Recent statistics have shown that Violence Against Women (VAW) affects one in three women worldwide. Not only is the issue prevalent at a global scale, it is embedded in the societal fabric of South Africa. Women and girls disproportionately experience public and private environments as unsafe due to the fear or threat of violence against them. Thus, limiting their movement, use and occupation of space. In essence, such instances of violence infringe upon a women’s human rights. In 1996, two years after South Africa became a democracy, it was necessary to manifest physically through architecture the symbolic significance of South Africa’s Constitution. An opportunity for architectural intervention is identified at the Constitution Hill Precinct. The aim is to make more visible and practical advocacy of women’s rights through establishing an association of the Precinct as a safe space for women. The study, through mixed qualitative methods, explores the feminist notion of safe space to understand safety, as both a practical and social construct, is integral to reflect the lived experiences of women. Design principles to guide the architectural intervention are subsequently synthetized from primarily theoretical informants, followed by conceptual, contextual and programmatic informants. The result is the translation of safe space into an architecture of lived experience; where the threat of fear or violence does not intimidate nor limit the occupation and use of space by women; but fosters spaces of empowerment, healing and upliftment. By programming underutilized in-between spaces along the East-West thoroughfare of the Precinct, through a transformative approach towards heritage, the advocacy for women’s rights is made visible and attains an association as a place where women are received and celebrated. Focus is placed on the Western edge of the Precinct to explore social and public programmes in support of women and the community at large. The existing parking lot structures, identified as lost space, are adapted to reflect an architectural intent of safe space and become spaces of meaning and contribution towards the Precinct. Finally, technical resolution of the project stems from the conceptual intentions of the design intervention; expressing a transformative approach between old and new. / Mini Dissertation (MArch (Prof))--University of Pretoria, 2020. / Architecture / MArch (Prof) / Unrestricted

Background: Sexual and Reproductive Health (SRH) is a cornerstone of overall health, particularly in fragile humanitarian contexts. Despite being recognized as a fundamental human right, access to quality SRH services is often significantly restricted in crisis situations. This limitation can lead to damaging health outcomes for women, children, and marginalized groups. Given this reality, there is an urgent need for an enriched understanding of SRH in area simpacted by conflicts, disasters, and population displacements. With global trends such as increasing forced migration and escalating crises, a thorough re evaluation of the challenges and potential solutions associated with SRH in these contexts is crucial. Aim: The aim of the integrative review is to describe the current status of sexual and reproductive health (SRH) services and interventions in humanitarian settings and explore key challenges in sexual and reproductive health services in these settings. Methodology: This integrative literature review analyzed and synthesized 22 research papers through inductive methodology by Elo and Kyngäs (2008). Results: This in-depth review of studies from a wide range of humanitarian environments worldwide, has unveiled critical insights into the hurdles surrounding Sexual and Reproductive Health (SRH) services. Firstly, barriers to accessibility and awareness prevent individuals from acquiring vital SRH knowledge and services, and this prevention is often intensified by sociocultural stigmas. Educational and language obstacles further amplify these challenges, particularly for migrants. This review also underscores the severe impact of gender-based violence (GBV) and early or forced marriages on SRH outcomes. Conclusions: This analysis reveals key obstacles that obstruct the provision of SRH services in humanitarian settings. Acknowledging these issues enables decision-makers to plan effectivestrategies and interventions to address the SRH needs in these settings. Exploration of each barrier and seeking holistic solutions to overcome these challenges is suggested.

The work for female empowerment is prominent on the Unguja island of Zanzibar. Governmental support and local and international organizations are investing in women to achieve gender equality. The government of Tanzania has added changes to the law to protect women and prevent gender-based violence, as well as strategic measures to assist the stakeholders of the Zanzibarian society. Simultaneously, the reports of gender-based violence (GBV) are increasing on the islands according to the Zanzibar Female Lawyer Association. The study explores the measures taken by the government to eliminate violence against women with a focus on the role of the man in these structural social and legal changes. The study also shows the challenges that the added laws have faced in practice, and the balance between culture and legal system in a society, when a change is to take place.

In 2022 Russia illegally invaded Ukraine starting a full-scale war against the country. The war has had severe humanitarian concerns for the civilian population, one of the consequences being increased levels of GBV and CRSV. This research paper analyzes the implications of GBV and the use of CRSV in the war against Ukraine, exploring vulnerable groups and pre-existing patriarchal structures affecting those exposed to the violence. The paper also explores challenges and ways to respond to these issues, providing recommendations to humanitarian and international actors supporting Ukraine in responding to these issues. This qualitative study is based on interviews with professionals working for humanitarian and international organizations in or with Ukraine in the fields of GBV, CRSV and gender providing knowledge on the situation on the ground and insights into local culture and norms, as well as secondary data. The conducted research shows that women and girls are a vulnerable group towards different forms of GBV, such as domestic violence and trafficking in times of war and peace, and CRSV, such as rape. Pre-existing patriarchal structures and traditional norms increases the threat towards women and girls being exposed to violence committed by men. It also indicates that the levels of GBV and CRSV, with violence in different forms such as domestic violence, trafficking, and rape, has increased since the escalation of the war, and that the rate of GBV will continue to increase after the war ends. Recommendations to humanitarian and international actors include working localized and focusing on the re-building of systems responding to GBV that existed prior to the war, promoting a survivor-centered approach in meeting survivors through training of staff, and raising awareness around GBV, CRSV, patriarchal structures and mental health to prevent violence against women and girls in the long-term.

Die vorliegende Habilitationsschrift befasst sich schwerpunktmäßig vor allem mit der Klinik und Therapie der Hepatitis C. Evaluiert wurden: 1. verschiedene therapeutische Strategien, 2. die Ursachen der "Non-Response" auf eine anti-virale Therapie sowie 3. die klinische Relevanz der neu entdeckten Hepatitis-assoziierten Viren und 4. ihre Bedeutung bei Patienten mit akuter bzw. chronischer Lebererkrankung unklarer Ätiologie sowie bei Patienten vor und nach Lebertransplantation. Ad 1. Aus dem Vergleich verschiedener Therapie-Konzepte wie der Kurzzeit- Kombinationstherapie, Triple-Therapie, Hochdosis-Interferon?-Therapie und der Anwendung antiviraler Substanzen wie Ribavirin und Amantadin ergaben sich neue Erkenntnisse hinsichtlich relevanter prognostischer Parameter für die Therapieresponse. Ad 2. Analysiert wurden die möglichen molekularen Mechanismen der Therapieresponse bzw. Non-Response sowie der Stellenwert von Interaktionen bestimmter HCV-Proteine (NS5A, E2, sogenannte PKR-eIF2a Phosphorylisations-Homologie-Domäne [PePHD]) mit den Interferon? induzierten Effektorproteinen. Es konnte gezeigt werden, daß die Anzahl der Mutationen innerhalb des NS5A Proteins einen prognostischen Parameter darstellen hinsichtlich der Response auf eine Interferon?-Therapie. Dagegen spielen Mutationen innerhalb der PePHD-Region keine Rolle. Ad 3. Aus den Untersuchungen zur klinischen Relevanz der neu entdeckten Hepatitis-assoziierten Viren GB Virus-C/Hepatitis G Virus (GBV-C/HGV) und TT-Virus (TTV) ergaben sich keine Hinweise bzgl. eines Einflusses von GBV-C/HGV bzw. TTV-Infektionen auf den Verlauf der chronischen Hepatitis C. Die durchgeführten Verlaufsuntersuchungen bei koinfizierten Patienten sprechen dafür, daß es sich um Interferon-sensitive Viren handelt; jedenfalls beeinflussen sie nicht die IFN?-induzierte Response. Ad 4. Untersucht wurden ferner die Prävalenz, Transmission und Relevanz der GBV-C/HGV und TTV-Infektion im Hinblick auf ihre Hepatitis-induzierenden Eigenschaften. Die Ergebnisse belegen, dass beide Viren parenteral übertragen werden, und dass sie eine hohe Prävalenz bei Patienten mit parenteralen Risikofaktoren besitzen. Eine Hepatitis-induzierende Potenz dieser Viren konnten wir nicht beobachten; bei der Mehrzahl aller chronisch infizierter Personen ließen sich keine Zeichen einer chronischen Hepatitis finden. / The major goal of this thesis is the analysis of the clinical outcome of patients with Hepatitis C virus (HCV) infection and the response to therapy. Analysed were 1. different types of therapeutic strategies 2. causes responsible for ineffective antiviral therapy (non-response) 3. clinical relevance of the newly discovered hepatitis-associated viruses and 4. the role of these viruses in patients with acute or chronic hepatitis of unknown causes and in those receiving liver grafts. Ad 1. Compared were different therapeutic concepts such as short-term combination therapy, triple-therapy, high dose IFN?-therapy and the use of antiviral substances such as ribavirin and amantadine. It emerged that relevant prognostic parameters can be deduced with respect to the therapeutic response rate. Ad 2. Analysed were possible molecular mechanisms, which may interfere with response or non-response to antiviral therapy. In this respect, we focussed on the interaction of certain HCV-proteins as NS5A, E2, so-called PKR-eIF2a phosphorylisation-homology-domain (PePHD). with the interferon-?-induced effector proteins. There is evidence, that number of mutations within the NS5A proteins are of prognostic relevance with respect to the response to interferon?-therapy. In contrast, mutations within the PePHD-region do not play any role in this respect. Ad 3. We also studied the clinical relevance of the newly discovered viruses GBV-C/HGV and TTV, and found, that they have no impact concerning the course of chronic hepatitis C. These viruses are interferon-sensitive and do not influence the IFNa-response as it could be documented by following the course of co-infected patients. Ad 4. Our studies also focused on the prevalence, transmission and relevance of GBV-C/HGV and TTV infections with respect to their role as hepatitis-inducing agents. We can show that both virus types are parenterally transmitted. There is a high prevalence for both types in patients confronted with risk factors for parenteral factors. From analysis of many patients being chronically infected with these viruses it became quite clear that they lack any important potency to provoke chronic liver disease.

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