Submitted by Eva Liliane dos Santos Silva (lilianezootecnia@gmail.com) on 2018-07-26T20:05:44Z No. of bitstreams: 1 Dissertação.pdf: 1148089 bytes, checksum: ac69c8450c4db0a881d7eccf4d700e97 (MD5) / Rejected by Isabel Pereira de Matos (isabel@fmva.unesp.br), reason: Citação errada no texto Referencias com erros on 2018-07-26T20:34:24Z (GMT) / Submitted by Eva Liliane dos Santos Silva (lilianezootecnia@gmail.com) on 2018-07-30T03:24:50Z No. of bitstreams: 1 reapresentação.pdf: 2393226 bytes, checksum: bc0779faeea41deef8789babdad651ce (MD5) / Approved for entry into archive by Ederson Vasconcelos Pereira null (edersonpereira@fmva.unesp.br) on 2018-07-30T17:53:44Z (GMT) No. of bitstreams: 1 silva_els_me_araca_int.pdf: 2393226 bytes, checksum: bc0779faeea41deef8789babdad651ce (MD5) / Made available in DSpace on 2018-07-30T17:53:44Z (GMT). No. of bitstreams: 1 silva_els_me_araca_int.pdf: 2393226 bytes, checksum: bc0779faeea41deef8789babdad651ce (MD5) Previous issue date: 2018-07-17 / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Este trabalho teve como objetivo mensurar a produção de hidroperóxidos e a capacidade antioxidante do plasma de cabras e seus cabritos, por meio do teste d-ROMs (Reactive Oxygen Metabolites) e BAP (Biological Antioxidant Potential), após as cabras serem submetidas a diferentes protocolos de corticoterapia antenatal, os animais foram aleatoriamente alocados em quatro grupos experimentais: grupo I - constituído por quatro cabras e sete cabritos, com uma única dosagem de 20 mg de dexametasona, por via IM/SID, dois dias antes da cirurgia eletiva (139 dias); grupo II - composto por quatro cabras e seis cabritos utilizando a dosagem de 2 mg de dexametasona, dos 133 aos 136 dias; 4 mg dos 137 aos 138; e 20 mg aos 139 dias de prenhes, por via IM/SID; grupo III - constituído por quatro cabras e sete cabritos, com dosagem de 16 mg de dexametasona aos 139, com doses repetidas a cada 12 horas até a cirurgia eletiva, por via IM/BID, e grupo IV - composto por quatro cabras e seis cabritos utilizando a dose de 4, 8, 16 e 20 mg de dexametasona, por via IM/SID, aos 137, 138, 139, 140 dias de gestação, respectivamente. Para analisar d-ROMs e BAP foram feitas coletas de sangue nas cabras por punção da veia jugular aos 15 minutos (M15) após o parto, e nos cabritos foram realizadas as coletas de sangue por punção da veia jugular nos respectivos momentos com referência ao nascimento de cada neonato: 15 minutos (M15), 24 horas (M24) e 48 horas (M48). / The objective of this work was to measure the production of hydroperoxides and the antioxidant capacity of goats and their goats by means of the d-ROMs test (Reactive Oxygen Metabolites) and BAP (Biological Antioxidant Potential), after the goats were submitted to different protocols of antenatal corticosteroid therapy, the animals were randomly assigned to four experimental groups: group I - consisting of four goats and seven goats, with a single dose of 20 mg of dexamethasone, IM / SID, two days before elective surgery (139 days); group II - composed of four goats and six goats using the dosage of 2 mg dexamethasone, from 133 to 136 days; 4 mg of 137 to 138; and 20 mg at 139 days of pregnancy, by IM/SID; group III - consisting of four goats and seven goats, with a dose of 16 mg of dexamethasone at 139, with repeated doses every 12 hours until elective surgery, by IM/BID, e group IV - composed of four goats and six goats using the dose of 4, 8, 16 and 20 mg dexamethasone, by IM / SID route, to the 137, 138, 139, 140 days of gestation, respectively. Blood samples were taken from the goats by puncture of the jugular vein at 15 minutes (M15) after calving and the kidneys were collected by puncturing the jugular vein at the respective moments with reference to the birth of each neonate: 15 minutes (M15), 24 hours (M24) and 48 hours (M48). / FAPESP: 16/00808-6

Made available in DSpace on 2015-07-22T20:49:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-05-26 / A redução da massa de anestésico local é utilizada para minimizar os efeitos da hipotensão arterial, relacionados com raquianestesia para cesariana, diminuindo a incidência de eventos adversos maternos e preservando o bem-estar fetal. Esta estratégia tem o risco de resultar em anestesia insuficiente. Por outro lado, a hipotensão associada às maiores massas de anestésico local no espaço subaracnóideo pode ser controlada com infusão contínua profilática de fenilefrina.! Objetivo: Avaliar os efeitos da infusão contínua e profilática de fenilefrina para controle pressórico sobre os eventos adversos maternos e conceptuais em cesarianas com diferentes doses de bupivacaína na raquianestesia. Métodos: Foi realizado um estudo clínico prospectivo, não-aleatório, com 60 gestantes a termo, admitidas para cesariana eletiva. Todas as pacientes receberam raquianestesia com bupivacaína hiperbárica, acrescida de 5 mcg de sufentanil e 100 mcg de morfina. Foram alocadas em dois grupos, G12 e G8, na dependência da dose de bupivacaína hiperbárica administrada, 12 ou 8 mg, respectivamente. Foi realizada hidratação com 10 ml/Kg de solução de Ringer Lactato, 10 a 15 minutos antes da realização do bloqueio. Logo após, iniciou-se infusão contínua de 100 mcg/min de fenilefrina, com o objetivo de manter a pressão arterial dentro de limites estritos. Foram avaliados níveis sensitivos de bloqueio anestésico, consumo de vasopressores, incidência de eventos adversos maternos e condições do recém-nascido. Resultados: Os dados maternos mostraram que os dois grupos foram semelhantes, quanto ao nível de bloqueio anestésico, consumo de fenilefrina por unidade de tempo e incidências de hipotensão e hipertensão arterial, bradicardia, náuseas, vômitos, dispnéia, dor e tremores. Os dados conceptuais evidenciaram que os grupos foram semelhantes quanto à gasometria de artéria e veia umbilicais e lactato arterial e venoso. Todos os RN apresentaram pH > 7,2 e apenas 1 obteve pontuação < 7 no Apgar do primeiro minuto. Conclusões: Quando a pressão arterial é mantida dentro de controle rígido, por meio da infusão profilática contínua de fenilefrina, a incidência de eventos adversos maternos e conceptuais não difere quando a raquianestesia é realizada com 12 mg ou 8 mg de bupivacaína hiperbárica. / Background: Reduced local anesthetic dose is used for minimizing hypotension changes related with spinal anesthesia for cesarean section, optimizing both maternal and fetal outcomes. This strategy can result in neuroaxial block failure. On the other hand, the higher doses associated with hypotension can be controlled with continuous prophylactic infusion of phenylephrine. The present study assessed the effects of continuous infusion of phenylephrine under strict blood pressure control and the maternal-fetal outcomes in patients under spinal anesthesia for elective cesarean section with two anesthetic solution. Methods: The number of 60 patients, scheduled for elective cesarean section, was allocated into 2 non-randomized groups (30 individuals each) for this prospective clinical study identified as Group 12 (G12), who were administered 12 mg hyperbaric bupivacaine and; Group 8 (G8), who were injected with 8 mg hyperbaric bupivacaine. In both groups, the anesthetic solution was added to sufentanyl 5 !g and morphine 100 !g. Pre-hydration with Ringer Lactate solution – 10 ml/Kg. Continuous phenylephrine infusion started at the end of the spinal block, with a infusion rate of 100 !g/min under strict blood pressure control. Comparatively, sensitive anesthetic block level, vasopressor consumption, adverse maternal and neonate outcomes were evaluated. Results: The incidence of maternal adverse effects such as nausea, vomiting, dispnea, pain, tremor, and bradicardy, necessity of atropine, hypotension and hypertension showed no significant difference between groups. In addition, other parameters were evaluated in neonates, pH, pCO2, BE and lactate of umbilical vases and the consumption of phenylephrine per time unit. All neonates showed pH higher than 7.20, as well as the Apgar score higher than 7 at 5`; only one neonate of G12 showed the Apgar score lower than 7 at 1`. Conclusion: Strict arterial blood pressure performed with prophylactic continuous infusion of phenylephrine, doesn’t change the maternal and fetal outcomes in patients scheduled for elective cesarean section under spinal anesthesia. / TEDE / BV UNIFESP: Teses e dissertações

Over 18 million caesarean sections (CS) are performed around the world each year, with many being planned repeat CS which may lack absolute indications. Abdominal delivery on this scale demands an appreciation of the lasting impact, positive or negative, on the health of women and children. Maternal outcomes of planned CS birth have been extensively investigated, but knowledge of outcomes for offspring is largely limited to those occurring in the neonatal period. Avoiding labour and vaginal birth may protect offspring from birth injuries, but could also adversely affect their later health due to avoidance of physiological processes which aid immunity and gut function. Concern that CS may compromise offspring health has arisen from studies which demonstrate an increased risk of chronic health problems following CS compared with vaginal birth. However, the clinical implications of existing studies are unclear due to high risk of selection bias, confounding and lack of power. Studies which can overcome these issues are required. Studies focusing on offspring of women with a history of CS mean the risk of confounding by indication for CS is minimised, as the majority of repeat CS are planned due to maternal preference rather than medical indications. At present, it is not known whether perceived offspring health outcomes of mode of delivery drive women's birth choices after a previous CS, and if so, whether such beliefs reflect evidence-based information on offspring risks. The existing literature highlights a number of factors that may play a role in shaping these birth choices, but no studies have attempted to identify beliefs which independently predict birth preferences after a CS. Such a study has potential to identify key beliefs to target in future interventions designed to optimise women's birth choices. This project investigated both the health of offspring delivered by planned repeat CS and women's beliefs which predict their preferred mode of delivery after CS. Offspring health was investigated using a population-based cohort study. Pregnant women's beliefs about birth after CS were investigated using a synthesis of qualitative literature and a theory based interview and questionnaire study.

Orientador: Eliana Martorano Amaral / Dissertação (mestrado) - Universidade Estadual de Campinas. Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-15T15:29:14Z (GMT). No. of bitstreams: 1 Moreira_CristianeMenabo_M.pdf: 2436149 bytes, checksum: d5b0e854b0557df822a87c69461aaeee (MD5) Previous issue date: 2010 / Resumo: Objetivo: Avaliar a efetividade e segurança do uso do eletrocautério para coagulação na da ferida operatória da cesárea. Métodos: Foi realizado um ensaio clínico piloto duplo cego controlado aleatorizado. Mulheres com indicação de cesárea, com até uma cesárea prévia, que fizeram pré-natal foram aleatorizadas na hora da cirurgia para uso ou não de eletrocautério para coagulação. As 224 voluntárias que participaram foram examinadas na alta hospitalar (3o dia) e pós-alta, no 7°.ao 10° dia e 30° ao 40° dia. Foram avaliados sinais infecciosos, hematoma, seroma e deiscência. A amostra foi calculada baseada em uma prevalência de infecção pós-alta de 14,4%, estimando-se um risco adicional de 15% para o grupo com uso de eletrocautério, totalizando 224 voluntárias. Os dados foram analizados por intenção de tratamento e a razão de risco foi calculada. Resultados: Os grupos foram similares quanto à demografia, paridade, consultas de pré-natal, índice de massa corporal e cesárea prévia. Durante a internação, apenas 2,8% das mulheres com uso de eletrocautério apresentaram complicações na ferida operatória. As taxas de complicações alcançaram 15,4% no grupo sem cautério, chegando a 23% no outro grupo, 7-10 dias pós-alta (RR=1,50 0,84-2,60). Foram observadas poucas complicações no 30° ao 40°dia e no grupo sem cautério (RR=1,15, 95% IC=0,61-2,16). A cesárea durou 105 e 100 minutos sem e com cautério, respectivamente (p=0,54). Não foi observada nenhuma arritmia cardíaca neonatal. Conclusão: O uso de cautério não se mostrou de maior risco para complicações na ferida operatória de cesárea, sendo necessários mais estudos que deem continuidade e ampliem os conhecimentos em procedimentos realizados em gestantes / Abstract: Purpose: To estimate the risk for wound complications when electrocautery is available for coagulation during cesarean section. Methods: A randomized controlled trial of using electrocautery for coagulation was performed among 224 women with none or one previous cesarean who had their pregnancy terminated with an abdominal delivery. Volunteers who accepted to participate were examined before discharge (3rd day), when the skin suture was removed (7-10 days), and 30-40 days after surgery. Infection signs, haematoma, seroma, and scar dehiscence were searched during visits. Sample size was calculated based on 14.4% prevalence of infection after discharge, estimating 15% added risk for the group using electrocautery, totalizing 224 volunteers. Unadjusted and adjusted prevalence risk (age, schooling, obesity, previous cesarean) were calculated. Results: Both groups were similar regarding demographics, parity, antenatal care, body mass index, and previous cesarean. During hospital stay, none among 96 women without electrocautery, and 2.8% of 97 women using electrocautery showed wound complications. The figures reached 15.4% and 23% respectively after 7-10 days (unadjusted RR = 1.50, 0.84-2.60). Few other complications were observed later, only among the non-intervention group (RR=1.15, 95% CI = 0.61-2.16). The lack of effect was maintained after adjusting for age, schooling, obesity, and previous cesarean (RR=1.47, 0.77-2.81). Surgical procedure lasted 105 and 100 minutes for both groups (p=0.54). No neonatal arrhythmia was observed. Conclusion: There is no evidence to recommend the use of electrocautery for coagulation during cesarean delivery. Wound complications were concentrated on post-discharge period for both groups / Mestrado / Tocoginecologia / Mestre em Tocoginecologia

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第22690号 / 医博第4634号 / 新制||医||1045(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 古川 壽亮, 教授 滝田 順子, 教授 万代 昌紀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Orientador: Francisco Leydson Formiga Feitosa / Banca: Flávia de Almeida Lucas / Banca: Vanessa Veronese Ortunho / Resumo: Este trabalho teve como objetivo mensurar a produção de hidroperóxidos e a capacidade antioxidante do plasma de cabras e seus cabritos, por meio do teste d-ROMs (Reactive Oxygen Metabolites) e BAP (Biological Antioxidant Potential), após as cabras serem submetidas a diferentes protocolos de corticoterapia antenatal, os animais foram aleatoriamente alocados em quatro grupos experimentais: grupo I - constituído por quatro cabras e sete cabritos, com uma única dosagem de 20 mg de dexametasona, por via IM/SID, dois dias antes da cirurgia eletiva (139 dias); grupo II - composto por quatro cabras e seis cabritos utilizando a dosagem de 2 mg de dexametasona, dos 133 aos 136 dias; 4 mg dos 137 aos 138; e 20 mg aos 139 dias de prenhes, por via IM/SID; grupo III - constituído por quatro cabras e sete cabritos, com dosagem de 16 mg de dexametasona aos 139, com doses repetidas a cada 12 horas até a cirurgia eletiva, por via IM/BID, e grupo IV - composto por quatro cabras e seis cabritos utilizando a dose de 4, 8, 16 e 20 mg de dexametasona, por via IM/SID, aos 137, 138, 139, 140 dias de gestação, respectivamente. Para analisar d-ROMs e BAP foram feitas coletas de sangue nas cabras por punção da veia jugular aos 15 minutos (M15) após o parto, e nos cabritos foram realizadas as coletas de sangue por punção da veia jugular nos respectivos momentos com referência ao nascimento de cada neonato: 15 minutos (M15), 24 horas (M24) e 48 horas (M48). / Abstract: The objective of this work was to measure the production of hydroperoxides and the antioxidant capacity of goats and their goats by means of the d-ROMs test (Reactive Oxygen Metabolites) and BAP (Biological Antioxidant Potential), after the goats were submitted to different protocols of antenatal corticosteroid therapy, the animals were randomly assigned to four experimental groups: group I - consisting of four goats and seven goats, with a single dose of 20 mg of dexamethasone, IM / SID, two days before elective surgery (139 days); group II - composed of four goats and six goats using the dosage of 2 mg dexamethasone, from 133 to 136 days; 4 mg of 137 to 138; and 20 mg at 139 days of pregnancy, by IM/SID; group III - consisting of four goats and seven goats, with a dose of 16 mg of dexamethasone at 139, with repeated doses every 12 hours until elective surgery, by IM/BID, e group IV - composed of four goats and six goats using the dose of 4, 8, 16 and 20 mg dexamethasone, by IM / SID route, to the 137, 138, 139, 140 days of gestation, respectively. Blood samples were taken from the goats by puncture of the jugular vein at 15 minutes (M15) after calving and the kidneys were collected by puncturing the jugular vein at the respective moments with reference to the birth of each neonate: 15 minutes (M15), 24 hours (M24) and 48 hours (M48). / Mestre

No description available.

Thesis (M.Sc.)--Memorial University of Newfoundland, 2005. / Restricted until October 2006. Bibliography: leaves 103-113.

Thesis (M.S.)--University of Michigan, 1993.

Thesis (M.S.)--University of Michigan, 1993.