Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:44Z No. of bitstreams: 5 patricia.pdf: 1377961 bytes, checksum: 55ce7c1439d8b1123461e7f1f40d7a17 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T10:38:49Z (GMT) No. of bitstreams: 5 patricia.pdf: 1377961 bytes, checksum: 55ce7c1439d8b1123461e7f1f40d7a17 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T10:38:49Z (GMT). No. of bitstreams: 5 patricia.pdf: 1377961 bytes, checksum: 55ce7c1439d8b1123461e7f1f40d7a17 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2013 / Os estudos sobre o desenvolvimento de defeitos de esmalte e a associa??o com as condi??es natais e p?s-natais ainda s?o escassos. Assim, este estudo teve como objetivo avaliar a preval?ncia de defeitos de esmalte em dentes dec?duos e verificar se prematuridade, peso ao nascimento e vari?veis sociodemogr?ficas podem estar associados a tais defeitos. Foi realizado um estudo transversal com 381 crian?as com idade entre 3 e 5 anos. Os dados foram coletados atrav?s de exame cl?nico e entrevistas com os pais durante Campanha Nacional de Vacina??o. O diagn?stico dos defeitos de esmalte foi realizado utilizando-se o Developmental Defects of Enamel Index (DDE Index). Atrav?s de entrevista foram coletadas informa??es sobre aspectos sociodemogr?ficos, gesta??o, peso ao nascimento, prematuridade da crian?a e amamenta??o. A an?lise dos dados foi realizada utilizando-se o programa SPSS for Windows 17.0 e incluiu a distribui??o de frequ?ncia, testes qui-quadrado e Exato de Fisher e regress?o de Poisson. A preval?ncia de defeito de esmalte foi de 29,9% e a opacidade demarcada foi o tipo de defeito mais frequente. Crian?as com peso muito baixo ao nascimento apresentam mais chance de desenvolver defeitos de esmalte [RP (IC95%) = 2,7 (1,66-4,61)]. A prematuridade e as vari?veis sociodemogr?ficas n?o foram fatores associados aos defeitos de esmalte. Crian?as com peso muito baixo ao nascimento apresentaram maior preval?ncia de defeitos de esmalte nos dentes dec?duos. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2011. / ABSTRACT Studies regarding the development of enamel defects and association with natal and postnatal conditions are scarce. Thus, the aim of this study was to evaluate the prevalence of enamel defects in primary teeth and determine whether prematurity, birth weight and sociodemographic variables may be associated with such defects. This was a cross-sectional study with 381 children aged between 3 and 5 years. Data were collected through clinical examination and interviews with parents during the National Immunization Day. The diagnosis of enamel defects was performed using the Development Defects of Enamel Index (DDE Index). During interviews, information were collected on sociodemographic aspects, pregnancy, birth weight, child prematurity and breastfeeding. Statistical analysis was performed using the SPSS software for Windows 17.0 and involved descriptive analysis, the Fisher?s test, qui-square test and Poisson regression. The prevalence of enamel defects was 29.9% and demarcated opacity was the most frequent type of defect. Children with low birth weight presented greater prevalence of enamel defects [PR (CI 95%) = 2,7 (1.66-4.61)]. Prematurity and the sociodemographic variables were not factors associated with enamel defects. In this study, children with very low birth weight had higher prevalence of enamel defects in deciduous teeth.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:42Z No. of bitstreams: 5 carlos.pdf: 1077384 bytes, checksum: 83eb6b248c6848161b2017a683c19682 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T11:09:38Z (GMT) No. of bitstreams: 5 carlos.pdf: 1077384 bytes, checksum: 83eb6b248c6848161b2017a683c19682 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T11:09:38Z (GMT). No. of bitstreams: 5 carlos.pdf: 1077384 bytes, checksum: 83eb6b248c6848161b2017a683c19682 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2013 / O objetivo do presente estudo foi realizar uma avalia??o comparativa do efeito da dexametasona e da metilprednisolona no controle da dor, edema e limita??o da abertura bucal ap?s a extra??o de terceiros molares impactados. Dezesseis pacientes saud?veis (3 homens e 13 mulheres) com m?dia de 20,3 (DP= 1,25) anos de idade foram submetidos ? extra??o bilateral dos terceiros molares com intervalo de tr?s a quatro semanas entre as duas cirurgias. Uma hora antes de cada procedimento cir?rgico foi administrada em dose ?nica, por via oral, dexametasona 8 mg ou metilprednisolona 40 mg. Durante os intervalos p?s-operat?rios de 24, 48 e 72 horas e sete dias, o edema linear foi determinado utilizando medidas na face e o trismo atrav?s da abertura bucal m?xima. A dor p?s-operat?ria foi auto-registrada pelo paciente utilizando escala anal?gica visual durante as 72 horas iniciais, em intervalos de oito horas. A an?lise estat?stica envolveu an?lise descritiva, teste McNemar, Teste T pareado e Wilcoxon (p<0,05). A dexametasona apresentou melhor controle do edema em todos os per?odos p?s-operat?rios (p <0,02) e da abertura bucal dois dias ap?s a cirurgia (p = 0,029). Com rela??o ? dor n?o foi observada diferen?a estatisticamente significativa entre os medicamentos. A administra??o pr?-perat?ria de 8 mg de dexametasona apresentou melhor controle do edema e da limita??o da abertura bucal do que a metilprednisolona na dose de 40 mg, muito embora os medicamentos n?o diferiram no controle da dor. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2012. / ABSTRACT The?aim of this study?was to make a comparative assessment of the effect of?dexamethasone and methylprednisolone?to control pain, swelling?and limitation?of mouth opening after extraction of?impacted third molars.?Sixteen healthy patients (3 men and 13 women)?with a mean age?of 20.3 (SD = 1,25) years underwent bilateral extraction?of?third molars with na interval of three to four weeks between the two surgeries. One hour?before each?surgical procedure?a single oral dose?of?dexamethasone 8?mg or methylprednisolone?40?mg was administered.?During the postoperative?intervals?of 24,?48?and 72?hours and?seven days, the swelling was determined using?linear?measures?in the?face and trismus?by?maximum mouth opening. The?postoperative pain?was self-recorded?by the patient using?visual analogue scale?in?72 hours with an interval of eight hours. Statistical analysis involved descriptive analysis, McNemar test, Wilcoxon?and paired T test (p?<0.05). Dexamethasone showed better control of swelling in all?postoperative periods (p?<0.02) and of mouth opening two days after surgery (p = 0.029). Regarding pain there was no statistically significant difference between the drugs. Preemptive dexamethasone?8 mg showed better control of swelling?and limitation?of mouth opening than methylprednisolone 40 mg, but there was no difference?in pain control.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:44Z No. of bitstreams: 5 lopes.pdf: 4584389 bytes, checksum: 490508b2570ae9d7329524ffc42068ef (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T10:36:20Z (GMT) No. of bitstreams: 5 lopes.pdf: 4584389 bytes, checksum: 490508b2570ae9d7329524ffc42068ef (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T10:36:20Z (GMT). No. of bitstreams: 5 lopes.pdf: 4584389 bytes, checksum: 490508b2570ae9d7329524ffc42068ef (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2013 / A presente disserta??o consiste em dois artigos cient?ficos, sendo um artigo original e outro de revis?o. Em um dos artigos, os autores fizeram uma revis?o da literatura sobre c?ncer e pr?polis, abordando a carcinog?nese experimental induzida quimicamente pelo 9,10-dimetil-1,2-benzantraceno (DMBA), a composi??o qu?mica da pr?polis e seus efeitos quimiopreventivos. O objetivo do artigo de pesquisa foi avaliar a rea??o tecidual da mucosa lingual de hamsters, submetida ? aplica??o di?ria e alternada de DMBA e extrato etan?lico de pr?polis (EEP) de uma apresenta??o comercial. Materiais e m?todos: 60 hamsters foram divididos em tr?s grupos, com dois per?odos experimentais, 13 e 20 semanas. A borda lateral da l?ngua foi submetida ? aplica??o t?pica, di?ria e alternada de DMBA 0,5 % e EEP 30 % (grupo EEP, n = 20), DMBA 0,5 % e extrato aquoso de pr?polis (EAP) (grupo EAP, n = 20), DMBA 0,5 % e soro fisiol?gico (grupo DMBA, n = 20). Realizou-se an?lise da ocorr?ncia dos tipos de altera??es cl?nicas e histol?gicas. Mensurou-se a ?rea e volume das altera??es cl?nicas, a ocorr?ncia das altera??es estruturais (AE) e citol?gicas (AC) do tecido epitelial escamoso com atipias e a ?rea histol?gica dos carcinomas de c?lulas escamosas (CCE). Para a an?lise estat?stica, aplicaram-se os testes ANOVA, qui-quadrado, Kruskal-Wallis e Mann-Whitney. Resultados: Para todas as vari?veis analisadas, n?o houve diferen?as significativas na compara??o entre os grupos nos dois tempos experimentais. Em 13 semanas ocorreu uma ?nica les?o de CCE no grupo EEP. Em 20 semanas, a maior ocorr?ncia de CCE tamb?m foi no grupo EEP. Conclus?o: o EEP, com teor alco?lico de 30 %, favoreceu a rea??o tecidual da inicia??o e da promo??o da carcinog?nese, por mecanismos ainda n?o elucidados. / ABSTRACT This dissertation consists of two papers, the first one is a review and the second is an original paper. In the first article, the authors reviewed the literature on cancer and propolis, addressing experimental carcinogenesis, chemically induced by 9,10-dimethyl-1,2-benzanthracene (DMBA), the chemical composition of propolis and its chemopreventive effects. The aim of the research paper was to evaluate the?tissue response?of tongue mucosa of hamsters, subjected to daily and alternating application of ethanolic extract of propolis (EEP) of a commercial presentation. Materials and methods: 60 hamsters were divided into three groups, and two experimental periods, 13 and 20 weeks. The lateral edge of the tongue underwent daily and alternate topical application of DMBA 0.5% and 30% EEP (EEP group, n = 20), DMBA and 0.5% aqueous extract of propolis (EAP) (EAP group; n = 20), and DMBA 0.5%?saline (DMBA?group, n =?20). The occurrence of types of clinical and histological changes was analysed. The area and volume of clinical changes, the occurrence of structural (AE) and cytological (CA) changes of squamous epithelial tissue with atypia and the histological area of squamous cell carcinoma (SCC) were measured. For statistical analysis, ANOVA, chi-square and Kruskal-Wallis and Mann-Whitney test were applied. Results: For all variables, there were no significant differences when comparing the groups in the two experimental periods. In 13 weeks, a single lesion of SCC in EEP group was observed. At 20 weeks, the highest occurrence of SCC was also in the group EEP. Conclusion: the EEP, with an alcohol content of 30% favored tissue reaction of initiation and promotion of carcinogenesis by mechanisms not yet elucidated.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:44Z No. of bitstreams: 5 paulo.pdf: 587935 bytes, checksum: 87aa85ba53d81494c9eabf55750f07b7 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T10:41:39Z (GMT) No. of bitstreams: 5 paulo.pdf: 587935 bytes, checksum: 87aa85ba53d81494c9eabf55750f07b7 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T10:41:39Z (GMT). No. of bitstreams: 5 paulo.pdf: 587935 bytes, checksum: 87aa85ba53d81494c9eabf55750f07b7 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2013 / Uma sa?de bucal prec?ria pode afetar aspectos da vida di?ria das crian?as, como a capacidade mastigat?ria, o sono, o desempenho escolar, a intera??o social, a autoestima, bem como o peso e o crescimento. No entanto, h? poucas evid?ncias sobre a influ?ncia de problemas bucais no bem-estar biopsicossocial de pr?-escolares e suas fam?lias, sobretudo comparando aqueles que vivem em zonas urbanas e rurais. O objetivo deste estudo foi avaliar os fatores determinantes da qualidade de vida relacionada ? sa?de bucal (OHRQoL) de crian?as pr?-escolares e suas fam?lias residentes em zona urbana e em zonas rurais de extrema pobreza. Foi realizado um estudo transversal com 391 crian?as, entre dois e cinco anos de idade, das zonas urbana e rural de Diamantina/MG, selecionadas aleatoriamente durante a Campanha Nacional de Vacina??o Infantil. Os pais das crian?as responderam ? vers?o brasileira do Early Childhood Oral Health Impact Scale (B-ECOHIS) e forneceram dados socioecon?micos. Exames cl?nicos das crian?as foram realizados para avaliar c?rie dent?ria, defeitos de desenvolvimento de esmalte, fluorose dent?ria, les?es ou varia??es de normalidade da mucosa bucal e m? oclus?o. An?lise estat?stica envolveu an?lise descritiva, teste de Mann-Whitney, teste do qui-quadrado e regress?o linear m?ltipla. O n?vel de signific?ncia estabelecido foi de 5%. Os valores m?dios do ECOHIS para cada condi??o bucal avaliada foram: c?rie dent?ria 4.52 (DP=6.84), defeitos de desenvolvimento de esmalte 3,82 (DP=6,86), fluorose dent?ria 4,56 (DP=7,53), les?es ou varia??es da normalidade da mucosa bucal 2,84 (DP=5,46) e m? oclus?o 2,16 (DP=4,56). Diferen?as significativas foram encontradas entre o local de resid?ncia e: g?nero (P = 0,008), n?mero de filhos (P = 0,001) e defeitos de desenvolvimento de esmalte (P = 0,035). Fam?lias da zona rural apresentaram valores significativamente inferiores nos aspectos socioecon?micos (P < 0,005), quando comparadas ? fam?lias da zona urbana. Na zona urbana, foram encontradas associa??es significativas entre impacto na OHRQoL e: idade da crian?a em meses (P = 0,004), g?nero (feminino) (P = 0,034), n?mero de dentes cavitados (P < 0,001) e presen?a de defeitos de desenvolvimento de esmalte (P = 0,004). Na zona rural foi encontrada associa??o significativa somente entre impacto na OHRQoL e n?mero de dentes cavitados (P <0,001). Problemas bucais como c?rie dent?ria e defeitos de desenvolvimento de esmalte afetaram negativamente a qualidade de vida de crian?as pr?-escolares e suas fam?lias. Na zona urbana, o n?mero de dentes cavitados, defeitos de desenvolvimento de esmalte, al?m da idade e g?nero (feminino) contribu?ram para diminui??o da qualidade de vida das crian?as pr?-escolares e suas fam?lias. Na zona rural, somente o n?mero de dentes cavitados comprometeu significativamente a vida di?ria dos pr?-escolares e suas fam?lias. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2011. / ABSTRACT Poor oral health can affect aspects of children's daily lives, such as the ability to chew, sleep, school performance, social interaction, self-esteem as well as weight and growth. However, there is little evidence about the influence of oral health problems on biopsychosocial well-being of preschool children and their families, especially comparing those living in urban and rural areas. The aim of this study was to assess the determinants of oral health-related quality of life (OHRQoL) of preschool children and their families living in urban and rural areas of extreme poverty. A cross-sectional study was conducted with 391 children between two and five years of age, from urban and rural areas in Diamantina/MG randomly selected during the National Immunization Campaign. The children's parents answered the Brazilian version of the Early Childhood Oral Health Impact Scale (B-ECOHIS) and provided socioeconomic data. Clinical examination of the children was conducted to assess dental caries, developmental defects of enamel, dental fluorosis, injury or damage to the oral mucosa and malocclusion. Statistical analysis involved descriptive analysis, Mann-Whitney test, chi-square test and multiple linear regression. Significance level was set at 5%. The mean ECOHIS total scores for each oral condition were: dental caries 4.52 (SD = 6.84), developmental defects of enamel, 3.82 (SD = 6.86), dental fluorosis 4:56 (SD = 7.53), injury or oral mucosa lesions 2.84 (SD = 5.46) and malocclusion 2.16 (SD = 4.56). Significant differences were found between place of residence and: gender (P = 0.008), number of children (P = 0.001) and developmental defects of enamel (P = 0.035). Families from rural area had significantly lower socioeconomic aspects (P <0.005), when compared to families from urban area. In urban areas, significant associations were found between the impact on OHRQoL and children's age in months (P = 0.004), gender (female) (P = 0.034), number of cavitated teeth (P <0.001) and presence of developmental defects of enamel (P = 0.004). In rural areas significant association was found only between the impact on OHRQoL and the number of cavitated teeth (P <0.001). Oral health problems such as dental caries and developmental defects of enamel negatively affected the quality of life of preschool children and their families. In the urban area, number of cavitated teeth, developmental defects of enamel, in addition to age and gender contributed to decreased quality of life of preschool children and their families. In rural areas, only the number of cavitated teeth impaired significantly the daily lives of preschool children and their families.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:44Z No. of bitstreams: 5 george.pdf: 1321962 bytes, checksum: 4431a511a9e919efedb58883c89d3635 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T10:47:26Z (GMT) No. of bitstreams: 5 george.pdf: 1321962 bytes, checksum: 4431a511a9e919efedb58883c89d3635 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T10:47:26Z (GMT). No. of bitstreams: 5 george.pdf: 1321962 bytes, checksum: 4431a511a9e919efedb58883c89d3635 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2013 / O objetivo deste estudo foi avaliar a influ?ncia da qualidade do tratamento de canal radicular (TCR), de fatores relacionados ? restaura??o coron?ria (RC), les?es por c?rie e par?metros cl?nicos periodontais no estado periapical de dentes tratados endodonticamente. Os pacientes foram tratados por estudantes de gradua??o na Cl?nica de Endodontia da Universidade Federal dos Vales do Jequitinhonha e Mucuri, entre o per?odo de 2004 a 2009. A reavalia??o cl?nica e radiogr?fica foi realizada entre Setembro de 2010 e Fevereiro de 2011. Foram coletados dados contidos nos prontu?rios odontol?gicos (idade, g?nero, dente tratado, estado periapical pr?-operat?rio, tipo de tratamento, t?cnicas de instrumenta??o e obtura??o empregadas, radiografia final da obtura??o e tipo de restaura??o coron?ria). Clinicamente, foram considerados fatores relacionados a sinais e sintomas endod?nticos, les?es por c?rie, RC e par?metros periodontais. Radiograficamente avaliou-se o estado periapical, les?es por c?rie, RC e pino intrarradicular. Os resultados foram analisados estatisticamente usando os testes qui-quadrado de Pearson, exato de Fisher, McNemar e regress?o log?stica bivariada e multivariada (p<0,05). Foram reavaliados 122 pacientes ap?s per?odo de acompanhamento de 12 a 66 (37,7?16,4) meses, e estes apresentaram 154 dentes tratados endodonticamente. Os dados foram organizados e analisados conforme o desenho de estudo e vari?veis estudadas, sendo apresentados em dois artigos cient?ficos. No geral a taxa de sucesso cl?nico-radiogr?fico do TCR foi de 73,4%. No estudo longitudinal observou-se frequ?ncias elevadas de obtura??es perfeitas (41,6%) e satisfat?rias (46,1%) e frequ?ncia reduzida de obtura??es deficientes (12,3%). A qualidade das obtura??es e das restaura??es coron?rias, analisadas isoladamente, influenciou no sucesso cl?nico-radiogr?fico (p<0,05); a presen?a de pr?via les?o periapical (OR=10,24; IC=3,15-33,22) foi o fator decisivo para o insucesso do tratamento. No estudo transversal observou-se que a presen?a de les?es por c?rie (p=0,017), sangramento gengival ? sondagem (p=0,043) e mobilidade dent?ria (p=0,022) foram os fatores associados ao insucesso do TCR. As outras vari?veis relacionadas ?s les?es por c?rie, RC, qualidade da obtura??o e par?metros cl?nicos periodontais, n?o influenciaram no insucesso do tratamento (p>0,05). Concluiu-se que, no estudo longitudinal, o pr?vio estado periapical foi o principal fator que influenciou o progn?stico do TCR e, no estudo transversal, a presen?a de les?es por c?rie e aspectos periodontais influenciaram negativamente no estado periapical dos dentes tratados endodonticamente. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2012. / ABSTRACT The aim of this study was to evaluate the influence of root canal treatment (RCT) quality, factors related to the coronal restoration (CR), carious lesions and periodontal clinical parameters in the periapical status of endodontically treated teeth. The patients were treated by undergraduate students at the Clinic of Endodontics, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM) in the period between 2004-2009. The clinical and radiographic recall was performed between September 2010 and February 2011. Data were collected in records dentistry (age, gender, treated tooth, periapical status preoperative, type of treatment, instrumentation and obturation techniques, final radiography of the filling and the type of coronal restoration). Clinically, factors related to carious lesions, CR and periodontal parameters were considered. Radiographic parameters were evaluated the periapical status, carious lesions, CR and cast post. The results were statistically analyzed using Pearson chi-square, Fisher?s exact and McNemar tests, bivariate and multivariate logistic regression (p<0.05). A total of 122 patients were reassessed after a follow-up of 12-66 (37.7?16.4) months which had 154 endodontically treated teeth. Data were organized and analyzed according to the study design and variables, and are presented in two papers. Overall, the success rate of the RCT was 73.4%. In the longitudinal study it was observed a high frequency of perfect (41.6%) and satisfactory (46.1%) fillings and a reduced frequency of deficient (12.3%) fillings. The quality of fillings and coronal restorations, when analyzed individually, influenced the clinical and radiographic success (p<0,05); preoperative periapical lesion was the main factor for the treatment insuccess (OR=10.24, CI=3.15-33.22). In cross-sectional study it was observed that the presence of carious lesions (p=0.017), gingival bleeding (p=0,043) and tooth mobility (p=0.022) were the factors associated with insuccess of RCT. The other variables related to carious lesions, CR, quality of fillings and periodontal clinical parameters, did not influence the insuccess treatment (p>0.05). In conclusion, the prior periapical status was the main factor affecting the prognosis of the RCT in the longitudinal study and, in the cross-sectional study the presence of carious lesions and periodontal aspects negatively influenced the periapical status of endodontically treated teeth.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:44Z No. of bitstreams: 5 raquel.pdf: 1403025 bytes, checksum: eea55372117e73565bb98bcc2880e7b3 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T10:48:20Z (GMT) No. of bitstreams: 5 raquel.pdf: 1403025 bytes, checksum: eea55372117e73565bb98bcc2880e7b3 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T10:48:20Z (GMT). No. of bitstreams: 5 raquel.pdf: 1403025 bytes, checksum: eea55372117e73565bb98bcc2880e7b3 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2011 / Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG) / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Pouco conhecimento est? dispon?vel em torno da preval?ncia e dos fatores associados ?s altera??es de mucosa bucal em crian?as pr?-escolares procedentes da zona urbana ou rural. O objetivo do presente estudo foi verificar a preval?ncia e os fatores associados com varia??es da normalidade e les?es de mucosa bucal em 541 pr?-escolares saud?veis da zona urbana e rural do munic?pio de Diamantina, Minas Gerais, Brasil. Atrav?s de question?rio aplicado aos pais/respons?veis investigaram-se informa??es sociodemogr?ficas como proced?ncia da crian?a (zona urbana ou rural), escolaridade da m?e e renda mensal do grupo familiar, al?m da presen?a de h?bitos nocivos como bruxismo, suc??o e mordiscagem de objetos. Em seguida, exames bucais foram realizados para verificar altera??es de mucosa e higiene bucal, al?m da presen?a de c?rie dent?ria. An?lise descritiva, testes Kruskal-Wallis, Mann-Whitney, qui-quadrado, Exato de Fisher e regress?o log?stica multivariada foram utilizados para an?lise dos dados (p<0,05). A preval?ncia de altera??es de mucosa bucal foi de 49,5%. As varia??es da normalidade mais frequentes foram: l?ngua saburrosa (23,4%), manchas mel?nicas (14,4%) e gr?nulos de Fordyce (8,1%). Por outro lado, as les?es mais prevalentes foram: les?es ulceradas (11,8%), queilite angular (3,0%) e f?stula (1,3%). Independentemente do g?nero, idade, escolaridade da m?e, renda familiar e proced?ncia da crian?a, pr?-escolares de 3 a 5 anos possu?ram maior chance de apresentar l?ngua saburrosa [OR:2,55; (IC95%: 1,6-4,1)], manchas mel?nicas [OR:4,07; (IC95%: 2,3-7,2)] e gr?nulos de Fordyce [OR:12,70; (IC95%: 7,2-28,6)]. L?ngua saburrosa foi mais prevalente em crian?as de baixa renda [OR:2,35; (IC95%: 1,3-4,3)] e higiene bucal insatisfat?ria [OR:4,65; (IC 95%: 2,9-7,4)]. Crian?as da zona rural [OR:3,86; (IC 95%: 2,1-7,1)] e do g?nero feminino [OR:2,23; (IC 95%: 1,3-3,8)] apresentaram maior ocorr?ncia de manchas mel?nicas. Pr?-escolares com c?rie possu?ram maior chance de apresentar linha alba [OR: 6,19; (IC95%: 1,1-26,1)], ulcera??es bucais [OR:2,15; (IC95%: 1,2-3,9)] e f?stula [OR:12,0; (IC95%: (1,4-11,3)]. Pr?-escolares com bruxismo apresentaram maior ocorr?ncia de queilite angular [OR:5,55; (IC95%: 1,9-16,3)]. Concluiu-se que a preval?ncia de altera??es de mucosa bucal em crian?as pr?-escolares foi alta. Os fatores mais frequentemente associados ?s varia??es da normalidade foram o g?nero feminino, idade entre 3 e 5 anos, higiene bucal insatisfat?ria, baixa renda familiar, proced?ncia rural e c?rie dent?ria. Por outro lado, os ?nicos fatores associados ?s les?es de mucosa bucal foram c?rie dent?ria e bruxismo. / ABSTRACT Narrow knowledge is available about the prevalence of alterations in the oral mucosa and associated factors among preschool children coming from urban or rural area. The aim of the present study was to determine the prevalence of abnormalities and lesions in the oral mucosa and associated factors among 541 healthy preschool children in urban and rural areas of the city of Diamantina, Minas Gerais, Brazil. A questionnaire administered to parents/guardians investigated socio-demographic variables, such as child?s place of residence (urban or rural area), mother's schooling and monthly household income as well as harmful habits such as bruxism (teeth grinding/clenching), sucking habits and chewing on objects. Oral examinations were performed to determine mucosa alterations, oral hygiene and dental caries. Descriptive analysis, Fisher?s Exact test, the Kruskal-Wallis, Mann-Whitney and chi-square tests and multivariate logistic regression were used for data analysis (p < 0.05). The prevalence of alterations in the oral mucosa was 49.5%. The most prevalent abnormalities were coated tongue (23.4%), melanotic macules (14.4%) and Fordyce granules (8.1%). The most prevalent lesions were oral ulcers (11.8%), angular cheilitis (3.0%) and fistula (1.3%). Preschool children aged three to five years had a greater chance of exhibiting coated tongue (OR: 2.55; 95% CI: 1.6-4.1), melanotic macules (OR: 4.07; 95% CI: 2.3-7.2) and Fordyce granules (OR: 12.70; 95% CI: 7.2-28.6). Coated tongue (OR: 2.35; 95% CI: 1.3-4.3) and poor oral hygiene (OR: 4.65; 95% CI: 2.9-7.4) were more prevalent among low-income children. Children in rural areas (OR: 3.86; 95% CI: 2.1 to 7.1) and the female gender (OR: 2.23; 95% CI: 1.3-3.8) had a higher occurrence of melanotic macules. Preschool children with dental caries had a greater chance of exhibiting linea alba (OR: 6.19; 95% CI: 1.1-26.1), oral ulcers (OR: 2.15; 95% CI: 1.2-3.9) and fistula (OR: 12.0; 95% CI: 1.4-11.3). Children with bruxism had higher incidence of angular cheilitis (OR: 5.55; 95% CI: 1.9-16.3). The prevalence of alterations in the oral mucosa of preschool children was high. The factors most often associated with such abnormalities were the female gender, age between three and five years, poor oral hygiene, low income, residing in a rural area and dental caries. However, the only factors associated with oral mucosa lesions were dental caries and bruxism.

Submitted by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-01-23T16:14:44Z No. of bitstreams: 5 saulo.pdf: 2174121 bytes, checksum: 837d6359c95ce3c616f0b0f600ff2489 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2015-02-10T10:50:10Z (GMT) No. of bitstreams: 5 saulo.pdf: 2174121 bytes, checksum: 837d6359c95ce3c616f0b0f600ff2489 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) / Made available in DSpace on 2015-02-10T10:50:10Z (GMT). No. of bitstreams: 5 saulo.pdf: 2174121 bytes, checksum: 837d6359c95ce3c616f0b0f600ff2489 (MD5) license_url: 52 bytes, checksum: 3d480ae6c91e310daba2020f8787d6f9 (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) license.txt: 2109 bytes, checksum: aa477231e840f304454a16eb85a9235f (MD5) Previous issue date: 2013 / Muito ainda se discute com rela??o ? fisiopatologia das les?es perif?ricas de c?lulas gigantes (LPCG) e les?es centrais de c?lulas gigantes (LCCG). Ambas as les?es apresentam caracter?sticas cl?nicas distintas, apesar de possu?rem caracter?sticas histol?gicas semelhantes. Assim, estudos imunoistoqu?micos em LPCG e LCCG est?o sendo realizados, para permitir um melhor entendimento dessas les?es. Tem sido relatado que a express?o aumentada de FASN e a angiog?nese est?o diretamente ligadas com desenvolvimento dos tumores. No entanto, ainda n?o se sabe se estes eventos est?o envolvidos na patog?nese das LPCG e LCCG. O objetivo deste trabalho foi avaliar a express?o de FASN e o grau de angiog?nese entre LPCG e LCCG, al?m de verificar a correla??o entre essas vari?veis. Assim, 13 casos de LCCG e 14 casos de LPCG foram selecionados para an?lise da express?o imunoistoqu?mica de FASN, CD34, CD105 e D2-40. A express?o de FASN foi avaliada nos componentes celulares da les?o, seguida da mensura??o da densidade microvascular (DMV) e ?rea microvascular (AMV) para cada uma das amostras selecionadas. Os dados coletados foram submetidos ? an?lise descritiva e sequencialmente aos testes de Mann Whitney, teste t para amostras independentes e testes de correla??o de Pearson e Spearman. Os resultados do nosso estudo indicam que: (1) n?o h? diferen?as na imunoexpress?o de FASN entre os grupos de les?es (CM ? 8% FASN+ / CGM ? 38% FASN+); (2) LPCG possuem maior DMV em CD34; n?o houve diferen?as na DMV em CD105 e D2-40 entre as les?es. A AMV em LPCG foi maior que em LCCG para CD34, CD105 e D2-40; (3) em LPCG houve correla??o positiva entre (CM ? FASN+ com DMV/CD105); (4) nas LCCG houve correla??o positiva entre (CM ? FASN+ com DMV/CD105), (CM ? FASN+ com AMV/CD105 e CD34), (CGM ? FASN+ com AMV/CD105). A partir dos resultados obtidos concluiu-se que os n?veis similares da express?o imunoistoqu?mica de FASN indicam processos constitutivos da manuten??o tissular de ambas as les?es. No entanto, as diferen?as na vasculariza??o, entre os grupos de les?es, parecem ser influenciadas por CM positivas para FASN. / Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Odontologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2012. / ABSTRACT There is still a lot of discussion about the pathophysiology of Peripheral Giant Cell Lesion (PGCL) and Central Giant Cell Lesion (CGCL). These lesions show distinct clinical features, although they have similar histological characteristics. Thus, immunohistochemical studies in PGCL and CGCL are being done to improve understanding these diseases. It has been reported that high level of FASN and angiogenesis are linked with tumors development. However, remains unknown whether these events are involved in the pathogenesis of LPCG and LCCG. The aim of this research was to study FASN expression and angiogenesis degree between PGCL and CGCL, in addition, verify the correlation between this variables. Thus, 13 cases of CGCL and 14 cases of PGCL were selected and examined by immunoexpression of FASN, CD34, CD105 and D2-40. The immunoexpression of FASN was assessed in components cells of lesions, followed by measurement of Microvassel Density (MVD) and Microvassel Area (MVA) for each selected sample. Data collected was submitted to descriptive analysis and followed by Mann Whitney test, ?t? test to independent samples and Person?s and Spearman?s correlation. The results of this study indicate that: (1) there are no differences in FASN immunoexpression between group lesions (MC ? 8% FASN+ / MGC ? 38% FASN+); (2) PGCL have greater MVD in CD34 than CGCL; there are no MDV differences in CD105 and D2-40 between lesions. PGCL have greater MVA in CD34, CD105 and D2-40 than CGCL; (3) in PCGL there was a positive correlation between (MC ? FASN+ and MVD/CD105); (4) in CGCL there was a positive correlation between (MC ? FASN+ and MVD/CD105), (MC ? FASN+ and MVA/CD105 and CD34), (MGC ? FASN+ and MVA/CD105). With base on these results it is concluded that similar expression of FANS levels indicate constituent process of tissue maintenance in both lesions. On the other hand, differences on angiogenesis between lesions seem be influenced by FASN+ mononuclear cells.