abstract: This dissertation critically evaluated methodologies and devices for assessing and protecting the health of human populations, with particular emphasis on groundwater remediation and the use of wastewater-based epidemiology (WBE) to inform population health. A meta-analysis and assessment of laboratory-scale treatability studies for removing chlorinated solvents from groundwater found that sediment microcosms operated as continuous-flow columns are preferable to batch bottles when seeking to emulate with high fidelity the complex conditions prevailing in the subsurface in contaminated aquifers (Chapter 2). Compared to monitoring at the field-scale, use of column microcosms also showed (i) improved chemical speciation, and (ii) qualitative predictability of field parameters (Chapter 3). Monitoring of glucocorticoid hormones in wastewater of a university campus showed (i) elevated stress levels particularly at the start of the semester, (ii) on weekdays relative to weekend days (p = 0.05) (161 ± 42 μg d-1 per person, 122 ± 54 μg d-1 per person; p ≤ 0.05), and (iii) a positive association between levels of stress hormones and nicotine (rs: 0.49) and caffeine (0.63) consumption in this student population (Chapter 4). Also, (i) alcohol consumption determined by WBE was in line with literature estimates for this young sub-population (11.3 ± 7.5 g d-1 per person vs. 10.1 ± 0.8 g d-1 per person), whereas caffeine and nicotine uses were below (114 ± 49 g d-1 per person, 178 ± 19 g d-1 per person; 627 ± 219 g d-1 per person, 927 ± 243 g d-1 per person). The introduction of a novel continuous in situ sampler to WBE brought noted benefits relative to traditional time-integrated sampling, including (i) a higher sample coverage (93% vs. 3%), (ii) an ability to captured short-term analyte pulses (e.g., heroin, fentanyl, norbuprenorphine, and methadone), and (iii) an overall higher mass capture for drugs of abuse like morphine, fentanyl, methamphetamine, amphetamine, and the opioid antagonist metabolite norbuprenorphine (p ≤ 0.01). Methods and devices developed in this work are poised to find applications in the remediation sector and in human health assessments. / Dissertation/Thesis / Doctoral Dissertation Civil, Environmental and Sustainable Engineering 2018

High-dose alcohol intoxication is commonly associated with impaired inhibition, but the boundary conditions, as well as associated neurocognitive/neuroanatomical changes have remained rather unclear. This study was motivated by the counterintuitive finding that high-dose alcohol intoxication compromises response inhibition performance when working memory demands were low, but not when they were high. To investigate whether this is more likely to be caused by deficits in cognitive control processes or in attentional processes, we examined event-related (de)synchronization processes in theta and alpha-band activity and performed beamforming analyses on the EEG data of previously published behavioral findings. This yielded two possible explanations: There may be a selective decrease of working memory engagement in case of relatively low demand, which boosts response automatization, ultimately putting more strain on the remaining inhibitory resources. Alternatively, there may be a decrease in proactive preparatory and anticipatory attentional gating processes in case of relatively low demand, hindering attentional sampling of upcoming stimuli. Crucially, both of these interrelated mechanisms reflect differential alcohol effects after the actual motor inhibition process and therefore tend to be processes that serve to anticipate future response inhibition affordances. This provides new insights into how high-dose alcohol intoxication can impair inhibitory control.

Das Demokratieprinzip ist im Völkerrecht verankert. Seine normativen Grundlagen sind zum einen das Vertragsrecht, insbesondere der Internationale Pakt über bürgerliche und politische Rechte, sowie die regionalen Verankerungen in Europa und in Amerika durch die Satzungen der jeweiligen internationaler Organisationen und ihrer Menschenrechtsinstrumente. Substantielle vertragliche Verpflichtungen ergeben sich auch aus den bilateralen Verträgen der EG. Zum anderen fußt es auf der Staatenpraxis, insbesondere im Rahmen der UNO. So ist die internationale Gemeinschaft auf die Errichtung demokratischer Strukturen verpflichtet, wenn sie staatliche Funktionen in failed states übernimmt oder den Wiederaufbau eines Staatswesens begleitet. Die Demokratieresolutionen der UNO lassen erkennen, daß alle Staaten verpflichtet sind, das Ziel der Demokratie anzustreben und erreichte demokratische Errungenschaften zu gewährleisten. Das Demokratieprinzip beinhaltet normativ die Legitimation staatlichen Handelns durch freie Wahlen und die Absicherung durch Menschenrechte, Gewaltenteilung und Rechtsstaatlichkeit. Staatliche Entscheidungen bedürfen daher einer legitimierenden Rückbindung an den frei geäußerten Willen des konstituierenden Staatsvolkes, wobei die Freiheit dieser Willensäußerung in dynamischer Perspektive die Freiheit der Willensänderung garantiert. Sowohl der Vertragsschluß als Akt staatlichen Handelns als auch der Inhalt des Vertrages bedürfen der Legitimation, und zwar über die Zeit hinweg. Das geltende Völkervertragsrecht berücksichtigt das Demokratieprinzip jedoch nur unzureichend. Die Verletzung innerstaatlichen Rechts beim Vertragsschluß kann nur eingeschränkt geltend gemacht werden. Es existiert auch kein Verfahren, mit dem die fortdauernde Legitimation eines Vertrages überprüft werden könnte. Angesichts der Zunahme von Verträgen, die innere Angelegenheiten der Gesellschaften regeln, bedarf das Spannungsverhältnis einer Lösung. Das Problem wird illustriert durch Frankreichs Ausstieg aus der NATO, Senegals Kündigung der Seerechtskonventionen, den Streit um den deutschen Atomausstieg, das Verfahren um den Donaustaudamm Gabcíkovo Nagymaros, die Frage der Vereinbarkeit von Drogenkonsumräumen mit den UN-Anti-Drogenkonventionen, das Schiedsverfahren zwischen Aminoil und Kuwait sowie der Kündigung des ABM-Vertrages durch die USA. Ein erster Ansatz zur Lösung kann in einer Neuinterpretation der völkervertragsrechtlichen Regeln liegen. So bietet sich der Grundsatz der "demokratiefreundlichen Interpretation" an. Internes Recht, das der Kontrolle der Exekutive dient, muß beim Vertragsschluß Berücksichtigung finden. Und Verträgen, die "innere Angelegenheiten" betreffen, kann ein implizites Kündigungsrecht zugebilligt werden. Der wesentliche Ansatz ist aber kautelarjuristischer Natur. Revisions-, Experimentier- und Kündigungsklauseln können bei der Abfassung von Verträgen die Vertragsbeziehung so ausgestalten, daß zukünftige Meinungsänderungen berücksichtigt werden können. Schließlich ist de lege ferenda ein Recht auf Revision, kombiniert mit einem subsidiären Kündigungsrecht, wünschenswert. Mit einem solchen Mechanismus könnten neue normative Lösungen eingeführt werden und die Legitimation bestehender Normen auf den Prüfstand gestellt werden. / International law provides for a democratic principle. It is based both on treaty law and customary law. The International Covenant for Civil and Political Rights as well as the regional treaties in Europe and the Americas - the statutes of the respective regional organisations and their human rights instruments - form a substantial body of treaty obligations toward democracy, which is complemented by bilateral treaties of the EC safeguarding democracy. State practice, especially within the framework of the UN, indicates an obligation to establish democratic structures whenever the international community takes upon itself the task of nation building in failed states. The democracy resolutions of the UN point out that all member states are obliged to strive for democracy and uphold democratic achievements so far. The normative democratic principle includes the legitimation of public affairs through free and fair elections and the guarantee of human rights, separation of powers and the rule of law. Acts of states therefore must be legitimised through the freely expressed will of the people. Under a dynamic perspective, the free will includes the possibility for changes of policy. The conclusion of treaties as an act of state as well as the content of the treaty as a rule of law need to be legitimised through the times. The current law of treaties does not acknowledge the democratic principle, however. Violations of internal law at the conclusion of a treaty can only be claimed to a limited extent. Nor does international law provide for a formal procedure to validate the on-going support for the content of the treaty. Facing an ever-growing expansion of the number of treaties dealing with the internal affairs of societies, solutions must be found. The problem is being illustrated by France's withdrawal from NATO, Senegal's withdrawal from the Geneva Conventions on the Law of the Sea, the dispute related to the question of the use of nuclear energy in Germany, the judgement of the ICJ in the Gabcíkovo-Nagymaros case, the question of the compatibility of drug consumption rooms with UN anti-drug conventions, the dispute settlement award in the Aminoil case and last not least the denunciation of the ABM treaty by the US. Realigning the interpretation of the law of treaties to the democratic principle is one way to deal with the problem. Interpretation of treaties should take into account the democratic principle. Internal law controlling the executive has to be complied with where conclusion of treaties is concerned. And treaties dealing with "internal affairs" can be considered to contain an implicit right of withdrawal or denunciation. The proper solution lies in respecting the democratic principle when drafting treaties, though. Clauses of revision, clauses allowing for experiments and clauses of denunciation or withdrawal help shaping a contractual relationship that can take into account changes of the political will. Last not least, a right of revision is recommended de lege ferenda, combined with a subsidiary right of denunciation or withdrawal. Such a mechanism allows for introducing new normative solutions and for validating the on-going legitimation of existing treaty rules. (See also the English summary at the end of the thesis.)