und Thurston [FST06] konstruieren wir eine Bijektion zwischen gewissen Kurven auf einem Zylinder und den Fadenmoduln über einer Wege-Algebra vom Typ Ãn. Wir zeigen, daß unter dieser Bijektion sowohl irreduzible Abbildungen als auch die Auslander-Reiten-Verschiebung eine geometrische Interpretation haben. Weiterhin beweisen wir, daß sich die Dimension der Erweiterungsgruppen mittels Anzahlen von Schnittpunkten ausdrücken läßt. Schließlich erklären wir die Verbindung zu Cluster-Algebren und verwenden unsere Ergebnisse um den Austauschgraph im Typ Ãn zu beschreiben.

Numerical studies of two-dimensional laminar conjugate natural convection flow and heat transfer in horizontal annuli formed between inner heat generating solid cylinders and outer isothermal circular boundary are performed with and without the effect of surface radiation. The two configurations of the concentrically placed inner cylinder are a circular cylinder (CC configuration) and a square cylinder (SOS, i.e., Square-On-Side, configuration). The mathematical formulation consists of the continuity equation, momentum equations with Boussinesq approximation and the solid and fluid energy equations. Numerical solutions are obtained by discretising the governing equations on a collocated mesh (non-staggered mesh) and the pressure-velocity coupling is taken into account via the SIMPLE (Semi-Implicit Method for Pressure-Linked Equations) algorithm. A cylindrical polar coordinate system is employed for CC configuration and a Cartesian coordinate system is used for the SOS configuration. The convective terms are discretised with donor-cell differencing scheme and the diffusion terms, with central differencing scheme. The algebraic equations resulting from the discretisation of the governing equations are solved using the line by line TDMA (Tri-Diagonal Matrix Algorithm). A global iteration scheme over each time step is used for better coupling of temperature and the flow variables and steady-state solutions are obtained by time-marching. Steady-state results of conjugate pure natural convection are obtained for the volumetric heat generation and outer radius based Grashof number ranging from 104 to 1010, for solid-to-fluid thermal conductivity ratios of 1, 5, 10, 50 and 100, and for the aspect ratios of 0.2 and 0.4, with air as the working medium (Pr=0.708) for the CC and SOS configurations. The flow and temperature distributions are presented in terms of isotherms and streamline maps. Results are presented for several quantities of interest such as local and average Nusselt numbers on the inner and outer boundaries, dimensionless local temperatures on the inner boundary and dimensionless maximum and average solid cylinder temperatures. The results show that the flow in the annulus is characterized by double or quadruple vortex patterns. Of the dimensionless maximum solid temperature, average solid temperature and average inner boundary temperature, the first two are much sensitive to solid-to-fluid thermal conductivity ratio. Surface radiation effects are studied numerically in conjugation with natural convection. The coupling with surface radiation arises through the solid-fluid interface thermal condition. To account for the radiation effects, configuration factors among the subsurfaces of the inner and outer boundaries formed by the computational mesh are determined. Results are obtained for CC and SOS configurations for emissivities ranging from 0.2-0.8, with the other parameters as in pure natural convection case. It is found that even at low surface emissivity, radiation plays a significant role in bringing down the convective component and enhancing the total Nusselt numbers across the annulus. The presence of radiation is found to reduce the dimensionless temperatures inside the solid and homogenise the temperature distribution in the fluid. The radiative Nusselt number is about 50-70 % of the total Nusselt number depending on the radiative parameters chosen. This factor emphasizes the need for taking into account the coupling of radiation and natural convection for the accurate prediction of the flow and heat transfer characteristics in the annulus. The solution of the conjugate problem facilitates the determination of the solid temperature distribution, which is important in connection with the safety aspects of various thermal energy systems. Correlations as functions of Grashof number and thermal conductivity ratio are constructed for the estimation of various quantities of interest for the two configurations and aspect ratios for pure natural convection and for combined natural convection and radiation cases. The results are expected to be useful in the design of thermal systems such as spent nuclear fuel casks during transportation and storage, underground transmission cables and cooling of electrical and electronic components.

INTRODUÇÃO: A plastia valvar mitral é o tratamento de escolha para a correção da insuficiência mitral mixomatosa. Estudos ecocardiográficos tridimensionais demonstram que a plastia mitral com implante de anéis protéticos altera a morfologia e a função do anel valvar mitral, porém a literatura é escassa em relação ao comportamento do anel mitral após a plastia mitral sem utilização de anéis protéticos. OBJETIVO: Analisar a morfologia e a função cardíaca de indivíduos submetidos à plastia valvar mitral pela técnica de Duplo Teflon, através da ecocardiografia tridimensional em tempo real. CASUÍSTICA: Foram incluídos 14 pacientes portadores de insuficiência mitral secundária a degeneração mixomatosa, que foram submetidos à plastia valvar mitral pela técnica de Duplo Teflon. Destes, 10 pacientes eram do sexo masculino e a idade média foi de 61,3 ± 11,2 anos. Em relação à classe funcional, 13 pacientes encontravam-se em classe III ou IV no período pré-operatório. Na análise ecocardiográfica pré-operatória, o valor médio do volume diastólico final do ventrículo esquerdo foi 156,57 ± 46,61ml, e a fração de ejeção do ventrículo esquerdo variou de 38 a 68%, com média de 57,93 ± 6,67%. O valor médio do anel mitral posterior foi 6,97 ± 0,13 cm. MÉTODOS: Os pacientes foram avaliados nos períodos pré-operatório, pós-operatório imediato (POI), 6 meses e 1 ano após a plastia mitral. A ecocardiografia tridimensional avaliou a morfologia do anel mitral através das medidas do anel anterior e posterior, dos diâmetros transversos e da área valvar. A função anular foi avaliada pela relação entre as áreas valvares internas durante a sístole e diástole. Foram avaliados os volumes e a função do átrio e do ventrículo esquerdos. Foi utilizado teste de análise de variância de medidas repetidas para o estudo estatístico, sendo considerado estatisticamente significante p < 0,05. RESULTADOS: O anel mitral posterior demonstrou uma redução significativa (p<0,001) no POI, que manteve-se estável durante o estudo. Não houve variação significativa na área valvar durante o estudo. Houve uma redução significativa nos diâmetros ântero-posterior e médio-lateral no POI (p<0,001), porém houve um aumento significativo no diâmetro médio-lateral entre POI e 1 ano. A fração de variação do anel mitral durante o ciclo cardíaco, ao longo do estudo, variou entre 30,92 e 35,75%, não havendo diferença estatisticamente significante. A análise dos volumes sistólicos, atrial e ventricular, demonstrou uma redução volumétrica significativa entre POI e 1 ano (p=0,028 e p=0,020, respectivamente). Entre o pré-operatório e 1 ano, houve uma redução média de 19,9% e 15,4% nos volumes atrial e ventricular, respectivamente. Os volumes diastólicos atrial e ventricular apresentaram uma redução significativa no POI (p<0,001 e p=0,024, respectivamente), permanecendo estáveis ao longo do estudo. Houve aumento na fração de ejeção do átrio esquerdo após 6 meses (p<0,001), porém não houve variação na função ventricular esquerda. CONCLUSÕES: A plastia mitral com a anuloplastia segmentar pela técnica do Duplo Teflon reduziu o anel posterior da valva mitral, que permaneceu estável no período de um ano. A variação da área anular mitral durante o ciclo cardíaco permaneceu estável durante o estudo. Além disso, houve um remodelamento reverso atrial e ventricular esquerdo, associado à melhora na função do átrio esquerdo / INTRODUCTION: Mitral valve repair is the treatment of choice to correct mixomatous mitral insufficiency. Tridimensional echocardiography studies demonstrate that mitral repair using prosthetic ring implant modifies mitral valve annulus morphology and function, although the literature related to mitral valve annulus behavior after mitral repair without use of prosthetic rings is scarce. OBJECTIVE: Analyze cardiac morphology and function using real time tridimensional echocardiography in individuals submitted to mitral valve repair with Double Teflon technique. CASUISTIC: Were included 14 patients with mitral valve insufficiency secondary to mixomatous degeneration that were submitted to mitral valve repair with the Double Teflon technique. Of them, 10 patients were male and the mean age was 61.3 ± 11.2 years. According to preoperatively functional class, 13 patients were in class III or IV. In preoperative echocardiographic analysis, the mean value of left ventricle end diastolic volume was 156.57 ± 46.61ml, and the left ventricle ejection fraction ranged between 38 and 68%, with average of 57.93 ± 6.67%. The mean value of the posterior annulus was 6.97 ± 0.13 cm. METHODS: Patients were evaluated in preoperative period, immediate postoperative period, 6 months and 1 year after mitral repair. Tridimensional echocardiography evaluated mitral annulus morphology by anterior and posterior measurements, transverse diameters and valve area. The annular function was evaluated through the ratio between internal valve areas during systole and diastole. Were evaluated left atrial and ventricle volumes and function. Statistic analysis was made by repeated measures ANOVA test and was considered statistically significant p < 0.05. RESULTS: Posterior mitral annulus demonstrated a significant reduction in immediate postoperative period (p<0.001), remaining stable during the study. There was no significant variation in valve area during the study. There was a significant reduction in anteroposterior and mediolateral diameters in the immediate postoperative period (p<0.001), although there was a significant increase in mediolateral diameter between immediate postoperative period and 1 year. Annular area variation over the cardiac cycle during the study ranged between 30.92 and 35.75%, without statistic significance. The analysis of systolic volumes, atrial and ventricular, demonstrated a significant volumetric reduction between immediate postoperative period and 1 year (p=0.028 and p=0.020, respectively). Between preoperative period and 1 year, there was a mean reduction in atrial and ventricle volumes of 19.9% and 15.4%, respectively. Atrial and ventricle diastolic volumes presented a significant reduction in immediate postoperative period (p<0.001 and p=0.024, respectively), remaining stable during the study. There was an increase in left atrial ejection fraction after 6 months (p<0.001), although there was no significant variation in left ventricle ejection fraction. CONCLUSIONS: Mitral valve repair with segmentar annuloplasty with the Double Teflon technique reduced the posterior mitral annulus, which remained stable in 1 year period. The variation in mitral annulus area during cardiac cycle remained stable during the study. Furthermore, there was a left atrial and ventricle reverse remodeling, associated with an improvement in left atrial function

Master's thesis will deal with the second phase of shifting I/9 Dubice - Dolni Libchava passing west of the Ceska Lipa with an approximate length of 3 km stretch. Estimated start-up of this section is in 2014. This project should build on in the future by-pass Ceska Lipa and Novy Bor, which is currently without funds for implementation by 2025. Traffic load after completion of the by-pass should be approximately 16500 vehicles / 24 hours in 2030. The section is designed in the category S 9.5 with optional solving two major intersections. This thesis will focus on reducing the cost of construction of the section.

Inspired by work of Hubery [Hub] and Fomin, Shapiro and Thurston [FST06] related to cluster algebras, we construct a bijection between certain curves on a cylinder and the string modules over a path algebra of type Ãn. We show that under this bijection irreducible maps and the Auslander-Reiten translation have a geometric interpretation. Furthermore we prove that the dimension of extension groups can be expressed in terms of intersection numbers. Finally we explain the connection to cluster algebras and apply our results to describe the exchange graph in type Ãn. / Angeregt durch Arbeiten zu Cluster-Algebren von Hubery [Hub] und Fomin, Shapiro und Thurston [FST06] konstruieren wir eine Bijektion zwischen gewissen Kurven auf einem Zylinder und den Fadenmoduln über einer Wege-Algebra vom Typ Ãn. Wir zeigen, daß unter dieser Bijektion sowohl irreduzible Abbildungen als auch die Auslander-Reiten-Verschiebung eine geometrische Interpretation haben. Weiterhin beweisen wir, daß sich die Dimension der Erweiterungsgruppen mittels Anzahlen von Schnittpunkten ausdrücken läßt. Schließlich erklären wir die Verbindung zu Cluster-Algebren und verwenden unsere Ergebnisse um den Austauschgraph im Typ Ãn zu beschreiben.

No description available.

The thermally-driven rotating annulus is a laboratory experiment used to study the dynamics of planetary atmospheres under controlled and reproducible conditions. The predictability of this experiment is studied by applying the same principles used to predict the atmosphere. A forecasting system for the annulus is built using the analysis correction method for data assimilation and the breeding method for ensemble generation. The results show that a range of flow regimes with varying complexity can be accurately assimilated, predicted, and studied in this experiment. This framework is also intended to demonstrate a proof-of-concept: that the annulus could be used as a testbed for meteorological techniques under laboratory conditions. First, a regime diagram is created using numerical simulations in order to select points in parameter space to forecast, and a new chaotic flow regime is discovered within it. The two components of the framework are then used as standalone algorithms to measure predictability in the perfect model scenario and to demonstrate data assimilation. With a perfect model, regular flow regimes are found to be predictable until the end of the forecasts, and chaotic regimes are predictable over hundreds of seconds. There is a difference in the way predictability is lost between low-order chaotic regimes and high-order chaos. Analysis correction is shown to be accurate in both regular and chaotic regimes, with residual velocity errors about 3-8 times the observational error. Specific assimilation scenarios studied include information propagation from data-rich to data-poor areas, assimilation of vortex shedding observations, and assimilation over regime and rotation rate transitions. The full framework is used to predict regular and chaotic flow, verifying the forecasts against laboratory data. The steady wave forecasts perform well, and are predictable until the end of the available data. The amplitude and structural vacillation forecasts lose quality and skill by a combination of wave drift and wavenumber transition. Amplitude vacillation is predictable up to several hundred seconds ahead, and structural vacillation is predictable for a few hundred seconds.