Na atualidade, uma das causas importantes de lesão encefálica em neonatos é a anóxia neonatal. Este é um problema grave nos serviços de perinatologia dos hospitais em todo o mundo sendo ainda pior em países subdesenvolvidos, devido à carência de precauções e cuidados requeridos. Modelos animais de anóxia vêm sendo empregados para avaliar seus efeitos, tanto em nível neurológico, como em nível comportamental. A anóxia neonatal tem sido estudada pelo laboratório de Neurociências do Instituto de Ciências Biomédicas da Universidade de São Paulo, com modelos de estudo já desenvolvidos, adaptados e validados. Para investigar se a anóxia neonatal afeta o desenvolvimento motor somático e sensorial, ratos foram submetidos a um modelo não invasivo de anóxia global (Takada et. al., 2011). Ratos Wistar com 30 h de idade (6-8 gramas), machos e fêmeas, foram expostos por 25 minutos a gás nitrogênio 100% num fluxo de 3L/min, pressão 101.7 kPa e temperatura de 37ºC em câmara semi-hermética de policarbonato. O grupo controle foi submetido às mesmas condições porem com o ar ambiente normal. Os animais foram avaliados durante o período de aleitamento (P2 a P21) quanto a parâmetros do desenvolvimento somático; desenvolvimento ontogenético e quanto a reflexos sensório motores. Os resultados indicaram que o grupo Anoxia macho(AM) apresentou aumento no peso corporal {AM(42.25±3.62);CM(38.76±5.60);AF(40.64±5.08);CF(41.33±5.45)}e diminuição do eixo longitudinal do corpo {AM(10.15±0.27);CM(10.39±0.50);AF(9.82±0.44);CF(10.82±0.46)} em relação ao grupo Controle macho(CM) e Anoxia fêmea(AF), AF foi menor em relacao ao Controle fêmea (CF). AM apresentou maior eixo látero-lateral do crânio em relação CM e AF {AM (3.18 ±0.10); CM (3.17 ±0.13); AF(3.06 ±0.16); CF(3.00 ±0.15)} No desenvolvimento ontogenético houve retardo na abertura do canal auditivo {AM (13.79± 0.58); CM (13.75±0.83); AF(14.21±1.01); CF(13.36±0.50)} e abertura dos olhos {AM (14.00± 0.88); CM (14.64±1.28); AF(15.14±0.86); CF(13.79±0.42)} no grupo AF em relação a CF e AM, mas no grupo AM não houve diferença significante. Na erupção dos incisivos superiores {AM (10.79± 0.43); CM(11.71±1.68); AF(11.43±0.65); CF(10.07±0.27)} o grupo AM adiantou enquanto o AF atrasou em relação ao grupo controle. A avaliação dos reflexos sensóriais mostrou que a anoxia adiantou a colocação pelas vibrissas {AM (8.80± 1.21); CM (9.50±1.56); AF (9.93±1.14); CF(10.14±1.28) no AF e AM. Apenas o AM adiantou {AM (10.93± 2.09); CM(13.43±0.94); AF(10.50±0.85); CF(9.57±0.76)} no reflexo de aversão ao precipício. Nos relfexos de geotaxia negativa {AM (14.87± 1.30); CM (13.57±2.34); AF(14.57±1.40);CF (12.00±2.11)} e sobressalto ao susto {AM (14.00±0.53); CM (13.21±1.31); AF (13.29±0.61); CF (11.93±0.27)} e preensão palmar {AM (6.60±0.83); CM (4.71±0.47); AF(10.14±0.83); CF(4.71±0.47)} a anóxia provocou atraso tanto em macho quanto em fêmeas motores. Houve atraso na ontogênese da maioria dos testes de reflexos dos filhotes do grupo Anóxia. Os resultados deste estudo demonstraram que a anóxia causa danos persistentes na maioria dos parâmetros avaliados em relação aos grupos controle, e diminuição no número de neurônios do córtex sensóriomotor {M2: AM (46.84±1.72); CM (52±1.66); AF (45.55±1.80); CF (52±1.55)M1: AM (23.70±1.33); CM (41.89±1.49); AF (25.69±0.83); CF (43.88±1.46) S1HL: AM (27.93±2.69); CM (30.19±1.31); AF(23.42±2.38); CF (38.88±1.48) S1FL: AM (31.85±1.09); CM (33.88±0.48); AF(27.66±1.36); CF(32.28±1.70)}, com diferença de gênero o que evidencia a importância de que estratégias e procedimentos para minimizar os efeitos desse estímulos sejam consideradas em relação ao gênero / At present, one of the important causes of brain injury is the neonatal anoxia. This is a serious problem in the perinatology services of hospitals around the world being even worse in underdeveloped countries because of the lack of precautions and care required. Animal models of anoxia have been employed to assess their effects, both at the neurological level and at the behavioral level. Neonatal anoxia has been studied by the Neuroscience Laboratory of the Biomedical Sciences Institute of the University of São Paulo, with animal models already developed, adapted and validated. To investigate whether neonatal anoxia affects somatic and sensory motor development, rats were subjected to a non-invasive model of global anoxia (Takada et al., 2011). Male and female 30-h old (6-8 grams) Wistar rats were exposed for 25 minutes to 100% nitrogen gas in a flow of 3 L/min, pressure 101.7 kPa and temperature of 37ºC in a semi-hermetic chamber of polycarbonate. The control group was subjected to the same conditions but with normal ambient air. The animals were evaluated during the lactation period (P2 to P21) for parameters of somatic development; Ontogenetic development and for sensorimotor reflexes. The results indicated that the male Anoxia (AM) group presented increase in body weight (AM (42.25 ± 3.62), CM (38.76 ± 5.60), FA (40.64 ± 5.08), CF (41.33 ± 5.45)) and decrease in the longitudinal (10.82 ± 0.46), in relation to the male control group (CM) and the female Anoxia (AF), AF was lower in relation to the control group (AM) (10.15 ± 0.27), CM (10.39 ± 0.50), AF (9.82 ± 0.44) Female control (CF). AM increase in the cranio-lateral axis in relation to CM and AF (AM (3.18 ± 0.10); CM (3.17 ± 0.13); AF (3.06 ± 0.16); CF (3.00 ± 0.15). Concerning the ontogenetic development there was delay in opening the (13.79 ± 0.58), and the eyes {AM (14.00 ± 0.88); CM (14.64 ± 1.28), AF (15.14 ± 0.86), CF (13.79 ± 0.42)} in the AF group in relation to CF and AM, but in the AM group there was no significant difference. In the eruption of maxillary incisors (AM (10.79 ± 0.43), CM (11.71 ± 1.68), AF (11.43 ± 0.65), CF (10.07 ± 0.27), the AM group advanced while the AF delayed in control ration. The evaluation of the sensory reflexes showed that anoxia improved the placement of vibrissae (AM (8.80 ± 1.21), CM (9.50 ± 1.56), AF (9.93 ± 1.14), CF (10.14 ± 1.28) in AF and AM. Only AM advanced (AM (10.93 ± 2.09), CM (13.43 ± 0.94), AF (10.50 ± 0.85), CF (9.57 ± 0.76) in the reflex of aversion to the precipice. In negative geotaxia relays (AM (14.87 ± 1.30); CM (13.57 ± 2.34), AF (14.57 ± 1.40), CF (12.00 ± 2.11)} and startle reflex {AM (14.00 ± 0.53); CM (13.21 ± 1.31); AF (13.29 ± 0.61); CF (11.93 ± 0.27) and palmar grip (AM (6.60 ± 0.83); CM (4.71 ± 0.47), AF (10.14 ± 0.83), CF (4.71 ± 0.47)), anoxia caused delay in both male and female groups. There was a delay in the ontogenesis of most of the reflex tests of the puppies of the anoxia group. The results of this study demonstrated that anoxia causes persistent damage in most of the parameters evaluated in relation to the control groups, and a decrease in the number of sensory motor cortex neurons (M2: AM (46.84 ± 1.72), CM (52 ± 1.66), AF 1.80), CF (52 ± 1.55) M1: AM (23.70 ± 1.33), CM (41.89 ± 1.49), AF (25.69 ± 0.83), CF (43.88 ± 1.46) S1HL: AM (27.93 ± 2.69), CM (30.19 (31.88 ± 1.48), FA (27.66 ± 1.36), CF (32.28 ± 1.70), , which shows that strategies and procedures to minimize the effects of such stimuli should be considered in relation to gender

Bakgrund: Ungdomars sexuella och reproduktiva hälsa och rättigheter (SRHR) är ett viktigt folkhälsoarbete och barnmorskan har en central roll när det kommer till att nå ungdomarna med kunskap och information. Det förefaller finnas få studier om barnmorskors uppfattningar om vad ungdomar behöver veta mer om när det kommer till deras sexuella och reproduktiva hälsa och rättigheter. Syfte: Syftet med denna studie var att beskriva barnmorskors uppfattningar om vad ungdomar behöver veta mer om inom området sexuell och reproduktiv hälsa och rättigheter. Metod: Kvalitativ intervjustudie med åtta semistrukturerade intervjuer med barnmorskor. Datamaterial analyserades med en kvalitativ innehållsanalys med induktiv ansats. Resultat: Barnmorskorna uppfattade att ungdomarna hade behov av att veta mer om kroppsutveckling. Även mer om sexuellt överförbara infektioner (STI) och preventivmedel samt att killarna behövde veta mer om deras reproduktiva ansvar. Ungdomarna behövde också veta mer om sexuella relationer och rättigheter, innefattande bland annat lagar och homosexualitet. Barnmorskorna ser idag en ökning av sexuella problem bland ungdomarna och barnmorskorna hade en gemensam uppfattning om att det beror på pornografikonsumtion. Slutsats: Barnmorskor har insikt i vad ungdomar behöver veta mer om inom SRHR. Det finns fortfarande brister i undervisning och utbildning till ungdomar inom SRHR och det är angeläget att fokusera och investera i arbeten för att stärka och främja ungdomars SRHR. Klinisk tillämpbarhet: Denna studie lyfter barnmorskors uppfattningar om vad ungdomar behöver veta mer om inom ämnet SRHR. Studien kan användas i klinisk verksamhet till förbättringsarbeten för olika yrkeskategorier som arbetar med ungdomar gällande SRHR. / Background: The sexual and reproductive health and rights (SRHR) of young people is an important public health work and the midwife has a central role in reaching the young people with knowledge and information. There seem to be few studies on midwives' perceptions about what young people need to know more about when it comes to their sexual and reproductive health and rights. Purpose: The purpose of this study was to describe the views of midwives about what young people need to know more about in the area of sexual and reproductive health and rights. Method: Qualitative interview study with eight semi-structured interviews with midwives. The data material was analyzed with a qualitative content analysis with inductive approach. Result: The midwives perceived that the young people needed to know more about body development. In addition, more about sexually transmitted infections (STIs) and contraceptives and that the young men needed to know more about their reproductive responsibilities. The youth also needed to know more about sexual relations and rights, including, among other things, laws and homosexuality. The midwives today see an increase in sexual problems among young people and the midwives had a common view that this is due to pornography consumption. Conclusion: Midwives have insight into what young people need to know more about in SRHR. There are still shortcomings in education for young people within SRHR, and it is important to focus and invest in work to strengthen and promote young people's SRHR. Clinical application: This study highlights the views of midwives on what young people need to know more about in the subject of SRHR. The study can be used in clinical activities for improvement work for various occupational categories that work with young people regarding SRHR.

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Der Karosseriebau stellt einen der bedeutendsten Schritte in der Wertschöpfungskette moderner Fahrzeuge dar. Der Einsatz unterschiedlicher Werkstoffe sowie Ausführungen derzeitiger Fahrzeugkarosserien führt zu neuen Karosseriekonzepten wie dem Multi-Material-Design. Die spezifischen Eigenschaften einzelner Werkstoffe stellen jedoch insbesondere für die Fügetechnik neue Herausforderungen dar. Dementsprechend steigt die Vielfalt der zur Auswahl stehenden Fügetechnologien zum Verbinden der Werkstoffkombinationen. Die Auswahl der einzusetzenden Fügetechnologie basiert grundsätzlich auf den Erfahrungen der Produktentwicklung. Wissenschaftliche Ansätze beschränken sich im Rahmen des Auswahlprozesses von Fügetechnologien oftmals auf die ökonomische Bewertung für einzelne Fügepunkte. Ein integrierter Bewertungsansatz, welcher bereits während der Festlegung von Werkstoff und Konstruktion die Aspekte der Fügetechnik hinsichtlich ökonomischer, ökologischer sowie technologischer Faktoren für eine gesamte Baugruppe umfasst, existiert bisher nicht. Aufgrund der Intransparenz hinsichtlich monetärer und nicht-monetärer Eigenschaften der jeweiligen Fügetechnologie sowie der zunehmenden Entscheidungskomplexität leitet sich der Bedarf nach einer methodischen Unterstützung des Auswahlprozesses ab. Ziel der Forschung ist es, durch die Entwicklung einer multidimensionalen Auswahlmethodik eine optimierte Entscheidungsfindung in der Karosserieentwicklung zu ermöglichen. / The car body shop has become one of the most significant steps in the automobile value chain nowadays. The usage of a variety of different materials and configurations of current vehicle bodies in lightweight construction leads to new body concepts such as the multi-material design. However, the specific properties of individual materials lead to new challenges, especially in the joining technology where existing technologies face numerous restrictions. Therefore, new joining processes are required, which also results in an increased diversity of joining technologies and complexity of the decision-making. To date, the selection of a joining technology for a component is mostly based on the experience of the product development. The selection process of extant scientific approaches, however, is often limited to the economic assessment of joining technologies for individual joints. An integrated assessment approach, which already includes the aspects of joining technologies with regards to economic, ecological and technological factors for an entire assembly during the definition of material and design, does not exist. Due to the non-transparency of the overall monetary and non-monetary impact of the respective joining technology, the need for a methodological support for the selection process is derived. An essential part of this research work is the development of a multidimensional selection methodology to allow an optimized decision-making in the early stage of car body development.

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