High-speed digital-to-analog converters are critical components in many radiofrequency (RF) applications. The resistive DAC (RDAC) architecture is suitable for high-speed implementation in extremely scaled digital circuit nodes. An RDAC core can be implemented as a resistance network and a digital block, consisting of inverters as drivers to the resistive network. One disadvantage of the architecture is the input code-dependent supply current. Combined with a non-zero supply network impedance, the code-dependent current will introduce non-linearity in the output voltage. One way to circumvent the problem is to use a high-performance voltage regulator, which counteracts the voltage variation in the impedance in the RDAC supply network. In this thesis work, two alternative solutions are investigated; Compensation with another signal-dependent impedance in parallel with the RDAC core to reduce the impedance variations and a digital predistorter (DPD) which corrects the non-linearities of RDAC output voltage. The investigated techniques can be used for improving the linearity of an RDAC in certain cases. The current compensation technique works best at low frequencies, while the DPD can be used for all frequencies to relax requirements on routing resistance or voltage regulation design.

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Ce travail répond à un besoin industriel accru en termes d’amplification des signaux sur porteuses à enveloppes variables utilisés par les systèmes de télécommunications actuels. Ces signaux disposent d’un fort PAPR et d’une distribution statistique d’enveloppe centrée en-deçà de la valeur crête d’enveloppe. La raison pour laquelle les industriels télécoms requièrent alors des amplificateurs de très fortes puissances de sortie, robustes, fiables et ayant une dépense énergétique optimale le long de la dynamique d’enveloppe associée à un niveau de linéarité acceptable. Ce document expose les résultats d’étude et de réalisation de deux Amplificateurs de Puissance Doherty (APD) à haut rendement encapsulés en boîtiers plastiques QFN. Le premier est un amplificateur Doherty symétrique classique (APD-SE) et le second est un amplificateur à deux entrées RF (APD-DE). Ces démonstrateurs fonctionnant en bande C sont fondés sur l’utilisation de la technologie Quasi-MMIC associant des barrettes de puissance à base des transistors HEMTs AlGaN/GaN sur SiC à des circuits d’adaptation en technologie ULRC. L’approche Quasi-MMIC associée à la solution d’encapsulation plastique QFN permettant une meilleure gestion des comportements thermiques offre des performances électriques similaires à celles de la technologie MMIC avec des coûts et des cycles de fabrication très attractifs. Durant ces travaux, une nouvelle méthode d’évaluation des transistors dédiés à la conception d’amplificateurs Doherty a été développée et mise en oeuvre. L’utilisation intensive des simulations électromagnétiques 2.5D et 3D a permis de bien prendre en compte les effets de couplages entre les différents circuits dans l’environnement du boîtier QFN. Les résultats des tests des amplificateurs réalisés fonctionnant sur une bande de 1GHz ont permis de valider la méthode de conception et ont montré que les concepts avancés associés à l’approche Quasi-MMIC ainsi qu’à des technologies d’encapsulation plastique, peuvent générer des fonctions micro-ondes innovantes. Les caractérisations de l’APD-DE ont relevé l’intérêt inhérent à la préformation des signaux d’excitation et des points de polarisation de chaque étage de l’amplificateur. / This work responds to an increased industrial need for on carrier signals with variable envelope amplification used by current telecommunications systems. These signals have a strong PAPR and an envelope statistical distribution centred below the envelope peak value, the reason why the telecom industrialists then require a robust and reliable high power amplifiers having an energy expenditure along of the envelope dynamics associated with an acceptable level of linearity. This document presents the results of the study and realization of two, high efficiency, Doherty Power Amplifiers (DPA) encapsulated in QFN plastic packages. The first is a conventional Doherty power Amplifier (DPA-SE) and the second is a dual-input Doherty power amplifier (DPA-DE). These C-band demonstrators are based on the use of Quasi-MMIC technology combining power bars based on the AlGaN/GaN transistors on SiC to matching circuits in ULRC technology. The Quasi-MMIC approach combined with Quasi-MMIC approach combined with QFN plastic package solution for better thermal behaviour management offers electrical performances similar to those of MMIC technology with very attractive coasts and manufacturing cycles. During this work, a new evaluation method for the transistors dedicated to the design of DPA was developed and implemented. The intensive use of 2.5D and 3D electromagnetic simulations made it possible to take into account the coupling effects existing between the different circuits in the QFN package environment. The results of the tests of the amplifiers realised and operating on 1GHz bandwidth validated the design method and showed that the advanced concepts associated with the Quasi-MMIC approach as well as plastic encapsulation technologies can generate innovative microwave functions. The characterizations of the DPA-DE have noted the interest inherent in the preformation of the excitation signals and the bias points of each stage of the amplifier.

Given the ever increasing reliance of today’s society on ubiquitous wireless access, the paradigm of dynamic spectrum access (DSA) as been proposed and implemented for utilizing the limited wireless spectrum more efficiently. Orthogonal frequency division multiplexing (OFDM) is growing in popularity for adoption into wireless services employing DSA frame- work, due to its high bandwidth efficiency and resiliency to multipath fading. While these advantages have been proven for many wireless applications, including LTE-Advanced and numerous IEEE wireless standards, one potential drawback of OFDM or its non-contiguous variant, NC-OFDM, is that it exhibits high peak-to-average power ratios (PAPR), which can induce in-band and out-of-band (OOB) distortions when the peaks of the waveform enter the compression region of the transmitter power amplifier (PA). Such OOB emissions can interfere with existing neighboring transmissions, and thereby severely deteriorate the reliability of the DSA network. A performance-enhancing digital pre-distortion (DPD) technique compensating for PA and in-phase/quadrature (I/Q) modulator distortions is proposed in this dissertation. Al- though substantial research efforts into designing DPD schemes have already been presented in the open literature, there still exists numerous opportunities to further improve upon the performance of OOB suppression for NC-OFDM transmission in the presence of RF front-end impairments. A set of orthogonal polynomial basis functions is proposed in this dissertation together with a simplified joint DPD structure. A performance analysis is presented to show that the OOB emissions is reduced to approximately 50 dBc with proposed algorithms employed during NC-OFDM transmission. Furthermore, a novel and intuitive DPD solution that can minimize the power regrowth at any pre-specified frequency in the spurious domain is proposed in this dissertation. Conventional DPD methods have been proven to be able to effectively reduce the OOB emissions that fall on top of adjacent channels. However more spectral emissions in more distant frequency ranges are generated by employing such DPD solutions, which are potentially in violation of the spurious emission limit. At the same time, the emissions in adjacent channel must be kept under the OOB limit. To the best of the author’s knowledge, there has not been extensive research conducted on this topic. Mathematical derivation procedures of the proposed algorithm are provided for both memoryless nonlinear model and memory-based nonlinear model. Simulation results show that the proposed method is able to provide a good balance of OOB emissions and emissions in the far out spurious domain, by reducing the spurious emissions by 4-5 dB while maintaining the adjacent channel leakage ratio (ACLR) improvement by at least 10 dB, comparing to the PA output spectrum without any DPD.

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Indiana University-Purdue University Indianapolis (IUPUI) / Colorectal cancer is the third most common type of cancer and the third most common cause of cancer-related mortality. There are three types of treatment available to patients, either individually or in combination. Treatments are radiation, chemotherapy, and surgery. In a Phase II clinical trial at IUSM, a multimodality approach was chosen. The patients with locally advanced rectal cancer received preoperative treatment with capecitabine and irinotecan (CPT-11) combination followed by chemoradiation with capecitabine and finally surgery to improve response and decrease local recurrence. Irinotecan and Capecitabine are both prodrugs activated in vivo to SN-38 and 5-FU, respectively. Identification of the molecular markers for 5-FU and Irinotecan efficacy and toxicity is important for the development of more efficient and less toxic treatment strategies for patients with colorectal cancer. The goal of this study was to determine the expression levels of the genes involved in activation and metabolism of capecitabine and irinotecan in pre and post treatment specimens from these patients. The genes quantitated by real-time PCR were carboxylesterase 1 and 2 (CES1 and CES2), thymidylate synthase (TS), β-glucoronidase (β-GUS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and topoisomerase I (Topo I). The UGT1A1*28 polymorphism in UDP glucuronosyltransferase 1 is associated with SN-38 toxicity. Therefore, the UGT1A1*28 polymorphism status in patients was determined by PCR-sequencing. Correlative analysis of gene expression and UGT1A1*28 mutation with clinical outcome in this Phase II study was completed.