<p>I Estland 2007 utbröt vad som kommit att kallas ”Cyberwar I”, vari ett stort antal centrala myndigheters, tillika finansiella institutioners servrar attackerades av massiva så kallade Computer Network Attacks (CNA), utfört av framförallt ryska aktörer. Estland protesterade högljutt, men frågan huruvida CNA är att beteckna som olovligt är allt annat än klar. Prövningen sker mot den folkrättsliga regimen <em>Jus ad Bellum, </em>och huruvida metoden uppfyller vissa centrala begrepp. Men hur skall denna regim<em> </em>appliceras CNA?</p><p>De frågeställningar som avses besvaras är: hur kan CNA utgöra <em>våld </em>eller <em>hot om våld</em> i enlighet med FN-stadgans artikel 2(4) samt hur kan CNA utgöra <em>väpnat angrepp</em> i enlighet med FN-stadgans artikel 51? Detta avses göras genom en studie inbegripande flertalet folkrättsliga experters teorier på området CNA och våldsanvändning, samt applicering av desamma på en fallstudie av händelserna i Estland 2007.</p><p>Sammanfattningsvis konstateras att flertalet variabler har bärighet i hur CNA kan uppfylla artiklarnas centrala begrepp, vari frågan om <em>association, effekt, aktör </em>och <em>mål</em> tydligast faller ut. I en efterföljande diskussion påvisas dock hur variablerna endast är att betrakta som indicier på hur CNA kan klassas så som olovligt, varvid endast statspraxis kan ge den slutgiltiga bedömningen.</p>

I Estland 2007 utbröt vad som kommit att kallas ”Cyberwar I”, vari ett stort antal centrala myndigheters, tillika finansiella institutioners servrar attackerades av massiva så kallade Computer Network Attacks (CNA), utfört av framförallt ryska aktörer. Estland protesterade högljutt, men frågan huruvida CNA är att beteckna som olovligt är allt annat än klar. Prövningen sker mot den folkrättsliga regimen Jus ad Bellum, och huruvida metoden uppfyller vissa centrala begrepp. Men hur skall denna regim appliceras CNA? De frågeställningar som avses besvaras är: hur kan CNA utgöra våld eller hot om våld i enlighet med FN-stadgans artikel 2(4) samt hur kan CNA utgöra väpnat angrepp i enlighet med FN-stadgans artikel 51? Detta avses göras genom en studie inbegripande flertalet folkrättsliga experters teorier på området CNA och våldsanvändning, samt applicering av desamma på en fallstudie av händelserna i Estland 2007. Sammanfattningsvis konstateras att flertalet variabler har bärighet i hur CNA kan uppfylla artiklarnas centrala begrepp, vari frågan om association, effekt, aktör och mål tydligast faller ut. I en efterföljande diskussion påvisas dock hur variablerna endast är att betrakta som indicier på hur CNA kan klassas så som olovligt, varvid endast statspraxis kan ge den slutgiltiga bedömningen.

I cambiamenti verificatisi nel sistema internazionale nel corso degli ultimi anni hanno avuto una profonda incidenza sul dibattito teorico circa l'uso della forza e i conflitti armati. In particolare, il cambiamento che si è avuto nel warfare ha portato a concentrare l'attenzione su due aspetti particolari della guerra, ovvero la sua giustificazione morale e la relazione tra uso della forza e diritto internazionale. Inoltre, rispetto al passato, la fase successiva ai conflitti assume una rilevanza sempre maggiore. Scopo di questo lavoro è, quindi, da un lato analizzare la teoria della guerra giusta in relazione al diritto internazionale e alle sfide poste dall'attuale sistema internazionale, evidenziandone gli elementi teorici più problematici e, dall'altro, delineare gli elementi normativi necessari per una teoria della pace giusta. Se, infatti, la tradizione teorica relativa a ius ad bellum e ius in bello è ben consolidata, i problemi teorici ed empirici che si pongono circa lo ius post bellum sono nuovi e ancora senza risposta. Il lavoro cerca quindi di formulare gli elementi normativi che dovrebbero regolare lo ius post bellum affinché vengano soddisfatti i requisiti di giustizia post-conflittuale Infine, alla luce degli elementi teorici emersi sono stati analizzati tre conflitti che ben si prestano a valutare empiricamente la teoria della guerra giusta, ovvero il primo conflitto in Iraq del 1991, l'intervento in Kosovo del 1999 e il secondo conflitto in Iraq del 2003. / The changes occurred in the international system during the last decade had a deep influence on the theoretical debate about use of force and armed conflicts. In particular, changes in warfare focused attention on two different aspects of war its moral justifiability and the relation between the use of force and international law. Furthermore, the post-conflict phase is becoming more and more important. The aim of this work is twofold: on one hand, to analyse the relationship between Just War Theory and international law and the challenges raising from the new international system, underlining the most problematic aspects from a theoretical point of view. On the other hand, the aim is to sketch some normative elements of Just Peace Theory. If jus ad bellum and jus in bello theories are well-established, there are many theoretical and empirical problems related to jus post bellum Consequently, this work tries to advance some normative elements required to regulate jus post bellum in order to satisfy requirements of post-conflict justice. Finally, in the light of the elements arisen in the theoretical part of the work, three conflicts particularly relevant for Just War Theory are taken into account: the 1991 war in Iraq, the 1999 intervention in Kosovo e and the 2003 conflict in Iraq.

No description available.

This dissertation offers a new understanding about wartime decision making in the face of likely, but unintended, harm to foreign civilians. It empirically identifies conditions under which leaders in democratic nations are more or less likely to choose to attack a target when confronted with a dilemma between pursuing national security objectives and avoiding civilian casualties. An innovative targeting decision model was constructed that described both the theorized structure of the decisions inputs and the process by which these inputs are assembled into a choice. The model went beyond the normal target benefit and civilian casualty cost considerations of proportionality to also include the contextual input of prospect frame. Decision makers were expected to address the same benefit and cost differently depending on whether they were winning or losing the conflict. This was because the prospect frame would influence their risk attitudes, as predicted by prospect theory. This model was then tested via two decision-making experiments that used military officers and defense civilians as participants. Additionally, a statistical analysis of data collected from an extended period of the second Intifada was done to seek evidence that the model also applied in actual wartime decision making. All three tests supported portions of the targeting decision model. Higher target benefit and lower civilian casualty estimates increased support for the planned attack. Prospect frame influenced decisions in the cases where both target value and the civilian casualty estimates were high and the resulting dilemma was very difficult. In these situations, those told that their forces were losing the conflict were less sensitive to humanitarian harm and more likely to support the attack than when they were told their side was winning. Furthermore, the Intifada data analysis of attacks approved by Israeli officials against Palestinians found this same effect of prospect frame held generally across all six years of observations.

Inspired by the visual allegory ("Conquista, embarcáronse a las Indias" fol. 73 of the Nueva corónica), Legnani contends that the development of the laws of peoples (jus gentium) by 16th century Spanish jurists should be analyzed within the corpus of commercial law (lex mercatoria) employed by sea merchants, bankers and mercenaries throughout the 15th and 16th centuries. This dissertation explores the movement from figure to fiction in discourses of capital and violence. / Romance Languages and Literatures

Paprotys - vienas reikšmingiausių ir seniausių teisės šaltinių. Kartu, nepaisant egzistuojančių priešingų nuomonių, tai vienas reikšmingiausių tarptautinės teisės šaltinių. Tarptautinį paprotį sudaro du elementai: 1. objektyvus - valstybių praktika, kuri turi atitikti bendrumo, vieningumo, nuoseklumo, trukmės reikalavimus; 2. subjektyvus - atitinkamos praktikos pripažinimas teisiškai privaloma. Abu minėti elementai yra reikšmingi ir būtini paprotinės normos susiformavimui. Kartu tarptautinis paprotys yra glaudžiai susijęs su "pastovaus prieštarautojo", "greito" papročio bei jus cogens normų doktrinomis. Pažymėtina, jog, nepaisant egzistuojančių kodifikavimo tendencijų, tarptautinis paprotys išlieka reikšmingu tarptautinės teisės šaltiniu. / Custom is one of the oldest and widely recognized legal sources. In addition, despite existing different approaches, custom is considered to be one of the most significant legal sources of international law. International custom consists of two elements: 1. objective - state practice, which must also fulfill the requirements of consistency, repetition, duration and generality; 2. subjective - the recognition of certain practice as legally binding. Both above mentioned elements are of significant importance in the formation of customary rule. International custom is also closely related to the doctrines of "persistent objector", "instant" custom and jus cogens norms. Finally, it must be noticed that, despite the existing codification tendencies, international custom still remains a very important source of international law.

Le bleuet démontre un potentiel thérapeutique dans le traitement du cancer et des maladies cardiovasculaires et neurodégénératives. Ces effets bénéfiques sont attribuables aux composés phénoliques abondants dans le bleuet, tels que les anthocyanines et les flavonoïdes. La biotransformation du jus de bleuet avec les bactéries Serratia vaccinii augmente sa teneur en composés phénoliques et son activité anti-oxydante, et modifie ses activités physiologiques. L’objectif de la présente étude est d’évaluer l’activité neuroprotectrice et le potentiel antidiabétique du jus de bleuet biostranformé (BJ). Le BJ est étudié dans différents tests dont : 1) La protection des neurones (N2a) contre le stress oxydatif (SO) induit par le peroxyde d’hydrogène; 2) La stimulation de la prise de glucose par les cellules musculaires (C2C12) et adipeuses (3T3-L1); 3) L’activité anti-hyperglycémique chez les souris obèses diabétiques KKAy. En effet, tandis que le jus de bleuet normal n’a aucun effet, le BJ augmente l’activité des enzymes anti-oxydantes, comme la catalase et la SOD (Superoxide Dimutase) et protège les neurones contre les changements de la signalisation des MAPKs et contre la toxicité induite par le peroxyde d’hydrogène. Le BJ augmente aussi la prise de glucose de 48% dans les cellules C2C12 et de 142% dans les cellules 3T3-L1. Cette augmentation n’est pas expliquée par une augmentation du calcium cytosolique mais plutôt par une stimulation de la phosphorylation de l’AMPK. De plus, le BJ inhibe l’adipogenèse chez les 3T3-L1. Le BJ diminue également l’hyperglycémie chez les souris obèses diabétiques KKAy et protège les jeunes souris pré-diabétiques contre le développement de l’obésité et du diabète. L’activité anti-hyperglycémique du BJ pourrait impliquer les adipokines puisque le BJ augmente le niveau d’adiponectine chez les souris diabétiques. Le BJ représente ainsi une approche prometteuse pour le traitement du diabète et les maladies neurodégénératives et une source de nouveaux agents thérapeutiques contre ces maladies. / Blueberry demonstrates therapeutic potential against cancer, cardiovascular and neurodegenerative diseases. These desirable effects are thought to involve abundant phenolic compounds in blueberry such as anthocyanins and flavonoids. Blueberry juice biotransformation by Serratia vaccinii bacteria increases its phenolics content, its antioxidant activity and modifies its physiological properties. The purpose of the present study was to evaluate the neuroprotection activity and the antidiabetic potential of biostranformed blueberry juice (BJ). BJ was studied for: 1) Protection of neurons (N2a) against oxidative stress caused by hydrogen peroxide; 2) Stimulation of glucose uptake by muscle cells (C2C12) and adipocytes (3T3-L1); 3) Anti-hyperglycemic activity in diabetic obese KKAy mice. Indeed, whereas normal blueberry juice did not show any effect, BJ increased antioxidant enzymes activities (catalase, SOD) and protected neurons against modifications in MAPKs pathways and toxicity induced by hydrogen peroxide. BJ also increased glucose uptake by 48% in C2C12 cells and by 142% in 3T3-L1 cells. Enhanced glucose uptake could not be explained by an increase of cytosolic calcium but was related to the stimulation of AMPK phosphorylation. Moreover, BJ inhibited 3T3-L1 adiopogenesis. BJ also reduced hyperglycemia of obese diabetic KKAy mice and protected pre-diabetic young mice against the development of obesity and diabetes mellitus. The anti-hyperglycemic effect of BJ may involve adipokine pathways since BJ increased adiponectin levels in diabetic mice. Thus, BJ represents a promising approach for the prevention and treatment of diabetes mellitus and possibly neurogenerative diseases as well as a source of novel therapeutic agents against these disorders.

No description available.

Compte tenu de l'importance des pigments naturels dans les aliments et leur sensibilité aux traitements thermiques, les cinétiques de dégradation des anthocyanes ont été étudiées à très hautes températures (100 à 180 ºC). Pour obtenir une base de données expérimentale fiable dissociant les transferts d'énergie et de matière, un mini-réacteur étanche a été utilisé pour le traitement d'une matrice modèle (jus de mûre et sable) en faisant varier la température et l'activité de l'eau (0,20<aw<0,99). L'hypothèse d'une réaction d'ordre 1 pour la dégradation des anthocyanes a permis de modéliser et de déterminer les paramètres cinétiques suivant une méthode non-isotherme prenant en compte à la fois le profil de température et indépendamment l'homogénéité ou l'hétérogénéité du champs de température au sein de la matrice. Il a été démontré que les constantes de réaction sont très influencées par la diminution de l'activité de l'eau, facteur qui fait augmenter la réactivité. Ces résultats originaux ont été validés sur une matrice alimentaire (papaye verte-jus de mûre) soumise au couplage d'un procédé de formulation par déshydratation par immersion-imprégnation, suivi d'une opération de friture, à l'aide d'un modèle qui intègre les transferts de vapeur et d'énergie et la cinétique réactionnelle. Le modèle permet une meilleure compréhension des phénomènes et il peut être intégré dans une démarche d'optimisation séquentielle associant différentes opérations unitaires avec des traitements thermiques à très hautes températures. / Given the importance of natural pigments in foods and their sensitivity to heat treatment, degradation kinetics of anthocyanins have been studied at very high temperatures (100 to 180 ºC). For a reliable experimental database that dissociates heat and mass transfer, a hermetic mini-reactor was used for the treatment of a model matrix (blackberry juice and sand) by varying the temperature and activity water (0.20<aw<0.99). The assumption of a first order reaction for the anthocyanins degradation was used to model and determine the kinetic parameters using a non-isothermal method taking into account both the temperature profile and independently the homogeneity or heterogeneity of the matrix temperature field. It has been shown that the rate constants are strongly influenced by the water activity reduction, a factor that increases the anthocyanins reactivity. These original results were validated on a food matrix (green papaya-blackberry juice) submitted to the coupling of a formulation process by osmotic dehydration, followed by a deep-fat frying operation, using a model which includes the vapor and heat transfer and the reaction kinetics. The model allows a better understanding of the phenomena and can be integrated into a sequential optimization approach combining different unit operations with heat treatments at high temperatures.