Childhood maltreatment increases risk for Posttraumatic Stress Disorder (PTSD). Maladaptive patterns of attention to threat-related stimuli warrant examination as possible contributing risk factors. It remains unclear whether persistent threat-processing biases are differentially apparent in adults who were maltreated as children and either did, or did not, develop later PTSD. The present study examined associations among attention bias, childhood maltreatment, and PTSD in adults. We hypothesized that attentional bias toward threat significantly mediates associations between childhood maltreatment and adult PTSD symptoms. 183 adults with and without childhood maltreatment histories participated in this study, which involved completion of a range of clinical measures; attention bias was measured by the Dot Probe task. We found that attention bias toward happy faces partially mediated the relationship between childhood maltreatment and PTSD avoidance and numbing symptoms. Childhood maltreatment, happy face attention bias, and perceived racially discriminative experiences all accounted for significant variance in PTSD symptoms.

Childhood maltreatment increases risk for Posttraumatic Stress Disorder (PTSD). Maladaptive patterns of attention to threat-related stimuli warrant examination as possible contributing risk factors. It remains unclear whether persistent threat-processing biases are differentially apparent in adults who were maltreated as children and either did, or did not, develop later PTSD. The present study examined associations among attention bias, childhood maltreatment, and PTSD in adults. We hypothesized that attentional bias toward threat significantly mediates associations between childhood maltreatment and adult PTSD symptoms. 183 adults with and without childhood maltreatment histories participated in this study, which involved completion of a range of clinical measures; attention bias was measured by the Dot Probe task. We found that attention bias toward happy faces partially mediated the relationship between childhood maltreatment and PTSD avoidance and numbing symptoms. Childhood maltreatment, happy face attention bias, and perceived racially discriminative experiences all accounted for significant variance in PTSD symptoms.

Tabagistas atendem seletivamente a estímulos ambientais relacionados ao cigarro, um processo cognitivo implícito denominado viés na atenção (VA). Contudo, não está claro se o VA persiste em ex-fumantes. Por isso, avaliou-se a influência do tempo de abstinência no VA em 62 ex-fumantes (de 50±11 anos) através de uma tarefa de atenção visual em computador. Independente do tempo de abstinência, os participantes evitaram as pistas associadas ao tabaco. Esta esquiva foi mais pronunciada em tempos de exposição maiores. Os ex-fumantes também atribuíram pouca valência emocional às imagens associadas ao cigarro e reportaram índices baixos de fissura antes e após a tarefa. O VA negativo e a menor valência emocional destas pistas podem constituir um processo de modulação da atenção típico da abstinência prolongada, no qual estratégias cognitivas são empregadas para manter este estado. Os resultados obtidos contribuem para a compreensão da cognição implícita na adição e sua importância no tratamento e prevenção do tabagismo. / Smokers selectively attend to smoking-related cues, an implicit cognitive process called attentional bias (AB). However, it is unclear whether former smokers present AB. Therefore, we evaluated the influence of abstinence time in VA in 62 exsmokers (50 ± 11 years-old) through a visual probe task. Participants avoided smoking cues despite of abstinence time. This avoidance was more pronounced in longer stimuli exposition. Former smokers also attributed little emotional valence to smoking cues and reported low craving rates both before and after the task. The negative AB and low emotional valence of smoking cues might constitute a process of attentional modulation typical of longer abstinence, in which cognitive strategies are employed to maintain this state. The results contribute to the understanding of implicit cognition in addiction and its importance to smoking treatment and prevention.

Tabagistas atendem seletivamente a estímulos ambientais relacionados ao cigarro, um processo cognitivo implícito denominado viés na atenção (VA). Contudo, não está claro se o VA persiste em ex-fumantes. Por isso, avaliou-se a influência do tempo de abstinência no VA em 62 ex-fumantes (de 50±11 anos) através de uma tarefa de atenção visual em computador. Independente do tempo de abstinência, os participantes evitaram as pistas associadas ao tabaco. Esta esquiva foi mais pronunciada em tempos de exposição maiores. Os ex-fumantes também atribuíram pouca valência emocional às imagens associadas ao cigarro e reportaram índices baixos de fissura antes e após a tarefa. O VA negativo e a menor valência emocional destas pistas podem constituir um processo de modulação da atenção típico da abstinência prolongada, no qual estratégias cognitivas são empregadas para manter este estado. Os resultados obtidos contribuem para a compreensão da cognição implícita na adição e sua importância no tratamento e prevenção do tabagismo. / Smokers selectively attend to smoking-related cues, an implicit cognitive process called attentional bias (AB). However, it is unclear whether former smokers present AB. Therefore, we evaluated the influence of abstinence time in VA in 62 exsmokers (50 ± 11 years-old) through a visual probe task. Participants avoided smoking cues despite of abstinence time. This avoidance was more pronounced in longer stimuli exposition. Former smokers also attributed little emotional valence to smoking cues and reported low craving rates both before and after the task. The negative AB and low emotional valence of smoking cues might constitute a process of attentional modulation typical of longer abstinence, in which cognitive strategies are employed to maintain this state. The results contribute to the understanding of implicit cognition in addiction and its importance to smoking treatment and prevention.

Previous studies completed with humans have revealed insight into the effects of anxiety on attention tasks such the dot-probe task, but there is little information about such effects on non-human primates. This study aimed to assess whether anxiety or anxious behaviors would impact rhesus macaque performance on a three stimuli paradigm similar to the dot-probe task. Utilizing images of conspecifics (strong threat, mild threat, and neutral), eight monkeys were video recorded completing a task that required them to slide two doors, which held these images, to the side to obtain a treat. We hypothesized that behavioral phenotype (high or low anxiety) would affect attention on this modified dot-probe task. Additionally, we predicted that time spent looking at mildly threatening stimuli would be positively correlated with high levels of anxious behaviors (e.g., scratching, yawning, pacing, self-biting) and cortisol concentrations over a four month period. We also predicted that a higher percentage of the mildly threating stimuli as a first choice would be positively correlated with high levels of anxious behaviors and cortisol concentrations. However, anxious behaviors and cortisol concentrations did not affect performance on this task. Interestingly, a sex difference was found for the mild threat stimuli, with females taking significantly more time to complete the task when presented with the mild stimuli (p = 0.01), and also looking at the mild stimuli longer than males (p = 0.03). These data suggest that males and females interpret ambiguous facial expressions differently, possibly indicating the significance of attention in female dominance hierarchies in macaque social groups.

付記する学位プログラム名: 霊長類学・ワイルドライフサイエンス・リーディング大学院 / 京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第22034号 / 理博第4538号 / 新制||理||1652(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 友永 雅己, 准教授 宮地 重弘, 教授 濱田 穣 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

<p>The aim of this research study was to examine the clinical, behavioural and neurobiological characteristics of children who are considered to be at increased risk for developing anxiety disorders. The study population included high-risk children who have at least one parent with social phobia and normal-risk control subjects. The first objective of the study was to examine the prevalence of anxiety disorders in high-risk children. We determined the proportion of high-risk children who met criteria for a psychiatric disorder using structured clinical interviews and assessed symptom severity using measures of anxiety and depression. We found the prevalence of anxiety disorders to be elevated in high-risk children with 77% meeting criteria for a lifetime psychiatric disorder. High-risk subjects also had significantly higher levels of anxiety symptoms relative to normal-risk subjects. The second objective of the study was to examine threat-related attention processing in high-risk and normal-risk children using the dot-probe attention orienting task. We compared probe detection reaction times of high-risk children and normal-risk control children when they were exposed to emotional facial stimuli. We did not find any significant within-group or between-group differences in reaction times in our high-risk and normal-risk subjects. However, we did observe a trend towards longer reaction times in high-risk subjects for all trial types relative to normal-risk subjects, which could indicate general processing deficits in the high-risk group. The third objective of this study was to examine the activity of emotion processing brain regions using functional magnetic resonance imaging (<em>f</em>MRI) in children who are at increased risk for developing anxiety disorders. We compared the blood oxygenation level dependant (BOLD) response while high-risk and normal-risk subjects were engaged in the dot probe attention orienting task. Using <em>f</em>MRI, the BOLD response was measured while subjects were exposed to masked emotional (angry, happy or neutral) facial stimuli. We found increased activation of several frontal, temporal and limbic regions in high-risk subjects relative to normal-risk subjects during the presentation of emotional facial stimuli. These regions included the prefrontal cortex, anterior cingulate, hippocampus, insula, basal ganglia and temporal regions. To our knowledge this is the first study to characterize a sample of children at-risk for anxiety disorders using clinical, behavioural and neuroimaging data. The findings from this study demonstrate that high-risk children experience heightened anxiety symptoms and that they also present with functional abnormalities of brain regions involved in emotion processing. These results highlight the need for early identification and intervention for children at-risk for anxiety disorders. Future studies should aim for longitudinal study designs combined with neuroimaging techniques to examine changes in anxiety symptoms over time and to study the effects of treatment on the function of limbic and prefrontal structures in children at-risk for anxiety disorders.</p> / Doctor of Philosophy (PhD)

Cognitive theories postulate that attention toward threatening information and away from neutral cues plays an etiological role in anxiety. The present study examines whether a preconscious attentional bias (AB) toward threatening stimuli exists in individuals with public speaking anxiety. Participants included 61 undergraduates with high and low speech anxiety. AB was measured using a dot-probe paradigm with threatening and neutral words. Reaction times to dot-probes on threatening and neutral trials were compared between the two groups. Results indicated that, contrary to expectations, high and low speech anxious participants did not differ in their mean reaction times to threat words. Thus, AB may not be measurable in individuals with public speaking anxiety using the method that the current study employed. / Master of Science

Submitted by PPG Psicologia (psicologia-pg@pucrs.br) on 2018-05-17T22:24:00Z No. of bitstreams: 1 GUSTAVO_RAMOS_SILVA_DIS.pdf: 5111917 bytes, checksum: f33b0b4365f06eb2178942b893f56de5 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-05-30T18:09:15Z (GMT) No. of bitstreams: 1 GUSTAVO_RAMOS_SILVA_DIS.pdf: 5111917 bytes, checksum: f33b0b4365f06eb2178942b893f56de5 (MD5) / Made available in DSpace on 2018-05-30T18:14:39Z (GMT). No. of bitstreams: 1 GUSTAVO_RAMOS_SILVA_DIS.pdf: 5111917 bytes, checksum: f33b0b4365f06eb2178942b893f56de5 (MD5) Previous issue date: 2018-03-08 / A aten??o ? um construto multifacetado, que esteve historicamente por diversas vezes no centro de discuss?es filos?ficas e psicol?gicas. O car?ter influente da aten??o sobre diversos outros processos psicol?gicos (e.g., consci?ncia, mem?ria, tomada de decis?o) salienta sua import?ncia, e logicamente resulta em uma dificuldade na segrega??o de suas fronteiras te?ricas e na defini??o clara desse fen?meno. Em um campo de pesquisa emp?rica atual sobre aten??o, vieses da orienta??o atencional para est?mulos amea?adores s?o investigados. Por?m, falta aos modelos embasados em 10 achados emp?ricos nesse campo a sustenta??o em modelos te?ricos bem estabelecidos de aten??o, e existe confus?o nos estudos experimentais publicados. Al?m disso, tarefas experimentais para avaliar vieses da aten??o para a amea?a necessitam de integra??o com novas tecnologias e estrat?gias de an?lise, as quais podem gerar mais sensibilidade, validade e confiabilidade, como o rastreamento ocular e o novo ?ndice de variabilidade do vi?s atencional (ABV). Esta disserta??o est? inclu?da na sub?rea de n?mero 7.07.02.03-9 do Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) ? Psicologia Experimental (Processos Cognitivos e Atencionais) ? a qual integra a grande ?rea de Psicologia. Dois estudos s?o apresentados para suprir a necessidade de avan?o no estudo sobre aten??o, controle atencional (AC) e vi?s atencional em rela??o ? amea?a (ABT). Em primeiro lugar, um estudo te?rico fornece uma vis?o hist?rica da pesquisa psicol?gica da aten??o, desde os fundadores da Psicologia moderna at? a pesquisa neuropsicol?gica integrativa atual e os modelos orientados empiricamente. Esta revis?o busca esclarecer conceitos da aten??o e diferenciar esses conceitos dos de outros dom?nios psicol?gicos. Em vez de segregar ?reas de pesquisa, ? prov?vel que essa estrat?gia promova um di?logo entre campos que pesquisam o mesmo fen?meno - mas o medem de forma diferente e atribuem-lhe nomes diferentes. Na sequ?ncia dessa revis?o te?rica, ? apresentado um estudo emp?rico, que prop?e duas adapta??es de tarefas experimentais cl?ssicas para medir o ABT: a Tarefa Dot-Probe (DPT) e a Tarefa Stroop Emocional (EST). Na EST, o desenho da tarefa foi alterado para levar em conta considera??es te?ricas importantes e para melhor adaptar a tarefa ? medida de ABV. Na DPT, uma integra??o surpreendentemente rara de tempos de rea??o e medidas de rastreamento ocular ? estabelecida, e novos ?ndices para calcular o ABT e o ABV s?o propostos. A confiabilidade e validade dos ?ndices em ambas as 11 tarefas foi investigada com estudantes universit?rios e atrav?s da diferencia??o dos mesmos ?ndices entre grupos de sintomas altos vs. baixos de ansiedade e estresse p?straum?tico. A import?ncia de progressivamente melhorar as qualidades psicom?tricas dessas tarefas experimentais ? discutida em profundidade levando em conta os achados do estudo, incluindo recomenda??es para futuras adapta??es dessas tarefas / Attention is a multifaceted construct, one that has been at the center of discussions across several moments in the history of philosophy and psychology. The characteristic of attention to influence and regulate many other psychological process (e.g., consciousness, memory, decision-making) stresses its importance, and logically results in a hardship in segregating its theoretical boundaries and clearly defining this phenomenon. In a current empirical field of research on attention, biases of attentional orientation to threatening stimuli are investigated. However, models generated from empirical findings lack sustentation on well-established theoretical models of attention, and confusion exists across published experimental studies. Furthermore, experimental tasks to assess biases towards threat require integration with new operationalization and analysis strategies, which can provide better sensitivity, validity and measurement reliability, such as eye tracking and the novel index of attentional bias variability (ABV). This dissertation is included in the subarea number 7.07.02.03-9 of the Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) ? Experimental Psychology (Attentional and Cognitive Processes) ? which integrates the broader area of Psychology. Two studies are presented to answer to the need of advancing research about attention, attentional control (AC) and attentional bias relative to threat (ABT). Firstly, a theoretical study provides a historical overview of psychological research on attention, from the founders of modern Psychology to current neuropsychological integrative research and empirically-oriented models. This review is expected to clarify constructs of attention and to differentiate these constructs from those of other Psychological domains. Instead of segregating research fields, this is likely to promote a 9 dialogue between fields that research the same phenomena ? but measure them differently and attribute to them different names. Following this theoretical review, an empirical study is presented, which proposes two adaptations of classical experimental tasks to measure ABT: the DotProbe Task (DPT) and the Emotional Stroop Task (EST). On the EST, task design is altered to account for important theoretical considerations and to better adapt the task to the measurement of ABV. On the DPT, a surprisingly rare integration of reaction times and eye tracking measures is established, and novel indices to calculate ABT and ABV are proposed. The reliability and validity of indices in both tasks is investigated with university students and through the differentiation of such indices between groups of high vs. low symptoms of anxiety and posttraumatic stress. The importance of pursuing the improvement of psychometric qualities of experimental tasks is discussed in depth upon the findings of the study, including recommendations to future experimental designs.

O consumo excessivo de álcool é recorrente entre universitários e está associado a inúmeras conseqüências negativas. Fatores ambientais (bottom-up) podem favorecer este consumo (ex.: influência do grupo, pistas associadas à droga). Além destes, fatores individuais podem influenciar o comportamento de beber desta população, entre eles fatores cognitivos (top-down). Bebedores freqüentes tendem a apresentar um viés atencional para estímulos associados ao álcool. Com o uso repetido do álcool, pistas ambientais associadas aos efeitos desta droga tornam-se salientes, em função de suas propriedades reforçadoras, atraindo a atenção do usuário em detrimento de outros estímulos e exacerbam o desejo de beber. O uso freqüente de álcool também tem sido relacionado a um conjunto de expectativas predominantemente positivas acerca dos seus efeitos e riscos para desenvolver dependência que podem influenciar o início e a manutenção do uso. Neste contexto, o objetivo deste estudo foi: a) examinar a relação entre o padrão de consumo e expectativas em relação aos efeitos do álcool entre universitários e b) desenvolver uma tarefa para investigar o viés atencional para pistas relacionadas ao álcool em indivíduos com diferentes padrões de consumo. Participaram deste estudo graduandos da UFRGS (N=79), do sexo masculino, com 22 anos de idade em média (dp=2,81). O padrão de consumo de risco e as expectativas positivas foram acessados através do Alcohol Use Disorders Identification Test (AUDIT) e do Inventário de Expectativas e Crenças Pesssoais acerca do Álcool (IECPA), respectivamente. Participaram deste estudo graduandos da UFRGS (N=79), do sexo masculino, com 22 anos de idade em média (dp=2,81). O padrão de consumo de risco e as expectativas positivas foram acessados através do Alcohol Use Disorders Identification Test (AUDIT) e do Inventário de Expectativas e Crenças Pesssoais acerca do Álcool (IECPA), respectivamente. Examinou-se o viés atencional através de uma tarefa computadorizada. O consumo de risco de álcool, que inclui o beber problemático e o padrão binge, estava associado a altas expectativas positivas em relação aos seus efeitos. Constatou-se que 43% dos participantes eram bebedores de alto risco para desenvolver dependência, conforme o AUDIT. Além disso, 68,4% deles foram caracterizados como bebedores com padrão binge de uso de álcool e 44,3% possuíam expectativas positivas em relação aos efeitos do álcool altas. Houve correlação entre beber problemático e expectativas positivas. Quanto à avaliação do viés atencional, não foi observado nenhum efeito de grupo, de tempo de exposição, nem de interação entre grupo e tempo de exposição. Identificar os fatores top down e bottom-up envolvidos no consumo de álcool de risco é essencial para formulação de modelos teóricos que compreendam este preocupante fenômeno. A avaliação das expectativas a respeito dos efeitos do álcool contribui para o planejamento de intervenções terapêuticas e estratégias preventivas mais precisas, visando a reduzir os riscos comportamentais e de saúde associados ao álcool. Além disso, o estudo do viés atencional pode favorecer o entendimento da relação entre fissura e atenção, da transição do uso ocasional para a dependência e da recaída. / The excessive alcohol consumption is recurrent among college students and it is associated with a variety of negative consequences. Environmental factors (bottom-up) can contribute to this phenomenon (group influences, drug cues). Furthermore, individual factors can also influence drinking behavior of this population, such as cognitive factors (top-down). Drug cues become highly salient as a result of their reinforcing properties, attracting the attention of the drug user in detriment of other stimuli. The exposure to drug cues can increase the desire to drink. Thus, heavy social drinkers show an attentional bias towards alcohol cues. The frequent alcohol use has also been related to a set of positive outcome expectancies and risk to develop drug dependence. These expectancies can influence the maintenance of drug intake. The aim of this study was: to examine the association of risk pattern and alcohol expectancies among college students and b) to develop a task to investigate attentional bias for alcohol cues in individuals with different drink patterns. Participants (N=79, mean age 22, dp=2,81) were college students. The risk pattern and the positive alcohol expectancies were assessed through Alcohol Use Disorders Identification Test (AUDIT) and Inventário de Expectativas e Crenças Pessoais acerca do Álcool (IECPA). The attentional bias was examined using a computerized task. The risk pattern, which includes drinking problematic and binge drinking, was associated with high positive expectancies. Results indicated that 43% of the participants had high risk to develop alcohol dependence. Moreover, 68.4% were binge drinkers and 44.3% had high positive alcohol expectancies. Risk pattern was associated with higher levels of positive alcohol expectancies. Related to the atencional bias assessment, there was not observed any group effect, exposition time, interaction between group and exposition time. Identifying bottom-up and top-down factors associated with the risk pattern of alcohol consumption is important to understand this preoccupant phenomenon. The alcohol expectancies assessment contributes to more efficient planning for therapeutical interventions and preventing strategies to reduce behavioral and health risks associated to the alcohol consumption. Moreover, the study of atencional bias can contribute to the understanding of the relationship between craving and attention, of the transition of the occasional use for the dependence and relapse.