La préparation d'interventions de maintenance dans les installations industrielles a dorénavant recours à des outils d'étude, de modélisation et de simulation basés sur l'exploitation de modèles virtuels 3D des installations. L'acquisition de ces modèles tridimensionnels s'effectue à partir de nuages de points mesurés, depuis plusieurs points de vue, par balayage angulaire horizontal et vertical d'un faisceau laser par scanner laser terrestre. L'expression dans un repère commun de l'ensemble des données acquises est appelée consolidation, au cours de laquelle les paramètres de changement de repères entre les stations sont calculés. L'objectif de cette thèse est d'améliorer la méthode d'acquisition de données laser en environnements industriels. Celle-ci doit, au final, garantir la précision et l'exactitude nécessaires des données tout en optimisant le temps et les protocoles d'acquisition sur site, en libérant l'opérateur d'un certain nombre de contraintes inhérentes au relevé topographique classique. Nous examinons, dans un premier temps, l'état de l'art des moyens et méthodes mis en œuvre lors de l'acquisition de nuages de points denses de scènes d'intérieurs complexes (Partie I). Dans un deuxième temps, nous étudions et évaluons les données utilisables pour la consolidation: données laser terrestres, algorithmes de reconstruction de primitives et systèmes de géolocalisation d'intérieur (Partie II). Dans une troisième partie, nous formalisons et expérimentons ensuite un algorithme de recalage basé sur l'utilisation de primitives appariées, reconstruites dans les nuages de points (Partie~III). Nous proposons finalement une approche probabiliste de l'appariement de primitives permettant l'intégration des informations et incertitudes a priori dans le système de contraintes utilisé pour le calcul des poses (Partie IV). / Many pre-maintenance operations of industrial facilities currently resort on to three-dimensional CAD models. The acquisition of these models is performed from point clouds measured by Terrestrial Laser Scanning (TLS). When the scenes are complex, several viewpoints for scanning, also known as stations, are necessary to ensure the completeness and the density of the survey data. The generation of a global point cloud, i.e. the expression of all the acquired data in a common reference frame, is a crucial step called registration. During this process, the pose parameters are estimated. If the GNSS systems are now a solution for many outdoor scenes, the registration of indoor TLS data still remains a challenge. The objective of this thesis is to improve the acquisition process of TLS data in industrial environments. The aim is to guarantee the precision and accuracy of acquired data, while optimizing on-site acquisition time and protocols by, as often as possible, freeing the operator from the constraints inherent to conventional topographic surveys. In a first part, we consider the state of the art of the means and methods used during the acquisition of dense point clouds of complex interior scenes (Part I). In a second part, we study and evaluate the data available for the registration: terrestrial laser scanner data, primitive reconstruction algorithms in point clouds and indoor geolocation systems (Part II). In the third part, we then formalize and experiment a registration algorithm based on the use of matched primitives, reconstructed from per station point clouds (Part III). We finally propose a probabilistic approach for matching primitives, allowing the integration of a priori information and uncertainty in the constraints system used for calculating poses (Part IV).

La réalité augmentée permet d'aider les chirurgiens à localiser pendant l'opération la position des structures d'intérêt, comme les vaisseaux sanguins. Dans le cadre de la chirurgie laparoscopique, les modèles 3D affichés durant l'intervention ne correspondent pas à la réalité à cause des déformations dues au pneumopéritoine. Cette thèse a pour objectif de corriger ces déformations afin de fournir un modèle du foie réaliste. Nous proposons de déformer le modèle préopératoire du foie à partir d'une acquisition intraopératoire de la surface antérieure du foie. Un champ de déformations entre les modèles préopératoire et intraopératoire est calculé à partir de la distance géodésique à des repères anatomiques. De plus, une simulation biomécanique du pneumopéritoine est réalisée pour prédire la position de la cavité abdomino-thoracique qui est utilisée comme condition limite. L'évaluation de cette méthode montre que l'erreur de position du foie et de ses structures internes est réduite à 1cm. / Augmented reality can provide to surgeons during intervention the positions of critical structures like vessels. The 3D models displayed during a laparoscopic surgery intervention do not fit to reality due to pneumperitoneum deformations. This thesis aim is to correct these deformations to provide a realistic liver model during intervention. We propose to deform the preoperative liver model according to an intraoperative acquisition of the liver anterior surface. A deformation field between the preoperative and intraoperative models is computed according to the geodesic distance to anatomical landmarks. Moreover, a biomechanical simulation is realised to predict the position of the abdomino-thoracic cavity which is used as boundary conditions. This method evaluation shows that the position error of the liver and its vessels is reduced to 1cm.

La fusion d’images TDM de phase artérielles et veineuses est cruciale afin d’assurer une meilleure planification chirurgicale. Cependant, le recalage non-rigide d’images abdominales est encore un challenge à cause de la respiration qui fait glisser les viscères abdominaux le long de la paroi abdominale, créant ainsi un champ de déformation discontinu. L’objectif de cette thèse est de fournir un outil de recalage précis pour les images TDM multi-phases de l’abdomen.Comme la zone de glissement dans l’abdomen est difficile à segmenter, nous avons d’abord implémenté deux outils de segmentation interactifs permettant une délinéation en 10 minutes de la paroi abdominale et du diaphragme. Pour intégrer ces zones de glissement comme a priori, nous réalisons le recalage sur de nouvelles images dans lesquelles la paroi abdominale et les viscères thoraciques ont été enlevés. Les évaluations sur des données de patient ont montré que notre approche fournit une précision d’environ 1 mm. / The fusion of arterial and venous phase CT images of the entire abdominal viscera is critical for a better diagnosis, surgi-cal planning and treatment, since these two phase images contain complementary information. However, non-rigid regis-tration of abdominal images is still a big challenge due to the breathing motion, which causes sliding motion between the abdominal viscera and the abdo-thoracic wall. The purpose of this thesis is to provide an accurate registration method for abdominal viscera between venous and arterial phase CT images.In order to remove the sliding motion effect, we decide to separate the image into big motion and less motion regions, and perform the registration on new images where abdo-thoracic wall and thoracic viscera are removed. The segmentation of these sliding interfaces is completed with our fast interactive tools within 10 minitues. Two state-of-the-art non-rigid registration algorithms are then applied on these new images and compared to registration obtained with original images. The evaluation using four abdominal organs (liver, kidney, spleen) and several vessel bifurcations shows that our approach provides a much higher accuracy within 1 mm.

The goal of the thesis is to find general nonlinear geometric transformation, which compensates irregular deformation of images, so that they could be registered. In the introductory part, necessary mathematical tools are stated, especially convolution, correlation and Fourier transform. In the next part, method of phase correlation is stated, followed by algorithms used for finding the geometric transformation. Those algorithms are implemented in computer program, that is included.

Les travaux présentés dans ce manuscrit s’inscrivent dans le contexte de l’inspection automatisée d’assemblages mécaniques aéronautiques par vision artificielle. Il s’agit de décider si l’assemblage mécanique a été correctement réalisé (assemblage conforme). Les travaux ont été menés dans le cadre de deux projets industriels. Le projet CAAMVis d’une part, dans lequel le capteur d’inspection est constitué d’une double tête stéréoscopique portée par un robot, le projet Lynx© d’autre part, dans lequel le capteur d’inspection est une caméra Pan/Tilt/Zoom (vision monoculaire). Ces deux projets ont pour point commun la volonté d’exploiter au mieux le modèle CAO de l’assemblage (qui fournit l’état de référence souhaité) dans la tâche d’inspection qui est basée sur l’analyse de l’image ou des images 2D fournies par le capteur. La méthode développée consiste à comparer une image 2D acquise par le capteur (désignée par « image réelle ») avec une image 2D synthétique, générée à partir du modèle CAO. Les images réelles et synthétiques sont segmentées puis décomposées en un ensemble de primitives 2D. Ces primitives sont ensuite appariées, en exploitant des concepts de la théorie de graphes, notamment l’utilisation d’un graphe biparti pour s’assurer du respect de la contrainte d’unicité dans le processus d’appariement. Le résultat de l’appariement permet de statuer sur la conformité ou la non-conformité de l’assemblage. L’approche proposée a été validée à la fois sur des données de simulation et sur des données réelles acquises dans le cadre des projets sus-cités. / The work presented in this manuscript deals with automated inspection of aeronautical mechanical parts using computer vision. The goal is to decide whether a mechanical assembly has been assembled correctly i.e. if it is compliant with the specifications. This work was conducted within two industrial projects. On one hand the CAAMVis project, in which the inspection sensor consists of a dual stereoscopic head (stereovision) carried by a robot, on the other hand the Lynx© project, in which the inspection sensor is a single Pan/Tilt/Zoom camera (monocular vision). These two projects share the common objective of exploiting as much as possible the CAD model of the assembly (which provides the desired reference state) in the inspection task which is based on the analysis of the 2D images provided by the sensor. The proposed method consists in comparing a 2D image acquired by the sensor (referred to as "real image") with a synthetic 2D image generated from the CAD model. The real and synthetic images are segmented and then decomposed into a set of 2D primitives. These primitives are then matched by exploiting concepts from the graph theory, namely the use of a bipartite graph to guarantee the respect of the uniqueness constraint required in such a matching process. The matching result allows to decide whether the assembly has been assembled correctly or not. The proposed approach was validated on both simulation data and real data acquired within the above-mentioned projects.

Nous présentons dans cette étude nos travaux concernant le recalage 3D/2D d'images de dissection aortique. Son but est de de proposer une visualisation de données médicales, qui pourra servir dans le contexte de l'assistance peropératoire durant les procédures endovasculaires.Pour effectuer cette tâche, nous avons proposé un modèle paramétrique de l'aorte, appelé enveloppe tubulaire. Il sert à exprimer la forme globale et les déformations de l'aorte, à l'aide d'un nombre minimal de paramètres.L'enveloppe tubulaire est utilisée par les algorithmes de recalage proposés dans cette étude.Notre méthode originale consiste à proposer un recalage par calcul direct de la transformation entre image 2D, i.e. sans procéssus d'optimisation, et est appelée recalage par ITD .Les descripteurs, que nous avons définis pour le cas des images d'aorte, permettent de trouver rapidement un alignement grossier des données. Nous proposons également l'extension de notre approche pour la mise en correspondance des images 3Det 2D.La chaîne complète du recalage 3D/2D, que nous présentons dans ce document, est composée de la technique ITD et de méthodes précises iconiques et hybrides. L'intégration de notre algorithme basé sur les descripteurs en tant qu'étape d'initialisation réduit le temps de calcul nécessaire et augmente l'efficacité du recalage, par rapport aux approches classiques.Nous avons testé nos méthodes avec des images médicales, issues de patients trîtés par procédures endovasculaires. Les résultats ont été vérifiés par les spécialistes cliniques et ont été jugés satisfaisants; notre chaine de recalage pourrait ainsi être exploitée dans les salles d'interventions à l'avenir. / In this study, we present our works related to 3D/2D image registrationfor aorti dissition. Its aim is to propose a visualization of medial datawhih an be used by physians during endovas ular proedures.For this purpose, we have proposed a parametrimodel of aorta, alleda Tubular Envelope. It is used to express the global shape and deformationsof the aorta, by a minimal number of parameters. The tubular envelope isused in our image registration algorithms.The registration by ITD (Image Transformation Descriptors) is our ori-ginal method of image alignment : itomputes the rigid 2D transformation between data sets diretly, without any optimization process.We provide thedefinition of this method, as well as the proposition of several descriptors' formulae, in the base of images of aorta. The technique allows us to quickly and a poarse alignment between data. We also propose the extension of theoriginal approach for the registration of 3D and 2D images.The complete chain of 3D/2D image registration techniques, proposedin this document, consists of the ITD stage, followed by an intensity basedhybrid method. The use of our 3D/2D algorithm, based on the image trans-formation descriptors as an initialization phase, reduces the computing timeand improves the efficiency of the presented approach.We have tested our registration methods for the medical images of several patients after endovasular treatment. Results have been approved by our clinical specialists and our approach.We have tested our registration methods for the medical images of several patients after endovascular treatment. Results have been approved by our clinical specialists and our approach may appear in the intervention rooms in the futur.

Background: Little Canadian research exists which examines equitable access to public pharmaceutical insurance. In order to better understand issues related to access to publicly funded, universal prescription drug insurance in Canada, my thesis examines participation with (and therefore access to) the Fair PharmaCare program in BC. Specifically, my thesis: 1) describes methodologies that can be used to create area-level cultural variables for use with BC administrative data; and 2) studies the impact of household and area-level factors, particularly area-level cultural factors, on non-senior households’ registration for Fair PharmaCare in 2003. I hypothesized that the process of registration may act as a barrier to participation with Fair PharmaCare, particularly for households belonging to various culturally defined communities. Methods: Dissemination area (DA) level census data were obtained from Statistics Canada to create dichotomous, ecological variables which capture the collective ethnic composition, English language capacity and immigration status of residents within each DA. In turn, these variables were employed in multivariate, logistic regression analyses, which also included household-level measures of demographics, enabling resources and health status as well as area-level measures of income and health care resources. The outcome of interest was registration for Fair PharmaCare. Findings: Controlling for area-level income and health care resources, household-level demographics, enabling resources and health status, as well as area-level cultural factors, influenced households’ likelihood of registration for Fair PharmaCare. Households belonging to DAs with a high concentration of individuals reporting a Chinese or Punjabi ethnic background, or DAs that were ethnically homogeneous, regardless of the ethnic background, were more likely to register. In contrast households belonging to DAs consisting of a high concentration of recent immigrants or individuals belonging to ethnic minority groups that are underrepresented in BC were less likely to register. Conclusions: Considering the policy context surrounding the implementation of Fair PharmaCare, the findings from my thesis suggest that specific subpopulations within BC may face difficulties with the registration process, thereby reducing their participation in the program. Government interventions however, appear to have improved registration amongst other subpopulations. Consideration should be given to interventions that may reduce inequities in participation amongst other subgroups. / Medicine, Faculty of / Population and Public Health (SPPH), School of / Graduate

This thesis covers the development of a series of new methods and the application of adaptive filter theory which are combined to produce a generalised adaptive filter system which may be used to perform such tasks as pattern recognition. Firstly, the relevant background adaptive filter theory is discussed in Chapter 1 and methods and results which are important to the rest of the thesis are derived or referenced. Chapter 2 of this thesis covers the development of a new adaptive algorithm which is designed to give faster convergence than the LMS algorithm but unlike the Recursive Least Squares family of algorithms it does not require storage of a matrix with n2 elements, where n is the number of filter taps. In Chapter 3 a new extension of the LMS adaptive notch filter is derived and applied which gives an adaptive notch filter the ability to lock and track signals of varying pitch without sacrificing notch depth. This application of the LMS filter is of interest as it demonstrates a time varying filter solution to a stationary problem. The LMS filter is next extended to the multidimensional case which allows the application of LMS filters to image processing. The multidimensional filter is then applied to the problem of image registration and this new application of the LMS filter is shown to have significant advantages over current image registration methods. A consideration of the multidimensional LMS filter as a template matcher and pattern recogniser is given. In Chapter 5 a brief review of statistical pattern recognition is given, and in Chapter 6 a review of relevant connectionist models. In Chapter 7 the generalised adaptive filter is derived. This is an adaptive filter with the ability to model non-linear input-output relationships. The Volterra functional analysis of non-linear systems is given and this is combined with adaptive filter methods to give a generalised non-linear adaptive digital filter. This filter is then considered as a linear adaptive filter operating in a non-linearly extended vector space. This new filter is shown to have desirable properties as a pattern recognition system. The performance and properties of the new filter is compared with current connectionist models and results demonstrated in Chapter 8. In Chapter 9 further mathematical analysis of the networks leads to suggested methods to greatly reduce network complexity for a given problem by choosing suitable pattern classification indices and allowing it to define its own internal structure. In Chapter 10 robustness of the network to imperfections in its implementation is considered. Chapter 11 finishes the thesis with some conclusions and suggestions for future work.

This thesis deals with the descriptive analysis of entire process of the pharmaceutical industry's distribution and the verification of its effective functioning in the Czech Republic. The first part is focused on the definition of key terms and presents the theoretical basis for this thesis (specifics of pharma industry, history of pharmaceutics and pharma industry, actual situation and predictions of pharma industry). The second part is concerned the individual subjects of the distribution - pharmaceutical company, wholesaler and pharmacy.

Diploma thesis is focused on specifications in pharmaceutical business. It is based on knowledge of pharmacy and economy and their synthesis is describing the most significant differences in pharmacy business and other markets. Overall goal of diploma thesis was to create overview about pharmaceutical industry, its progress, trends and behavior of companies to this high risk and volatile market with keeping the rules and norms of Czech and European authorities. Target was also to form group of recommendations for companies participated in this market. To keep this target I described in the first part of diploma thesis basic terminology and theoretical knowledge about pharmaceutical market including research and development, marketing and sales and pharmakovigilance. Practical part was based on case studies specifying the most common and difficult problems and steps leading to their solutions. My personal contribution in diploma thesis is based on detailed and professional handling of the topic and in the choice of parametres which influence the most timing and capital demands of R&D projects in pharmacy and mitigation of their negative aspects.