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The indigenous ontology has been differentiated from the western one by having a close relationship between humans and non-humans, and by not exerting human supremacy against the rest of the living beings. Nevertheless, throughout the periods of colonization and western influence to which they have been subjected, the notion of human supremacy and the fracture between humans and all beings have been reinforced. These relationships have been altered, perhaps forgotten, due to the aspiration to follow economic models of progress based on extractive activities such as mining that not only affects their territories but also the loss of their culture and identity causing serious socio-environmental problems.  In order to deepen these relationships, raise awareness and understanding the changes that vulnerable populations have to face in a dominant system, this work studies the Harakbut indigenous community of Puerto Luz, in the Madre de Dios region of Peru, and relates a design field in the form of journey which involves research and analysis with stages of knowing and non-knowing from the social science and humanities perspective. Through the anthropological framework, the indigenous and western ontological postulates are understood allowing the development of a creative writing and the correspondence between an interaction of ethnography with the production of new knowledge realities that allow for the verification of the changes this indigenous society, influenced by western dominant power, experiences. This somewhat decolonizing design process gives on to the understanding of new knowledge and challenges that address realities outside Western spheres to generate awareness and change.

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. Nowadays the fibrillatory process is known to be provoked by the high-frequency reentrant activity of certain atrial regions that propagates the fibrillatory activity to the rest of the atrial tissue, and the electrical isolation of these key regions has demonstrated its effectiveness in terminating the fibrillatory process. The location of the dominant regions represents a major challenge in the diagnosis and treatment of this arrhythmia. With the aim to detect and locate the fibrillatory sources prior to surgical procedure, non-invasive methods have been developed such as body surface electrical mapping (BSPM) which allows to record with high spatial resolution the electrical activity on the torso surface or the electrocardiographic imaging (ECGI) which allows to non-invasively reconstruct the electrical activity in the atrial surface. Given the novelty of these systems, both technologies suffer from a lack of scientific knowledge about the physical and technical mechanisms that support their operation. Therefore, the aim of this thesis is to increase that knowledge, as well as studying the effectiveness of these technologies for the localization of dominant regions in patients with AF. First, it has been shown that BSPM systems are able to noninvasively identify atrial rotors by recognizing surface rotors after band-pass filtering. Furthermore, the position of such surface rotors is related to the atrial rotor location, allowing the distinction between left or right atrial rotors. Moreover, it has been found that the surface electrical maps in AF suffer a spatial smoothing effect by the torso conductor volume, so the surface electrical activity can be studied with a relatively small number of electrodes. Specifically, it has been seen that 12 uniformly distributed electrodes are sufficient for the correct identification of atrial dominant frequencies, while at least 32 leads are needed for non-invasive identification of atrial rotors. Secondly, the effect of narrowband filtering on the effectiveness of the location of reentrant patterns was studied. It has been found that this procedure allows isolating the reentrant electrical activity caused by the rotor, increasing the detection rate for both invasive and surface maps. However, the spatial smoothing caused by the regularization of the ECGI added to the temporal filtering causes a large increase in the spurious reentrant activity, making it difficult to detect real reentrant patterns. However, it has been found that maps provided by the ECGI without temporal filtering allow the correct detection of reentrant activity, so narrowband filtering should be applied for intracavitary or surface signal only. Finally, we studied the stability of the markers used to detect dominant regions in ECGI, such as frequency maps or the rotor presence. It has been found that in the presence of alterations in the conditions of the inverse problem, such as electrical or geometrical noise, these markers are significantly more stable than the ECGI signal morphology from which they are extracted. In addition, a new methodology for error reduction in the atrial spatial location based on the curvature of the curve L has been proposed. The results presented in this thesis showed that BSPM and ECGI systems allows to non-invasively locate the presence of high-frequency rotors, responsible for the maintenance of AF. This detection has been proven to be unambiguous and robust, and the physical and technical mechanisms that support this behavior have been studied. These results indicate that both non-invasive systems provide information of great clinical value in the treatment of AF, so their use can be helpful for selecting and planning atrial ablation procedures. / La fibrilación auricular (FA) es una de las arritmias cardiacas más frecuentes. Hoy en día se sabe que el proceso fibrilatorio está provocado por la actividad reentrante a alta frecuencia de ciertas regiones auriculares que propagan la actividad fibrilatoria en el resto del tejido auricular, y se ha demostrado que el aislamiento eléctrico de estas regiones dominantes permite detener el proceso fibrilatorio. La localización de las regiones dominantes supone un gran reto en el diagnóstico y tratamiento de la FA. Con el objetivo de poder localizar las fuentes fibrilatorias con anterioridad al procedimiento quirúrgico, se han desarrollado métodos no invasivos como la cartografía eléctrica de superficie (CES) que registra con gran resolución espacial la actividad eléctrica en la superficie del torso o la electrocardiografía por imagen (ECGI) que permite reconstruir la actividad eléctrica en la superficie auricular. Dada la novedad de estos sistemas, existe una falta de conocimiento científico sobre los mecanismos físicos y técnicos que sustentan su funcionamiento. Por lo tanto, el objetivo de esta tesis es aumentar dicho conocimiento, así como estudiar la eficacia de ambas tecnologías para la localización de regiones dominantes en pacientes con FA. En primer lugar, ha visto que los sistemas CES permiten identificar rotores auriculares mediante el reconocimiento de rotores superficiales tras el filtrado en banda estrecha. Además, la posición de los rotores superficiales está relacionada con la localización de dichos rotores, permitiendo la distinción entre rotores de aurícula derecha o izquierda. Por otra parte, se ha visto que los mapas eléctricos superficiales durante FA sufren una gran suavizado espacial por el efecto del volumen conductor del torso, lo que permite que la actividad eléctrica superficial pueda ser estudiada con un número relativamente reducido de electrodos. Concretamente, se ha visto que 12 electrodos uniformemente distribuidos son suficientes para una correcta identificación de frecuencias dominantes, mientras que son necesarios al menos 32 para una correcta identificación de rotores auriculares. Por otra parte, también se ha estudiado el efecto del filtrado en banda estrecha sobre la eficacia de la localización de patrones reentrantes. Así, se ha visto que este procedimiento permite aislar la actividad eléctrica reentrante provocada por el rotor, aumentando la tasa de detección tanto para señal obtenida de manera invasiva como para los mapas superficiales. No obstante, este filtrado temporal sobre la señal de ECGI provoca un gran aumento de la actividad reentrante espúrea que dificulta la detección de patrones reentrantes reales. Sin embargo, los mapas ECGI sin filtrado temporal permiten la detección correcta de la actividad reentrante, por lo el filtrado debería ser aplicado únicamente para señal intracavitaria o superficial. Por último, se ha estudiado la estabilidad de los marcadores utilizados en ECGI para detectar regiones dominantes, como son los mapas de frecuencia o la presencia de rotores. Se ha visto que en presencia de alteraciones en las condiciones del problema inverso, como ruido eléctrico o geométrico, estos marcadores son significativamente más estables que la morfología de la propia señal ECGI. Además, se ha propuesto una nueva metodología para la reducción del error en la localización espacial de la aurícula basado en la curvatura de la curva L. Los resultados presentados en esta tesis revelan que los sistemas de CES y ECGI permiten localizar de manera no invasiva la presencia de rotores de alta frecuencia. Esta detección es univoca y robusta, y se han estudiado los mecanismos físicos y técnicos que sustentan dicho comportamiento. Estos resultados indican que ambos sistemas no invasivos proporcionan información de gran valor clínico en el tratamiento de la FA, por lo que su uso puede ser de gran ayuda para la selección y planificaci / La fibril·lació auricular (FA) és una de les arítmies cardíaques més freqüents. Hui en dia es sabut que el procés fibrilatori està provocat per l'activitat reentrant de certes regions auriculars que propaguen l'activitat fibril·latoria a la resta del teixit auricular, i s'ha demostrat que l'aïllament elèctric d'aquestes regions dominants permet aturar el procés fibrilatori. La localització de les regions dominants suposa un gran repte en el diagnòstic i tractament d'aquesta arítmia. Amb l'objectiu de poder localitzar fonts fibril·latories amb anterioritat al procediment quirúrgic s'han desenvolupat mètodes no invasius com la cartografia elèctrica de superfície (CES) que registra amb gran resolució espacial l'activitat elèctrica en la superfície del tors o l'electrocardiografia per imatge (ECGI) que permet obtenir de manera no invasiva l'activitat elèctrica en la superfície auricular. Donada la relativa novetat d'aquests sistemes, existeix una manca de coneixement científic sobre els mecanismes físics i tècnics que sustenten el seu funcionament. Per tant, l'objectiu d'aquesta tesi és augmentar aquest coneixement, així com estudiar l'eficàcia d'aquestes tecnologies per a la localització de regions dominants en pacients amb FA. En primer lloc, s'ha vist que els sistemes CES permeten identificar rotors auriculars mitjançant el reconeixement de rotors superficials després del filtrat en banda estreta. A més, la posició dels rotors superficials està relacionada amb la localització d'aquests rotors, permetent la distinció entre rotors de aurícula dreta o esquerra. També s'ha vist que els mapes elèctrics superficials durant FA pateixen un gran suavitzat espacial per l'efecte del volum conductor del tors, el que permet que l'activitat elèctrica superficial pugui ser estudiada amb un nombre relativament reduït d'elèctrodes. Concretament, s'ha vist que 12 elèctrodes uniformement distribuïts són suficients per a una correcta identificació de freqüències dominants auriculars, mentre que són necessaris almenys 32 per a una correcta identificació de rotors auriculars. D'altra banda, també s'ha estudiat l'efecte del filtrat en banda estreta sobre l'eficàcia de la localització de patrons reentrants. Així, s'ha vist que aquest procediment permet aïllar l'activitat elèctrica reentrant provocada pel rotor, augmentant la taxa de detecció tant pel senyal obtingut de manera invasiva com per als mapes superficials. No obstant això, aquest filtrat temporal sobre el senyal de ECGI provoca un gran augment de l'activitat reentrant espúria que dificulta la detecció de patrons reentrants reals. A més, els mapes proporcionats per la ECGI sense filtrat temporal permeten la detecció correcta de l'activitat reentrant, per la qual cosa el filtrat hauria de ser aplicat únicament per a senyal intracavitària o superficial. Per últim, s'ha estudiat l'estabilitat dels marcadors utilitzats en ECGI per a detectar regions auriculars dominants, com són els mapes de freqüència o la presència de rotors. S'ha vist que en presència d'alteracions en les condicions del problema invers, com soroll elèctric o geomètric, aquests marcadors són significativament més estables que la morfologia del mateix senyal ECGI. A més, s'ha proposat una nova metodologia per a la reducció de l'error en la localització espacial de l'aurícula basat en la curvatura de la corba L. Els resultats presentats en aquesta tesi revelen que els sistemes de CES i ECGI permeten localitzar de manera no invasiva la presència de rotors d'alta freqüència. Aquesta detecció és unívoca i robusta, i s'han estudiat els mecanismes físics i tècnics que sustenten aquest comportament. Aquests resultats indiquen que els dos sistemes no invasius proporcionen informació de gran valor clínic en el tractament de la FA, pel que el seu ús pot ser de gran ajuda per a la selecció i planificació de procediments d'ablació auricular. / Rodrigo Bort, M. (2016). Non-invasive identification of atrial fibrillation drivers [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/75346 / Premios Extraordinarios de tesis doctorales

京都大学 / 新制・論文博士 / 博士(医学) / 乙第13631号 / 論医博第2322号 / 新制||医||1074(附属図書館) / (主査)教授 伊藤 能永, 教授 森信 暁雄, 教授 上野 英樹 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

The main aspiration behind the contributions of this research work is the achievement of simultaneuos delay-efficiency, autonomy, and security through innovative protocol design to address complex real-life problems. To achieve this, we take a holistic approach. We apply theoretical mathematical modeling implementing implications of social-economic behavioral characteristics to propose a cross-layer network security protocol. We further complement this approach by a layer-specific focus with implementations at two lower OSI layers. For the cross-layer design, we suggest the use of game and mechanism design theories. We design a network-wide consumer-centric and delay-efficient security protocol, DSIC-S. It induces a Dominant Strategy Incentive Compatible equilibrium among all rational and selfish nodes. We prove it is network-wide socially desirable and Pareto optimal. We address resource management and delay-efficiency through synergy of several design aspects. We propose a scenario-based security model with different levels. Furthermore, we design a valuation system to integrate the caused delay in selection of security algorithms at each node without consumer's knowledge of the actual delays. We achieve this by incorporating the consumer's valuation system, in the calculation of the credit transfers through the Vickrey-Clarke-Groves (VCG) payments with Clarke's pivotal rule. As the utmost significant contribution of this work, we solve the revelation theorem's problem of misrepresentation of agents' private information in mechanism design theory through the proposed design. We design an incentive model and incorporate the valuations in the incentives. The simulations validate the theoretical results. They prove the significance of this model and among others show the correlation of the credit transfers to actual delays and security valuations. In the layer-specific approach for the network-layer, we implement the DSIC-S protocol to extend current IPsec and IKEv2 protocols. IPsec-O and IKEv2-O inherit the strong properties of DSIC-S through the proposed extensions. Furthermore, we propose yet another layer-specific protocol, the SME_Q, for the datalink layer based on ATM. We develop an extensive simulation software, SMEQSIM, to simulate ATM security negotiations. We simulate the proposed protocol in a comprehensive real-life ATM network and prove the significance of this research work. / Ph. D.

Die Dissertation von Lars Mackel befasst sich mit der Gestaltung Service-Dominanter Geschäftsmodelle in der Frühphase von Startups. Untersucht wird, welche Veränderungen Startup-Unternehmer an ihren Geschäftsmodellen vornehmen und welche Faktoren diese beeinflussen. Als Bezugsrahmen dient die Service-Dominant Logic (SD-Logic) von Vargo & Lusch, die den Fokus auf Service als generische Form des Austauschs und den Cocreation-Prozess der Akteure legt. Nach einer Einführung in die Grundlagen des Entrepreneurship und der verschiedenen Definitionen und Elemente von Geschäftsmodellen, wird die SD-Logic erläutert. Es wird gezeigt, wie Geschäftsmodelle als Basis für die Beziehungen zwischen Akteuren dienen, die gemeinsam Wert schaffen. Die Dissertation verwendet einen qualitativen Forschungsansatz, um die Anpassungen von Geschäftsmodellen in der Frühphase und insbesondere in der Erprobungsphase eines Startups zu untersuchen. Die empirischen Ergebnisse zeigen, dass die Cocreation-Prozesse mit den ersten Kunden nicht nur entscheidend für die Weiterentwicklung der Geschäftsmodelle sind, sondern darüber hinaus die Ausrichtung des Designs der jeweiligen Geschäftsmodelle an der SD-Logic dazu beiträgt, dass die betrachteten Startups besser gerüstet sind, die Erprobungsphase und das sogenannte ‚Valley of Death‘ zu überstehen. Die Arbeit schließt mit Empfehlungen für die Praxis und einem Ausblick auf zukünftige Forschungsfelder.:1 Einleitung 2 Grundlagen im Kontext Entrepreneurship 3 Entwicklung von Geschäftsmodellen 4 Geschäftsmodelle im Kontext der Service-Dominant Logic 5 Entwicklung des Untersuchungsrahmens und methodisches Vorgehen 6 Ergebnisse der empirischen Untersuchung 7 Schlussbetrachtungen

his dissertation advocates that value and its creation are often misunderstood concepts since both lack robust comprehensive conceptual foundations from which to advance rigorous theoretical development and analysis. Furthermore, this dissertation characterized value as the subjective assessment of the total worth of benefits received for the price paid or costs, i.e. money, time, energy, etc. The purpose of this dissertation was to conduct a holistic examination of value through the lens of service-dominant logic (S-D) and several historical economic periods of thought. I conducted a comprehensive S-D literature review in conjunction with a conceptual Boardman Soft Systems Methodology to develop a systemigram that captured the most critical S-D concepts and interrelationships to clarify its purpose and future research opportunities. During this process, value was recategorized and simplified into five primary dimensions, i.e. nature, perspectives, measures, storage, and creation. I employed Maslow's hierarchy of needs theory to illustrate that value at the lowest level of abstraction is the efficient satisfaction of human needs. I also investigated value creation and introduced a comprehensive value creation conceptual framework. Value creation is seen as a continuum of activity of key processes, i.e. value co-production, value in exchange, and value co-creation, and key procedural elements, i.e. actors, resource integration, ecosystems, services exchange, institutions and institutional arrangements as essentials to value creation. In addition, this dissertation also presented a Leyden value concept to the S-D lexicon. This concept complements use-value to capture associate upstream co-production activities and efforts as stored potential value. This dissertation then employed this conceptual framework to perform two survey based empirical studies. The first tested Lusch et al. (2007) value-co-production framework and incorporated other constructs such as transaction cost, satisfaction, and future purchase intent into a single testable model. This study leveraged covariance based structural equation modeling with 477 respondents to simultaneously test the proposed model and advance Self Determination Theory and Transaction Cost Economics within the realm of value creation and S-D Logic. This research found that most of Lusch et al. (2007) hypotheses were supported and found statistical support for the inclusion of transaction cost as a construct that influences value-co-production. In addition, this study illustrated that value-co-production has a positive statistical association with satisfaction and its impact on consumer future purchase intent. Managerial, this study highlighted those customer characteristics and behaviors necessary to maximize value generation during co-production opportunities. Finally, this dissertation empirically investigated the importance of benefits and equivalent cost reductions to entice consumer purchase intention across two different products and services scenarios. In total, this research gathered over 2,500 observations through a series of eight between subject survey experiments. This research found that consumers choose benefits such as warranty enhancements for new vehicle purchases and complementary desserts for dining experiences to enhance purchase intention. In addition, this research often revealed that consumers significantly decrease purchase intention when offered small value enhancements, i.e. 1% price reductions. This research also discovered that narcissism is negatively associated with those consumers who chose a donation to social causes. Finally, enhanced value offerings for expensive vacations, either through benefit enhancements or cost reductions, fail to significantly impact consumer purchase intention. The results of this research advance rational choice theory into the realm of value creation and S-D. Managerially, this research found that benefits, whether singular or offered as a menu, are powerful tools for retailers to employ to enhance consumer purchase intention.

Text in English / This exploratory study creates a post-modern narrative context for psychotherapy and extends these ideas to an individual living with a psychiatric disorder, namely obsessive-compulsive disorder. The present study explores OCD through the ecosystemic perspective and aims to obtain a holistic understanding of an individual's experience of living with OCD and to describe the recursive connections between OCD and the individual's ecological context. This investigation includes the re-authoring therapy of Michael White and David Epston and the application of their ideas to the individual's life story. A qualitative method within the naturalistic paradigm is employed focussing on the unique experience of the individual, which allows for an understanding of the individual's personal meaning. The dominant narratives, that emerged from the individual's life story, were deconstructed. Significant shifts in attribution of meaning took place. / Psychology / M.A.(Clinical Psychology)