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Neuroblastoma (NB) is a childhood cancer with a highly complex nature. High-risk NB patients undergo intensive treatment regimens that are often followed by long-term side effects. This, in addition to the emergence of resistant cancer cells, highlights a need for novel therapeutic targets and treatment strategies to improve outcome in NB. P21 is a cyclin-dependent kinase inhibitor considered to play a role in tumor resistance and aggressiveness due to its involvement in cell cycle and/or apoptosis. This project aimed to explore the expression of endogenous p21 in high-risk NB cell lines and whether p21 could be a therapeutic target for high-risk NB. Endogenous p21 levels were investigated using RT-qPCR and quantitative immunocytochemistry in eight high-risk NB cell lines. A small molecular inhibitor of p21, UC2288, was used in these cell lines to investigate tumour cell viability following p21 inhibition. In addition, combination treatment with UC2288 and the chemotherapy drug cisplatin was performed on resistant NB cell lines. Our results show variable expression of p21, where cell lines with high endogenous p21 expression showed sensitivity to single agent treatment with cisplatin or UC2288. Moreover, resistant NB cell lines showed lower endogenous p21 expression, however, combination treatment with UC2288 and cisplatin showed reduced viability, indicating sensitivity to combination treatment. This project highlights the potential of using p21 as a therapeutic target as well as a predictive biomarker in high-risk NB.

<p>The aim of this research study was to examine the clinical, behavioural and neurobiological characteristics of children who are considered to be at increased risk for developing anxiety disorders. The study population included high-risk children who have at least one parent with social phobia and normal-risk control subjects. The first objective of the study was to examine the prevalence of anxiety disorders in high-risk children. We determined the proportion of high-risk children who met criteria for a psychiatric disorder using structured clinical interviews and assessed symptom severity using measures of anxiety and depression. We found the prevalence of anxiety disorders to be elevated in high-risk children with 77% meeting criteria for a lifetime psychiatric disorder. High-risk subjects also had significantly higher levels of anxiety symptoms relative to normal-risk subjects. The second objective of the study was to examine threat-related attention processing in high-risk and normal-risk children using the dot-probe attention orienting task. We compared probe detection reaction times of high-risk children and normal-risk control children when they were exposed to emotional facial stimuli. We did not find any significant within-group or between-group differences in reaction times in our high-risk and normal-risk subjects. However, we did observe a trend towards longer reaction times in high-risk subjects for all trial types relative to normal-risk subjects, which could indicate general processing deficits in the high-risk group. The third objective of this study was to examine the activity of emotion processing brain regions using functional magnetic resonance imaging (<em>f</em>MRI) in children who are at increased risk for developing anxiety disorders. We compared the blood oxygenation level dependant (BOLD) response while high-risk and normal-risk subjects were engaged in the dot probe attention orienting task. Using <em>f</em>MRI, the BOLD response was measured while subjects were exposed to masked emotional (angry, happy or neutral) facial stimuli. We found increased activation of several frontal, temporal and limbic regions in high-risk subjects relative to normal-risk subjects during the presentation of emotional facial stimuli. These regions included the prefrontal cortex, anterior cingulate, hippocampus, insula, basal ganglia and temporal regions. To our knowledge this is the first study to characterize a sample of children at-risk for anxiety disorders using clinical, behavioural and neuroimaging data. The findings from this study demonstrate that high-risk children experience heightened anxiety symptoms and that they also present with functional abnormalities of brain regions involved in emotion processing. These results highlight the need for early identification and intervention for children at-risk for anxiety disorders. Future studies should aim for longitudinal study designs combined with neuroimaging techniques to examine changes in anxiety symptoms over time and to study the effects of treatment on the function of limbic and prefrontal structures in children at-risk for anxiety disorders.</p> / Doctor of Philosophy (PhD)

From a positive psychology perspective, the last few decades have seen continuous growth in research emphasising well-being in school communities. Schools should be viewed as spaces that enable life success, as opposed to mere learning environments aimed at academic success. Well-being is often associated with relational well-being and building, enhancing and maintaining positive relationships at schools. Along with academic performance, relational well-being is vital to learners‟ current and future development. Such social well-being may, in turn, affect psychological well-being positively, as these two influence each other greatly. In this context, positive educator-learner relationships must be based on mutual respect, as it may provide a vast array of benefits to secondary learners‟ well-being and academic performance. Moreover, positive interpersonal connections between educators and learners based on mutual respect are valuable tools for managing effective discipline in classrooms, which means that educators also benefit from protecting and promoting good relationships with their learners. Positive educator-learner relationships are highly relevant for secondary school learners living in high-risk communities, where support and resources for enhancing and developing their psychosocial well-being are limited. For such leaners school is often the only safe and supportive environment they have. It is therefore imperative to bring the personal into the educational environment by building, enhancing and maintaining respectful educator-learner relationships based on mutual respect. However, educator-learner relationships have specifically been neglected in regard to learners‟ perceptions of respect as experienced from and given to educators. Due to the identified gap in the literature, the main aim of this study was to qualitatively explore and describe, through qualitative, phenomenological research design, learners‟ perceptions of respect in educator-learner relationships in a secondary school community within a high-risk environment in the South African context. The participants for this study were fifteen secondary school Grade 12 learners. The data were gathered in two phases, namely written assignments, and, the World Café technique was applied. Thematic analysis was used to identify relevant themes. The findings revealed three main themes, and each theme includes several subthemes. Firstly, respect is well-intended behaviour, with the subthemes being listening and paying attention; good communication; obeying educators and school rules; good manners such as being helpful, polite and kind, and greeting others; saying thank you and please; academic responsibility; and receiving support and praise from educators. Secondly, respect is positive relationships, with the subthemes being building a relationship; parent-child relationship; as well as trust and confidentiality. Thirdly, respect is consistent, fair and mutual, with the subthemes being respect as a two-way street; respect as something to be earned; respect as something that is consistent over time; and respect that means treating everyone equally, fairly and with acceptance. It can be summarised that all participants‟ responses illustrated a collective yet subjective learners‟ perceptions of respect in educator-learner relationships in a secondary school community within a high risk community in South Africa. For further research it was recommended to gain better understanding how learners in secondary school communities perceive respect in educator-learner relationships in regard to various cultures. / MA (Psychology), North-West University, Potchefstroom Campus, 2015

From a positive psychology perspective, the last few decades have seen continuous growth in research emphasising well-being in school communities. Schools should be viewed as spaces that enable life success, as opposed to mere learning environments aimed at academic success. Well-being is often associated with relational well-being and building, enhancing and maintaining positive relationships at schools. Along with academic performance, relational well-being is vital to learners‟ current and future development. Such social well-being may, in turn, affect psychological well-being positively, as these two influence each other greatly. In this context, positive educator-learner relationships must be based on mutual respect, as it may provide a vast array of benefits to secondary learners‟ well-being and academic performance. Moreover, positive interpersonal connections between educators and learners based on mutual respect are valuable tools for managing effective discipline in classrooms, which means that educators also benefit from protecting and promoting good relationships with their learners. Positive educator-learner relationships are highly relevant for secondary school learners living in high-risk communities, where support and resources for enhancing and developing their psychosocial well-being are limited. For such leaners school is often the only safe and supportive environment they have. It is therefore imperative to bring the personal into the educational environment by building, enhancing and maintaining respectful educator-learner relationships based on mutual respect. However, educator-learner relationships have specifically been neglected in regard to learners‟ perceptions of respect as experienced from and given to educators. Due to the identified gap in the literature, the main aim of this study was to qualitatively explore and describe, through qualitative, phenomenological research design, learners‟ perceptions of respect in educator-learner relationships in a secondary school community within a high-risk environment in the South African context. The participants for this study were fifteen secondary school Grade 12 learners. The data were gathered in two phases, namely written assignments, and, the World Café technique was applied. Thematic analysis was used to identify relevant themes. The findings revealed three main themes, and each theme includes several subthemes. Firstly, respect is well-intended behaviour, with the subthemes being listening and paying attention; good communication; obeying educators and school rules; good manners such as being helpful, polite and kind, and greeting others; saying thank you and please; academic responsibility; and receiving support and praise from educators. Secondly, respect is positive relationships, with the subthemes being building a relationship; parent-child relationship; as well as trust and confidentiality. Thirdly, respect is consistent, fair and mutual, with the subthemes being respect as a two-way street; respect as something to be earned; respect as something that is consistent over time; and respect that means treating everyone equally, fairly and with acceptance. It can be summarised that all participants‟ responses illustrated a collective yet subjective learners‟ perceptions of respect in educator-learner relationships in a secondary school community within a high risk community in South Africa. For further research it was recommended to gain better understanding how learners in secondary school communities perceive respect in educator-learner relationships in regard to various cultures. / MA (Psychology), North-West University, Potchefstroom Campus, 2015

Purpose: The primary objective of this study was to estimate the prevalence of vaccination and HBV infection status of adults and to evaluate the trend in self reported vaccination and seroprevalence for Hepatitis B for this population. Additionally, this study sought to assess the association between vaccination rates, seroprevalence (HBsAg, anti-HBc, and anti-HBs), demographic (age, gender, location of birth, race/ethnicity), and socioeconomic (annual household income, education level, insurance coverage and access to care, marital status) characteristics. Methods: Eight years, 1999-2006, of the National Health and Nutrition Examination Survey (NHANES) data were used. NHANES participants aged 20-59 years who contributed data via the household interview and laboratory component were eligible for this study. Two sources of vaccination status were available. The vaccination status was identified through self-report. Those who answered yes to “less than three doses” and “at least three doses” were classified as vaccinated. Vaccination status was also verified through serologic markers. All analyses were weighted to consider the complex weighting scheme and adjusted to the 2000 US census population. Vaccination rates were calculated for both low and high risk populations. 95% confidence intervals (95% CI) of each estimate were also calculated. The association between potential predictors of vaccination (demographic variables, socioeconomic status, high risk, and health care access and utilization variables) and vaccination status was assessed using bivariate analysis. We used logistic regression model to obtain odds ratios and their 95% confidence intervals for the association between predictor variables and vaccination status after adjusting for all potential confounding factors. Results: Vaccinated adults were more likely to be female, younger (20-29), Non-Hispanic white, married, born in the United States, have some education beyond high school, have a household income greater than $20000, health insurance coverage, a source of usual medical care, report a health status of good or higher, be non-smokers, and have no history of alcohol abuse. High risk adults comprised about 16% of adults who had received at least one dose of the Hepatitis B vaccine. Unvaccinated adults were more likely to be male, over the age of 40, Non-Hispanic white, born in the United States, married, have some education beyond high school, have a household income greater than $20,000, live in a household of 6 or fewer people, have health insurance coverage, and a source of usual care. When comparing the self reported vaccination status with serologic status, almost half of the adults who reported receiving all three doses of the vaccine tested negative for immunity. For all adults the prevalence increased from 23.4% to 39.1%. Compared to adults in 1999-2000, adults were twice as likely to report vaccination in 2005-2006 (OR=2.1 95% CI [1.77, 2.49]). Conclusions: Although, hepatitis B vaccination rates are rising, only 32% of high risk adults are vaccinated. The rise in vaccination rates in young adults is mostly related to childhood immunization strategies and not strategies aimed at adults. Older males, those with less than high school education, without health insurance coverage and a source of usual care were least likely to be vaccinated. More targeted interventions are needed to educate and vaccinate the adult population and to create a means for identifying those at risk and those already vaccinated.

A pré-eclâmpsia afeta 3 a 5% das gestantes em todo o mundo, contribuindo para complicações materno-fetais graves. Sendo a isquemia placentária considerada um dos fatores primordiais para o desenvolvimento da doença. Essa isquemia está associada à alterações de fatores pró e anti angiogênicos, o presente estudo avaliou os fatores pró angiogênicos angiopoetina 1 e 2 (Ang-1 e Ang-2), que atuam na formação e no crescimento de novos vasos durante a placentação. O objetivo do estudo foi avaliar as concentrações plasmática de Ang-1 e Ang-2 na predição de pré-eclâmpsia e verificar a sensibilidade e especificidade dos mesmos por meio da curva ROC. Foram avaliadas 120 gestantes com idade gestacional entre 20 e 25 semanas, que participaram do projeto Coortes BRISA, que contava com um banco de 1400 gestantes, sendo que 30 gestantes com diagnóstico de pré-eclâmpsia (PE) e que realizaram o parto no Hospital das Clínicas de Ribeirão Preto e 90 gestantes saudáveis (GS) que realizaram parto na MATER ( Maternidade do Centro de Referência da saúde da Mulher). As concentrações plasmáticas de Ang-1 e de Ang- 2 foram determinadas utilizando o método ELISA. Para a análise dos dados, foi realizado ANOVA quando comparamos os grupos quanto às variáveis quantitativas. Para as comparações dos níveis pressóricos das gestantes com pré-eclâmpsia grave x pré-eclâmpsia não grave, no momento do recrutamento e com a doença estabelecida, foi utilizado o modelo de regressão linear com efeitos mistos (efeitos aleatórios e fixos). Para as comparações dos dados foi utilizado o pós-teste por contrastes ortogonais. Na comparação das concentrações de Ang-1 entre GS e PE não houve diferença estatística entre os grupos (P= 0,185) o mesmo foi observado para Ang-2 (P= 0,583). Em relação à razão Ang-1/Ang-2, também não observamos diferença estatística (P= 0,107). A capacidade preditiva dos biomarcadores foi avaliada através da curva ROC e a área sobre a curva para Ang-1, Ang-2 e a razão Ang-1/Ang-2 foram 0,47, 0,52 e 0,57 respectivamente. Nosso estudo não encontrou diferença significativa nas concentrações de Ang-1 E Ang-2 e nem na razão entre Ang-1/Ang-2. Ao realizar a curva ROC observamos, que esses biomarcadores não são bons preditores para pré-eclâmpsia. / Preeclampsia affects 3 to 5% of pregnant women worldwide, contributing to severe maternal-fetal complications. As placental ischemia, a set of primordial factors for the development of the disease was proposed. This ischemia is associated with changes in pro and anti-angiogenic functions, the present study is angiography and angiopoietin 1 and 2 (Ang-1 and Ang-2), which act in the formation and growth of new vessels during placentation. The evaluation of the evaluation of Angio-1 and Ang-2 in the prediction of pre-eclampsia and to verify their sensitivity and specificity by means of the ROC curve. There were 20 pregnant women with gestational age between 20 and 25 weeks, who participated in the BRISA Cohorts project, which had a bank of 1400 pregnant women, 30 pregnant women diagnosed with preeclampsia (PE) and who gave birth at Hospital das Clínicas of Ribeirão Preto and 90 healthy pregnant women (GS) who performed part of MATER (Maternity of the Reference Center for Women\'s Health). Plasma Ang-1 and Ang-2 tests were already using the ELISA method. For an analysis of the data, we performed ANOVA when comparing the groups as the quantitative variables. For the comparisons of pressure levels of pregnant women with severe preeclampsia vs. non-severe preeclampsia at the moment of recruitment and with the disease installed, the linear regression model with mixed effects (random and fixed lexus) was used. For the data comparisons, the orthogonal contrasts post-test was used. When comparing the Ang-1 combinations between GS and PE, it was not possible to compare the groups (P = 0.185). The same was observed for Ang-2 (P = 0.583). In relation to the Ang-1 / Ang-2 ratio, we also did not observe the statistical difference (P = 0.107). The ability to distribute the biomarkers was evaluated through the ROC curve and the area over the curve for Ang-1, Ang-2 and the Ang-1 / Ang-2 ratio were 0.47, 0.52 and 0.57 respectively. Our needs were not as significant at Ang-1 and Ang-2 concentrations nor at the Ang-1 / Ang-2 ratio. When performing a ROC curve we observed that these biomarkers are not good predictors of preeclampsia.

A gestação é um período marcado por diversas transformações na vida da mulher e envolve aspectos sociais, biológicos, conjugais e psicológicos. No entanto, a maneira como cada gestante reage varia de acordo com as circunstâncias em que ocorreu a gravidez. Todos esses fatores são agravados na gestação de risco. O suporte social tem sido considerado como importante fator de proteção às adversidades desse período. Avaliar e considerar aspectos sociais e psicológicos se destaca como uma forma de contribuir para a melhoria da qualidade de vida da gestante. O objetivo deste estudo foi realizar uma caracterização psicossocial de 66 gestantes de alto risco, diabéticas em acompanhamento pré-natal, quanto aos aspectos sociodemográficos e psicológicos e buscar possíveis associações estatísticas entre tais aspectos. Quanto aos aspectos psicológicos, foram avaliados níveis de ansiedade, depressão, estresse e suporte social referido. Como resultados, pode-se constatar que 57,57% das pacientes avaliadas tinham idade entre 26 e 35 anos, 60,60% tinham de nove a onze anos de estudo e 92,42% tinham um companheiro. Dentre as pacientes, 4,55% tinham diabetes mellitus tipo 1, 33,33% tinham diabetes mellitus tipo 2 e 62,12% tinham diabetes mellitus gestacional. As pacientes avaliaram sua gravidez como planejada em 51,51% da amostra. Com relação a aspectos psicológicos, 36,36% das pacientes apresentaram sintomas significativos de ansiedade e depressão e a média da pontuação para o estresse foi de 24,24, em uma escala de até 56 pontos. Na amostra, 48,48% das pacientes referiram ter atividades de lazer em sua rotina e 93,94% apresentam uma boa percepção do apoio familiar. Foram encontradas associações entre número de gestações e depressão, sendo que dentre as pacientes que apresentaram sintomas depressivos, 50% delas estavam na segunda gestação. Não foram encontradas associações estatísticas entre idade, nível socioeconômico, escolaridade, planejamento da gravidez com sintomas de ansiedade e depressão. Pacientes que apresentaram maiores níveis de ansiedade e depressão apresentaram mais sintomas de estresse e menores níveis de suporte social. Ampliar o conhecimento sobre variáveis psicológicas no ciclo gravídico-puerperal possibilitará a estruturação de intervenções psicológicas específicas a este período tão particular. / Pregnancy is a period marked by several changes in women\'s lives and involves social, biological, psychological and marital aspects. However, the way each woman reacts varies according to the circumstances in which the pregnancy occurred. All these factors are worsen in high-risk pregnancies. Social support has been considered an important protective factor for the adversities of that period. Evaluating and considering social and psychological aspects stand out as a way to contribute to the improvement of the pregnant womans quality of life. The aim of this study was to make a psychosocial characterization of 66 high-risk diabetic pregnant women, in prenatal care, in terms of socio-demographic and psychological aspects, and search for possible statistical associations between these aspects. Concerning psychological aspects, levels of anxiety, depression, stress and related social support were evaluated. In the results, it can be seen that 57.57% of the patients evaluated were aged between 26 and 35 years, 60.60% had between nine to eleven years of study and 92.42% had a partner. Among the patients, 4.55% had diabetes mellitus type 1, 33.33% had diabetes mellitus type 2 and 62.12% had gestational diabetes mellitus. The patients rated their pregnancy as planned in 51.51% of the sample. Regarding psychological aspects, 36.36% of the patients had significant symptoms of anxiety and depression and the average score for stress was 24.24 out of a 56 points scale. In the sample, 48.48% of the patients reported having leisure activities routine and 93.94% have a good perception of family support. It was found associations between number of pregnancies and depression, whereas among patients with depressive symptoms, 50% were in their second pregnancy. There were no statistical associations between age, socioeconomic status, education and pregnancy planning with symptoms of anxiety and depression. Patients who had higher levels of anxiety and depression showed more symptoms of stress and lower levels of social support. Increasing the knowledge of psychological variables in pregnancy and childbirth will enable the structuring of specific psychological interventions to such a particular period.

A pré-eclâmpsia afeta 3 a 5% das gestantes em todo o mundo, contribuindo para complicações materno-fetais graves. Sendo a isquemia placentária considerada um dos fatores primordiais para o desenvolvimento da doença. Essa isquemia está associada à alterações de fatores pró e anti angiogênicos, o presente estudo avaliou os fatores pró angiogênicos angiopoetina 1 e 2 (Ang-1 e Ang-2), que atuam na formação e no crescimento de novos vasos durante a placentação. O objetivo do estudo foi avaliar as concentrações plasmática de Ang-1 e Ang-2 na predição de pré-eclâmpsia e verificar a sensibilidade e especificidade dos mesmos por meio da curva ROC. Foram avaliadas 120 gestantes com idade gestacional entre 20 e 25 semanas, que participaram do projeto Coortes BRISA, que contava com um banco de 1400 gestantes, sendo que 30 gestantes com diagnóstico de pré-eclâmpsia (PE) e que realizaram o parto no Hospital das Clínicas de Ribeirão Preto e 90 gestantes saudáveis (GS) que realizaram parto na MATER ( Maternidade do Centro de Referência da saúde da Mulher). As concentrações plasmáticas de Ang-1 e de Ang- 2 foram determinadas utilizando o método ELISA. Para a análise dos dados, foi realizado ANOVA quando comparamos os grupos quanto às variáveis quantitativas. Para as comparações dos níveis pressóricos das gestantes com pré-eclâmpsia grave x pré-eclâmpsia não grave, no momento do recrutamento e com a doença estabelecida, foi utilizado o modelo de regressão linear com efeitos mistos (efeitos aleatórios e fixos). Para as comparações dos dados foi utilizado o pós-teste por contrastes ortogonais. Na comparação das concentrações de Ang-1 entre GS e PE não houve diferença estatística entre os grupos (P= 0,185) o mesmo foi observado para Ang-2 (P= 0,583). Em relação à razão Ang-1/Ang-2, também não observamos diferença estatística (P= 0,107). A capacidade preditiva dos biomarcadores foi avaliada através da curva ROC e a área sobre a curva para Ang-1, Ang-2 e a razão Ang-1/Ang-2 foram 0,47, 0,52 e 0,57 respectivamente. Nosso estudo não encontrou diferença significativa nas concentrações de Ang-1 E Ang-2 e nem na razão entre Ang-1/Ang-2. Ao realizar a curva ROC observamos, que esses biomarcadores não são bons preditores para pré-eclâmpsia. / Preeclampsia affects 3 to 5% of pregnant women worldwide, contributing to severe maternal-fetal complications. As placental ischemia, a set of primordial factors for the development of the disease was proposed. This ischemia is associated with changes in pro and anti-angiogenic functions, the present study is angiography and angiopoietin 1 and 2 (Ang-1 and Ang-2), which act in the formation and growth of new vessels during placentation. The evaluation of the evaluation of Angio-1 and Ang-2 in the prediction of pre-eclampsia and to verify their sensitivity and specificity by means of the ROC curve. There were 20 pregnant women with gestational age between 20 and 25 weeks, who participated in the BRISA Cohorts project, which had a bank of 1400 pregnant women, 30 pregnant women diagnosed with preeclampsia (PE) and who gave birth at Hospital das Clínicas of Ribeirão Preto and 90 healthy pregnant women (GS) who performed part of MATER (Maternity of the Reference Center for Women\'s Health). Plasma Ang-1 and Ang-2 tests were already using the ELISA method. For an analysis of the data, we performed ANOVA when comparing the groups as the quantitative variables. For the comparisons of pressure levels of pregnant women with severe preeclampsia vs. non-severe preeclampsia at the moment of recruitment and with the disease installed, the linear regression model with mixed effects (random and fixed lexus) was used. For the data comparisons, the orthogonal contrasts post-test was used. When comparing the Ang-1 combinations between GS and PE, it was not possible to compare the groups (P = 0.185). The same was observed for Ang-2 (P = 0.583). In relation to the Ang-1 / Ang-2 ratio, we also did not observe the statistical difference (P = 0.107). The ability to distribute the biomarkers was evaluated through the ROC curve and the area over the curve for Ang-1, Ang-2 and the Ang-1 / Ang-2 ratio were 0.47, 0.52 and 0.57 respectively. Our needs were not as significant at Ang-1 and Ang-2 concentrations nor at the Ang-1 / Ang-2 ratio. When performing a ROC curve we observed that these biomarkers are not good predictors of preeclampsia.

Submitted by Suzana Dias (suzana.dias@famerp.br) on 2018-11-06T15:55:11Z No. of bitstreams: 1 MarianaAlvesPorto_dissert.pdf: 1070764 bytes, checksum: 7919d343ffed842594579b5a0bca49ee (MD5) / Made available in DSpace on 2018-11-06T15:55:11Z (GMT). No. of bitstreams: 1 MarianaAlvesPorto_dissert.pdf: 1070764 bytes, checksum: 7919d343ffed842594579b5a0bca49ee (MD5) Previous issue date: 2018-03-20 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / The Program of Qualified Hospital Discharge, composed by a multidisciplinary team, aims to evaluate and identify the social, physical and psychological needs of pregnant women those are high risk and are hospitalized, in order to these women would contact the Health Care Network in the moment of their hospital discharge, to prevent new complications with the patients under discussion. The goal of this present study was outline the sociodemographic profile, lifestyle and personality, as well as, to understand the experiences of women included in this program. Data collection involved the surveys: sociodemographic, “Fantastic” Lifestyle, Personal Beliefs (PBQ – SF) and comprehensive interview. The quantitative data were submitted to descriptive analysis, while the qualitative data were analyzed in the phenomenological modality. The sample included 13 hospitalized risk pregnant women, with average age of 24 years. Among them, mostly are in stable union, completed high school, have a religious belief and declare themselves as housewives. The multiparity is present in 61.5% (N=8) and 61.5% did not have an abortion history before. The majority showed a good lifestyle and the personality profiles those are more common are: schizoid, avoidant and dependent. In relation to the experiences, five categories emerged: Fear, Concern, Faith as a confrontation appeal, importance of the social support and professional-patient relationship. The study is relevant, since the demand comprehension of the assisted population provides subsidies to the assistance adjustment and the elaboration of a more reliable therapeutic plan. / O Programa da Alta Hospitalar Qualificada, realizado por equipe multidisciplinar, tem por objetivo avaliar e identificar as necessidades sociais, físicas e psicológicas de gestantes de alto risco hospitalizadas, para que no momento de sua alta hospitalar, possa contatar com a Rede de Assistência à Saúde e ações preventivas a novas intercorrências com a paciente em questão. O objetivo do estudo foi delinear o perfil sociodemográfico, estilo de vida e personalidade, bem como compreender as vivências de mulheres inseridas no programa de alta qualificada do Hospital da Criança e Maternidade (HCM) de São José do Rio Preto. Para coleta dos dados foram utilizados os questionários: sociodemográfico, Estilo de Vida “Fantástico”, Crenças Pessoais (PBQ – SF) e entrevista compreensiva. Os dados quantitativos foram submetidos à análise descritiva, enquanto os qualitativos, analisados na modalidade fenomenológica. A amostra incluiu 13 gestantes de risco hospitalizadas, com a média de idade de 24 anos (desvio padrão 5,1). A maioria se encontra em união estável, possui ensino médio, crença religiosa e se autodeclara do lar. A multiparidade está presente em aproximadamente 61,5% (N=8) e 61,5% (N=8) não tiveram histórico de aborto anterior. A maioria apresentou um bom estilo de vida e os perfis de personalidade que se sobressaíram foram: esquizoide, evitativa e dependente. Quanto às vivências, emergiram cinco categorias: Medo; Preocupação; Fé como recurso de enfretamento; Importância do suporte social e Relação profissional-paciente. Os dados são relevantes, pois a compreensão da demanda da população atendida propicia subsídios para adequação do atendimento e elaboração de um plano terapêutico mais adequado às necessidades das pacientes.