d-Limonene is a monoterpene found in high concentration in citrus peel oil. Evidence from animal models and cell culture indicate that it has strong anti-cancer effects, particularly in mammary cancer models. Chapter 1; "D-LIMONENE: A BIOACTIVE FOOD COMPONENT FROM CITRUS AND EVIDENCE FOR A POTENTIAL ROLE IN BREAST CANCER PREVENTION AND TREATMENT" is a review paper accepted to Oncology Reviews. This review describes the evidence for <italic>d<italic>-limonene's anti-cancer mechanisms, bioavailability and safety, focusing on relevance to breast cancer prevention. Chapter 2; "ADIPOSE TISSUE ACCUMULATION OF D-LIMONENE WITH THE CONSUMPTION OF A LEMONADE PREPARATION RICH IN D-LIMONENE CONTENT" is published in Nutrition and Cancer journal and describes a phase I clinical trial in which participants consumed 40 oz of high-limonene lemonade daily. This study demonstrated that after 4 weeks of oral consumption of high-limonene lemonade, d-limonene deposits in high levels in adipose tissue. Chapter 3; "A CLINICAL BIOMARKER STUDY OF TOPICALLY APPLIED D-LIMONENE FOR BREAST CANCER PREVENTION" was submitted to Nutrition and Cancer journal. In this phase 0 clinical study, four weeks of a 10% d-limonene formulation resulted in minimal change in NAF and plasma biomarkers or d-limonene levels. Biomarkers in NAF and plasma, however, were significantly differently correlated with BMI and menopausal status, perhaps suggesting effect modifications. Chapter 4: "MOUSE MAMMARY TISSUE DISTRIBUTION OF D-LIMONENE AND PERILLIC ACID FOLLOWING ORAL AND TOPICAL D-LIMONENE ADMINISTRATION," was a study comparing d-limonene and perillic acid disposition after administration of 10% and 20% d-limonene in coconut oil in topical and oral forms to SKH-1 mice. This study demonstrated that d-limonene deposits in high levels in mouse mammary tissue after both oral and topical administration short-term, but is largely cleared after 24 hours in this model. Perillic acid deposits in high levels in adipose after oral administration, and these high concentrations remained after 24 hours. Chapter 5: "IMPLICATIONS AND FUTURE DIRECTIONS" provides a summary of the key findings from these three projects and proposals for future research. The appendices provide results from smaller d-limonene projects, as well as extensions of the body of the dissertation work.

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Physiologically based pharmacokinetic (PBPK) modeling is a tool used in drug discovery and human health risk assessment. PBPK models are mathematical representations of the anatomy, physiology and biochemistry of an organism. PBPK models, using both compound and physiologic inputs, are used to predict a drug’s pharmacokinetics in various situations. Tissue to plasma partition coefficients (Kp), a key PBPK model input, define the steady state concentration differential between the tissue and plasma and are used to predict the volume of distribution. Experimental determination of these parameters once limited the development of PBPK models however in silico prediction methods were introduced to overcome this issue. The developed algorithms vary in input parameters and prediction accuracy and none are considered standard, warranting further research. Chapter 2 presents a newly developed Kp prediction algorithm that requires only readily available input parameters. Using a test dataset, this Kp prediction algorithm demonstrated good prediction accuracy and greater prediction accuracy than preexisting algorithms. Chapter 3 introduced a decision tree based Kp prediction method. In this novel approach, six previously published algorithms, including the one developed in Chapter 2, were utilized. The aim of the developed classifier was to identify the most accurate tissue-specific Kp prediction algorithm for a new drug. A dataset consisting of 122 drugs was used to train the classifier and identify the most accurate Kp prediction algorithm for a certain physico-chemical space. Three versions of tissue specific classifiers were developed and were dependent on the necessary inputs. The use of the classifier resulted in a better prediction accuracy as compared to the use of any single Kp prediction algorithm for all tissues; the current mode of use in PBPK model building. With built-in estimation equations for those input parameters not necessarily available, this Kp prediction tool will provide Kp prediction when only limited input parameters are available. The two presented innovative methods will improve tissue distribution prediction accuracy thus enhancing the confidence in PBPK modeling outputs.

Saarbrücken, Univ., Diplomarb., 2003.

Diss. Nr. 3626 Wirtschaftswiss. St. Gallen. / Literaturverz.

Made available in DSpace on 2014-06-11T19:23:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-10-23Bitstream added on 2014-06-13T19:09:01Z : No. of bitstreams: 1 santos_jls_me_mar.pdf: 262276 bytes, checksum: 93d60345dc900d1ac4bddebf047709c7 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Neste trabalho propomos a análise da natureza dos estados mentais, um tema central nos estudos em Filosofia da Mente. Para isso, sugerimos um percurso investigativo que começa com a análise da noção cartesiana de dualismo substancial definido por postular uma mente distinta do corpo e responsável pela produção de estados mentais. Em seguida, procuramos problematizar a concepção cartesiana tendo como base as críticas que Ryle dirige à por ele denominada 'doutrina oficial'. Com esse propósito, é considerado, em especial, o conceito de disposição sugerido por Ryle (2000) para combater o que ele denomina concepções intelectualistas de mente. Por fim, analisamos algumas das principais teses externalistas, iniciadas com o trabalho de Putnam (1975), sobretudo a perspectiva representacional concebida por Dretske (1997) a respeito da relação do indivíduo com o meio ambiente. Procuramos mostrar que o conceito de disposição sugerido por Ryle fornece subsídios para uma teorização externalista dos estados mentais, servindo como base para uma concepção externalista de indivíduo muito diversa da cartesiana. / In this dissertation we propose the analysis of the nature of the mental states that is a very main issue in the studies of Philosophy of Mind. In order to this, we suggested doing a research which begins with the analysis of the cartesian notion of the substantial dualism, defined by postulating a distinct mind from the body and responsible for producing mental states. Afterwards we tried to argue about the cartesian conception based on the criticisms whose Ryle refers himself as being designated official doctrine. With this purpose, it is considered, in special, the concept of disposition, suggested by Ryle (2000) in opposition to what he designates as intellectual conceptions. Finally, we analysed some of the main externalists theses which were started with Putnam (1975), above all the representational perspective conceived by Dretske (1997) as far as the relationship between the person and the environment is concerned. All things considered we tried to show that the concept of disposition suggested by Ryle supports an externalist theorisation of the mental states, considering itself as the basis for an externalist conception of the person which is very different from the cartesian conception.

Philosophiae Doctor - PhD / This study assesses the policies for managing recovered proceeds of crime in three countries, namely, Tanzania, South Africa and Nigeria. It considers the role and relevance of asset management in the asset recovery regimes of the three countries. Managing the proceeds of crime divides into two stages: the pre-confiscation stage and the post-confiscation stage. International best practices (IBPs) in asset management have been employed as a yardstick for the assessment. On the face of it, asset management is complementary to asset recovery policy. The management of preserved and recovered assets maintains their value and enables states to apply the assets to other policy objectives after the finalisation of the recovery process. From this perspective, proper asset management arguably lies at the heart of asset recovery policy. Asset recovery as a policy is concerned with the pursuit of two objectives, namely, combating crime and correcting the harm caused by crime. These objectives are encapsulated in two prominent principles: the principle that crime should not pay and the principle of corrective justice. Thus, asset management policy, as an element of asset recovery policy, needs to express these two principles and address their corresponding policy objectives. A number of challenges face the asset management institutions (AMIs) in the three designated states. They fall into two categories: policy challenges and legal challenges. The main policy challenge pertains to unbalanced or skewed policy objectives. Tanzania and Nigeria, in particular, give too much consideration to combating crime and too little to correcting the harm caused by crime to the community. These policy objectives need to be balanced by the states taking seriously the principle of corrective justice as fundamental to asset management policy. In this connection, compensation to victims, funding of institutions dealing with the victims of crime, funding of public good projects and funding of law enforcement agencies are available as ways of addressing the harm caused by the offence and showing commitment to ensuring that nobody suffers loss as a result of crime. Despite the existence and implementation of a proper asset management regime, certain factors affect the value of the preserved and recovered assets negatively. They include enforcement of certain rights in favour of the defendant, such as payment of legal, living and business expenses from the preserved assets, and certain asset recovery procedures, such as plea bargaining, non-conviction based asset recovery and administrative asset recovery. Proper legal controls are required in order to reduce the impact of such factors upon the value of preserved and recovered assets. The study concludes with a focus on the asset management regime of Tanzania. Various recommendations are offered towards the attainment of a Tanzanian regime structured in terms of balanced policy objectives. The recommendations cover three aspects: the general coverage of the law, the functioning of AMIs and the legal control of the factors that were identified as affecting the value of assets during the recovery process.

The Law of Insolvency in South Africa is regulated by the provisions of the Insolvency Act 24 of 1936, with foundations in our common law, which has been influenced by different legal systems from Western Europe. But currently there is also other legislation affecting the insolvent debtor and the property in the insolvent estate. The courts too have had to formulate rules to govern aspects of insolvency law in South Africa. These variables created problem areas in insolvency law and in respect of the of the policies upon which the insolvency system hinges. The predominant policy in South African insolvency is the collection of the maximum assets of the debtor for the advantage of creditors in insolvent estates. This strict creditor orientated approach created further problem areas in respect of assets in the insolvent estates of individual debtors. If advantage to creditors cannot be shown in an application for the sequestration of a debtor’s estate, a court will refuse to grant that order. This strict policy overshadows policy concerns in respect of assets in insolvent estates, and regarding exemption law in respect of those assets. This has resulted in insolvency law reformers in South Africa missing the bigger picture, namely, that South Africa is a creditor driven developing society. It is conceivable that in the transformed South Africa, and in the present world economic chaos, there will be an escalation of sequestrations of the estates of individual debtors. Bearing this in mind, a reformed insolvency law system must become more debtor friendly. A change in the philosophy is needed in favour of an exemption policy for insolvent estates. Exemption policy must be based on the interest of the debtor and his dependants, his dignity, creditor and third party interests, social welfare, and human rights imperatives within the South African constitutional framework. Exemption policy must be linked to the policy of a “fresh start” for the debtor. The different policies in insolvency however create a conflict of interest among the different stakeholders, particularly regarding the assets in insolvent estates, thereby creating problem areas. In this thesis several problem areas are identified and critically analysed. The position of property included in, and excluded from, individuals’ insolvent estates is investigated from a brief historical perspective, and in a brief comparative survey of the insolvency systems of the United Kingdom and the United States of America. Acute problem areas are critically analysed in detail, and the constitutional impact on property in insolvent estates is considered in a separate chapter. The South African Law Reform Commission’s review of South African insolvency law is critically analysed in a chapter of this thesis, concluding that the Commission’s review is inadequate. This thesis concludes that there is a need to reform the insolvency system in South Africa and proposes a way forward in respect of property included in, and property excluded or exempt from insolvent estates. This thesis states the law to the end of October 2008. / Thesis (LLD)--University of Pretoria, 2009. / Mercantile Law / unrestricted

1 Resumé This thesis deals with the topic of "Parties to contentious proceedings". The parties involved in the dispute represent the cornerstone of any civil proceedings. Without the parties, there would be no civil procedure at all. The parties, the courts and other subjects make up the basic elements of the civil proceedings. Which is also the reason why the definition of the parties have the significant impact on the entire civil procedure. The civil procedure can be defined as a body of law that sets out the procedure rules for courts, disputing parties and other subjects, while defence to breached or threatened subjective rights and lawful interests is provided. The thesis offers a scope into the historical consequences of the concept of parties to present form along with the development of civil procedure with its changes. Besides that there is description of subjects who are involved in the civil procedure. For better differentiating a proceedings of proceedings there are listed other types of civil proceedings. Especially the contentious and non-contentious proceedings. The introductory chapters for the parties address the issue of who can become a party to the proceedings and what the conditions are. The conditions include, in particular, the capacity to possess rights and duties and the capacity...

This study examines morally ambiguous characters in television dramas and they represent their respect brand. The goal of the study is to examine how these MACs define their respective brands, specifically the brands, AMC and Showtime. Recent studies observed people chose brands based on their affective disposition and social cognition towards specific influencers. These theories could inform how people relate to characters from TV shows and brands. An observation and narrative analysis of four characters promotional videos from AMC were Don Draper (Mad Men), Saul Goodman (Better Call Saul) and from Showtime Jackie Peyton (Nurse Jackie) and Dexter Morgan (Dexter). Interviews were conducted with 13 people about their views of the character's moral ambiguity and brand interest. Promo videos were observed along with videos of characters in their environment. Results found MACs defined their brand and their overall character arc appealed to the audience's interests in their brands.