This document deals with the pre-processing and the segmentation of human vertebrae from computed tomography 3D image data. It describes image registration and segmentation methods concretely and commonly used in image data processing during the automated spine canal localization process and the localization of each vertebrae centroid. The 3D deformable model development is described in the work together with the introduction to the previous state of art and the progress of vertebrae segmentation using 3D deformable models registration. This work presents the evaluation of the accuracy and the reliability from the segmentation and localization results.

This thesis is devoted to groups as value added tax payers. This concept was introduced into Czech law on 1st January 2008. A VAT group enables persons that meet the criteria required by the VAT Act to be considered a single taxable person, i.e. a single tax payer. The Czech VAT group legislation is based on article 11 of Council Directive 2006/112/EC of 28 November 2006 on the common system of value added tax. The aim of this thesis is to present and thoroughly analyze VAT group legislation in Czech law, and to point out certain pitfalls of this legislation, including its interaction with EU law, and the law of some of the other EU member states. A secondary goal is to assess the rate at which VAT groups are being used in the Czech Republic. The first chapter describes VAT group in EU law, and its introduction into the Czech legal order. The second chapter discusses the requirements that the law puts on members of a VAT group, with extra emphasis on the requirement of close binding of persons, including the membership of physical persons and non-taxable persons in a VAT group. The third chapter deals with VAT group as a subject of legal relations, describing in more detail the concept of a representative member and the responsibilities of a VAT group member. The next chapter takes a more practical...

Occupational Therapy is a client centred, holistic allied health profession in which the quality of a supportive, empowering therapist-client relationship is seen as having a key and central role in effective therapy. A minimum of a 1000 hours of practice placement education (PPE) must be successfully completed in pre-registration programmes, which are charged with ensuring graduates are fit for practice and purpose. This Work Based Project focussed on how pre-registration education can best equip students for a first PPE in terms of sufficient inter-personal communication skills. Primary data collection was conducted between November 2008 and March 2010. The project firstly employed thematic content analysis of data elicited from two rounds of focus group surveys of practice placement educators (PPEds) to identify a baseline of inter-personal communication skills required prior to embarking on a first PPE. This data was used to formulate an objective structured clinical examination (OSCE) checklist of inter-personal communication skills, which was then utilised as a formative assessment and in role play scenarios in taught sessions with one first year pre-registration occupational therapy cohort. This cohort was surveyed via a questionnaire and in addition five students were interviewed. Subsequently a group of third year students, who role played clients for the OSCE, participated in a facilitated discussion on their perceptions of the OSCE. The data on students’ perceptions and an analysis and comparison of staff and student ratings of performance in the formative OSCE, were utilised in a critical evaluation of the use of this OSCE as a teaching and assessment tool. The findings indicate a level of agreement on the content of the OSCE checklist, providing content validity to this particular assessment. PPEds, and first and third year students are positive about the use of an OSCE when it is used as a formative experience. Students recommend that if used as a summative assessment the OSCE is combined with a reflective piece. Objective structured clinical examinations have long been established in other health care professions such as medicine and nursing. This project has provided evidence indicating that an OSCE of inter-personal communication skills is a valid assessment tool for occupational therapy pre-registration students, and that it can also facilitate student reflection, self-awareness and learning. It has also identified profession specific inter-personal communication skills required for embarking on a first PPE.

The aim of the study is to explore how school absenteeism as a material-discursive phenomenon is produced in the practices of humans and nonhumans, when absences and presences are registered and managed through digital technologies. How is the phenomenon of school absenteeism produced when absences and presences are digitally registered? How does the phenomenon of school absenteeism emerge when both human and nonhuman entanglements are included in the apparatuses of knowing? Through a posthumanist approach, the study engages empirically with two types of software for the registration of absences and presences at three Swedish schools. The results show that digital registration blurs the division between absences and presences, and queers what is absent and what is present. Digital registration produces school absenteeism as a phenomenon for all students every day, and at the same time as mainly for the students who are present most of the time. A conclusion that is drawn from the study is that digital registration makes absences present, by the visualization and performative repetition of the registration. The study points to how school absenteeism is always ‘in the making’, and proposes the concept of school absenteeing as a productive way to open up new possibilities in relation to students’ absences. / Syftet med studien är att undersöka hur skolfrånvaro som materiellt-diskursivt fenomen produceras i mänskliga/icke-mänskliga praktiker, när frånvaro och närvaro hanteras och registreras med hjälp av digitala system. Hur produceras fenomenet skolfrånvaro när elevers frånvaro och närvaro registreras digitalt? Hur framträder fenomenet skolfrånvaro när människor såväl som icke-människor inkluderas i kunskapsproduktionen? I studien skapas empiriska engagemang tillsammans med två digitala system för registrering av frånvaro och närvaro på tre svenska skolor. Genom ett posthumanistiskt perspektiv visar studien att den digitala registreringen suddar ut gränserna mellan frånvaro och närvaro. I sammanvävningar med digitala system blir fenomenet skolfrånvaro mer komplext, eftersom den digitala registreringen producerar skolfrånvaro som ett fenomen för alla elever, varje dag. Samtidigt reducerar den digitala registreringen skolfrånvarons komplexitet och skapar ett fenomen för de elever som för det mesta är närvarande. En slutsats från studien är att registreringen gör vad som är osynligt – det frånvarande – synligt. Studien pekar på hur skolfrånvaro alltid är ett görande och introducerar begreppet school absenteeing [skolfrånvarogöra]. Detta begrepp möjliggör en förståelse av skolfrånvaro som en pågående produktion i mänskliga/icke-mänskliga relationer, snarare än något som elever har eller är och öppnar upp för nya sätt att engagera sig i den alltid närvarande frånvaron.

When a family in British Columbia (B.C.) chooses to educate their child at home, they have two legal options: enrollment in a Distributed Learning (DL) program or registration under Section 12 (S12) of the School Act as a homeschooler. To date, there has been very little published on trends in participation rates and growth rates with regards to home educating options in B.C. The current study employs a quantitative archival design to document trends in DL and S12 across age, gender and location. Home educating is on the rise in B.C. over the past twenty years, largely due to an increase in enrollment in DL programs while registration under S12 has declined. Distinct patterns in age, gender and location between S12 and DL are apparent in the data. Growth rates among age categories in DL mirror declines in S12. While there are slightly more males than females in the total school-aged population in B.C., within DL programs there are more females than males at the secondary level. In 1993/1994 rural children were more likely to be educated at home than urban children in B.C.; today the opposite is true. Further research is needed to ascertain why these trends persist. / Graduate / 0525 / 0529 / ngardner@uvic.ca

De acordo com a teoria tradicional, governantes eleitos adotam políticas conforme as preferências do eleitor mediano. No entanto, a presença de abstenção nas eleições pode levar a uma diferença entre a preferência dos eleitores efetivos e da população com um todo. O Brasil se destaca por ser um dos países com voto obrigatório com maior percentual de eleitores faltosos nas eleições. O recadastramento biométrico representa uma oportunidade para se estudar os mecanismos de incentivo para participação política, permitindo verificar seu impacto sobre as políticas públicas, em particular as despesas públicas municipais. Por meio de uma metodologia que combina variáveis instrumentais e um modelo de diferenças em diferenças, encontram-se evidências de que o recadastramento biométrico aumentou, em média, oito pontos percentuais a taxa de participação eleitoral nos municípios que passaram pela política. Por sua vez, esta elevação da participação reduziu as despesas em saúde e assistência social. Além do uso do recadastramento biométrico ser inédito na literatura brasileira na área de Economia Política, o mesmo fornece um mecanismo para se verificar como a ampliação da votação entre indivíduos com maior educação influencia as despesas públicas, uma abordagem pouco comum na literatura já existente, cujo foco é a ampliação da partipação eleitoral de camadas menos privilegiadas da sociedade / According to mainstream theory, elected governments adopt policies in order to address the preferences of the median voter. However, low turnout rates can lead to a difference between the preference of voters and the preference of the population as a whole. Despite compulsory voting, Brazil stands out among other countries as it computed high rates of abstention during recent elections. Biometric registration represents an opportunity for the study of the mechanisms behind the decision of voting, which ultimately impacts public policies. By means a methodology that combines instrumental variables and differences in differences, we find evidence that the biometric registration increased, on average, eight percentage points the turnout rate in the cities that have already been completed the registration. This increase of turnout, in turn, decreased health and social assistance expenditures. In addition, the study of the biometric registration has no precedent in the Brazilian Political Economy literature, as it provides a mechanism to verify how the enfranchisement of individuals with higher education affects public expenditure, and unusual fact in the traditional literature, which focuses on the enfranchisement of less educated voters

Durante um procedimento cirúrgico cerebral existe o deslocamento das estruturas que é um problema tipicamente não-rígido e não-linear. A ultrassonografia intra-operatória é utilizada como guia cirúrgico e pode ser utilizada para correção das imagens pré- operatórias através do corregistro rígido entre estas e um sistema de rastreio. Isto torna possível a visualização do deslocamento das estruturas devida a remoção de parte delas durante o ato cirúrgico. O objetivo deste trabalho é um estudo do corregistro livre não-rígido a partir de um modelo in vitro experimental que simule uma situação cirúrgica de retirada de uma inclusão líquida, de forma controlada, para medir os deslocamentos das estruturas próximas, utilizando imagens de ultrassom. Alguns fantomas que simulam o tecido humano nas imagens de ultrassom, feitos de gelatina e parafina, foram escolhidos como modelo. Para realizar o corregistro foi escolhida a transformação geométrica por splines simples (B-Splines), o otimizador Limited- memory BroydenFletcherGoldfarbShanno (LBFGS) e a métrica de similaridade soma do quadrado das diferenças (SQD) e, utilizada a biblioteca Insight Segmentation and Registration Toolkit (ITK), assim como o estudo dos parâmetros adequados para a nossa tarefa. Foi demonstrado para as condições envolvidas que para as imagens em modo B as deformações até 5% e mapas de RF até 9%, sem nenhuma otimização dos parâmetros do corregistro, é factível sem uso excessivo de tempo computacional. Foi analisada a influência da grade em relação a dois tipos diferentes de deformação, ambas com valor de 2%. O tamanho da grade, levando em consideração o erro e o tempo, foram a 5x11 para as imagens em Modo B e 11x17 para os mapas de RF, independentemente do tipo de deformação. Os parâmetros do otimizador (Default Step Length, Gradient Convergence Tolerance e Line Search Accuraccy) também foram avaliados e os valores obtidos foram 1,6; 0,03 e 0,8 para as imagens modo B e 1,2; 0,05 e 1,0 para os mapas de RF. No entanto ao comparamos, utilizando os parâmetros propostos obtidos, os campos de deslocamentos esperados com os gerados pelo modo B e pelos mapas RF, foi demonstrado que os mapas de RF fornecem valores abaixo do esperado e que as imagens em modo B retratam mais fielmente os deslocamentos e isto se deve a escolha do conjunto de valores testados para o otimizador. Foram aplicados estes parâmetros em dois fantomas de parafina- gel e em dois de gelatina. Nos três primeiros fantomas foi retirada um inclusão líquida em várias etapas. Os deslocamentos das estruturas vizinhas foram avaliados durante as etapas de remoção para demonstrar os campos de sução e de torção. No último fantoma, que simula morfologicamente um cérebro humano, foram retiradas, em várias etapas, regiões sólidas, simulando a retirada de tecido e foram calculados os deslocamentos e demonstrados os campos provenientes deste tipo de intervenção. Os trabalhos futuros se concentrarão em utilizar os volumes para medir os movimentos das estruturas e em novos parâmetros do otimizador para os mapas de RF. / During a brain surgery there is the displacement of the structures that is a typical non- rigid and non-linear problem. Intraoperative ultrasound is used as a surgical guide and can be used for spatial correction of preoperative images through the rigid registration between these and a track system. This makes it possible to visualize the displacement of structures due to removal of some piece of them during surgery. This work is a study of the non-rigid free-from registration using an experimental in vitro model to simulate a surgical situation withdrawal of a fluid inclusion in a controlled manner, to measure the displacement of nearby structures, using ultrasound images. Some phantoms that simulate the human tissue in the ultrasound images made of gelatin and paraffin were chosen as a model. To perform the registration it was used the framework Insight Segmentation and Registration Toolkit (ITK) and were chosen a geometric transformation of simple splines (B-splines), the Limited-memory Broyden-Fletcher- Goldfarb-Shanno (LBFGS) optimizer and the similarity metric sum of the squared differences (SQD). The search for the suitable parameters for our task are done and it has been shown that for the conditions involved for B-mode images deformations up to 5% and RF maps up to 9% without any optimization of the parameters of registration, is feasible without excessive use of computational time. The influence of the grid was examined for two different types of deformation, both for 2%. The size of the grid, taking into account the error and time were the 5x11 for the images in B mode and 11x17 maps for RF, regardless of the type of deformation. The parameters of the optimizer (Default Step Length, Gradient Convergence Tolerance and Line Search Accuraccy) were also evaluated and the values obtained were 1.6, 0.03 and 0.8 for the B-mode images and 1.2, 0.05 and 1.0 for RF maps. However when comparing the expected displacement fields with the generated by B-mode images and the RF maps, using the obtained parameters, it have been shown that RF maps provide values are lower than expected and that the B-mode images portray more faithfully displacements. This is due to the choice set of values tested for the optimizer. Finally, image registration parameters for B-mode were applied in two paraffin-gel and two gelatin phantoms. In the first three phantoms the fluid inclusion was removed in several stages and the displacements of neighboring structures were evaluated during the removal steps to demonstrate the fields of suction and torsion. The last phantom, which morphologically mimics a human brain, a solid region was removed, also in several stages, simulating a surgery. The displacements were calculated and demonstrated the fields from this type of intervention. Future work will focus on using the volumes to measure the movements of the structures and new parameters test of the optimizer to RF maps.

Apesar dos avanços recentes na tecnologia dos aparelhos de ressonância magnética (RM) permitirem a aquisição de imagens de alta resolução, ainda não é possível delinear de forma confiável os limites entre regiões de diferentes citoarquiteturas baseando-se somente nesta modalidade. As imagens de histologia são mandatórias quando se necessita saber o limite exato entre diferentes regiões neuroanatômicas. Contudo, o processamento histológico inevitavelmente causa grandes deforma¸coes no tecido, o que torna a compara- ção direta entre as duas modalidades inviável. Os estudos de neuroimagem/neuroanatomia que necessitam de comparação com a histologia devem necessariamente incluir uma etapa de alinhamento entre as duas modalidades; tarefa que muitas vezes acaba sendo realizada manualmente. Entretanto, o registro manual ´e demorado e pouco acurado, se tornando inviável quando os exames de histologia geram centenas de imagens. Este trabalho propõe um método para registro de imagens de histologia e RM, composto por um conjunto de recomenda¸coes para o preparo das imagens cujo objetivo ´e otimizá-las para o registro; e por uma pipeline computacional capaz de registrar as imagens consideradas. O trabalho aqui descrito foi desenvolvido primeiramente com o intuito de registrar imagens de espécimens de hipocampo provenientes do projeto CINAPCE e, posteriormente, para registro de imagens de encéfalo inteiro provenientes do Banco de Cérebros da Faculdade de Medicina da Universidade de São Paulo. A pipeline computacional foi testada com sucesso em imagens reais de dois encéfalos inteiros. A avaliação quantitativa dos registros realizados foi feita comparando segmenta¸coes manuais do hipocampo direito, núcleo caudado esquerdo e ventrículos laterais superiores, realizadas no volume de RM e da histologia registrada. A quantificação do resultado foi feita através do cálculo das métricas coeficiente de Dice (CSD) e distancia espectral ponderada (DEP) sobre as segmentações. A pipeline obteve um CSD médio de aproximadamente 0,77 e um DEP médio de aproximadamente 0,003. Os resultados mostraram que o método foi capaz de registrar as imagens de histologia nas respectivas imagens de RM exigindo interação mínima com o usuário. / Although latest advances in MRI technology have allowed the acquisition of higher resolution images, reliable delineation of cytoarchitectural boundaries is not yet possible based solely on that modality. Histological images are regularly required to locate the exact limits between neuroanatomical structures. Histological processing is nevertheless prone to cause a high amount of tissue distortion, which prevents direct comparison between the two modalities. Neuroimage/neuroanatomy studies that require direct comparison between histology am MRI must include a registration step. Such task is usually manually performed, but that becames infeasible for large histology volumes. Moreover, manual registration is time consuming and inaccurate. This thesis proposes a set of tissue processing recommendations aiming at optimizing the registration proccess, together with a computational pipeline for registering histology to MRI. The herein described work was initially designed to proccess hippocampi specimens from the CINAPCE project and posteriorly improved to process full brain images from the Brain Bank of the Brazilian Aging Brain Study Group. The pipeline was tested on two full brain histology volumes from the Brain Bank of the Brazilian Aging Brain Study Group. Results were assessed by comparison of manual segmentations of the left caudate nucleus, right hippocampus and superior lateral ventricles, performend on both MRIs and registered histology volumes. Quatitative evaluation was performed by computing the Dice coeficient (DC) and normalized weighted spectral distance (WESD) on the segmentations. The pipeline precessing yielded mean DC of 0.77 and mean WESD of 0.0033. The described method was able to sucessfuly register histology to their corresponding MRI volumes with minimal user interaction.

Esta investigação teve por objetivos elaborar e experimentar uma proposta de intervenção colaborativa junto à professora que atua em Sala de Apoio Pedagógico de uma Escola Municipal de Ensino Fundamental de São Paulo; analisar, criticamente, seu encaminhamento e discutir os resultados das ações pedagógicas, empreendidas e do percurso formativo da professora colaboradora. O desenvolvimento desta pesquisa-ação ocorreu ao longo de um semestre letivo, recorreu aos pressupostos teóricos da concepção construtivista de aprendizagem, e teve como referências a Psicogênese da Língua Escrita, a Sociolingüística e a Psicolingüística do ensino da Língua Portuguesa. As ações colaborativas desenvolvidas abrangeram o planejamento, organização, acompanhamento e avaliação de rotinas alfabetizadoras, e potencializou a reflexão sobre a prática pedagógica, o registro como instrumento de investigação e as situações didáticas como organizadoras do ensino de leitura e escrita. A análise crítica do percurso permitiu constatar alterações significativas na concepção de ensino e aprendizagem da professora-colaboradora, na organização didática, metodologia de ensino e nas formas e entendimento das avaliações empregadas. Como descobertas relevantes, destacam-se a relação intrínseca entre a ação alfabetizadora e os conhecimentos dos pressupostos teóricos da abordagem citada, bem como dos aspectos didático-metodológicos com ela convergentes: planejamento, registro dos procedimentos de ensino, análise dos resultados das aprendizagens dos alunos e estabelecimento de parcerias e reflexões dialéticas entre profissionais. / This investigation objectives to experiment and elaborate a proposal of collaborative intervention, along with the responsible teacher, for the Pedagogical support room in a Municipal school of Ensino Fundamental in São Paulo; to analyze critically, its directions and to discuss the results of pedagogical action applied in the training process of the assistant teacher. The development of this action-research took place during one academic semester, in the light of the theory presumption of the constructivist learning approach, using as references the Psychogenesis of the Written language, the Socio-linguistic and the Psycho-linguistic of the Portuguese language teaching. The collaborative action developed included the planning, the organization, the follow-up and assessment of the routines for alphabetization, increased the reflection over pedagogical practice and the registration as an instrument of investigation, as well as the didactical proposals to organize the teaching of reading and writing. The critical analyses of the path used allow us to realize the significant changes in the teaching and learning concept of the assistant-teacher, in the didactical organization, the teaching methodology and the understanding and formats of the assessment used. As relevant discoveries we highlight the intrinsic relationship between the literace and the knowledge theory of the approach mentioned previously, and also the methodological-didactical convergent aspects with the approach such as: planning, register of the procedure of teaching, pupils learning results analyses, and establishment of partnership and professional dialectic reflection.

A doença de Chagas possui uma importante relevância clínica, sendo uma das principais causas de mortalidade e morbidade na América Latina. As relações entre a lesão tecidual miocárdica e os defeitos na inervação autonômica na doença de Chagas são pouco conhecidas. Este trabalho descreve o desenvolvimento e aplicação de métodos de segmentação, corregistro e análise de imagens capazes de prover uma análise integrada das lesões teciduais através do imageamento de ressonância magnética (MRI), perfusão miocárdica e inervação autonômica, disponíveis através da tomografia de emissão de fótons (SPECT). O método proposto é baseado na segmentação e corregistro entre as imagens MRI e imagens SPECT usando 99mTc-MIBI e 123I-MIBG. Para realizar a segmentação do miocárdio, foi utilizada a técnica de Contorno Ativo Geodésico. A segmentação de fibrose em imagens MRI foi realizada com base na maximização da entropia de Tsallis. O corregistro não-rígido foi realizado através do método B-Spline. Os resultados de quantificação indicam correlações entre a presença de fibrose, desnervação e isquemia, além de mostrar a presença de regiões de miocárdio vivo, isquêmico e desnervado. Assim, a ferramenta desenvolvida fornece uma análise integrada de informação, permitindo uma melhor compreensão da relação entre o dano ao tecido do miocárdio e defeitos de inervação autonômica causadas pela doença de Chagas. / Chagas disease is of major clinical relevance, and a major cause of morbidity and mortality in Latin America. The relations between the myocardial tissue damage, myocardial perfusion and defects in autonomic innervations are poorly understood. This study proposes the development and application of image analysis methods capable of providing an integrated visualization and analysis of tissue injuries through enhanced magnetic resonance imaging (MRI), autonomic innervations and myocardial perfusion, available through photon emission tomography (SPECT). The proposed method is based on segmentation and registration between MRI images and SPECT images using 99mTc-MIBI and 123I-MIBG. To perform the segmentation of myocardium, we used Geodesic Active Contour. Fibrosis segmentation in MRI images was performed based on the algorithm of maximum Tsallis entropy. Nonrigid registrations was performed based on B-Spline method. The quantification results showed correlations between the presence of fibrosis, denervation and ischemia, as well as showing the regarded presence of regions of healthy myocardium, ischemic and denervated. Thus, the developed tool provides an integrated analysis of information contributing to a better understanding of the relationship between myocardial tissue damage and autonomic innervations injuries caused by Chagas disease.