Although seasonal influenza epidemics represent a significant threat to public health, their treatment options remain limited. With deaths from the 1918 influenza pandemic estimated at >50,000,000 worldwide and future pandemics predicted, the need for a potent broad-spectrum influenza therapy is critical. In this thesis, I describe the use of a structurally modified zanamivir, an influenza neuraminidase inhibitor that blocks the release of nascent virus, to deliver attached therapeutic agents specifically to the surfaces of viruses and virus-infected cells, leading to simultaneous inhibition of virus release and immune-mediated destruction of both free virus and virus-infected cells. Chapter 1 describes the major characteristics of the influenza virus, the morbidity and mortality associated with annual infections by current strains of the virus, and the treatments available to reduce the disease burden associated with these infections. Chapter 2 describes the design, synthesis, and evaluation of a zanamivir-related targeting ligand and its conjugation to two orthogonal imaging agents which are then used to characterize the binding specificity and biodistribution of the targeting ligand in influenza virus-infected cells and in infected mice. Chapter 3 describes the development of an influenza virus-targeted immunotherapy, where a zanamivir-targeted hapten is exploited to redirect the immune system to destroy influenza virus and virus-infected cells. When tested in vivo, this immunotherapy is shown to be significantly superior to zanamivir in protecting mice from lethal influenza virus infections. Finally, both a zanamivir-targeted chemotherapy and a CAR-T cell therapy with different mechanisms of cytotoxicity against neuraminidase expressing cells are introduced in Chapter 4.

L'objectif de cette thèse est l'accélération des solveurs de Gradient Conjugué avec déflation utilisés pour la résolution de l'équation de Poisson pour la pression, dans le cas de la simulation d'écoulements à faible nombre de Mach sur des maillages non structurés. Une méthode de redémarrage basée sur une estimation de l'effet des erreurs numériques a été mise en œuvre et validée. Par la suite, une méthode à trois niveaux de maillage a été créée, et deux techniques ont dû être développées pour réduire le nombre d'itérations sur les niveaux grossiers : l'une permet la création de solutions initiales grâce à une méthode de projection adaptée, l'autre consiste en une adaptation du critère de convergence sur les niveaux grossiers. Les résultats numériques sur des simulations massivement parallèles montrent entre autres une réduction considérable du temps de calcul global. D'autres pistes de recherche sont introduites, notamment concernant l'équilibrage dynamiques de charge de calcul. / The main objective of this thesis is to accelerate deflated Conjugate Gradient solvers used for solving the pressure Poisson equation, for the simulation of low-Mach number flows on unstructured meshes. A restart method based on an estimation of the effect of numerical errors has been implemented and validated. Then, a three-level deflation method has been created, and two techniques are developed in order to reduce the number of iterations on the coarse levels : one of them is the creation of initial guesses thanks to a well-suited projection method, the other one consists in adapting the convergence criterion on the coarse grids. Numerical results on massively parallel simulations show, among others, a drastic reduction of the computational times of the solver. Other lines of research are introduced, especially regarding dynamic load balancing.

La problématique associée à ce travail de thèse concerne la détermination des causes de fatigue thermique dans des conduites hydrauliques. Ce travail porte plus particulièrement sur l’étude d’une zone de mélange orthogonale dans laquelle débouchent deux écoulements à différentes températures et présentant des régimes dynamiques turbulents. Ce type de configuration est utilisé afin de favoriser la baisse de température de l’écoulement (ou l’augmentation de température selon les cas). Pour des valeurs élevées du nombre de Reynolds et des écarts de températures des écoulements en confluence, la charge thermique engendrée par les fluctuations pariétales de température peut entraîner la formation de fissures dans les canalisations.Pour faire face à ce problème, les méthodes de dimensionnement des conduites hydrauliques mettent en évidence la nécessité de connaître la charge thermique imposée sur la paroi sensible. Le besoin attendu en termes de caractérisation dynamique et thermique de ces écoulements est à l’origine de ce projet de recherche qui s’attache ainsi à déterminer pour une configuration industrielle simplifiée, les phénomènes dynamiques et thermiques instationnaires et tridimensionnels à proximité de la paroi. Pour cela, l’étude s’organise en deux phases. Une approche expérimentale, faisant appel à la vélocimétrie par images de particules et la thermographie infrarouge, est mise en oeuvre dans un écoulement turbulent à la jonction entre une conduite de section rectangulaire et un piquage cylindrique. L’étude expérimentale permet de mesurer l’effet de différents paramètres de l’écoulement (régime dynamique, rapport des vitesses de l’écoulement, écart de température). Une des configurations expérimentales est de plus modélisée par simulations des grandes échelles dans laquelle le transfert thermique conjugué entre le fluide et la paroi d’intérêt est pris en compte. Les champs statistiques de vitesse et température issus du calcul numérique sont comparés à la base de données expérimentale. L’analyse des mécanismes thermodynamiques près de la paroi et dans la paroi, est de plus réalisée au moyen des grandeurs statistiques de l’écoulement, des corrélations de vitesse-température et de l’enregistrement temporel de sondes numériques placées dans l’écoulement et dans la paroi. / This research work originates from thermal stress issues in hydraulic pipes. It specifically focuses on determination of thermal load created by mixing flows in orthogonal pipe junctions. Such mixing zones are commonly used to cool or heat the main flow. For high Reynolds number values and high difference of temperature of the two flows, thermal load created by strong temperature fluctuations at the wall can initiate and propagate cracks through the pipe. Standards in pipe design pointed out the need in knowing these thermal loads applied at the downstream junction wall. Thus, this study aims to characterize three-dimensional and unsteady dynamical and thermal phenomena in a simplified industrial configuration. First, an experimental investigation based on particle image velocimetry and infrared thermography has been carried out on a cylindrical jet pipe flowing through a main rectangular channel flow. Different parameters have been studied such as Reynolds number influence, velocity ratio between secondary and main flow and temperature difference. One of the experimental configurations has also been investigated using numerical simulations. LargeEddy Simulations with conjugate heat transfer model has been developed and compared to the experimental database. Dynamics and Thermal mechanisms have been analysed near the wall and within the wall with obtained statistical flow fields, velocity-temperature moments and numerical probes extracted from fluid and solid parts.

<p>A battery assembly experiences both mechanical and thermal loadings during its operation. It is critical to perform the thermomechanical analysis to propose a novel design for the highest efficiency.In this study,two main goals include mechanical characterization and deformation responses for a battery cell and assembly, as well as air-cooled concepts design and analysis.Initially, the cell dimensions were measured by cell-sectioning method, and then the mechanical properties were empirically measured by both 3-point flexural, and nanoindentation experiments. Moreover, three pairs of experiments and simulations were conducted to study mechanical behaviors on both a single cell and a battery assembly. They include (1) point-force loading for single, open cell; (2) internal pressurization for single, sealed cell; and (3) internal pressurization for battery assembly.Additionally, both parametric and experimental studies were executed to design, analyze,and validate air-cooled concepts based on the idea of microchannel heatsink. The proposed concepts have the features, which are integrated into the battery cell for generating the cooling channels. A series of thermomechanical simulations and a forced convection testbed were built for computationally and empirically analyzing the performances of the concepts. The results from the mechanical characterization showed a significant difference between the actual and nominal values of both cell dimensions and mechanical properties. Therefore, the effect of the manufacturing process to such values must be considered before inputting for analyzing the deformation responses. From the thermomechanical analyses, it was found that the mechanical loading might negatively influence the thermal performance if there were not enough mechanical supports from the air-cooling structure. The impact was minimal in the tapered-channel battery assembly. This configuration also significantly reduced the temperature difference on the cell compared with other concepts and the reference design.<br></p>

The new generation of giant ground-based telescopes will see their first light this decade. These state-of-the-art facilities will significantly surpass the resolving power of modern space-based observatories such as the James Webb telescope, thanks to their enormous aperture size and adaptive optics (AO) facilities. Without AO, atmospheric turbulence would degrade the image quality of these enormous telescopes to that of a 50 cm amateur one. These extremely large telescopes (ELTs) will further benefit from a particular branch of AO called multi-conjugate adaptive optics (MCAO), which provides an extremely high resolving power over a much wider field of view as compared to classical AO systems. The design and fabrication of such systems, as well as their optimal use for science operation, pose a great challenge as they are an order of magnitude more complicated than current AO systems. To face such a challenge, the combined knowledge of MCAO system design and fabrication, working in tandem with scientific insights into new astronomy science cases, is an extremely valuable and essential pairing. This thesis is an effort to not only contribute to the design and fabrication of ELT MCAO facilities, but also provide guidance on the optimal method to utilize these giant telescopes to achieve unprecedented astrometric measurements. On the instrumentation side, in partnership with the National Research Council of Canada's - Herzberg Astronomy and Astrophysics Institute as well as W.M. Keck Observatory in Hawaii, I was involved in the design and fabrication of a cutting edge new wavefront sensor, which is the eye of an AO system. I performed opto-mechanical design and verification studies for components of the Keck infrared pyramid wavefront sensor (IR-PWFS) as well as the Keck Planet Imager and characterizer (KPIC) instrument, which have both been commissioned and are in science operation. Furthermore, I designed the alignment plan and participated in the modification and alignment operation of a few components on the Keck II adaptive optics bench on the summit of Mauna Kea. To pave the way for the design verification of future MCAO systems for ELTs, I proposed a new method for an old challenge in the path of AO system design and verification: a flexible method for precise intensity pattern injection into laboratory AO benches. AO benches are the backbone of instrument design and modeling. One of the challenges especially important for the future generation of MCAO systems for ELTs is the verification of the effect of shadowed regions on the primary mirror. During my PhD, I successfully demonstrated the feasibility of a new proposed method to accurately model the telescope pupil. This work was done in partnership with the Laboratoire d'Astrophysique de Marseille (LAM) in France. The method I developed at LAM will be implemented in the AO Lab at NRC Herzberg Astronomy and Astrophysics. As an observational astronomer, I focused on developing methods for making optimal astrometric measurements with MCAO-enabled telescopes. The expected unparalleled astrometric precision of ELTs comes with many unprecedented challenges that if left unresolved, would jeopardize the success of these facilities as they would not be able to reach their science goals. I used observations with the only available MCAO system in science operation, the Gemini MCAO system on the 8-meter Gemini South telescope in Chile, to develop and verify a pipeline specifically designed for very high-precision astrometric studies with MCAO-fed imagers. I successfully used the pipeline to provide the precise on-sky differential distortion of the Gemini South telescope and its MCAO facilities by looking deep into the core of globular cluster NGC~6723. Using this pipeline, I produced high quality proper motions with an uncertainty floor of $\sim 45$\,$\mu$as~yr$^{-1}$ as well as measured the proper motion dispersion profile of NGC~6723 from a radius of $\sim 10$ arcseconds out to $\sim 1$\,arcminute, based on $\sim 12000$ stars. I also produced a high-quality optical-near-infrared color magnitude diagram which clearly shows the extreme horizontal branch and main-sequence knee of this cluster. / Graduate

ortalidad en niños menores de 5 años, a pesar de contar con medidas preventivas como la vacunación.  Objetivo: Evaluar el impacto de la vacuna antineumocócica conjugada sobre la incidencia de neumonía en niños menores de 5 años, a nivel nacional y departamental, así como las hospitalizaciones y mortalidad a nivel nacional, desde 2001-2019 en el Perú. Además, realizar un análisis entre departamentos con coberturas altas de vacunación y aquellos que alcanzan coberturas bajas.  Metodología: Diseño: Series de tiempo definidas por la introducción de la vacuna antineumocócica heptavalente (PCV7) en el periodo de tiempo entre 2009 y 2011 a nivel nacional y departamental. Posteriormente, se realizó un análisis multivariado contrastando la incidencia de casos entre los departamentos con alta y baja cobertura de vacunación. Procedimiento de obtención de datos: Los datos agrupados sobre la incidencia, hospitalización y mortalidad por neumonía fue obtenida de la CDC (Centro de Enfermedades Contagiosas); la cobertura de vacunación fue obtenida como base de datos del Ministerio de Salud (MINSA) Análisis específicos: se realizó un análisis multivariado contrastando la incidencia de casos de neumonía entre los departamentos con alta y baja cobertura de vacunación.  Resultados: Para las hospitalizaciones a nivel nacional, la tendencia de cambio post vacunación fue negativa y significativa (p <0.001). La incidencia y mortalidad tuvieron cambios no significativos. A nivel regional, Callao, Lima, Moquegua, Cusco, Huancavelica, Pasco, Loreto, San Martín y Ucayali tuvieron tendencia de cambio post vacunación negativa y significativa (p <0.001). Conclusiones: La vacunación ha demostrado ser efectiva para disminuir hospitalizaciones por neumonía en algunos departamentos y a nivel nacional. Sin embargo, existen factores individuales que pueden alterar la efectividad de la intervención, propias de la estrategia aplicada y del tipo de estudio utilizado. / Introduction: Pneumonia is an acute respiratory infection, the most common bacterial cause is Streptococcus pneumoniae and represents one of the major causes of mortality in children under 5 years of age, despite preventive measures. Objective: Assess the impact of the pneumococcal vaccine on the incidence of pneumonia in children under 5 years of age, at the national and departmental level, as well as hospitalizations and mortality at the national range, over 2001-2019 in Peru. In addition, perform an analysis between departments that achieve high vaccination coverage and those with low coverage.  Methodology: Study design: Time series interrupted by the inclusion of the heptavalent pneumococcal vaccine (PCV7) in the period between 2009 and 2011 at the national and departmental level. Multivariate analysis, contrasting the incidence of cases between departments with high and low vaccination coverage. Data collection procedure: Pooled data on pneumonia incidence, hospitalization, and mortality obtained from the CDC (Center for Communicable Diseases); vaccination coverage obtained as a database from the Ministry of Health (MINSA) Specific analyzes: multivariate contrasting the incidence of pneumonia cases between departments with high and low vaccination coverage. Results: Hospitalizations at the national level had a negative trend of change after vaccination (p <0.001). At regional level, Callao, Lima, Moquegua, Cusco, Huancavelica, Pasco, Loreto, San Martín and Ucayali had a negative and significant change trend post vaccination (p <0.001). Conclusions: Vaccination has proven to be effective in some departments and at the national level. However, there are individual factors and limitations of the study that may affect the outcome. / Tesis

Streptococcus pneumoniae est une bactérie cocci gram positif commensale de la flore oropharyngée qui colonise le rhinopharynx de l’Homme et dont près de 100 sérotypes sont connus. Les nourrissons et les jeunes enfants représentent son réservoir principal. Le pneumocoque peut être à l’origine d’infections graves, telles que la méningite, les bactériémies et la pneumonie, et moins graves mais plus courantes comme la sinusite et l’otite moyenne aiguë. Deux vaccins anti-pneumococciques conjugués ont été introduits en France : le PCV7 (couvrant contre 7 sérotypes) en 2003 et le PCV13 (couvrant contre 6 sérotypes supplémentaires) en 2010. L’objectif général de ce travail de thèse est d’évaluer l’impact des politiques vaccinales sur les infections invasives à pneumocoque en France, en s’intéressant principalement aux évolutions temporelles et géographiques des plus graves : les méningites à pneumocoque (MP). Un premier travail a étudié les dynamiques temporelles des MP sur la période 2001–2014 afin d’identifier l’impact de l’introduction des vaccins conjugués. Des techniques statistiques de modélisations adaptées aux séries temporelles ont été utilisées. Les résultats de ce travail retrouvent des effets rapportés dans la littérature : une réduction des MP à sérotypes vaccinaux mais aussi une augmentation des MP dues aux sérotypes non inclus dans le vaccin (phénomène de « remplacement sérotypique »).Par conséquent, le premier bénéfice, à l’échelle de la population générale, de l’introduction de cette vaccination a été observé seulement onze ans après l’introduction du PCV7, et principalement suite à l’introduction du PCV13 en 2010, avec une diminution de 25% du nombre de MP en 2014. La composante géographique a ensuite été prise en compte afin d’étudier le rôle de la de couverture vaccinale dans la variabilité des MP annuelles entre les départements sur la période 2001-2016. Les résultats confirment l’efficacité des deux formulations du vaccin sur les MP dues aux sérotypes vaccinaux et suggèrent une certaine homogénéité de cet effet entre les différents départements. Inversement, le remplacement sérotypique a été confirmé mais uniquement suite à l’introduction de la première formulation du vaccin et ces effets présentent une répartition géographique hétérogène et variable. La variabilité de la couverture vaccinale entre les départements n’explique pas celle observée dans le nombre de MP, ce qui suggère l’intervention d’autres facteurs tel que la densité géographique. Enfin, une modélisation dynamique, permettant de prendre en compte des aspects fondamentaux des dynamiques de transmission et d’infection du pneumocoque non intégrés dans les méthodes de modélisation statique, a été proposée afin de prédire l’impact de différentes stratégies de vaccination pour les adultes de 65 ans et plus et ainsi évaluer leur rapport coût-utilité. / Streptococcus pneumoniae is a Gram-positive commensal bacterium of the oropharyngeal flora usually colonizing human’s rhino pharynx, of which almost 100 serotypes are known. Infants and young children constitute its main reservoir. Pneumococcus may cause serious infections, such as meningitis, bacteremia and pneumonia, or less serious but more common such as sinusitis and acute otitis media (AOM). Two conjugate pneumococcal vaccines have been introduced in France: PCV7 (covering 7 serotypes) in 2003 and PCV13 (covering 6 additional serotypes) in 2010. The overall objective of this thesis is to assess the impact of vaccination policy on invasive pneumococcal diseases in France, by focusing on temporal and geographical trends of the most serious of them: pneumococcal meningitis (PM). An initial study of PMs temporal dynamics over the 2011-2014 period assessed the impact of conjugate vaccines’ introduction. Statistical modeling techniques were used for time series analysis. The results confirm the effects found in literature: a reduction of vaccine serotypes PMs but at the same time an increase of PMs, due to non-vaccine serotypes (effect of “serotype replacement”). Therefore, the first benefit of vaccine introduction at population scale has been observed no less than 11 years after PCV7 introduction, and then principally after PCV13 was introduced in 2010, with a 25% decrease in PMs in 2014. The geographic component was then implemented to analyze the role of vaccine coverage in annual PM variability between geographic units over the 2001-2016 period. Results confirm the effectiveness of both vaccine compositions on vaccine serotypes PMs and suggest homogeneity of this effect among geographic units. Conversely the serotype replacement has been confirmed only after the first vaccine composition was introduced and presents a variable and heterogeneous geographical repartition. Variability in vaccine coverage among geographic units doesn’t explain the differences in PMs, which could suggest the role of others factors such as demographic density. Finally, a dynamic modeling capable of taking into consideration fundamental aspects of pneumococcus transmission and infection mechanisms not integrated in static modeling has been proposed in order to predict the impacts of different vaccination strategies for 65+ adults and therefore assess their cost-utility ratios.

Climate change is a critical global issue that continues to shape the way we understand and interact with the world around us. It is discussed more than ever before, especially in politics. To slow down the temperature rise of our planet, decreasing the amount of green house gas emissions produced by our way of living, industries, and the production of energy is necessary. Ocean Harvesting Technologies (OHT), a company from Sweden based in Blekinge, is currently developing a new iteration of renewable, wave energy converters (WEC) that they claim to be ecient from both an energy and cost perspective. A new prototype is in development where thermal and fluid characteristics inside the WEC during operation, are important aspects that need to be evaluated. This project is aimed to develop a computational simulation model of the WEC and perform simulations in order to evaluate the cooling and heating performance of the current model that is under development. The methodology used for this project was divided into three stages to streamline the work: steady-state stationary conjugate heat transfer(CHT) simulations, and transient airflow simulations with motion and compressible air, that are combined into a full-system transient CHT model for operational conditions. CAD models and delimi- tations were provided by OHT and the model was broken down, simplified and assessed to begin the work. The computational software used for the simulations in this project was STAR-CCM+ and the complete process of pre-processing, simulation setup/run and post-processing was executed using the same software. To simulate the fluid and the oper- ational motion of the WEC, the Overset mesh methodology was used, and to resolve the turbulent flow, URANS k! SST was used in the solver. The thermodynamic simulations were initially set up and simulated in two sub-models in order to speed up the method development and to get an early indication of the performance of the WEC. The first sub-simulation handled the compressible air together with the Overset mesh motion while the second simulation aimed to model the thermodynamics of the generator components, ball screw, and other solids. Since OHT is in a relatively early development phase, no experimental data could be used for validation, however, data sheets for generator com- ponents and simple handbook calculations were used to validate the simulation models performance. The sub-simulations resulted in an ecient simulation strategy and a lot of knowledge and understanding of the system performance was gained to implement in the full-system model The final outcome of this thesis work was a complete CHT model that showed the ca- pability of running several hundreds of seconds of operational time while producing a significant amount of performance data such as temperature profiles of critical parts, air pressure/temperature fluctuations, and drag losses of the complete WEC. Furthermore, the sub-simulation models can be used individually as stand-alone models in order to op- timize the system on a component level, e.g., drag losses from the generator components during motion.

This thesis presents a comparison of a GPU implementation of the Conjugate Residual method as a sequence of generic library kernels against implementations ofthe method with custom kernels to expose the performance gains of a keyoptimization strategy, kernel fusion, for memory-bound operations which is to makeefficient reuse of the processed data. For massive MIMO the iterative solver is to be employed at the linear detection stageto overcome the computational bottleneck of the matrix inversion required in theequalization process, which is 𝒪(𝑛3) for direct solvers. A detailed analysis of howone more of the Krylov subspace methods that is feasible for massive MIMO can beimplemented on a GPU as a unified kernel is given. Further, to show that kernel fusion can improve the execution performance not onlywhen the input data is large matrices-vectors as in scientific computing but also inthe case of massive MIMO and possibly similar cases where the input data is a largenumber of small matrices-vectors that must be processed in parallel.In more details, focusing on the small number of iterations required for the solver toachieve a close enough approximation of the exact solution in the case of massiveMIMO, and the case where the number of users matches the size of a warp, twodifferent approaches that allow to fully unroll the algorithm and gradually fuse allthe separate kernels into a single, until reaching a top-down hardcodedimplementation are proposed and tested. Targeting to overcome the algorithms computational burden which is the matrixvector product, further optimization techniques such as two ways to utilize the faston-chip memories, preloading the matrix in shared memory and preloading thevector in shared memory, are tested and proposed to achieve high efficiency andhigh parallelism.

Wave power has been increasing the interest of many researchers looking for alternative sustainable energy sources since the reserves have proved to be capable of satisfying a considerable percentage of the world´s energy demands. This option has not been adopted as a sustainable source since there are some challenges in the process of designing a low cost device that converts the kinetic energy of the waves into electric energy and that could still be efficient enough to be competitive against other options. A new proposal from Anders Hagnestål looks like a very promising way of moving forward in this field. The structure of this newly proposed generator includes neodymium magnets that at temperatures over 60°C might suffer irreversible demagnetization, compromising the normal functioning of the machine. Because of the electrical losses in iron components, overheating is a possibility that must be studied. The aim of this study is to find the temperature distribution of the components that are subject to changing magnetic fields (where the losses will occur). This will be done for a variety of cases regarding environmental and working conditions with the purpose of determining if the generator will need a cooling technique to avoid damage to the magnets. The studied structure consists of a stator and a translator conformed by iron, FR4, glass fiber and, of course, the magnets. The task at hand was carried out first through a one-dimensional analytical model, then through a two-dimensional analytical model and finally by means of simulations on Comsol Multiphysics (Computer-Aided-Engineering software). All of the aforementioned methods implicate assumptions that deviate from reality, but are still useful for the task at hand. Results from the 1D calculation turned out to be unreliable due to the numerous approximations but helped to prove and understand the effect of each of the environmental conditions on the temperature distribution. On the other hand, the 2D calculations and the simulations had a very good agreement which provides some reliability. Furthermore, said results showed that the components might even reach temperatures as high as 380°C under certain conditions. As this number is clearly over the safe limit of the magnets, it was concluded that cooling techniques are needed to ensure the safety of the generator. After some discussion with Hagnestål, cooling methods were proposed. In addition to this, the seemingly most appropriate option was pointed out with the intention of achieving a low-enough temperature and keeping the costs as low as possible. This alternative was a combination of modifying geometric parameters (which would ultimately reduce heat generation) and inducing a low velocity air flow. / Vågkraft är en hittills outnyttjad förnybar energikälla som i framtiden kan tillgodose i storleksordningen 10 % av världens energibehov, om de tekniska utmaningarna kan lösas så att vågkraft kan levereras till konkurrenskraftiga priser. Därmed finns också ett starkt intresse från både akademi och näringsliv att lösa dessa utmaningar. Anders Hagnestål håller på att utveckla en ny linjär generatortyp som enligt beräkningar slår alla befintliga lösningar för effektomvandling för vågkraft med bred marginal. Maskinen har dock komplex geometri, och det är svårt att beräkna dess prestanda. Maskinen innehåller neodymmagneter, vilka kan avmagnetiseras om de blir för varma där 60°C kan ses som en gräns då magneterna börjar påverkas. Om magneterna avmagnetiseras blir maskinen svagare. Eftersom magneterna upphettas av virvelströmmar i magneterna och förluster i omgivande elektroplåt, är det av intresse att göra en termisk analys av maskinen vilket är syftet med detta examensarbete. Målet är att beräkna temperaturutbredningen i maskinens olika delar vid olika driftsfall, och se om man behöver tillföra extern kylning av maskinen för att skydda magneterna. Maskinen består av en translator som omsluter den inre statorn där magneterna är lokaliserade, vilka är byggda av fiberkompositer, elektroplåt, rostfritt stål och neodymmagneter. Beräkningar gjordes först med en endimensionell analytisk modell, därefter med en tvådimensionell analytisk modell och slutligen med numeriska beräkningar i 2D med det kommersiella finita elementmetodberäkningsprogrammet Comsol Multiphysics. Samtliga dessa modeller har avvikelser från det verkliga fallet, men är ändå användbara och ger en fingervisning om hur den termiska situationen för maskinen kan se ut. 1D-beräkningarna visade sig innehålla lite för grova approximationer för att ge pålitliga resultat, men gav en del intuitiv insikt om problemet. Den analytiska 2D-beräkningen stämde bra överens med Comsol-beräkningen, vilket indikerar att beräkningarna är korrekta. Resultaten visade på mycket höga temperaturer i vissa driftsfall utan kylsystem, 380 °C, vilket är en indikator på att antingen någon form av kylning förmodligen behövs, i.a.f. i en del driftsfall, eller att värmeförlusterna i den delen av generatorn behöver minskas genom t.ex. att pollängden ökas. En kombination av luftflöden med låg hastighet och förändrad geometri har föreslagits i examensarbetet för att minska temperaturen.